Transcriptional Control of Neuronal Migration in the Developing Mouse Brain
Abstract
The molecular mechanisms controlling neuronal migration have many similarities with those described for axon guidance. For instance, migrating neurons and growing axons are instructed toward their final destination by the same guidance molecules and are able to adapt their response to those cues by modulating the expression of guidance receptors. Transcriptional regulation is thought to be a key determinant in this later process, although we are just beginning to identify the contribution of these mechanisms in neuronal migration. In this review, we will describe recent progress made in understanding the contribution of transcription factors in controlling neuronal migration in the developing mouse brain, with a special focus on the developing telencephalon.
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Pyramidal excitatory neurons born in the ventricular and subventricular zones of prefrontal subdomains migrate radially toward the cortical plate under the influence of Fgfs.
“The pyramidal excitatory neurons born in the VZ and SVZ of the prefrontal subdomains, similar to other cortical areas, start to migrate radially toward the proper position in the CP under the influence of Fgfs [50, 59, 60].”
From Development of prefrontal cortex (2022) · cites this paper as [59]
The sections “Role of Transcription Factors in the Migration of Cortical Projection Neurons” and “Transcription Factors as Multitasking Regulators during Brain Development” describe cortical projection neurons migrating radially and reaching the cortical plate, with progenitors in the VZ/SVZ. They do not specify prefrontal subdomains or say that Fgfs influence this migration; the factors discussed instead include Ngn1/2. Page numbers were unavailable in our copy. (LLM, conf=0.87)
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Cites
The Molecular Biology of Axon Guidance
Tessier‐Lavigne, M., & Goodman, C. S. (1996) · Science · doi:10.1126/science.274.5290.1123 · Cited by 3,295 · see citing works
Interneuron Migration from Basal Forebrain to Neocortex: Dependence on <i>Dlx</i> Genes
Anderson, S. A., Eisenstat, D. D., Shi, L., & Rubenstein, J. L. R. (1997) · Science · doi:10.1126/science.278.5337.474 · Cited by 1,462 · see citing works
Molecular Mechanisms of Axon Guidance
Dickson, B. J. (2002) · Science · doi:10.1126/science.1072165 · Cited by 1,431 · see citing works
Rakic, P. (1974) · Science · doi:10.1126/science.183.4123.425 · Cited by 1,161 · see citing works
Patterning the Vertebrate Neuraxis
Lumsden, A., & Krumlauf, R. K. (1996) · Science · doi:10.1126/science.274.5290.1109 · Cited by 1,146 · see citing works
Biology of the p21-Activated Kinases
Bokoch, G. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161742 · Cited by 1,080 · see citing works
A long, remarkable journey: Tangential migration in the telencephalon
Marín, Ó., & Rubenstein, J. L. R. (2001) · Nature reviews. Neuroscience · doi:10.1038/35097509 · Cited by 1,050 · see citing works
C ELL M IGRATION IN THE F OREBRAIN
Marín, Ó., & Rubenstein, J. L. R. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131058 · Cited by 917 · see citing works
Sussel, L., Marin, O., Kimura, S., & Rubenstein, J. L. R. (1999) · Development · doi:10.1242/dev.126.15.3359 · Cited by 873 · see citing works
CENTRAL NERVOUS SYSTEM NEURONAL MIGRATION
Hatten, M. E. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.511 · Cited by 797 · see citing works
Lavdas, A. A., Grigoriou, M., Pachnis, V., & Parnavelas, J. G. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-18-07881.1999 · Cited by 765 · see citing works
Wichterle, H., Turnbull, D. H., Nery, S., Fishell, G., & Alvarez-Buylla, A. (2001) · Development · doi:10.1242/dev.128.19.3759 · Cited by 722 · see citing works
Patterns of neuronal migration in the embryonic cortex
Kriegstein, A. R., & Noctor, S. C. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.05.001 · Cited by 648 · see citing works
Origin and Molecular Specification of Striatal Interneurons
Marín, Ó., Anderson, S. A., & Rubenstein, J. L. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06063.2000 · Cited by 627 · see citing works
Trekking across the Brain: The Journey of Neuronal Migration
Ayala, R., Shu, T., & Tsai, L.-H. (2007) · Cell · doi:10.1016/j.cell.2006.12.021 · Cited by 620 · see citing works
Transcriptional Codes and the Control of Neuronal Identity
Shirasaki, R., & Pfaff, S. L. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142916 · Cited by 522 · see citing works
Young neurons from medial ganglionic eminence disperse in adult and embryonic brain
Wichterle, H., Garcia-Verdugo, J. M., Herrera, D. G., & Alvarez-Buylla, A. (1999) · Nature Neuroscience · doi:10.1038/8131 · Cited by 506 · see citing works
Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements
Jessen, J. R., Topczewski, J., Bingham, S., Sepich, D. S., Marlow, F., Chandrasekhar, A., & Solnica-Krezel, L. (2002) · Nature Cell Biology · doi:10.1038/ncb828 · Cited by 504 · see citing works
LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons.
