The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.
Signalling scaffolds and local organization of cellular behaviour
Open accessAbstract
Cellular responses to environmental cues involve the mobilization of GTPases, protein kinases and phosphoprotein phosphatases. The spatial organization of these signalling enzymes by scaffold proteins helps to guide the flow of molecular information. Allosteric modulation of scaffolded enzymes can alter their catalytic activity or sensitivity to second messengers in a manner that augments, insulates or terminates local cellular events. This Review examines the features of scaffold proteins and highlights examples of locally organized groups of signalling enzymes that drive essential physiological processes, including hormone action, heart rate, cell division, organelle movement and synaptic transmission.
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Cites
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Brautigan, D. L., & Shenolikar, S. (2018) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062917-012332 · Cited by 191
Anton, S. E., Kayser, C., Maiellaro, I., Nemec, K., Möller, J., Koschinski, A., Zaccolo, M., Annibale, P., Falcke, M., Lohse, M. J., et al. (2022) · Cell · doi:10.1016/j.cell.2022.02.011 · Cited by 186
Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling
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Warnet, X. L., Bakke Krog, H., Sevillano‐Quispe, O. G., Poulsen, H., & Kjaergaard, M. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14842 · Cited by 50
Metadata
- Authors
- Langeberg, L. K., & Scott, J. D.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2015-03-18
- Volume
- 16
- Issue
- 4
- Pages
- 232-244
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2032755148
- Cited by
- 273
- References
- 140
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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