The visinin-like proteins VILIP-1 and VILIP-3 in Alzheimer’s disease—old wine in new bottles
Open accessAbstract
The neuronal Ca(2+)-sensor (NCS) proteins VILIP-1 and VILIP-3 have been implicated in the etiology of Alzheimer's disease (AD). Genome-wide association studies (GWAS) show association of genetic variants of VILIP-1 (VSNL1) and VILIP-3 (HPCAL1) with AD+P (+psychosis) and late onset AD (LOAD), respectively. In AD brains the expression of VILIP-1 and VILIP-3 protein and mRNA is down-regulated in cortical and limbic areas. In the hippocampus, for instance, reduced VILIP-1 mRNA levels correlate with the content of neurofibrillary tangles (NFT) and amyloid plaques, the pathological characteristics of AD, and with the mini mental state exam (MMSE), a test for cognitive impairment. More recently, VILIP-1 was evaluated as a cerebrospinal fluid (CSF) biomarker and a prognostic marker for cognitive decline in AD. In CSF increased VILIP-1 levels correlate with levels of Aβ, tau, ApoE4, and reduced MMSE scores. These findings tie in with previous results showing that VILIP-1 is involved in pathological mechanisms of altered Ca(2+)-homeostasis leading to neuronal loss. In PC12 cells, depending on co-expression with the neuroprotective Ca(2+)-buffer calbindin D28K, VILIP-1 enhanced tau phosphorylation and cell death. On the other hand, VILIP-1 affects processes, such as cyclic nucleotide signaling and dendritic growth, as well as nicotinergic modulation of neuronal network activity, both of which regulate synaptic plasticity and cognition. Similar to VILIP-1, its interaction partner α4β2 nicotinic acetylcholine receptor (nAChR) is severely reduced in AD, causing severe cognitive deficits. Comparatively little is known about VILIP-3, but its interaction with cytochrome b5, which is part of an antioxidative system impaired in AD, hint toward a role in neuroprotection. A current hypothesis is that the reduced expression of visinin-like protein (VSNLs) in AD is caused by selective vulnerability of subpopulations of neurons, leading to the death of these VILIP-1-expressing neurons, explaining its increased CSF levels. While the Ca(2+)-sensor appears to be a good biomarker for the detrimental effects of Aβ in AD, its early, possibly Aβ-induced, down-regulation of expression may additionally attenuate neuronal signal pathways regulating the functions of dendrites and neuroplasticity, and as a consequence, this may contribute to cognitive decline in early AD.
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VSNL1 is associated with neuropathologic lesions.
“the latter which is associated with neuropathologic lesions.52,79”
From Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific cis-regulatory elements (2023) · cites this paper as [52]
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Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Yoo, J., Ho, K. O., Yu, G.-Q., Kreitzer, A., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.025 · Cited by 1,653 · see citing works
Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
Palop, J. J., & Mucke, L. (2010) · Nature Neuroscience · doi:10.1038/nn.2583 · Cited by 1,651 · see citing works
Alzheimer’s Disease: The Challenge of the Second Century
Holtzman, D. M., Morris, J. C., & Goate, A. M. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002369 · Cited by 1,424 · see citing works
A Requirement for the Intercellular Messenger Nitric Oxide in Long-Term Potentiation
Schuman, E. M., & Madison, D. V. (1991) · Science · doi:10.1126/science.1720572 · Cited by 1,135 · see citing works
Blalock, E. M., Geddes, J. W., Chen, K. C., Porter, N. M., Markesbery, W. R., & Landfield, P. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308512100 · Cited by 1,025 · see citing works
Modulation of A-type potassium channels by a family of calcium sensors
An, W., Bowlby, M. R., Betty, M., Cao, J., Ling, H., Mendoza, G., Hinson, J., Mattsson, K. I., Strassle, B. W., Trimmer, J. S., et al. (2000) · Nature · doi:10.1038/35000592 · Cited by 959 · see citing works
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
Bezprozvanny, I., & Mattson, M. P. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.005 · Cited by 938 · see citing works
Levin, E. D., McClernon, F. J., & Rezvani, A. H. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0164-7 · Cited by 820 · see citing works
DREAM is a Ca2+-regulated transcriptional repressor
Carrión, Á. M., Link, W., Ledo, F., Mellström, B., & Naranjo, J. R. (1999) · Nature · doi:10.1038/18044 · Cited by 571 · see citing works
Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling
Burgoyne, R. D. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2093 · Cited by 527 · see citing works
Rezvani, A. H., & Levin, E. D. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01094-5 · Cited by 519 · see citing works
Molecular mechanics of calcium–myristoyl switches
Ames, J. B., Ishima, R., Tanaka, T., Gordon, J. I., Stryer, L., & Ikura, M. (1997) · Nature · doi:10.1038/38310 · Cited by 460 · see citing works
The neuronal calcium sensor family of Ca2+-binding proteins
Burgoyne, R. D., & Weiss, J. L. (2000) · Biochemical Journal · doi:10.1042/bj3530001 · Cited by 444 · see citing works
Sofouglu, M., Herman, A. I., Robinson, C. D., & Waters, A. J. (2014) · Lincoln (University of Nebraska) · Cited by 417 · see citing works
Palop, J. J., Jones, B., Kekonius, L., Chin, J., Yu, G.-Q., Raber, J., Masliah, E., & Mucke, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133381100 · Cited by 402 · see citing works
Iacopino, A. M., & Christakos, S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.11.4078 · Cited by 388 · see citing works
A Systems Level Analysis of Transcriptional Changes in Alzheimer's Disease and Normal Aging
Miller, J. A., Oldham, M. C., & Geschwind, D. H. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4098-07.2008 · Cited by 385 · see citing works
Calcium hypothesis of Alzheimer’s disease
Berridge, M. J. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0736-1 · Cited by 384 · see citing works
Amyloid beta from axons and dendrites reduces local spine number and plasticity
Wei, W., Nguyen, L. N., Kessels, H. W., Hagiwara, H., Sisodia, S., & Malinow, R. (2010) · Nature Neuroscience · doi:10.1038/nn.2476 · Cited by 357 · see citing works
Calcium-myristoyl protein switch.
