A day in the life of the spliceosome

Expansion of the eukaryotic proteome by alternative splicing

Nilsen, T. W., & Graveley, B. R. (2010) · Nature · doi:10.1038/nature08909 · Cited by 2,270

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

Fornerod, M. W. J., Ohno, M., Yoshida, M., & Mattaj, I. W. (1997) · Cell · doi:10.1016/s0092-8674(00)80371-2 · Cited by 2,086

Frequent pathway mutations of splicing machinery in myelodysplasia

Yoshida, K., Sanada, M., Shiraishi, Y., Nowak, D., Nagata, Y., Yamamoto, R., Sato, Y., Sato-Otsubo, A., Kon, A., Nagasaki, M., et al. (2011) · Nature · doi:10.1038/nature10496 · Cited by 2,029

Spliceosome Structure and Function

Will, C. L., & Luhrmann, R. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003707 · Cited by 1,829

A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy

Lorson, C. L., Hahnen, E., Androphy, E. J., & Wirth, B. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6307 · Cited by 1,536

Spliced segments at the 5′ terminus of adenovirus 2 late mRNA

Berget, S. M., Moore, C. L., & Sharp, P. A. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.8.3171 · Cited by 1,483

Understanding alternative splicing: towards a cellular code

Matlin, A. J., Clark, F., & Smith, C. W. J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1645 · Cited by 1,299

An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA

Chow, L. T., Gelinas, R. E., Broker, T. R., & Roberts, R. J. (1977) · Cell · doi:10.1016/0092-8674(77)90180-5 · Cited by 1,234

Are snRNPs involved in splicing?

Lerner, M. R., Boyle, J. A., Mount, S. M., Wolin, S. L., & STEITZ, J. A. (1980) · Nature · doi:10.1038/283220a0 · Cited by 1,192

Splicing regulation: From a parts list of regulatory elements to an integrated splicing code

Wang, Z., & Burge, C. B. (2008) · RNA · doi:10.1261/rna.876308 · Cited by 1,127

Deregulated Splicing Is a Major Mechanism of RNA-Induced Toxicity in Huntington's Disease

Schilling, J., Broemer, M., Atanassov, I., Duernberger, Y., Vorberg, I. M., Dieterich, C., Dagane, A., Dittmar, G., Wanker, E. E., van Roon‐Mom, W., et al. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.01.034 · Cited by 89

Mutations in spliceosome genes and therapeutic opportunities in myeloid malignancies

Taylor, J., & Lee, S. C.-W. (2019) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22784 · Cited by 88

Targeting Biomolecular Condensation and Protein Aggregation against Cancer

Silva, J. L., Foguel, D., Ferreira, V. F., Vieira, T. C. R. G., Marques, M. A., Ferretti, G. D. S., Outeiro, T. F., Cordeiro, Y., & de Oliveira, G. A. P. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00131 · Cited by 86

Dysregulation of the Splicing Machinery Is Associated to the Development of Nonalcoholic Fatty Liver Disease

del Río-Moreno, M., Alors‐Pérez, E., González‐Rubio, S., Ferrín, G., Reyes, Ó., Rodríguez‐Perálvarez, M., Sánchez‐Frías, M., Sánchez‐Sánchez, R., Ventura, S., López‐Miranda, J., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00021 · Cited by 84

Alternative splicing in plant abiotic stress responses

Punzo, P., Grillo, S., & Batelli, G. (2020) · Biochemical Society Transactions · doi:10.1042/bst20200281 · Cited by 84

Regulation of BCL-X splicing reveals a role for the polypyrimidine tract binding protein (PTBP1/hnRNP I) in alternative 5′ splice site selection

Bielli, P., Bordi, M., Biasio, V. D., & Sette, C. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku922 · Cited by 90

Cajal bodies and snRNPs - friends with benefits

Staněk, D. (2016) · RNA Biology · doi:10.1080/15476286.2016.1231359 · Cited by 84