Sharma, K., Sheng, H. Z., Lettieri, K., Li, H., Karavanov, A., Potter, S., Westphal, H., & Pfaff, S. (1998) · Cell · doi:10.1016/s0092-8674(00)81704-3 · Cited by 461 · see citing works
Sorting of Striatal and Cortical Interneurons Regulated by Semaphorin-Neuropilin Interactions
Marı́n, O., Yaron, A., Bagri, A., Tessier-Lavigne, M., & Rubenstein, J. L. R. (2001) · Science · doi:10.1126/science.1061891 · Cited by 433 · see citing works
Slit proteins: key regulators of axon guidance, axonal branching, and cell migration.
Brose, K., & Tessier-Lavigne, M. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00066-5 · Cited by 381 · see citing works
Lü, Q., Sun, E. E., Klein, R. S., & Flanagan, J. G. (2001) · Cell · doi:10.1016/s0092-8674(01)00297-5 · Cited by 376 · see citing works
Hand, R., Bortone, D. S., Mattar, P. A., Nguyen, L., Heng, J. I., Guerrier, S., Boutt, E., Peters, E. C., Barnes, A. P., Parras, C. M., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.032 · Cited by 358 · see citing works
Pleasure, S. J., Anderson, S. A., Hevner, R. F., Bagri, A., Marín, Ó., Lowenstein, D. H., & Rubenstein, J. L. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00149-5 · Cited by 356 · see citing works
New Directions in Neuronal Migration
Hatten, M. E. (2002) · Science · doi:10.1126/science.1074572 · Cited by 321 · see citing works
Castro, D. S., Skowronska‐Krawczyk, D., Armant, O., Donaldson, I. J., Parras, C. M., Hunt, C., Critchley, J. A., Nguyen, L., Gossler, A., Göttgens, B., et al. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.10.006 · Cited by 310 · see citing works
Spatial and temporal specification of neural fates by transcription factor codes
Guillemot, F. (2007) · Development · doi:10.1242/dev.006379 · Cited by 308 · see citing works
Kania, A., Johnson, R. L., & Jessell, T. (2000) · Cell · doi:10.1016/s0092-8674(00)00022-2 · Cited by 302 · see citing works
DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation
Eisenstat, D. D., Liu, J. K., Mione, M., Zhong, W., Yu, G. K., Anderson, S. A., Ghattas, I. R., Puelles, L., & Rubenstein, J. L. R. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19991115)414:2 · Cited by 286 · see citing works
Kania, A., & Jessell, T. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00292-7 · Cited by 281 · see citing works
Neurogenin 2 controls cortical neuron migration through regulation of Rnd2
Heng, J. I., Nguyen, L., Castro, D. S., Zimmer, C., Wildner, H., Armant, O., Skowronska‐Krawczyk, D., Bedogni, F., Matter, J.-M., Hevner, R. F., et al. (2008) · Nature · doi:10.1038/nature07198 · Cited by 276 · see citing works
Transcriptional Regulation of Cortical Neuron Migration by POU Domain Factors
McEvilly, R. J., de Diaz, M. O., Schonemann, M. D., Hooshmand, F., & Rosenfeld, M. G. (2002) · Science · doi:10.1126/science.1067132 · Cited by 271 · see citing works
Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish
Carreira-Barbosa, F., Concha, M. L., Takeuchi, M., Ueno, N., Wilson, S. W., & Tada, M. (2003) · Development · doi:10.1242/dev.00567 · Cited by 269 · see citing works
Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons
Sugitani, Y., Nakai, S., Minowa, O., Nishi, M., Jishage, K.-I., Kawano, H., Mori, K., Ogawa, M., & Noda, T. (2002) · Genes & Development · doi:10.1101/gad.978002 · Cited by 259 · see citing works
Nóbrega-Pereira, S., Kessaris, N., Du, T., Kimura, S., Anderson, S. A., & Marín, O. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.024 · Cited by 256 · see citing works