Zozulya, S., & Stryer, L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11569 · Cited by 343 · see citing works
Buxbaum, J. D., Choi, E., Luo, Y., Lilliehöök, C., Crowley, A. C., Merriam, D. E., & Wasco, W. (1998) · Nature Medicine · doi:10.1038/2673 · Cited by 341 · see citing works
The dysregulation of intracellular calcium in Alzheimer disease
Supnet, C. B., & Борисович, Б. И. (2010) · Cell Calcium · doi:10.1016/j.ceca.2009.12.014 · Cited by 324 · see citing works
Buckingham, S. D., Jones, A. K., Brown, L. A., & Sattelle, D. B. (2009) · Pharmacological Reviews · doi:10.1124/pr.108.000562 · Cited by 307 · see citing works
Sequestration of the membrane-targeting myristoyl group of recoverin in the calcium-free state
Tanaka, T., Amest, J. B., Harvey, T. S., Stryer, L., & lkura, M. (1995) · Nature · doi:10.1038/376444a0 · Cited by 303 · see citing works
Calcium homeostasis and modulation of synaptic plasticity in the aged brain
Foster, T. C. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00283.x · Cited by 302 · see citing works
A Gene Expression Profile of Alzheimer's Disease
Loring, J. F., Wen, X., Lee, J. M., Seilhamer, J. J., & Somogyi, R. (2001) · DNA and Cell Biology · doi:10.1089/10445490152717541 · Cited by 300 · see citing works
Hyun, D.-H., Emerson, S. S., Jo, D.-G., Mattson, M. P., & de Cabo, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608008103 · Cited by 267 · see citing works
Braunewell, K., & Gundelfinger, E. D. (1999) · Cell and Tissue Research · doi:10.1007/s004410051207 · Cited by 251 · see citing works
Self-citationReversal of long-term dendritic spine alterations in Alzheimer disease models
Smith, D. L., Pozueta, J., Gong, B., Arancio, O., & Shelanski, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908706106 · Cited by 229 · see citing works
Biomarkers of Alzheimer's disease
Craig‐Schapiro, R., Fagan, A. M., & Holtzman, D. M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.10.003 · Cited by 217 · see citing works
Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function
Burgoyne, R. D., O'Callaghan, D. W., Hasdemir, B., Haynes, L. P., & Tepikin, A. V. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.01.010 · Cited by 200 · see citing works
Saab, B. J., Georgiou, J., Nath, A., Lee, F. J. S., Wang, M., Michalon, A., Liu, F., Mansuy, I. M., & Roder, J. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.014 · Cited by 198 · see citing works
Petratos, S., Li, Q.-X., George, A. J., Hou, X., Kerr, M. L., Unabia, S. E., Hatzinisiriou, I., Maksel, D., Aguilar, M.-I., & Small, D. H. (2008) · Brain · doi:10.1093/brain/awm260 · Cited by 197 · see citing works
Lee, J. H., Cheng, R., Barral, S., Reitz, C., Medrano, M., Lantigua, R., Jiménez-Velazquez, I. Z., Rogaeva, E., St. George-Hyslop, P. H., & Mayeux, R. (2011) · Archives of Neurology · doi:10.1001/archneurol.2010.292 · Cited by 190 · see citing works
Acute changes in short-term plasticity at synapses with elevated levels of neuronal calcium sensor-1
Sippy, T., Cruz-Martín, A., Jeromin, A., & Schweizer, F. (2003) · Nature Neuroscience · doi:10.1038/nn1117 · Cited by 184 · see citing works
Visinin‐like protein‐1: Diagnostic and prognostic biomarker in Alzheimer disease
Tarawneh, R. M., D’Angelo, G., Macy, E., Xiong, C., Carter, D. R., Cairns, N. J., Fagan, A. M., Head, D. M., Mintun, M. A., Ladenson, J. H., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22448 · Cited by 167 · see citing works
Tang, W.-Y., Morey, L. M., Cheung, Y. Y., Birch, L., Prins, G. S., & Ho, S.-M. (2012) · Endocrinology · doi:10.1210/en.2011-1308 · Cited by 164 · see citing works
Myristoylation of hippocalcin is linked to its calcium-dependent membrane association properties.
Kobayashi, M., Takamatsu, K., Saitoh, S., & Noguchi, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46711-1 · Cited by 146 · see citing works
Hippocalcin functions as a calcium sensor in hippocampal LTD.