BRR2a Affects Flowering Time via FLC Splicing

Mahrez, W., Shin, J., Muñoz‐Viana, R., Figueiredo, D. D., Trejo‐Arellano, M. S., Exner, V., Siretskiy, A., Gruissem, W., Köhler, C., & Hennig, L. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005924 · Cited by 83

Roles of CircRNAs in Autoimmune Diseases

Xia, X., Tang, X., & Wang, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00639 · Cited by 83

Aberrant Splicing of Estrogen Receptor, HER2, and CD44 Genes in Breast Cancer

Inoue, K., & Fry, E. A. (2015) · Genetics & Epigenetics · doi:10.4137/geg.s35500 · Cited by 84

A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation

Qi, Y., Yu, J. Q., Han, W., Fan, X., Qian, H., Wei, H. Y., Tsai, Y.-H. S., Zhao, J., Zhang, W., Liu, Q., et al. (2016) · Nature Communications · doi:10.1038/ncomms11840 · Cited by 85

Transcriptome and long noncoding RNA sequencing of three extracellular vesicle subtypes released from the human colon cancer LIM1863 cell line

Chen, M., Xu, R., Ji, H. L., Greening, D. W., Rai, A., Izumikawa, K., Ishikawa, H., Takahashi, N., & Simpson, R. J. (2016) · Scientific Reports · doi:10.1038/srep38397 · Cited by 83

PTEN arginine methylation by PRMT6 suppresses PI3K–AKT signaling and modulates pre-mRNA splicing

Feng, J., Dang, Y., Zhang, W., Zhao, X., Zhang, C., Hou, Z., Jin, Y., McNutt, M. A., Marks, A. R., & Yin, Y. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811028116 · Cited by 82

Pre-mRNA Splicing in Plants: In Vivo Functions of RNA-Binding Proteins Implicated in the Splicing Process

Meyer, K., Köster, T., & Staiger, D. (2015) · Biomolecules · doi:10.3390/biom5031717 · Cited by 83

AtU2 AF 65b functions in abscisic acid mediated flowering via regulating the precursor messenger RNA splicing of ABI 5 and FLC in Arabidopsis

Xiong, F., Ren, J., Yu, Q., Wang, Y., Lu, C., Kong, L., Otegui, M. S., & Wang, X. (2019) · New Phytologist · doi:10.1111/nph.15756 · Cited by 81

In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactorsPreprint

Sutandy, F. X. R., Ebersberger, S., Huang, L., Busch, A., Bach, M., Kang, H.-S., Fallmann, J., Maticzka, D., Backofen, R., Stadler, P. F., et al. (2018) · Genome Research · doi:10.1101/gr.229757.117 · Cited by 83

A U1 snRNP–specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange

So, B. R., Wan, L., Zhang, Z., Li, P., Babiash, E. S., Duan, J., Younis, I., & Dreyfuss, G. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3167 · Cited by 82

Spliceosome component SF3B1 as novel prognostic biomarker and therapeutic target for prostate cancer

Jiménez‐Vacas, J. M., Herrero‐Aguayo, V., Gómez‐Gómez, E., León‐González, A. J., Sáez-Martínez, P., Alors‐Pérez, E., Fuentes-Fayos, A. C., Martínez-López, A., Sánchez‐Sánchez, R., González-Serrano, T., et al. (2019) · Translational research · doi:10.1016/j.trsl.2019.07.001 · Cited by 82

Analysis of subcellular transcriptomes by RNA proximity labeling with Halo-seq

Engel, K. L., Lo, H. G., Goering, R., Li, Y., Spitale, R. C., & Taliaferro, J. M. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab1185 · Cited by 82

Splicing of long non-coding RNAs primarily depends on polypyrimidine tract and 5′ splice-site sequences due to weak interactions with SR proteins

Krchňáková, Z., Thakur, P. K., Krausová, M., Bieberstein, N. I., Haberman, N., Müller-McNicoll, M., & Staněk, D. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1147 · Cited by 78

