The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
The structure, function and evolution of proteins that bind DNA and RNA
Open accessAbstract
Proteins that bind both DNA and RNA typify the ability of a single gene product to perform multiple functions. Such DNA- and RNA-binding proteins (DRBPs) have unique functional characteristics that stem from their specific structural features; these developed early in evolution and are widely conserved. Proteins that bind RNA have typically been considered as functionally distinct from proteins that bind DNA and studied independently. This practice is becoming outdated, in partly owing to the discovery of long non-coding RNAs (lncRNAs) that target DNA-binding proteins. Consequently, DRBPs were found to regulate many cellular processes, including transcription, translation, gene silencing, microRNA biogenesis and telomere maintenance.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins
Castello, A., Fischer, B., Eichelbaum, K., Horos, R., Beckmann, B. M., Strein, C., Davey, N. E., Humphreys, D. T., Preiss, T., Steinmetz, L. M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.031 · Cited by 2,132
TRF2 Protects Human Telomeres from End-to-End Fusions
van Steensel, B., Smogorzewska, A., & de Lange, T. (1998) · Cell · doi:10.1016/s0092-8674(00)80932-0 · Cited by 1,709
Yang-Yen, H.-F., Chambard, J.-C., Sun, Y.-L., Smeal, T., Schmidt, T. J., Drouin, J., & Karin, M. (1990) · Cell · doi:10.1016/0092-8674(90)90396-v · Cited by 1,553
A compendium of RNA-binding motifs for decoding gene regulation
Ray, D., Kazan, H., Cook, K. B., Weirauch, M. T., Najafabadi, H. S., Li, X., Gueroussov, S., Albu, M., Zheng, H., Yang, A., et al. (2013) · Nature · doi:10.1038/nature12311 · Cited by 1,480
Iliopoulos, D., Hirsch, H. A., & Struhl, K. (2009) · Cell · doi:10.1016/j.cell.2009.10.014 · Cited by 1,374
The evolution of lncRNA repertoires and expression patterns in tetrapods
Necsulea, A., Soumillon, M., Warnefors, M., Liechti, A., Daish, T., Zeller, U., Baker, J. C., Grützner, F., & Kaessmann, H. (2014) · Nature · doi:10.1038/nature12943 · Cited by 984
Feng, J., Bi, C., Clark, B. S., Mady, R., Shah, P., & Kohtz, J. D. (2006) · Genes & Development · doi:10.1101/gad.1416106 · Cited by 712
Surjit, M., Ganti, K. P., Mukherji, A., Ye, T., Hua, G., Metzger, D., Li, M., & Chambon, P. (2011) · Cell · doi:10.1016/j.cell.2011.03.027 · Cited by 551
Reddy, T. E., Pauli, F., Sprouse, R. O., Neff, N. F., Newberry, K. M., Garabedian, M. J., & Myers, R. M. (2009) · Genome Research · doi:10.1101/gr.097022.109 · Cited by 543
DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis
Zazopoulos, E., Lalli, E., Stocco, D. M., & Sassone-Corsi, P. (1997) · Nature · doi:10.1038/36899 · Cited by 433
Cited by
A brave new world of RNA-binding proteins
Hentze, M. W., Castello, A., Schwarzl, T., & Preiss, T. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.130 · Cited by 1,821
Glucocorticoid receptor control of transcription: precision and plasticity via allostery
Weikum, E. R., Knuesel, M. T., Ortlund, E. A., & Yamamoto, K. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.152 · Cited by 533
Self-citationRNA-binding proteins control gene expression and cell fate in the immune system
Turner, M., & Díaz-Muñoz, M. D. (2018) · Nature Immunology · doi:10.1038/s41590-017-0028-4 · Cited by 209
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism
Sun, L., Suo, C., Zhang, T., Shen, S., Gu, X., Qiu, S., Zhang, P., Wei, H., Ma, W., Yan, R., et al. (2023) · Nature Chemical Biology · doi:10.1038/s41589-023-01391-6 · Cited by 94
From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond
Michelini, F., Jalihal, A. P., Francia, S., Meers, C., Neeb, Z. T., Rossiello, F., Gioia, U., Aguado, J., Jones-Weinert, C., Luke, B., et al. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00487 · Cited by 85
Carnesecchi, J., Boumpas, P., van Nierop y Sanchez, P., Domsch, K., Pinto, H. D., Borges Pinto, P., & Lohmann, I. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkab1250 · Cited by 25
Korn, S. M., Von Ehr, J., Dhamotharan, K., Tants, J.-N., Abele, R., & Schlundt, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043286 · Cited by 4
In silico identification of archaeal DNA-binding proteins
Donvil, L., Housmans, J. A. J., Peeters, E., Vranken, W., & Orlando, G. (2025) · Bioinformatics · doi:10.1093/bioinformatics/btaf169 · Cited by 3
Molecular insights into nucleic acid triplexes: methodologies and biological applications
Klose, J. W., Urbina, G., & Pukala, T. L. (2025) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2025.2550728 · Cited by 1
Metadata
- Authors
- Hudson, W. H., & Ortlund, E. A.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2014-10-01
- Volume
- 15
- Issue
- 11
- Pages
- 749-760
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2046792302
- Cited by
- 410
- References
- 13
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
