H-NS: a universal regulator for a dynamic genome

Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd

Fleischmann, R. D., Adams, M. D., White, O., Clayton, R. A., Kirkness, E. F., Kerlavage, A. R., Bult, C. J., Tomb, J.-F., Dougherty, B. A., Merrick, J. M., et al. (1995) · Science · doi:10.1126/science.7542800 · Cited by 5,654

Growth Phase-Dependent Variation in Protein Composition of the Escherichia coli Nucleoid

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DNA Structure and Function

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Twelve Species of the Nucleoid-associated Protein from Escherichia coli

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Large‐scale monitoring of pleiotropic regulation of gene expression by the prokaryotic nucleoid‐associated protein, H‐NS

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The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri

Buchrieser, C., Glaser, P., Rusniok, C., Nedjari, H., D'Hauteville, H., Kunst, F., Sansonetti, P., & Parsot, C. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.02179.x · Cited by 378

Synthetic curved DNA sequences can act as transcriptional activators in Escherichia coli.

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H-NS mediated compaction of DNA visualised by atomic force microscopy

Dame, R. T. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.18.3504 · Cited by 311

Identification of a cold shock transcriptional enhancer of the Escherichia coli gene encoding nucleoid protein H-NS.

La Teana, A., Brandi, A., Falconi, M., Spurio, R., Pon, C. L., & Gualerzi, C. O. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10907 · Cited by 297

Thermoregulation of Shigella and Escherichia coli EIEC pathogenicity. A temperature-dependent structural transition of DNA modulates accessibility of virF promoter to transcriptional repressor H-NS

Falconi, M., Colonna, B., Prosseda, G., Micheli, G., & Gualerzi, C. O. (1998) · The EMBO Journal · doi:10.1093/emboj/17.23.7033 · Cited by 290

Posttranslational modification of MDM2.

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Multiple Control of Flagellum Biosynthesis in Escherichia coli : Role of H-NS Protein and the Cyclic AMP-Catabolite Activator Protein Complex in Transcription of the flhDC Master Operon

Soutourina, O. A., Kolb, A., Krin, E., Laurent‐Winter, C., Rimsky, S., Danchin, A., & Bertin, P. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.24.7500-7508.1999 · Cited by 270

The RNA-binding protein HF-I, known as a host factor for phage Qbeta RNA replication, is essential for rpoS translation in Escherichia coli.

Muffler, A., Fischer, D., & Hengge-Aronis, R. (1996) · Genes & Development · doi:10.1101/gad.10.9.1143 · Cited by 267

Stress response of Escherichia coli to elevated hydrostatic pressure

Welch, T. J., Farewell, A., Neidhardt, F. C., & Bartlett, D. H. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.22.7170-7177.1993 · Cited by 245

Regulation of gene expression by histone-like proteins in bacteria

Dorman, C. J., & Deighan, P. (2003) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(03)00025-x · Cited by 243

The chromatin-associated protein H-NS alters DNA topology in vitro.

Tupper, A. E., Owen-Hughes, T. A., Ussery, D. W., Santos, D. S., Ferguson, D. J., Sidebotham, J. M., Hinton, J. C., & Higgins, C. F. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06256.x · Cited by 226

Transcriptional regulation of type III secretion genes in enteropathogenic Escherichia coli: Ler antagonizes H‐NS‐dependent repression

Bustamante, V. H., Santana, F. J., Calva, E., & Puente, J. L. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02209.x · Cited by 224

A DNA structural atlas for Escherichia coli 1 1Edited by T. Richmond

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Transcriptional control of the invasion regulatory gene virB of Shigella flexneri: activation by virF and repression by H-NS

Tobe, T., Yoshikawa, M., Mizuno, T., & Sasakawa, C. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.19.6142-6149.1993 · Cited by 221

Escherichia coli protein analogs StpA and H-NS: regulatory loops, similar and disparate effects on nucleic acid dynamics.