HIV-1: To Splice or Not to Splice, That Is the Question

Swanstrom, R., & Emery, A. (2021) · Viruses · doi:10.3390/v13020181 · Cited by 90

m RNA trans ‐splicing in gene therapy for genetic diseases

Berger, A., Maire, S., Gaillard, M., Sahel, J., Hantraye, P., & Bemelmans, A. (2016) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1347 · Cited by 82

Uncovering the Role of RNA-Binding Proteins in Gene Expression in the Immune System

Díaz‐Muñoz, M. D., & Turner, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01094 · Cited by 79

Behind the scenes of HIV-1 replication: Alternative splicing as the dependency factor on the quiet

Sertznig, H., Hillebrand, F., Erkelenz, S., Schaal, H., & Widera, M. (2018) · Virology · doi:10.1016/j.virol.2018.01.011 · Cited by 87

SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling

Wang, F., Fu, X., Chen, P., Wu, P., Fan, X., Li, N., Zhu, H. M., Jia, T.-T., Ji, H., Wang, Z., et al. (2017) · Cell Research · doi:10.1038/cr.2017.7 · Cited by 76

Mutations in the Spliceosome Component CWC27 Cause Retinal Degeneration with or without Additional Developmental Anomalies

Xu, M., Xie, Y., Abouzeid, H., Gordon, C. T., Fiorentino, A., Sun, Z., Lehman, A., Osman, I. S., Dharmat, R., Riveiro-Álvarez, R., et al. (2017) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.02.008 · Cited by 77

Epigenetic regulation of alternative splicing.

Zhu, L., Zhu, Y., Dai, D., Wang, X., & Jin, H. (2018) · Europe PMC (PubMed Central) · Cited by 76

Analysis of RNA–protein networks with RNP-MaP defines functional hubs on RNA

Weidmann, C. A., Mustoe, A. M., Jariwala, P. B., Calabrese, J. M., & Weeks, K. M. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0709-7 · Cited by 78

Spliceosomes

Chen, W., & Moore, M. J. (2015) · Current Biology · doi:10.1016/j.cub.2014.11.059 · Cited by 75

Nucleocytoplasmic Transport of RNAs and RNA–Protein Complexes

Sloan, K. E., Gleizes, P., & Bohnsack, M. T. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.09.023 · Cited by 74

Small extracellular vesicle non-coding RNAs in pancreatic cancer: molecular mechanisms and clinical implications

Reese, M., & Dhayat, S. A. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01149-4 · Cited by 73

hnRNPM guides an alternative splicing program in response to inhibition of the PI3K/AKT/mTOR pathway in Ewing sarcoma cells

Passacantilli, I., Frisone, P., Paola, E. D., Fidaleo, M., & Paronetto, M. P. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx831 · Cited by 73

U1 snRNP Telescripting: Suppression of Premature Transcription Termination in Introns as a New Layer of Gene RegulationPreprint

Venters, C. C., Oh, J., Di, C., So, B. R., & Dreyfuss, G. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a032235 · Cited by 75

Splicing-related genes are alternatively spliced upon changes in ambient temperatures in plants

Verhage, L., Severing, E. I., Bucher, J., Lammers, M., Busscher‐Lange, J., Bonnema, G., Rodenburg, N., Proveniers, M. C. G., Angenent, G. C., & Immink, R. G. H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172950 · Cited by 71

All-atom simulations disentangle the functional dynamics underlying gene maturation in the intron lariat spliceosome

Casalino, L., Palermo, G., Spinello, A., Röthlisberger, U., & Magistrato, A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802963115 · Cited by 71

SART3-Dependent Accumulation of Incomplete Spliceosomal snRNPs in Cajal Bodies

Novotný, I., Malinová, A., Stejskalová, E., Matějů, D., Klimešová, K., Roithová, A., Švéda, M., Knejzlı́k, Z., & Staněk, D. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.030 · Cited by 71

