The DOI matches its Crossref record; 224 of the 224 references it cites were found in a registry or an index.
Regenerating CNS myelin — from mechanisms to experimental medicines
Open accessAbstract
Although the core concept of remyelination - based on the activation, migration, proliferation and differentiation of CNS progenitors - has not changed over the past 20 years, our understanding of the detailed mechanisms that underlie this process has developed considerably. We can now decorate the central events of remyelination with a host of pathways, molecules, mediators and cells, revealing a complex and precisely orchestrated process. These advances have led to recent drug-based and cell-based clinical trials for myelin diseases and have opened up hitherto unrecognized opportunities for drug-based approaches to therapeutically enhance remyelination.
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“Efficient myelin debris removal and clearance by phagocytic cells are critical to eliminate inhibitory signals interfering with OPC activation, recruitment to the site of demyelination and/or differentiation into myelinating mature OLs [14, 26, 27].”
From TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis (2020) · cites this paper as [14]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Central nervous system (CNS) remyelination reinstates axon health/ function1, yet fails in prevalent neurodegenerative disorders contributing to axon dysfunction/loss for which there is an unmet therapeutic need.”
From Central nervous system regeneration is driven by microglia necroptosis and repopulation (2019) · cites this paper as [1]
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Cites
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M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
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Self-citationOligodendroglia metabolically support axons and contribute to neurodegeneration
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Remyelination in the CNS: from biology to therapy
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Self-citationGlycolytic oligodendrocytes maintain myelin and long-term axonal integrity
Fünfschilling, U., Supplie, L. M., Mahad, D., Boretius, S., Saab, A. S., Edgar, J., Brinkmann, B. G., Kassmann, C. M., Tzvetanova, I. D., Möbius, W., et al. (2012) · Nature · doi:10.1038/nature11007 · Cited by 1,523
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Research works printed but not linked: 1
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Stem cell-based therapy for human diseases
Hoang, D. M., Pham, P. T., Bach, T. Q., Ngo, A. T. L., Nguyen, Q. T., Phan, T. T. K., Nguyen, G. H., Le, P. T. T., Hoang, V. T., Forsyth, N. R., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01134-4 · Cited by 1,074
Multiple Sclerosis: Mechanisms and Immunotherapy
Baecher-Allan, C., Kaskow, B. J., & Weiner, H. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.021 · Cited by 938
Myelin in the Central Nervous System: Structure, Function, and Pathology
Stadelmann, C., Timmler, S., Barrantes‐Freer, A., & Simons, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00031.2018 · Cited by 799
“fails in these lesions, an issue that was reviewed in detail recently (191).”
BackgroundMultiple sclerosis progression: time for a new mechanism-driven framework
Kuhlmann, T., Moccia, M., Coetzee, T., Cohen, J. A., Correale, J., Graves, J., Marrie, R. A., Montalban, X., Yong, V. W., Thompson, A. J., et al. (2023) · The Lancet Neurology · doi:10.1016/s1474-4422(22)00289-7 · Cited by 667
Oligodendrocytes in development, myelin generation and beyond
Kuhn, S., Gritti, L., Crooks, D., & Dombrowski, Y. (2019) · Cells · doi:10.3390/cells8111424 · Cited by 625
“However, CNS remyelination can also be mediated by infiltrating Schwann cells, which was described for multiple conditions including MS and traumatic brain injury [2].”
BackgroundInfluential
Metadata
- Authors
- Franklin, R. J. M., & ffrench-Constant, C.
- Affiliations
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- Corresponding author
- Franklin, Robin J. M.
- Venue
- Nature Reviews Neuroscience
- Published
- 2017-11-16
- Volume
- 18
- Issue
- 12
- Pages
- 753-769
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2770653478
- Semantic Scholar
- 873fe364632a01af9b64b05352afae59ba7235e0
- Cited by
- 647
- References
- 222
- Citations by year
- 2026: 84 · 2025: 72 · 2024: 84 · 2023: 58 · 2022: 83 · 2021: 83 · 2020: 70 · 2019: 79 · 2018: 33 · 2017: 1
- FWCI
- 7.99
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- Wellcome Trust (104783/Z/14/Z)
- Medical Research Council (MC_PC_12009)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- remyelination, central nervous system myelin, multiple sclerosis, demyelination, oligodendrocyte precursor cells, cell therapy, myelin diseases
- MeSH terms
- Animals, Cell Differentiation, Central Nervous System, Demyelinating Diseases, Humans, Myelin Sheath, Nerve Regeneration, Oligodendroglia
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