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Regulation of proteasome assembly and activity in health and disease

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Drugging the undruggables: exploring the ubiquitin system for drug development

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Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis

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Regulation of hippocampal synaptic plasticity by BDNF

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VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling

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Natural alleles of a proteasome α2 subunit gene contribute to thermotolerance and adaptation of African rice

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The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution

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Design and operation of the National Survey of Children with Special Health Care Needs, 2001.

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Functional Modules of the Proteostasis NetworkPreprint

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Dynamic Regulation of the 26S Proteasome: From Synthesis to Degradation

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Targeted Intracellular Delivery of Antibodies: The State of the Art

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Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis.

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Ubiquitin recognition by the proteasome

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FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation

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Autophagic Turnover of Inactive 26S Proteasomes in Yeast Is Directed by the Ubiquitin Receptor Cue5 and the Hsp42 Chaperone

Marshall, R. S., McLoughlin, F., & Vierstra, R. D. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.015 · Cited by 145 · see citing works

Degrons in cancer

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The Proteasome in Modern Drug Discovery: Second Life of a Highly Valuable Drug Target

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SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma

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Characterization of Fully Recombinant Human 20S and 20S-PA200 Proteasome Complexes

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Blockade of deubiquitylating enzyme Rpn11 triggers apoptosis in multiple myeloma cells and overcomes bortezomib resistance

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De novo disruption of the proteasome regulatory subunit PSMD12 causes a syndromic neurodevelopmental disorder

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The Proteasome Stress Regulon Is Controlled by a Pair of NAC Transcription Factors in Arabidopsis

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The Proteasome and Oxidative Stress in Alzheimer's Disease

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The dialogue between the ubiquitin-proteasome system and autophagy: Implications in ageing

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The biological functions of Naa10 — From amino-terminal acetylation to human disease

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Ubiquitin‐conjugated degradation of golden 2‐like transcription factor is mediated by CUL 4‐ DDB 1‐based E 3 ligase complex in tomato

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Recent advances in SCF ubiquitin ligase complex: Clinical implications

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Molecular mechanisms in multiple myeloma drug resistance

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Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis

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Cytoplasmic translocation, aggregation, and cleavage of TDP-43 by enteroviral proteases modulate viral pathogenesis

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Contribution of the Unfolded Protein Response (UPR) to the Pathogenesis of Proteasome-Associated Autoinflammatory Syndromes (PRAAS)

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The 26S proteasome is a multifaceted target for anti-cancer therapies

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Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis

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Targeting proteasome ubiquitin receptor Rpn13 in multiple myeloma

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NMR Studies of Large Proteins

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ERAD and how viruses exploit it

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Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome

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Isoform‐resolved correlation analysis between mRNA abundance regulation and protein level degradation

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Regulation of Toll-like Receptor-Mediated Sestrin2 Induction by AP-1, Nrf2, and the Ubiquitin-Proteasome System in Macrophages

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Cryo-EM structures of the archaeal PAN-proteasome reveal an around-the-ring ATPase cycle

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Synthetic Uncleavable Ubiquitinated Proteins Dissect Proteasome Deubiquitination and Degradation, and Highlight Distinctive Fate of Tetraubiquitin

Singh, S. K., Sahu, I., Mali, S. M., Hemantha, H. P., Kleifeld, O., Glickman, M. H., & Brik, A. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b09611 · Cited by 64 · see citing works

High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx

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Targeting proteasomes in infectious organisms to combat disease

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Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling

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A single MIU motif of MINDY‐1 recognizes K48‐linked polyubiquitin chains

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Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme

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CRISPR Genome-Wide Screening Identifies Dependence on the Proteasome Subunit PSMC6 for Bortezomib Sensitivity in Multiple Myeloma

Shi, C.-X., Kortüm, K. M., Zhu, Y. X., Bruins, L. A., Jedlowski, P. M., Votruba, P. G., Luo, M., Stewart, R. A., Ahmann, J. M., Braggio, E., et al. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0130 · Cited by 61 · see citing works

Rhus coriaria increases protein ubiquitination, proteasomal degradation and triggers non-canonical Beclin-1-independent autophagy and apoptotic cell death in colon cancer cells

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Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core