Non-Coding RNAs in Stroke and Neuroprotection

Saugstad, J. A. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00050 · Cited by 71

Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese

Li, Y., Si, L., Zhai, Y., Hu, Y., Hu, Z., Bei, J., Xie, B., Ren, Q., Cao, P., Yang, F., et al. (2016) · Nature Communications · doi:10.1038/ncomms11664 · Cited by 70

SPF45-related splicing factor for phytochrome signaling promotes photomorphogenesis by regulating pre-mRNA splicing in Arabidopsis

Xin, R., Zhu, L. Q., Salomé, P. A., Mancini, E., Marshall, C. M., Harmon, F. G., Yanovsky, M. J., Weigel, D., & Huq, E. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1706379114 · Cited by 69

Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assemblyPreprint

Xu, C., Ishikawa, H., Izumikawa, K., Li, L., He, H., Nobe, Y., Yamauchi, Y., Shahjee, H. M., Wu, X., Yu, Y., et al. (2016) · Genes & Development · doi:10.1101/gad.288340.116 · Cited by 69

The root‐knot nematode effector MiEFF18 interacts with the plant core spliceosomal protein SmD1 required for giant cell formation

Mejias, J., Bazin, J., My, T. N., Chen, Y., Marteu, N., Bouteiller, N., Sawa, S., Crespi, M. D., Vaucheret, H., Abad, P., et al. (2020) · New Phytologist · doi:10.1111/nph.17089 · Cited by 68

Signaling Pathways Driving Aberrant Splicing in Cancer Cells

Gonçalves, V., Pereira, J., & Jordan, P. (2017) · Genes · doi:10.3390/genes9010009 · Cited by 71

The Intronic cis Element SE1 Recruits trans-Acting Repressor Complexes to Repress the Expression of ELONGATED UPPERMOST INTERNODE1 in Rice

Xie, Y., Zhang, Y., Han, J., Luo, J., Li, G., Huang, J., Wu, H., Tian, Q., Zhu, Q., Chen, Y., et al. (2018) · Molecular Plant · doi:10.1016/j.molp.2018.03.001 · Cited by 68

Splicing and cancer: Challenges and opportunities

Coltri, P. P., dos Santos, M. G. P., & Silva, G. K. (2019) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1527 · Cited by 69

Role for LSM genes in the regulation of circadian rhythms

Perez-Santángelo, S., Mancini, E., Francey, L. J., Schlaen, R. G., Chernomoretz, A., Hogenesch, J. B., & Yanovsky, M. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409791111 · Cited by 67

The RNA helicase DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation

Nakata, D., Nakao, S., Nakayama, K., Araki, S., Nakayama, Y., Aparicio, S. A. J. R., Hara, T., & Nakanishi, A. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.12.153 · Cited by 69

Structural basis for RNA translocation by DEAH-box ATPases

Hamann, F., Enders, M., & Ficner, R. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz150 · Cited by 67

Misregulation of alternative splicing in a mouse model of Rett syndrome

Li, R., Dong, Q., Yuan, X., Zeng, X., Gao, Y., Chiao, C., Li, H., Zhao, X., Keles, S., Wang, Z., et al. (2016) · PLOS Genetics · doi:10.1371/journal.pgen.1006129 · Cited by 67

The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis

Liu, T., Feng, Y., Guo, S., Wang, P. L., Qi, T. F., Yue, Y. M., Wang, S. X., Zhang, S. N., Tang, C. X., La, T., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24099-4 · Cited by 66

MTSplice predicts effects of genetic variants on tissue-specific splicing

Cheng, J., Çelik, M. H., Kundaje, A. B., & Gagneur, J. (2021) · Genome biology · doi:10.1186/s13059-021-02273-7 · Cited by 68

Non-Coding RNAs in Human Cancer and Other Diseases: Overview of the Diagnostic Potential

Beňačka, R., Szabóová, D., Guľašová, Z., Hertelyová, Z., & Radoňak, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216213 · Cited by 68