Palmer, C. L., Lim, W., Hastie, P. G. R., Toward, M., Korolchuk, V. I., Burbidge, S. A., Banting, G., Collingridge, G. L., Isaac, J. T. R., & Henley, J. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.014 · Cited by 144 · see citing works
Kim, S. H., Fountoulakis, M., Cairns, N. J., & Lübec, G. (2001) · Springer eBooks · doi:10.1007/978-3-7091-6262-0_18 · Cited by 142 · see citing works
Ravetti, M. G., Rosso, O. A., Berretta, R. E., & Moscato, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010153 · Cited by 140 · see citing works
O'Callaghan, D. W., Ivings, L., Weiss, J. L., Ashby, M. C., Tepikin, A. V., & Burgoyne, R. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111750200 · Cited by 139 · see citing works
MERCER, E. A. J., Korhonen, L., Skoglösa, Y., Olsson, P., Kukkonen, J. P., & Lindholm, D. (2000) · The EMBO Journal · doi:10.1093/emboj/19.14.3597 · Cited by 131 · see citing works
Portrait of a myristoyl switch protein
Ames, J. B., Tanaka, T., Stryer, L., & Ikura, M. (1996) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(96)80106-0 · Cited by 129 · see citing works
Braunewell, K., & Klein-Szanto, A. J. (2008) · Cell and Tissue Research · doi:10.1007/s00441-008-0716-3 · Cited by 126 · see citing works
Self-citationLee, J., Blennow, K., Andreasen, N., Laterza, O., Modur, V., Olander, J. V., Gao, F., Ohlendorf, M. F., & Ladenson, J. H. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2008.104497 · Cited by 125 · see citing works
Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer’s disease
Takahashi, H., Brasnjevic, I., Rutten, B. P. F., Van Der Kolk, N., Perl, D. P., Bouras, C., Steinbusch, H. W. M., Schmitz, C., Hof, P. R., & Dickstein, D. L. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0242-4 · Cited by 124 · see citing works
Genome-wide association study of Alzheimer's disease with psychotic symptoms
Hollingworth, P., Sweet, R. A., Sims, R., Harold, D. H., Russo, G., Abraham, R., Stretton, A., Jones, N., Gerrish, A., Chapman, J., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.125 · Cited by 123 · see citing works
Lenz, S. E., Henschel, Y., Zopf, D., Voss, B., & Gundelfinger, E. D. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90160-d · Cited by 121 · see citing works
Calcium and Membrane Binding Properties of Bovine Neurocalcin δ Expressed in Escherichia coli
Ladant, D. (1995) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82908-8 · Cited by 120 · see citing works
Tzingounis, A. V., Kobayashi, M., Takamatsu, K., & Nicoll, R. A. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.011 · Cited by 120 · see citing works
The neuronal calcium sensor family of Ca2+-binding proteins
Burgoyne, R. D., & Weiss, J. L. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3530001 · Cited by 119 · see citing works
Expression of the neuronal calcium sensor protein family in the rat brain
Paterlini, M., Revilla, V. C., Grant, A. L., & Wisden, W. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00201-3 · Cited by 118 · see citing works
Bernstein, H., Baumann, B., Dános, P., Diekmann, S., Bogerts, B., Gundelfinger, E. D., & Braunewell, K. (1999) · Journal of Neurocytology · doi:10.1023/a:1007056731551 · Cited by 113 · see citing works
Self-citationMonfort, P., Muñoz, M.-D., Kosenko, E. A., & Felipo, V. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10116.2002 · Cited by 108 · see citing works
Lin, L., Jeanclos, E. M., Treuil, M. W., Braunewell, K., Gundelfinger, E. D., & Anand, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206857200 · Cited by 105 · see citing works
Self-citationBaglietto-Vargas, D., Moreno-Gonzalez, I., Sanchez-Varo, R., Jimenez, S., Trujillo-Estrada, L., Sanchez-Mejias, E., Torres, M., Romero-Acebal, M., Ruano, D., Vizuete, M., et al. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-100066 · Cited by 98 · see citing works
Bacher, I., Wu, B., Shytle, D. R., & George, T. P. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560903329102 · Cited by 96 · see citing works
Calsenilin reverses presenilin-mediated enhancement of calcium signaling
Leissring, M. A., Yamasaki, T. R., Wasco, W., Buxbaum, J. D., Parker, I., & LaFerla, F. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.15.8590 · Cited by 96 · see citing works
The darker side of Ca signaling by neuronal Ca-sensor proteins: from Alzheimer's disease to cancer
Braunewell, K. H. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.04.008 · Cited by 87 · see citing works
Self-citationSpilker, C., Dresbach, T., & Braunewell, K. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07331.2002 · Cited by 86 · see citing works
Self-citationCalbindin-D28k buffers intracellular calcium and promotes resistance to degeneration in PC12 cells
McMahon, A., Wong, B. S., Iacopino, A. M., Ng, M. C., Chi, S. N., & German, D. C. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00305-7 · Cited by 85 · see citing works
Coassembly of Two GluR6 Kainate Receptor Splice Variants within a Functional Protein Complex
Coussen, F., Perrais, D., Jaskolski, F., Sachidhanandam, S., Normand, E., Bockaert, J., Marin, P., & Mulle, C. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.033 · Cited by 83 · see citing works
Kajimoto, Y., Shirai, Y., Mukai, H., Kuno, T., & Tanaka, C. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03624.x · Cited by 82 · see citing works
Kalirin is Under-Expressed in Alzheimer's Disease Hippocampus
Youn, H., Jeoung, M., Koo, Y., Ji, H., Markesbery, W. R., Ji, I., & Ji, T. H. (2007) · Journal of Alzheimer's Disease · doi:10.3233/jad-2007-11314 · Cited by 77 · see citing works
Schnurra, I., Bernstein, H.-G., Riederer, P., & Braunewell, K.-H. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0432 · Cited by 76 · see citing works
Self-citationKobayashi, M., Masaki, T., Hori, K., Masuo, Y., Miyamoto, M., Tsubokawa, H., Noguchi, H., Nomura, M., & Takamatsu, K. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.02.034 · Cited by 76 · see citing works