Zhang, A., Rimsky, S., Reaban, M. E., Buc, H., & Belfort, M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00476.x · Cited by 217

The oligomeric structure of nucleoid protein H-NS is necessary for recognition of intrinsically curved DNA and for DNA bending

Spurio, R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.7.1795 · Cited by 197

Bending of the bacteriophage lambda attachment site by Escherichia coli integration host factor.

Robertson, C. A., & Nash, H. A. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68960-4 · Cited by 196

Increased Bending Rigidity of Single DNA Molecules by H-NS, a Temperature and Osmolarity Sensor

Amit, R., Oppenheim, A. B., & Stavans, J. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)75051-6 · Cited by 194

The H-NS protein is involved in the biogenesis of flagella in Escherichia coli

Bertin, P., Terao, E., Lee, E. H., Lejeune, P., Colson, C., Danchin, A., & Collatz, E. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.17.5537-5540.1994 · Cited by 189

Structural Basis for H-NS-mediated Trapping of RNA Polymerase in the Open Initiation Complex at the rrnB P1

Dame, R. T., Wyman, C., Wurm, R., Wagner, R., & Goosen, N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100603200 · Cited by 186

An Escherichia coli Protein That Preferentially Binds to Sharply Curved DNA1

Yamada, H., Muramatsu, S., & Mizuno, T. (1990) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a123216 · Cited by 182

Molecular analysis of the Escherichia coli has gene encoding a DNA-binding protein, which preferentially recognizes curved DNA sequences

Yamada, H., Yoshida, T., Tanaka, K.-I., Sasakawa, C., & Mizuno, T. (1991) · Molecular and General Genetics MGG · doi:10.1007/bf00290685 · Cited by 182

Synthesis of the Escherichia coli K‐12 nucleoid‐associated DNA‐binding protein H‐NS is subjected to growth‐phase control and autoregulation

Dersch, P., Schmidt, K., & Bremer, E. (1993) · Molecular Microbiology · doi:10.1111/j.1365-2958.1993.tb01634.x · Cited by 169

The virF promoter in Shigella: more than just a curved DNA stretch

Prosseda, G., Falconi, M., Giangrossi, M., Gualerzi, C. O., Micheli, G., & Colonna, B. (2004) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03848.x · Cited by 167

Lethal overproduction of the Escherichia coli nucleoid protein H-NS: ultramicroscopic and molecular autopsy

Spurio, R., Dürrenberger, M., Falconi, M., La Teana, A., Pon, C. L., & Gualerzi, C. O. (1992) · Molecular and General Genetics MGG · doi:10.1007/bf00279792 · Cited by 163

Systematic Mutational Analysis Revealing the Functional Domain Organization of Nucleoid Protein H-NS

Ueguchi, C., Suzuki, T., Yoshida, T., Tanaka, K.-I., & Mizuno, T. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0566 · Cited by 163

Identification of the Hfq-binding site on DsrA RNA: Hfq binds without altering DsrA secondary structure

BRESCIA, C. C., MIKULECKY, P. J., FEIG, A. L., & SLEDJESKI, D. D. (2003) · RNA · doi:10.1261/rna.2570803 · Cited by 162

Structure of the histone-like protein H-NS and its role in regulation and genome superstructure

Rimsky, S. (2004) · Current Opinion in Microbiology · doi:10.1016/j.mib.2004.02.001 · Cited by 159

Probing the structure, function, and interactions of the Escherichia coli H-NS and StpA proteins by using dominant negative derivatives

Williams, R. M., Rimsky, S., & BUC, H. C. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.15.4335-4343.1996 · Cited by 155

H-NS Oligomerization Domain Structure Reveals the Mechanism for High Order Self-association of the Intact Protein

Esposito, D., Petrović, A., Harris, R., Ono, S., Eccleston, J. F., Mbabaali, A., Haq, I., Higgins, C. F., Hinton, J. C. D., Driscoll, P. C., et al. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)01141-5 · Cited by 144

Autoregulatory expression of the Escherichia coli hns gene encoding a nucleoid protein: H-NS functions as a repressor of its own transcription

Ueguchi, C., Kakeda, M., & Mizuno, T. (1993) · Molecular and General Genetics MGG · doi:10.1007/bf00277109 · Cited by 129

HU: promoting or counteracting DNA compaction?