Splicing in immune cells—mechanistic insights and emerging topics

Schaub, A., & Glasmacher, E. (2017) · International Immunology · doi:10.1093/intimm/dxx026 · Cited by 68

Mutually exclusive alternative splicing of pre‐mRNAs

Jin, Y., Dong, H., Shi, Y., & Bian, L. (2018) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1468 · Cited by 69

RNA Polymerase II Activity of Type 3 Pol III Promoters

Gao, Z., Herrera-Carrillo, E., & Berkhout, B. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.05.001 · Cited by 65

Meta-analysis of gene expression profiles indicates genes in spliceosome pathway are up-regulated in hepatocellular carcinoma (HCC)

Xu, W., Huang, H., Yu, L., & Cao, L. (2015) · Medical Oncology · doi:10.1007/s12032-014-0425-6 · Cited by 64

Emerging Roles of RNA 3′-end Cleavage and Polyadenylation in Pathogenesis, Diagnosis and Therapy of Human Disorders

Nourse, J. P., Spada, S., & Danckwardt, S. (2020) · Biomolecules · doi:10.3390/biom10060915 · Cited by 68

A rust fungus effector directly binds plant pre‐mRNA splice site to reprogram alternative splicing and suppress host immunity

Tang, C., Xu, Q., Zhao, J., Yue, M., Wang, J., Wang, X., Wang, X., & Wang, X. (2022) · Plant Biotechnology Journal · doi:10.1111/pbi.13800 · Cited by 64

U6 snRNA Pseudogenes: Markers of Retrotransposition Dynamics in Mammals

Doucet, A. J., Droc, G., Siol, O., Audoux, J., & Gilbert, N. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv062 · Cited by 66

Combinatorial regulation of alternative splicing

Shenasa, H., & Hertel, K. J. (2019) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2019.06.003 · Cited by 67

Prospect of Circular RNA in Hepatocellular Carcinoma: A Novel Potential Biomarker and Therapeutic Target

Yao, R., Zou, H., & Liao, W. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00332 · Cited by 61

CRY2 interacts with CIS1 to regulate thermosensory flowering via FLM alternative splicing

Zhao, Z., Dent, C., Liang, H., Lv, J., Shang, G.-D., Liu, Y., Feng, F., Wang, F., Pang, J., Li, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34886-2 · Cited by 61

Recruitment of the NineTeen Complex to the activated spliceosome requires AtPRMT5

Deng, X. M., Lu, T.-C., Wang, L., Gu, L., Sun, J., Kong, X., Liu, C., & Cao, X. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522458113 · Cited by 61

S-CAP extends pathogenicity prediction to genetic variants that affect RNA splicing

Jagadeesh, K. A., Paggi, J. M., Ye, J. S., Stenson, P. D., Cooper, D. N., Bernstein, J. A., & Bejerano, G. (2019) · Nature Genetics · doi:10.1038/s41588-019-0348-4 · Cited by 62

Conditional U1 Gene Silencing in Toxoplasma gondii

Pieperhoff, M. S., Pall, G. S., Jiménez‐Ruiz, E., Das, S., Melatti, C., Gow, M., Wong, E., Heng, J., Müller, S., Blackman, M. J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130356 · Cited by 60

The Arabidopsis sickle Mutant Exhibits Altered Circadian Clock Responses to Cool Temperatures and Temperature-Dependent Alternative Splicing

Marshall, C. M., Tartaglio, V., Duarte, M. I., & Harmon, F. G. (2016) · The Plant Cell · doi:10.1105/tpc.16.00223 · Cited by 60

Aberrant splicing in B-cell acute lymphoblastic leukemia

Black, K. L., Naqvi, A. S., Asnani, M., Hayer, K. E., Yang, S. Y., Gillespie, E. B., Bagashev, A., Pillai, V., Tasian, S. K., Gazzara, M. R., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky946 · Cited by 61