Dlx transcription factors promote migration through repression of axon and dendrite growth
Cobos, I., Borello, U., & Rubenstein, J. L. R. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.024 · Cited by 246 · see citing works
Minichiello, L., & Klein, R. (1996) · Genes & Development · doi:10.1101/gad.10.22.2849 · Cited by 232 · see citing works
Coupling of cell migration with neurogenesis by proneural bHLH factors
Ge, W., He, F., Kim, K. J., Blanchi, B., Coskun, V., Nguyen, L., Wu, X., Zhao, J., Heng, J. I., Martinowich, K., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510419103 · Cited by 220 · see citing works
Thaler, J. P., Koo, S. J., Kania, A., Lettieri, K., Andrews, S. E., Cox, C. M., Jessell, T. M., & Pfaff, S. L. (2004) · Neuron · doi:10.1016/s0896-6273(04)00011-x · Cited by 180 · see citing works
Schwarz, Q., Gu, C., Fujisawa, H., Sabelko, K. A., Gertsenstein, M., Nagy, A., Taniguchi, M., Kolodkin, A. L., Ginty, D. D., Shima, D. T., et al. (2004) · Genes & Development · doi:10.1101/gad.322904 · Cited by 178 · see citing works
Turning heads: Development of vertebrate branchiomotor neurons
Chandrasekhar, A. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10444 · Cited by 173 · see citing works
Transcriptional regulation of vertebrate axon guidance and synapse formation
Polleux, F., Ince-Dunn, G., & Ghosh, A. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2118 · Cited by 168 · see citing works
Kappeler, C., Saillour, Y., Baudoin, J., Tuy, F. P. D., Alvarez, C., Houbron, C., Gaspar, P., Hamard, G., Chelly, J., Métin, C., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl062 · Cited by 163 · see citing works
Both Doublecortin and Doublecortin-Like Kinase Play a Role in Cortical Interneuron Migration
Friocourt, G., Liu, J. S.-H., Antypa, M., Rakić, S., Walsh, C. A., & Parnavelas, J. G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4530-06.2007 · Cited by 147 · see citing works
Neurotrophin–3 is required for proper cerebellar development
Bates, B., Rios, M., Trumpp, A., Chen, C. S., Fan, G., Bishop, J. M., & Jaenisch, R. (1999) · Nature Neuroscience · doi:10.1038/5669 · Cited by 136 · see citing works
Genetic and epigenetic mechanisms contribute to motor neuron pathfinding
Sharma, K., Leonard, A. E., Lettieri, K., & Pfaff, S. L. (2000) · Nature · doi:10.1038/35020078 · Cited by 135 · see citing works
Hox Paralog Group 2 Genes Control the Migration of Mouse Pontine Neurons through Slit-Robo Signaling
Geisen, M. J., Meglio, T. D., Pasqualetti, M., Ducret, S., Brunet, J., Chédotal, A., & Rijli, F. M. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060142 · Cited by 135 · see citing works
Li, S., Qiu, F., Xu, A., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4444-03.2004 · Cited by 126 · see citing works
Shirasaki, R., Lewcock, J. W., Lettieri, K., & Pfaff, S. L. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.030 · Cited by 123 · see citing works
Wilson, S. I., Shafer, B., Lee, K. J., & Dodd, J. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.020 · Cited by 123 · see citing works
Control of the migratory pathway of facial branchiomotor neurones
Garel, S., García‐Domínguez, M., & Charnay, P. (2000) · Development · doi:10.1242/dev.127.24.5297 · Cited by 120 · see citing works
Neuropilins as Semaphorin receptors: in vivo functions in neuronal cell migration and axon guidance.
