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Epsins: adaptors in endocytosis?
Abstract
Endocytic adaptor proteins select specific cargo for internalization by endocytosis through clathrin-coated pits or vesicles. Recent studies indicate that epsins might also be classified as adaptors.
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“Epsins are a class of ubiquitin adaptors that are implicated in internalization and sorting of plasma membrane receptors ( 39, 40, 47 ), and are implicated in tuning, among other, EGFR ( 27, 38 ), Notch ( 48 ), and VEFGR2 signaling ( 49 ).”
From The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation (2013) · cites this paper as [40]
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Curvature of clathrin-coated pits driven by epsin
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Kirchhausen, T. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.699 · Cited by 560
Disabled‐2 exhibits the properties of a cargo‐selective endocytic clathrin adaptor
Mishra, S. K., Keyel, P. A., Hawryluk, M. J., Agostinelli, N. R., Watkins, S. C., & Traub, L. M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf487 · Cited by 302
Chen, H., Slepnev, V. I., Di Fiore, P. P., & De Camilli, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.6.3257 · Cited by 138 · cited 1×
“Findings from several studies support a role for phosphorylation in the regulation of the interaction of epsin with its binding partner”
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Research works printed but not linked: 71
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Metadata
- Authors
- Wendland, B.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2002-12
- Volume
- 3
- Issue
- 12
- Pages
- 971-977
- ISSN
- 1471-0072
- 1471-0080
- Cited by
- 143
- References
- 4
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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