Cited by 1,074RNA Research and SplicingRNA and protein synthesis mechanismsRNA regulation and disease

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A day in the life of the spliceosome

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Matera, A. Gregory, Wang, Zefeng·2014·Nature Reviews Molecular Cell Biology

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Abstract

One of the most amazing findings in molecular biology was the discovery that eukaryotic genes are discontinuous, with coding DNA being interrupted by stretches of non-coding sequence. The subsequent realization that the intervening regions are removed from pre-mRNA transcripts via the activity of a common set of small nuclear RNAs (snRNAs), which assemble together with associated proteins into a complex known as the spliceosome, was equally surprising. How do cells coordinate the assembly of this molecular machine? And how does the spliceosome accurately recognize exons and introns to carry out the splicing reaction? Insights into these questions have been gained by studying the life cycle of spliceosomal snRNAs from their transcription, nuclear export and re-import to their dynamic assembly into the spliceosome. This assembly process can also affect the regulation of alternative splicing and has implications for human disease.

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Lorson, C. L., Hahnen, E., Androphy, E. J., & Wirth, B. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6307 · Cited by 1,536
Spliced segments at the 5′ terminus of adenovirus 2 late mRNA
Berget, S. M., Moore, C. L., & Sharp, P. A. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.8.3171 · Cited by 1,483
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An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA
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Are snRNPs involved in splicing?
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Additional file 5 of LncRNA CBR3-AS1 potentiates Wnt/β-catenin signaling to regulate lung adenocarcinoma cells proliferation, migration and invasion
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Additional file 4 of LncRNA CBR3-AS1 potentiates Wnt/β-catenin signaling to regulate lung adenocarcinoma cells proliferation, migration and invasion
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Additional file 3 of LncRNA CBR3-AS1 potentiates Wnt/β-catenin signaling to regulate lung adenocarcinoma cells proliferation, migration and invasion
Hou, M., Wu, N., & Yao, L. (2021) · Figshare · doi:10.6084/m9.figshare.13550604
Additional file 9 of Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex
Weigt, M., Gao, Q., Ban, H., He, H., Mastrobuoni, G., Kempa, S., Chen, W., & Li, F. (2021) · Figshare · doi:10.6084/m9.figshare.13612496
Additional file 2 of LncRNA CBR3-AS1 potentiates Wnt/β-catenin signaling to regulate lung adenocarcinoma cells proliferation, migration and invasion
Hou, M., Wu, N., & Yao, L. (2021) · Figshare · doi:10.6084/m9.figshare.13550601
Additional file 2 of Male guanine-rich RNA sequence binding factor 1 knockout mice (Grsf1−/−) gain less body weight during adolescence and adulthood
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Authors: Matera, A. G., & Wang, Z.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Matera, A. Gregory
Wang, Zefeng
ORCID: Matera, A. Gregory
Wang, Zefeng
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2014-01-23
Volume: 15
Issue: 2
Pages: 108-121
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm3742
PMC: PMC4060434
OpenAlex: W2009221497
Cited by: 1,074
References: 203
Citations by year: 2026: 56 · 2025: 92 · 2024: 95 · 2023: 83 · 2022: 94 · 2021: 122 · 2020: 102 · 2019: 90 · 2018: 85 · 2017: 86 · 2016: 79 · 2015: 65 · 2014: 23
FWCI: 8.01
Type: journal article
Language: en
Update notices: erratum (2014-03-11)
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5r01ns041617-13, 5r01gm053034-18)
National Cancer Institute (R01CA158283)
National Institute of General Medical Sciences (R01‑GM053034)
National Institute of Neurological Disorders and Stroke (R01‑NS041617)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21AR061640)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords: spliceosome assembly, small nuclear RNA, alternative splicing, pre-mRNA splicing, intron removal, nuclear export, splicing regulation, gene expression regulation, human disease
MeSH terms: Exons, Gene Expression Regulation, Humans, Introns, RNA Precursors, RNA, Small Nuclear, Spliceosomes, Alternative Splicing, Multiprotein Complexes

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A day in the life of the spliceosome

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