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Cited by 410

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

The structure, function and evolution of proteins that bind DNA and RNA

Open access
Hudson, William H., Ortlund, Eric A.·2014·Nature Reviews Molecular Cell Biology

Abstract

Proteins that bind both DNA and RNA typify the ability of a single gene product to perform multiple functions. Such DNA- and RNA-binding proteins (DRBPs) have unique functional characteristics that stem from their specific structural features; these developed early in evolution and are widely conserved. Proteins that bind RNA have typically been considered as functionally distinct from proteins that bind DNA and studied independently. This practice is becoming outdated, in partly owing to the discovery of long non-coding RNAs (lncRNAs) that target DNA-binding proteins. Consequently, DRBPs were found to regulate many cellular processes, including transcription, translation, gene silencing, microRNA biogenesis and telomere maintenance.

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Metadata

Authors
Hudson, W. H., & Ortlund, E. A.
Venue
Nature Reviews Molecular Cell Biology
Published
2014-10-01
Volume
15
Issue
11
Pages
749-760
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
OpenAlex
W2046792302
Cited by
410
References
13
FWCI
1.18
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The structure, function and evolution of proteins that bind DNA and RNA. https://app.cochat.ai/papers/10.1038/nrm3884
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Hudson, W. H., & Ortlund, E. A. (2014). The structure, function and evolution of proteins that bind DNA and RNA. Nature Reviews Molecular Cell Biology. https://doi.org/10.1038/nrm3884

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.