Dame, R. T., & Goosen, N. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03363-x · Cited by 127

Involvement of FIS in the H‐NS‐mediated regulation of virF gene of Shigella and enteroinvasive Escherichia coli ‡

Falconi, M., Prosseda, G., Giangrossi, M., Beghetto, E., & Colonna, B. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02646.x · Cited by 124

A molecular mechanism for the repression of transcription by the H‐NS protein

Rimsky, S., Zuber, F., Buckle, M., & BUC, H. C. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02706.x · Cited by 122

Interaction of Ler at the LEE5 ( tir ) Operon of Enteropathogenic Escherichia coli

Haack, K. R., Robinson, C. L., Miller, K. J., Fowlkes, J. W., & Mellies, J. L. (2002) · Infection and Immunity · doi:10.1128/iai.71.1.384-392.2003 · Cited by 122

Coordinated and differential expression of histone‐like proteins in Escherichia coli: regulation and function of the H‐NS analog StpA.

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Structural origins of adenine-tract bending

Barbič, A., Zimmer, D. P., & Crothers, D. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437877100 · Cited by 114

The Small Nucleoid-Binding Proteins H-NS, HU, and Fis Affect hilA Expression in Salmonella enterica Serovar Typhimurium

Schechter, L. M., Jain, S., Akbar, S., & Lee, C. A. (2003) · Infection and Immunity · doi:10.1128/iai.71.9.5432-5435.2003 · Cited by 112

Expression and mutational analysis of the nucleoid‐associated protein H‐NS of Salmonella typhimurium

Hinton, J. C. D., Santos, D. S., Seirafi, A., Hulton, C. S. J., Pavitt, G. D., & Higgins, C. F. (1992) · Molecular Microbiology · doi:10.1111/j.1365-2958.1992.tb01408.x · Cited by 111

H-NS-Dependent Regulation of Flagellar Synthesis Is Mediated by a LysR Family Protein

Ko, M., & Park, C. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.16.4670-4672.2000 · Cited by 105

A role for H-NS in the thermo-osmotic regulation of virulence gene expression in Shigella flexneri

Porter, M. E., & Dorman, C. J. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.13.4187-4191.1994 · Cited by 103

Expression of the gene encoding the major bacterial nucleoid protein H‐NS is subject to transcriptional auto‐repression

Falconi, M., Higgins, N. P., Spurio, R., Pon, C. L., & Gualerzi, C. O. (1993) · Molecular Microbiology · doi:10.1111/j.1365-2958.1993.tb01953.x · Cited by 103

Control of rRNA expression in Escherichia coli

Schneider, D. A., Ross, W., & Gourse, R. L. (2003) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(03)00038-9 · Cited by 100

Gene 5.5 protein of bacteriophage T7 inhibits the nucleoid protein H-NS of Escherichia coli.

Liu, Q., & Richardson, C. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1761 · Cited by 88

Fis, a DNA nucleoid‐associated protein, is involved in Salmonella typhimurium SPI‐1 invasion gene expression

Wilson, R. L., Libby, S. J., Freet, A. M., Boddicker, J. D., Fahlen, T. F., & Jones, B. D. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02192.x · Cited by 88

Three‐way interactions among the Sfh, StpA and H‐NS nucleoid‐structuring proteins of Shigella flexneri 2a strain 2457T

Deighan, P., Beloin, C., & Dorman, C. J. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03515.x · Cited by 78

A role for the Escherichia coli H‐NS‐like protein StpA in OmpF porin expression through modulation of micF RNA stability

Deighan, P., Free, A., & Dorman, C. J. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.02120.x · Cited by 76

Shigella flexneri 2a strain 2457T expresses three members of the H-NS-like protein family: characterization of the Sfh protein

Beloin, C., Deighan, P., Doyle, M., & Dorman, C. J. (2003) · Molecular Genetics and Genomics · doi:10.1007/s00438-003-0897-0 · Cited by 74