Dynamics and calcium sensitivity of the Ca2+/myristoyl switch protein hippocalcin in living cells
O'Callaghan, D. W., Tepikin, A. V., & Burgoyne, R. D. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200306042 · Cited by 76 · see citing works
Braunewell, K. H., Riederer, P. F., Spilker, C., Gundelfinger, E. D., Bogerts, B., & Bernstein, H. (2001) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051244 · Cited by 73 · see citing works
Self-citationChen, L., Yoo, S.-E., Na, R., Liu, Y., & Ran, Q. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.01.008 · Cited by 71 · see citing works
Early calcium dysregulation in Alzheimer’s disease: setting the stage for synaptic dysfunction
Chakroborty, S., & Stutzmann, G. E. (2011) · Science China Life Sciences · doi:10.1007/s11427-011-4205-7 · Cited by 70 · see citing works
Brackmann, M., Schuchmann, S., Anand, R., & Braunewell, K. (2005) · Journal of Cell Science · doi:10.1242/jcs.02376 · Cited by 70 · see citing works
Self-citationcDNA cloning of a neural visinin-like Ca2+-binding protein
Kuno, T., Kajimoto, Y., Hashimoto, T., Mukai, H., Shirai, Y., Saheki, S., & Tanaka, C. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80012-9 · Cited by 66 · see citing works
Dai, F. F., Zhang, Y., Kang, Y., Wang, Q., Gaisano, H. Y., Braunewell, K., Chan, C. B., & Wheeler, M. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512924200 · Cited by 64 · see citing works
Self-citationWu, L., Mellström, B., Wang, H., Ren, M., Domingo, S., Kim, S. S., Li, X., Chen, T., Naranjo, J. R., & Zhuo, M. (2010) · Molecular Brain · doi:10.1186/1756-6606-3-3 · Cited by 63 · see citing works
Braunewell, K., Brackmann, M., Schaupp, M., Spilker, C., Anand, R., & Gundelfinger, E. D. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00506.x · Cited by 62 · see citing works
Self-citationHippocalcin protects against caspase-12-induced and age-dependent neuronal degeneration
Korhonen, L., Hansson, I., Kukkonen, J. P., Brännvall, K., Kobayashi, M., Takamatsu, K., & Lindholm, D. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.08.015 · Cited by 61 · see citing works
Regulation of P2X2 Receptors by the Neuronal Calcium Sensor VILIP1
Chaumont‐Dubel, S., Compan, V., Toulmé, E., Richler, E., Housley, G. D., Rassendren, F., & Khakh, B. S. (2008) · Science Signaling · doi:10.1126/scisignal.1162329 · Cited by 61 · see citing works
Lack of DREAM Protein Enhances Learning and Memory and Slows Brain Aging
Fontán‐Lozano, Á., Romero‐Granados, R., Martín, Y. D. P., Suárez‐Pereira, I., Delgado-Garcia, J. M., Penninger, J. M., & Carrión, Á. M. (2008) · Current Biology · doi:10.1016/j.cub.2008.11.056 · Cited by 60 · see citing works
Ivings, L., Pennington, S. R., Jenkins, R., Weiss, J. L., & Burgoyne, R. D. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3630599 · Cited by 60 · see citing works
Braunewell, K., Spilker, C., Behnisch, T., & Gundelfinger, E. D. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052129.x · Cited by 59 · see citing works
Self-citationFew, A. P., Lautermilch, N. J., Westenbroek, R. E., Scheuer, T., & Catterall, W. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0452-05.2005 · Cited by 59 · see citing works
Spilker, C., Richter, K., Smalla, K., Manahan‐Vaughan, D., Gundelfinger, E. D., & Braunewell, K. H. (2000) · Neuroscience · doi:10.1016/s0306-4522(99)00536-9 · Cited by 57 · see citing works
Self-citationMahloogi, H., González-Guerrico, A. M., de Cicco, R. L., Bassi, D., Goodrow, T. L., Braunewell, K., & Klein–Szanto, A. J. (2003) · PubMed · Cited by 57 · see citing works
Self-citationKaufmann, W. A., Barnas, U., Humpel, C., Nowakowski, K., deCol, C., Gurka, P., Ransmayr, G., Hinterhuber, H., Winkler, H., & Marksteiner, J. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00121.x · Cited by 54 · see citing works
Jo, D., Joo‐Yong, L., Hong, Y., Sungmin, S., Mook‐Jung, I., Koh, J., & Jung, Y. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02159.x · Cited by 54 · see citing works
Gierke, P., Zhao, C., Brackmann, M., Linke, B., Heinemann, U., & Braunewell, K. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.055 · Cited by 49 · see citing works
Self-citationZhao, C., Noack, C., Brackmann, M., Gloveli, T., Maelicke, A., Heinemann, U., Anand, R., & Braunewell, K. H. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.11.001 · Cited by 48 · see citing works
Self-citationSpilker, C., Gundelfinger, E. D., & Braunewell, K. H. (2002) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/s1570-9639(02)00452-1 · Cited by 47 · see citing works
Self-citationSpilker, C., & Braunewell, K. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00242-2 · Cited by 45 · see citing works
Self-citationO'Callaghan, D. W., Haynes, L. P., & Burgoyne, R. D. (2005) · Biochemical Journal · doi:10.1042/bj20051001 · Cited by 44 · see citing works
Proteomics analysis of the temporal changes in axonal proteins during maturation
Yamatani, H., Kawasaki, T., Mita, S., Inagaki, N., & Hirata, T. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20794 · Cited by 43 · see citing works
Biomarkers for Alzheimer's disease
Pauwels, E. K. J., Volterani, D., & Marlani, G. (2009) · Drug News & Perspectives · doi:10.1358/dnp.2009.22.3.1354128 · Cited by 42 · see citing works
A role for calsenilin and related proteins in multiple aspects of neuronal function
Buxbaum, J. D. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.001 · Cited by 41 · see citing works
Li, C., Pan, W., Braunewell, K. H., & Ames, J. B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.173724 · Cited by 41 · see citing works
Self-citationLenz, S. E., Braunewell, K., Weise, C., Chittka, A., & Gundelfinger, E. D. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1298 · Cited by 40 · see citing works