RNA structures in alternative splicing and back‐splicing

Xu, B., Meng, Y., & Jin, Y. (2020) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1626 · Cited by 63

RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H

Zhang, S., Bao, Y., Shen, X., Pan, Y., Sun, Y., Xiao, M., Chen, K., Wei, H., Zuo, J., Saffen, D., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.103067 · Cited by 59

Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer

Cieśla, M., Ngoc, P. C. T., Cordero, E., Martínez, Á. S., Morsing, M., Muthukumar, S., Beneventi, G., Madej, M., Munita, R., Jönsson, T., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.01.034 · Cited by 62

Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organization

Neuenkirchen, N., Englbrecht, C., Ohmer, J., Ziegenhals, T., Chari, A., & Fischer, U. (2015) · The EMBO Journal · doi:10.15252/embj.201490350 · Cited by 59

Global Profiling of the Cellular Alternative RNA Splicing Landscape during Virus-Host Interactions

Boudreault, S., Martenon-Brodeur, C., Caron, M., Garant, J., Tremblay, M.-P., Armero, V. E. S., Durand, M., Lapointe, E., Thibault, P., Tremblay-Létourneau, M., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161914 · Cited by 59

The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing

Tanikawa, M., Sanjiv, K., Helleday, T., Herr, P., & Mortusewicz, O. (2016) · Oncogenesis · doi:10.1038/oncsis.2016.70 · Cited by 59

Basal-A Triple-Negative Breast Cancer Cells Selectively Rely on RNA Splicing for Survival

Chan, S., Sridhar, P., Kirchner, R., Lock, Y. J., Herbert, Z. T., Buonamici, S., Smith, P. G., Lieberman, J., & Petrocca, F. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0461 · Cited by 59

Exonic mutations and exon skipping: Lessons learned from DFNA5

Booth, K. T. A., Azaiez, H., Kahrizi, K., Wang, D., Zhang, Y., Frees, K. L., Nishimura, C. J., Najmabadi, H., & Smith, R. J. (2017) · Human Mutation · doi:10.1002/humu.23384 · Cited by 59

Nuclear Pre-snRNA Export Is an Essential Quality Assurance Mechanism for Functional Spliceosomes

Becker, D., Hirsch, A. G., Bender, L., Lingner, T., Salinas, G., & Krebber, H. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.031 · Cited by 60

The Splicing Factor PTBP1 Promotes Expression of Oncogenic Splice Variants and Predicts Poor Prognosis in Patients with Non–muscle-Invasive Bladder Cancer

Bielli, P., Panzeri, V., Lattanzio, R., Mutascio, S., Pieraccioli, M., Volpe, E., Pagliarulo, V., Piantelli, M., Giannantoni, A., Stasi, S. M. D., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-3850 · Cited by 58

Analysis of the human immunodeficiency virus-1 RNA packageome

Eckwahl, M. J., Arnion, H., Kharytonchyk, S., Zang, T., Bieniasz, P. D., Telesnitsky, A., & Wolin, S. L. (2016) · RNA · doi:10.1261/rna.057299.116 · Cited by 57

Non-coding functions of alternative pre-mRNA splicing in development

Mockenhaupt, S., & Makeyev, E. V. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.10.018 · Cited by 62

Environment-dependent regulation of spliceosome activity by the LSM2-8 complex in Arabidopsis

Carrasco‐López, C., Hernández‐Verdeja, T., Perea-Resa, C., Abia, D., Catalá, R., & Salinas, J. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx375 · Cited by 57

Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1)

Chung, F. F., Tan, P. F. T. M., Raja, V. J., Tan, B.-S., Lim, K., Kam, T., Hii, L., Tan, S. H., See, S.-J., Tan, Y.-F., et al. (2017) · Scientific Reports · doi:10.1038/srep42504 · Cited by 58

Messenger RNA Life-Cycle in Cancer Cells: Emerging Role of Conventional and Non-Conventional RNA-Binding Proteins?

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Genomic takeover by transposable elements in the Strawberry poison frog

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