Post-transcriptional control by global regulators of gene expression in bacteria

Nogueira, T., & Springer, M. (2000) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(00)00068-0 · Cited by 71

Coupling of Escherichia coli hns mRNA levels to DNA synthesis by autoregulation: implications for growth phase control

Free, A., & Dorman, C. J. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.mmi_18010101.x · Cited by 69

Effects of the Escherichia coli DNA‐binding protein H‐NS on rRNA synthesis in vivo

Afflerbach, H., Schröder, O., & Wagner, R. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00829.x · Cited by 68

Domain structure and RNA annealing activity of the Escherichia coli regulatory protein StpA

Cusick, M. E., & Belfort, M. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00848.x · Cited by 67

Multimeric Self-assembly Equilibria Involving the Histone-like Protein H-NS

Ceschini, S., Lupidi, G., Coletta, M., Pon, C. L., Fioretti, E., & Angeletti, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.729 · Cited by 65

Conformational changes of the upstream DNA mediated by H-NS and FIS regulate E. coli rrnB P1 promoter activity 1 1Edited by M. Yaniv

Afflerbach, H., Schröder, O., & Wagner, R. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2494 · Cited by 53

The StpA Protein Functions as a Molecular Adapter To Mediate Repression of the bgl Operon by Truncated H-NS in Escherichia coli

Free, A., Williams, R. M., & Dorman, C. J. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.4.994-997.1998 · Cited by 49

Vibrio cholerae H‐NS domain structure and function with respect to transcriptional repression of ToxR regulon genes reveals differences among H‐NS family members

Nye, M. B., & Taylor, R. K. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03701.x · Cited by 36

Posttranslational modification of E. coli histone‐like protein H‐NS and bovine histones by short‐chain poly‐(R)‐3‐hydroxybutyrate (cPHB)

Reusch, R. N., Shabalin, O., Crumbaugh, A. J., Wagner, R., Schröder, O., & Wurm, R. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03236-2 · Cited by 35

Host–microbe interactions: bacteria Host–pathogen interactions: interpreting the dialogue

Roy, C. R. (2004) · Current Opinion in Microbiology · doi:10.1016/j.mib.2003.12.014 · Cited by 28

The looped domain organization of the nucleoid in histone-like protein defective Escherichia coli strains***This work is dedicated to Maurice Hofnung, tragically deceased on June 28th, 2001.

Brunetti, R., Prosseda, G., Beghetto, E., Colonna, B., & Micheli, G. (2001) · Biochimie · doi:10.1016/s0300-9084(01)01331-1 · Cited by 24

Selective Silencing of Foreign DNA with Low GC Content by the H-NS Protein in Salmonella

Navarre, W. W., Porwollik, S., Wang, Y., McClelland, M., Rosen, H., Libby, S. J., & Fang, F. C. (2006) · Science · doi:10.1126/science.1128794 · Cited by 722

Escherichia coli Biofilms

Beloin, C., Roux, A., & Ghigo, J. M. (2008) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-540-75418-3_12 · Cited by 578

H-NS Mediates the Silencing of Laterally Acquired Genes in Bacteria

Lucchini, S., Rowley, G., Goldberg, M. D., Hurd, D., Harrison, M., & Hinton, J. C. D. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020081 · Cited by 554

RNA Chaperones, RNA Annealers and RNA Helicases

Rajkowitsch, L., Chen, D., Stampfl, S., Semrad, K., Waldsich, C., Mayer, O., Jantsch, M. F., Konrat, R., Bläsi, U., & Schroeder, R. (2007) · RNA Biology · doi:10.4161/rna.4.3.5445 · Cited by 332

The Fur regulon in anaerobically grown Salmonella enterica sv. Typhimurium: identification of new Fur targets

Troxell, B., Fink, R. C., Porwollik, S., McClelland, M., & Hassan, H. M. (2011) · BMC Microbiology · doi:10.1186/1471-2180-11-236 · Cited by 72