Self-citationKim, J. H., Lee, J., Song, Y. M., Park, C., Hwang, S., Kim, Y., Kaang, B., & Son, H. (2005) · The FASEB Journal · doi:10.1096/fj.05-4826fje · Cited by 39 · see citing works
Hyun, D. H., Mughal, M. R., Yang, H., Lee, J. H., Ko, E. J., Hunt, N. D., de Cabo, R., & Mattson, M. P. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.07.020 · Cited by 39 · see citing works
Popović, M., Caballero-Bleda, M., Kadish, I., & Van Groen, T. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.05.023 · Cited by 38 · see citing works
Braunewell, K. H., Dwary, A. D., Richter, F., Trappe, K., Zhao, C., Giegling, I., Schönrath, K., & Rujescu, D. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.20 · Cited by 35 · see citing works
Self-citationTranslational gene mapping of cognitive decline
Wilmot, B., McWeeney, S. K., Nixon, R. R., Montine, T. J., Laut, J., Harrington, C. A., Kaye, J. A., & Kramer, P. L. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.11.008 · Cited by 35 · see citing works
Kato, M., Watanabe, Y., Satoshi, I. I. N. O., TAKAOKA, Y., Kobayashi, S., Haga, T., & Hidaka, H. (1998) · Biochemical Journal · doi:10.1042/bj3310871 · Cited by 34 · see citing works
Lindholm, D., MERCER, E. A. J., Yu, L.-Y., Chen, Y., Kukkonen, J. P., Korhonen, L., & Arumäe, U. (2002) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/s1570-9639(02)00454-5 · Cited by 34 · see citing works
Fedorov, N. B., Benson, L. C., Graef, J. D., Lippiello, P. M., & Bencherif, M. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.146910 · Cited by 34 · see citing works
Brackmann, M., Zhao, C., Kuhl, D., Manahan‐Vaughan, D., & Braunewell, K. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.028 · Cited by 33 · see citing works
Self-citationNeuronal P2X2 Receptors Are Mobile ATP Sensors That Explore the Plasma Membrane When Activated
Richler, E., Shigetomi, E., & Khakh, B. S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3362-11.2011 · Cited by 32 · see citing works
Lian, L., Pandalaneni, S. R., Patel, P., McCue, H. V., Haynes, L. P., & Burgoyne, R. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027779 · Cited by 31 · see citing works
Hippocalcin protects hippocampal neurons against excitotoxin damage by enhancing calcium extrusion
Masuo, Y., Ogura, A., Kobayashi, M., Masaki, T., Furuta, Y., Ono, T., & Takamatsu, K. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.011 · Cited by 29 · see citing works
Neurodegeneration and energy metabolism: from chemistry to clinics
Blandini, F., Braunewell, K. H., Manahan‐Vaughan, D., Orzi, F., & Sarti, P. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401323 · Cited by 29 · see citing works
Self-citationBraunewell, K., & Gundelfinger, E. D. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00696-4 · Cited by 28 · see citing works
Self-citationPolymeropoulos, M. H., Ide, S. E., Soares, M. B., & Lennon, G. G. (1995) · Genomics · doi:10.1006/geno.1995.1244 · Cited by 28 · see citing works
Choi, W.-S., Chun, S.-Y., Markelonis, G. J., Oh, T. H., & Oh, Y. J. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5649 · Cited by 28 · see citing works
Villalobos, C. A., & Andrade, R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3440-10.2010 · Cited by 27 · see citing works
Braunewell, K. H., Brackmann, M., & Manahan‐Vaughan, D. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00051-0 · Cited by 25 · see citing works
Self-citationExpression of the neuronal calcium sensor visinin-like protein-1 in the rat hippocampus
Zhao, C., & Braunewell, K. H. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2007.10.067 · Cited by 24 · see citing works
Self-citationImplication of neuronal Ca2+-sensor protein VILIP-1 in the glutamate hypothesis of schizophrenia
Gierke, P., Zhao, C., Bernstein, H., Noack, C., Anand, R., Heinemann, U., & Braunewell, K. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.07.008 · Cited by 22 · see citing works
Self-citationFunctional analysis of calcium-binding EF-hand motifs of visinin-like protein-1
Lin, L., Braunewell, K., Gundelfinger, E. D., & Anand, R. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00943-9 · Cited by 22 · see citing works
Self-citationZhao, C., Anand, R., & Braunewell, K. (2008) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-008-9320-z · Cited by 22 · see citing works
Self-citationOikawa, K., Kimura, S., Aoki, N., Atsuta, Y., Takiyama, Y., Nagato, T., Yanai, M., Kobayashi, H., Sato, K., Sasajima, T., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312766200 · Cited by 22 · see citing works
Kraut, N., Frampton, J., & Graf, T. (1995) · PubMed · Cited by 21 · see citing works
The Action of ANP, BNP and Related Peptides on Motivated Behavior in Rats
Telegdy, G. (1994) · Reviews in the Neurosciences · doi:10.1515/revneuro.1994.5.4.309 · Cited by 18 · see citing works
Regulatory elements and functional implication for the formation of dimeric visinin‐like protein‐1
Chen, K., Wang, L., & Chang, L. (2008) · Journal of Peptide Science · doi:10.1002/psc.1097 · Cited by 18 · see citing works
Kobayashi, M., Takamatsu, K., Fujishiro, M., Saitoh, S., & Noguchi, T. (1994) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(94)90062-0 · Cited by 17 · see citing works
Redox Signaling Regulates Transcriptional Activity of the Ca 2+ -Dependent Repressor DREAM
Rivas, M., Aurrekoetxea, K., Mellström, B., & Naranjo, J. R. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3385 · Cited by 17 · see citing works
A novel role of hippocalcin in bFGF‐induced neurite outgrowth of H19‐7 cells
Oh, D., Cho, J. H., Park, S., Kim, Y. S., Yoon, Y., Yoon, S. H., Chung, K. C., Lee, K. S., & Han, J. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21602 · Cited by 17 · see citing works
Functional Contribution of Ca2+ and Mg2+ to the Intermolecular Interaction of Visinin-like Proteins
Jheng, F.-F., Wang, L., Lee, L., & Chang, L. (2006) · The Protein Journal · doi:10.1007/s10930-006-9008-5 · Cited by 16 · see citing works