Bagri, A., & Tessier‐Lavigne, M. (2002) · PubMed · Cited by 115 · see citing works
Garcı́a-Frigola, C., Carreres, M. I., Vegar, C., Mason, C. A., & Herrera, E. (2008) · Development · doi:10.1242/dev.020693 · Cited by 111 · see citing works
García, N. V. D. M., & Jessell, T. M. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.033 · Cited by 103 · see citing works
Neuropilins as semaphorin receptors
Bagril, A., & Tessier‐Lavigne, M. (2002) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0119-0_2 · Cited by 102 · see citing works
Song, M.-R., Shirasaki, R., Cai, C., Ruiz, E. C., Evans, S. Μ., Lee, S., & Pfaff, S. L. (2006) · Development · doi:10.1242/dev.02694 · Cited by 94 · see citing works
A molecular code dictates sequence‐specific DNA recognition by homeodomains.
Damante, G., Pellizzari, L., Esposito, G., Fogolari, F., Viglino, P., Fabbro, D., Tell, G., Formisano, S., & Lauro, R. D. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00879.x · Cited by 93 · see citing works
Wang, W., Mullikin-Kilpatrick, D., Crandall, J. E., Gronostajski, R. M., Litwack, E. D., & Kilpatrick, D. L. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0180-07.2007 · Cited by 82 · see citing works
The optic chiasm as a midline choice point
Williams, S. E., Mason, C. A., & Herrera, E. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.01.010 · Cited by 82 · see citing works
Le, T., Du, G., Fonseca, M. A., Zhou, Q.-P., Wigle, J. T., & Eisenstat, D. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607486200 · Cited by 80 · see citing works
Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons
Müller, M., Jabs, N., Lorke, D., Fritzsch, B., & Sander, M. (2003) · Development · doi:10.1242/dev.00815 · Cited by 79 · see citing works
Getting axons onto the right path: the role of transcription factors in axon guidance
Butler, S. J., & Tear, G. (2006) · Development · doi:10.1242/dev.02762 · Cited by 78 · see citing works
Lee, R. K., Petros, T. J., & Mason, C. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0632-08.2008 · Cited by 69 · see citing works
Samad, O. A., Geisen, M. J., Caronia, G., Varlet, I., Zappavigna, V., Ericson, J., Goridis, C., & Rijli, F. M. (2004) · Development · doi:10.1242/dev.01282 · Cited by 61 · see citing works
Reelin signaling is necessary for a specific step in the migration of hindbrain efferent neurons
Rossel, M., Loulier, K., Feuillet, C., Alonso, S., & Carroll, P. (2005) · Development · doi:10.1242/dev.01683 · Cited by 49 · see citing works
Initiation of facial motoneurone migration is dependent on rhombomeres 5 and 6
Studer, M. (2001) · Development · doi:10.1242/dev.128.19.3707 · Cited by 48 · see citing works
In vivo function of Rnd2 in the development of neocortical pyramidal neurons
Nakamura, K., Yamashita, Y., Tamamaki, N., Katoh, H., Kaneko, T., & Negishi, M. (2005) · Neuroscience Research · doi:10.1016/j.neures.2005.10.008 · Cited by 40 · see citing works
Yang, L., Yan, D., Bruggeman, M., Du, H., & Yan, C. (2004) · Biochemistry · doi:10.1021/bi049283o · Cited by 17 · see citing works
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Development of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378 · see citing works
“The pyramidal excitatory neurons born in the VZ and SVZ of the prefrontal subdomains, similar to other cortical areas, start to migrate radially toward the proper position in the CP under the influence of Fgfs [50, 59, 60].”
Background
- Authors
- Nobrega-Pereira, S., & Marin, O.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-04-08
- Volume
- 19
- Issue
- suppl 1
- Pages
- i107-i113
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2145675208
- Cited by
- 57
- References
- 68
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 6 · 2012: 4
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- neuronal migration, transcriptional regulation, transcription factors, axon guidance, guidance receptors, telencephalon development, mouse brain development, guidance molecules
- MeSH terms
- Animals, Brain, Cell Movement, Neurons, Transcription Factors, Transcriptional Activation, Mice, Neurogenesis
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