The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
The dynamic epitranscriptome: N6-methyladenosine and gene expression control
Open accessAbstract
N6-methyladenosine (m6A) is a modified base that has long been known to be present in non-coding RNAs, ribosomal RNA, polyadenylated RNA and at least one mammalian mRNA. However, our understanding of the prevalence of this modification has been fundamentally redefined by transcriptome-wide m6A mapping studies, which have shown that m6A is present in a large subset of the transcriptome in specific regions of mRNA. This suggests that mRNA may undergo post-transcriptional methylation to regulate its fate and function, which is analogous to methyl modifications in DNA. Thus, the pattern of methylation constitutes an mRNA 'epitranscriptome'. The identification of adenosine methyltransferases ('writers'), m6A demethylating enzymes ('erasers') and m6A-binding proteins ('readers') is helping to define cellular pathways for the post-transcriptional regulation of mRNAs.
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N6-methyladenosine-dependent regulation of messenger RNA stability
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Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
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Self-citationN6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
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ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
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Cited by
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
Wang, X., Zhao, B. S., Roundtree, I. A., Lu, Z., Han, D., Ma, H., Weng, X., Chen, K., Shi, H., & He, C. (2015) · Cell · doi:10.1016/j.cell.2015.05.014 · Cited by 3,483
A census of human RNA-binding proteins
Gerstberger, S., Hafner, M., & Tuschl, T. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3813 · Cited by 2,032
Extensive translation of circular RNAs driven by N6-methyladenosine
Yang, Y., Fan, X., Mao, M., Song, X., Wu, P., Zhang, Y., Jin, Y., Yang, Y., Chen, L.-L., Wang, Y., et al. (2017) · Cell Research · doi:10.1038/cr.2017.31 · Cited by 1,855
m6A RNA methylation promotes XIST-mediated transcriptional repression
Patil, D. P., Chen, C.-K., Pickering, B. F., Chow, A., Jackson, C., Guttman, M., & Jaffrey, S. R. (2016) · Nature · doi:10.1038/nature19342 · Cited by 1,747
Self-citationThe m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells
Lin, S., Choe, J., Du, P., Triboulet, R., & Gregory, R. I. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.03.021 · Cited by 1,531
Metadata
- Authors
- Meyer, K. D., & Jaffrey, S. R.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2014-04-09
- Volume
- 15
- Issue
- 5
- Pages
- 313-326
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1986988560
- Cited by
- 1,060
- References
- 10
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- green
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