Wang, C. K. L., Simon, A., Jessen, C., Oliveira, C. L. P., Mack, L. A., Braunewell, K., Ames, J. B., Pedersen, J. S., & Hofmann, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026793 · Cited by 15 · see citing works
Self-citationSchönrath, K., Pan, W., Klein–Szanto, A. J., & Braunewell, K. (2010) · Molecular Carcinogenesis · doi:10.1002/mc.20707 · Cited by 12 · see citing works
Self-citationImmunochemical assessment of neural visinin-like calcium-binding protein 3 expression in rat brain
Hamashima, H., Tamaru, T., Noguchi, H., Kobayashi, M., & Takamatsu, K. (2001) · Neuroscience Research · doi:10.1016/s0168-0102(00)00208-x · Cited by 11 · see citing works
Interactions of Visinin-like Proteins with Phospho-inositides
Braunewell, K., Paul, B., Altarche‐Xifró, W., Noack, C., Lange, K., & Hofmann, A. (2010) · Australian Journal of Chemistry · doi:10.1071/ch09355 · Cited by 10 · see citing works
Self-citationMolecular Determinants of Modulation of CaV2.1 Channels by Visinin-like Protein 2
Nanou, E., Martinez, G. Q., Scheuer, T., & Catterall, W. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.292581 · Cited by 10 · see citing works
Braunewell, K., & Klein–Szanto, A. J. (2009) · Cell and Tissue Research · doi:10.1007/s00441-008-0745-y · Cited by 9 · see citing works
Self-citationCerebrospinal Fluid Biomarkers in the Evaluation of Alzheimer Disease
Verbeek, M. M., & Rikkert, M. G. M. O. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2008.113027 · Cited by 5 · see citing works
Neuron specific calcium-sensors (the NCS subfamily)
Celio, M. R. (1996) · doi:10.1093/oso/9780198599517.003.0015 · Cited by 4 · see citing works
Some Notes on Visinin-Like Protein 1 and Alzheimer Disease
Bernstein, H., & Braunewell, K. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.116970 · Cited by 2 · see citing works
Self-citationLack of DREAM Protein Enhances Learning and Memory and Slows Brain Aging
Fontán‐Lozano, Á., Romero‐Granados, R., Martín, Y. D. P., Suárez‐Pereira, I., Delgado-Garcia, J. M., Penninger, J. M., & Carrión, Á. M. (2009) · Current Biology · doi:10.1016/j.cub.2009.06.055 · Cited by 2 · see citing works
Petratos, S. (., Li, Q. (., George, A. (., Hou, X. (., Kerr, M. (., Unabia, S. (., Hatzinisiriou, I. (., Maksel, D. (., Aguilar, M. (., & (14749594), D. S. (2008) · Figshare · Cited by 2 · see citing works
Braunewell, K. (2009) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a004095.01
Self-citation
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- Mahloogi H. Gonzalez-Guerrico A. M. De Cicco R. L. Bassi D. E. Goodrow T. Braunewell K. H. Klein-Szanto A. J. P. (2003). Graduate decrease of VILIP-1 Expression during mouse skin tumor progression and its role in regulating tumor cell invasive behavior. Cancer Res. 63, 4997– 5004 12941826
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Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease: Current Evidence and Future Perspectives
McGrowder, D. A., Miller, F. G., Vaz, K., Nwokocha, C. R., Wilson-Clarke, C. F., Anderson, M., Brown, J., Anderson-Jackson, L., Williams, L., Latore, L., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11020215 · Cited by 167 · see citing works
Sutphen, C. L., McCue, L., Herries, E. M., Xiong, C., Ladenson, J. H., Holtzman, D. M., Fagan, A. M., & On behalf of, A. D. N. I. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.01.012 · Cited by 162 · see citing works
Biomarkers used in Alzheimer’s disease diagnosis, treatment, and prevention
Mahaman, Y. A. R., Embaye, K. S., Huang, F., Li, L., Zhu, F., Wang, J.-Z., Liu, R., Feng, J., & Wang, X. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101544 · Cited by 149 · see citing works
Kester, M. I., Teunissen, C. E., Sutphen, C., Herries, E. M., Ladenson, J. H., Xiong, C., Scheltens, P., van der Flier, W. M., Morris, J. C., Holtzman, D. M., et al. (2015) · Alzheimer's Research & Therapy · doi:10.1186/s13195-015-0142-1 · Cited by 146 · see citing works
Dhiman, K., Blennow, K., Zetterberg, H., Martins, R. N., & Gupta, V. B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03040-5 · Cited by 114 · see citing works
Tarawneh, R. M., Head, D. M., Allison, S. L., Buckles, V., Fagan, A. M., Ladenson, J. H., Morris, J. C., & Holtzman, D. M. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.0202 · Cited by 96 · see citing works
New fluid biomarkers tracking non-amyloid-β and non-tau pathology in Alzheimer’s disease
Park, S. A., Han, S. M., & Kim, C. E. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0418-9 · Cited by 93 · see citing works
Calcium Sensors in Neuronal Function and DysfunctionPreprint
Burgoyne, R. D., Helassa, N., McCue, H. V., & Haynes, L. P. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a035154 · Cited by 87 · see citing works
Anderson, A. G., Rogers, B. B., Loupe, J. M., Rodriguez-Nunez, I., Roberts, S. C., White, L. M., Brazell, J. N., Bunney, W. E., Bunney, B. G., Watson, S. J., et al. (2023) · Cell Genomics · doi:10.1016/j.xgen.2023.100263 · Cited by 82 · see citing works
“We alsomeasured decreased expression of the Ca sensors calmodulin (CALM1,CALM2,CALM3) and VILIP-1 (VSNL1), the latter which is associated with neuropathologic lesions.(52,79) In contrast, two genes encoding calcium channel subunits (CACNA1C and CACNA1B) were upregulated in AD neurons.”
BackgroundResultZelaya, M. V., Pérez‐Valderrama, E., de Morentin, X. M., Tuñón, T., Ferrer, I., Luquín, M. R., Fernández‐Irigoyen, J., & Santamaría, E. (2015) · Oncotarget · doi:10.18632/oncotarget.6254 · Cited by 67 · see citing works
Luo, X., Hou, L., Shi, H., Zhong, X., Zhang, Y., Zheng, D., Tan, Y., Guoyan, H., Mu, N., Chan, J., et al. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12331 · Cited by 64 · see citing works
Differential expression and prognostic role of selected genes in colorectal cancer patients.