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ATP binding to neighbouring subunits and intersubunit allosteric coupling underlie proteasomal ATPase function

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Macromolecular Degradation Systems and Cardiovascular Aging

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DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks

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Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies

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A modular degron library for synthetic circuits in mammalian cells

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The role of K63-linked polyubiquitin in several types of autophagy

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Proteasome‐mediated proteostasis: Novel medicinal and pharmacological strategies for diseases

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Chaperone-mediated 26S Proteasome Remodeling Facilitates Free K63 Ubiquitin Chain Production and Aggresome Clearance

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20S proteasome from Archaeoglobus fulgidus

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Protein and Mitochondria Quality Control Mechanisms and Cardiac Aging

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Disassembly of Lys11 and Mixed Linkage Polyubiquitin Conjugates Provides Insights into Function of Proteasomal Deubiquitinases Rpn11 and Ubp6

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Iruka Eliminates Dysfunctional Argonaute by Selective Ubiquitination of Its Empty State

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Regulation of 26S Proteasome Activity in Pulmonary Fibrosis

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Prion degradation pathways: Potential for therapeutic intervention

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The ribosome-bound quality control complex: from aberrant peptide clearance to proteostasis maintenance

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Hydrogen sulfide regulates muscle RING finger‐1 protein S‐sulfhydration at Cys 44 to prevent cardiac structural damage in diabetic cardiomyopathy

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Development and Application of a Sensitive Peptide Reporter to Discover 20S Proteasome Stimulators

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Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit

Chojnacki, M., Mansour, W., Hameed, D. S., Singh, R. K., Oualid, F. E., Rosenzweig, R., Nakasone, M. A., Yu, Z., Glaser, F., Kay, L. E., et al. (2017) · Cell chemical biology · doi:10.1016/j.chembiol.2017.02.013 · Cited by 44 · see citing works

ER-Resident Transcription Factor Nrf1 Regulates Proteasome Expression and Beyond

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Regulation of PERK expression by FOXO3: a vulnerability of drug-resistant cancer cells

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Schistosoma haematobium Extracellular Vesicle Proteins Confer Protection in a Heterologous Model of Schistosomiasis

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Proteasome Activation to Combat Proteotoxicity

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<i>PSMD12</i> haploinsufficiency in a neurodevelopmental disorder with autistic features

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Bacterial Proteasome Activator Bpa (Rv3780) Is a Novel Ring-Shaped Interactor of the Mycobacterial Proteasome

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The where, what, and when of membrane protein degradation in neurons

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Diminished stress resistance and defective adaptive homeostasis in age-related diseases

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The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni

Bibo‐Verdugo, B., Wang, S. C., Almaliti, J., Ta, A. P., Jiang, Z., Wong, D. A., Lietz, C. B., Suzuki, B. M., El‐Sakkary, N., HOOK, V. Y. H., et al. (2019) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.9b00237 · Cited by 37 · see citing works

Targeting STAT3 by HO3867 induces apoptosis in ovarian clear cell carcinoma

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The benefits of local depletion: The centrosome as a scaffold for ubiquitin-proteasome-mediated degradation

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Functional characterization of EI24-induced autophagy in the degradation of RING-domain E3 ligases

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Lipopolysaccharide modulates p300 and Sirt1 to promote PRMT1 stability via an SCFFbxl17-recognized acetyldegron

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USP8 Deubiquitinates SHANK3 to Control Synapse Density and SHANK3 Activity-Dependent Protein Levels

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Antigen Translocation Machineries in Adaptive Immunity and Viral Immune Evasion

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Degradation systems in heart failure

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Regulation of Autophagic Flux by the 20S Proteasome

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Cytosolic Hsp60 Can Modulate Proteasome Activity in Yeast

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The immunoproteasome is induced by cytokines and regulates apoptosis in human islets

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Proteomic analysis of affinity-purified 26S proteasomes identifies a suite of assembly chaperones in Arabidopsis

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Fruiting-Body Development in Ascomycetes

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Topology and Oligomerization of Mono- and Oligomeric Proteins Regulate Their Half-Lives in the Cell

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Exploring paraptosis as a therapeutic approach in cancer treatment

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Break Breast Cancer Addiction by CRISPR/Cas9 Genome Editing

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