Cited by 99

Antibody-based therapies for malaria

Pleass, Richard J., Holder, Anthony A.·2005·Nature Reviews Microbiology

Abstract

Antibodies are multifunctional glycoproteins that are found in blood and tissue fluids, and can protect against malaria by binding and neutralizing malaria parasites and preparing them for destruction by immune cells. Important technical advances mean that it is now possible to synthesize antibodies against important Plasmodium antigens that could be used for therapeutic purposes. These reagents could be designed to act like a drug and kill parasites directly, or could be used in vaccine strategies to protect individuals from infection. In this article, we discuss the possible therapeutic uses of antibodies in the treatment and prevention of malaria.

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Crossref · 10.1038/nrmicro1267

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  • miRs are well-established regulators of key brain processes including neurodevelopment, synaptic plasticity, apoptosis, neuroinflammation, neurodegeneration, and epilepsy.

    “miRs are well-established regulators of key brain processes 4,5 , including neurodevelopment [6][7][8][9][10][11] , synaptic plasticity [12][13][14] , apoptosis 15,16 , neuroinflammation 17 , neurodegeneration 18,19 , and epilepsy 5,20 .”

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Authors
Pleass, R. J., & Holder, A. A.
Venue
Nature Reviews Microbiology
Published
2005-11-01
Volume
3
Issue
11
Pages
893-899
ISSN
  • 1740-1526
  • 1740-1534
Cited by
99
References
3
Language
en

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