Pitule, P., Vyčítal, O., Bruha, J., Novák, P., Hošek, P., Třeška, V., Hlavatá, I., Souček, P., Králíčková, M., & Liška, V. (2013) · PubMed · Cited by 63 · see citing works
Leko, M. B., Borovečki, F., Dejanović, N., Hof, P. R., & Šimić, G. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150705 · Cited by 56 · see citing works
Parkinson's and Lewy body dementia CSF biomarkers
Parnetti, L., Paciotti, S., Farotti, L., Bellomo, G., Sepe, F. N., & Eusebi, P. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.04.078 · Cited by 54 · see citing works
Fang, Y., Zeng, P. H., Qu, N., Ning, L., Chu, J., Zhang, T., Zhou, X., & Tian, Q. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14537 · Cited by 52 · see citing works
The Role of Visinin-Like Protein-1 in the Pathophysiology of Alzheimer’s Disease
Groblewska, M., Muszyński, P., Wojtulewska-Supron, A., Kulczyńska‐Przybik, A., & Mroczko, B. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150060 · Cited by 51 · see citing works
Girard, F., Venail, J., Schwaller, B., & Celio, M. R. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.02.018 · Cited by 42 · see citing works
Halbgebauer, S., Steinacker, P., Riedel, D., Oeckl, P., Anderl‐Straub, S., Lombardi, J., Arnim, C. A. F. V., Nagl, M., Giese, A., Ludolph, A. C., et al. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01122-4 · Cited by 40 · see citing works
Lista, S., Santos‐Lozano, A., Emanuele, E., Mercuri, N. B., Gabelle, A., López‐Ortiz, S., Martín-Hernández, J., Maisto, N., Imbimbo, C., Caraci, F., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02376-6 · Cited by 42 · see citing works
HPCAL 1 promotes glioblastoma proliferation via activation of Wnt/β‐catenin signalling pathway
Zhang, D., Liu, X., Xu, X., Xu, J., Yi, Z., Shan, B., & Liu, B. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14083 · Cited by 39 · see citing works
Muszyński, P., Kulczyńska‐Przybik, A., Borawska, R., Litman‐Zawadzka, A., Słowik, A., Klimkowicz‐Mrowiec, A., Pera, J., Dziedzic, T., & Mroczko, B. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170220 · Cited by 38 · see citing works
McDowell, E. N., Kisielewski, A. E., Pike, J. W., Franco, H. L., Yao, H. H., & Johnson, K. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047359 · Cited by 37 · see citing works
DCLK1 autoinhibition and activation in tumorigenesis
Cheng, L., Yang, Z., Guo, W., Wu, C., Liang, S., Tong, A., Cao, Z., Thorne, R. F., Yang, S., Yu, Y., et al. (2021) · The Innovation · doi:10.1016/j.xinn.2021.100191 · Cited by 37 · see citing works
Dulewicz, M., Kulczyńska‐Przybik, A., & Mroczko, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218335 · Cited by 34 · see citing works
Sadigh‐Eteghad, S., Majdi, A., Talebi, M., Mahmoudi, J., & Babri, S. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.02.047 · Cited by 28 · see citing works
Validity of the MPTP-Treated Mouse as a Model for Parkinson’s Disease
Klemann, C. J. H. M., Martens, G. J. M., Poelmans, G., & Visser, J. E. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9103-8 · Cited by 26 · see citing works
Fluid Candidate Biomarkers for Alzheimer’s Disease: A Precision Medicine Approach
Prete, E. D., Beatino, M. F., Campese, N., Giampietri, L., Siciliano, G., Ceravolo, R., & Baldacci, F. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10040221 · Cited by 27 · see citing works
Mavroudis, I. A., Petridis, F., Chatzikonstantinou, S., Karantali, E., & Kazis, D. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01458-2 · Cited by 24 · see citing works
Biomarkers and Tools for Predicting Alzheimer’s Disease in the Preclinical Stage
Li, T.-R., Yang, Q., Hu, X., & Han, Y. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210524153901 · Cited by 22 · see citing works
MicroRNAs and synapse turnover in Alzheimer’s disease
Dalal, S., Ramirez-Gomez, J., Sharma, B., Devara, D., & Kumar, S. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102377 · Cited by 21 · see citing works
A Review of Biomarkers of Amyotrophic Lateral Sclerosis: A Pathophysiologic Approach
Alshehri, R. S., Abuzinadah, A. R., Alrawaili, M. S., Alotaibi, M. K., Alsufyani, H. A., Alshanketi, R. M., & Alshareef, A. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252010900 · Cited by 23 · see citing works
Kelemen, K., & Szilágyi, T. (2021) · Brain Sciences · doi:10.3390/brainsci11050634 · Cited by 20 · see citing works
Wu, Y.-J., Schulz, H., Lin, C.-C. J., Saar, K., Patone, G., Fischer, H., Hübner, N., Heimrich, B., & Schwemmle, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214939110 · Cited by 19 · see citing works
Mohammadi, H., Ariaei, A., Ghobadi, Z., Gorgich, E. A. C., & Rustamzadeh, A. (2024) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2024.02.007 · Cited by 18 · see citing works
Biomarkers and Tools for Predicting Alzheimer's Disease in the Preclinical Stage
Li, T., Yang, Q. Z., Hu, X., & Han, Y. (2022) · Kölner Universitäts PublikationsServer (Universität zu Köln) · Cited by 17 · see citing works
Stephens, G. S., Park, J. K., Eagle, A. L., You, J. C., Silva‐Pérez, M., Fu, C.-H., Choi, S., Romain, C. P. S., Sugimoto, C., Buffington, S. A., et al. (2024) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2024.102612 · Cited by 15 · see citing works
Schaeverbeke, J. M., Gille, B., Adamczuk, K., Vanderstichele, H., Chassaing, E., Bruffaerts, R., Neyens, V., Stoops, E., Tournoy, J., Vandenberghe, R. R., et al. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14680 · Cited by 13 · see citing works
Saunders, T. S., Gadd, D. A., Spires‐Jones, T. L., King, D., Ritchie, C. W., & Terrera, G. M. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15656 · Cited by 12 · see citing works
Milos, T., Vuić, B., Balic, N., Farkaš, V., Erjavec, G. N., Štrac, D. Š., Perković, M. N., & Pivac, N. (2024) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2024.2400683 · Cited by 11 · see citing works
Novel CSF Biomarkers Tracking Autoimmune Inflammatory and Neurodegenerative Aspects of CNS Diseases
Kapaki, E. N., Vakrakou, A. G., & Boufidou, F. (2022) · Diagnostics · doi:10.3390/diagnostics13010073 · Cited by 11 · see citing works
Comparison of VILIP-1 and VILIP-3 Binding to Phospholipid Monolayers
Rebaud, S., Simon, A., Wang, C. K. L., Mason, L., Blum, L. J., Hofmann, A., & Girard-Egrot, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093948 · Cited by 10 · see citing works
Hamid, M. M. A. E., Shaheen, M., Omar, Y. M. K., & Mabrouk, M. S. (2022) · Ain Shams Engineering Journal · doi:10.1016/j.asej.2022.101986 · Cited by 9 · see citing works
Biofluid biomarkers for Alzheimer’s disease
Wang, S., Xie, S., Zheng, Q., Zhang, Z., Wang, T., & Zhang, G. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1380237 · Cited by 8 · see citing works
Dulewicz, M., Kulczyńska‐Przybik, A., Borawska, R., Słowik, A., & Mroczko, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810867 · Cited by 8 · see citing works
Liu, D., Dong, X., Yang, R., Guo, H., Wang, T., & Xu, G. (2020) · Medicine · doi:10.1097/md.0000000000019252 · Cited by 8 · see citing works
APOE ϵ4 Allele Is Associated with Elevated Levels of CSF VILIP-1 in Preclinical Alzheimer’s Disease
Wang, L., Zhang, M., Wang, Q., Jiang, X., Li, K., & Liu, J. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s235395 · Cited by 8 · see citing works
Yan, X.-J., Li, Y.-B., Liu, W. Y., Dai, W., & Wang, C. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.03.008 · Cited by 8 · see citing works
Hao, Y., Liu, X., & Zhu, R. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666211208142702 · Cited by 7 · see citing works
Giralt, A., Brito, V., Pardo, M., Rubio, S. E., Marion‐Poll, L., Martín‐Ibáñez, R., Zamora‐Moratalla, A., Bosch, C., Ballesteros, J. J., Blasco, E., et al. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113095 · Cited by 7 · see citing works
Izadi, F., & Soheilifar, M. H. (2018) · Europe PMC (PubMed Central) · Cited by 6 · see citing works
Parithathvi, A., Harshitha, P., Mumbrekar, K. D., & Dsouza, H. S. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01613-6 · Cited by 5 · see citing works
Liang, J., Hussainy, S., Lee, S. M., Wu, G., Bautista, N., Ding, M., Wang, H., LaFleur, B., Perry, G. L., Wang, X., et al. (2025) · Neurology · doi:10.1212/wnl.0000000000210250 · Cited by 5 · see citing works
Ma, M., Zeng, G., Li, J., Liang, J., Huang, L., Chen, J., & Lai, J. (2022) · Cancer Medicine · doi:10.1002/cam4.4897 · Cited by 5 · see citing works
Huangfu, S., Sang, X., Zhou, S., Liu, H., Cui, D., Du, Y., Xing, X., Liu, W., Jian-zhong, B., & Xie, Z. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01280-9 · Cited by 4 · see citing works
Demirci, S. C., Barun, S., Özaslan, A., Gülbahar, Ö., Bulut, T. S. D., Çamurdan, A. D., & İşeri, E. (2024) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.23.1149 · Cited by 5 · see citing works
Biomarker Modelling of Early Molecular Changes in Alzheimer’s Disease
Paterson, R. W., Toombs, J., Slattery, C. F., Schott, J. M., & Zetterberg, H. (2013) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-013-0069-9 · Cited by 4 · see citing works
Oikawa, K., Odero, G. L., Nafez, S., Ge, N., Zhang, D., Kobayashi, H., Sate, K., Kimura, S., Tateno, M., & Albensi, B. C. (2016) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-016-0753-6 · Cited by 3 · see citing works
A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal GangliaPreprint
Ding, W., Klein, A., Báez-Becerra, C. T., Rink, J. A., Bartlett, A., Wang, R., Zeng, Q., Castanon, R., Nery, J. R., Osgood, E., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.12.705594 · Cited by 2 · see citing works
Molecular Biomarkers for Diagnosis & Therapies of Alzheimer’s Disease
Potdar, P. D., & Shetti, A. (2016) · AIMS neuroscience · doi:10.3934/neuroscience.2016.4.433
Perkovic, M. N., Leko, M. B., Erjavec, G. N., Milos, T., Vuic, B., Borovečki, F., Šimić, G., & Pivac, N. (2025) · Brain Mechanisms · doi:10.1016/j.bramec.2025.202495
The Effect of Resistance and Endurance Exercise on Alzheimer's Biomarkers: A Review Article
Tabibvand, P., Asadollahi, S., & Dadkhah, M. (2024) · مجله دانشگاه علوم پزشکی اردبیل · doi:10.61186/jarums.24.3.241
Changes in transcriptional regulation in the temporal lobe in patients with Alzheimer's disease
Yang, Y., Li, Y., & Chen, Y. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251322536 · Cited by 1 · see citing works
Wang, Y., Yu, S., Zhang, M., Zhu, H., Chen, S., Zhou, Y., Zhou, X., Sun, Z., Yu, X., Zhu, X., et al. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251331000
Yu, Y., Chen, S.-B., Wang, H., Lin, C., Dybus, A., Hukowska-Szematowicz, B., & Li, Y. (2025) · Animal Bioscience · doi:10.5713/ab.25.0135
Halbgebauer, S., Steinacker, P., Riedel, D., Oeckl, P., Anderl-Straub, S., Lombardi, J., Arnim, C. A. F. V., Nagl, M., Giese, A., Ludolph, A. C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21622142
Greenlee, M., Amniouel, S., Rivera, I., Suh, J., Martinez, N. J., Simeonov, A. M., Head, E., Tycko, R., Zheng, W., Fleming, B. D., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117946
- Authors
- Braunewell, K. H.
- Affiliations
- Southern Research Institute (US)
- Corresponding author
- Braunewell, Karl H.
- Venue
- Frontiers in Molecular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2012
- Volume
- 5
- Pages
- 20-20
- ISSN
- 1662-5099 (ISSN-L)
- PMC
- PMC3284765
- OpenAlex
- W2055775727
- Cited by
- 66
- References
- 139
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 9 · 2023: 1 · 2022: 9 · 2021: 6 · 2020: 6 · 2019: 6 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 7 · 2014: 1 · 2013: 4 · 2012: 1
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Frontiers in Molecular Neuroscience (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Alzheimer's Drug Discovery Foundation
- Deutsche Forschungsgemeinschaft (SPP1226)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Keywords
- VILIP-1, Alzheimer's disease, neuronal calcium sensor, calcium homeostasis, cerebrospinal fluid biomarkers, cognitive decline, neurofibrillary tangles, amyloid plaques, tau phosphorylation, nicotinic acetylcholine receptors, calbindin-D28k, cytochrome b5, neuroprotection, late-onset Alzheimer's disease, psychosis, hippocampus, synaptic plasticity, neuronal vulnerability
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