Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors
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The homeodomain transcription factor Nkx2-1 plays key roles in the developing telencephalon, where it regulates the identity of progenitor cells in the medial ganglionic eminence (MGE) and mediates the specification of several classes of GABAergic and cholinergic neurons. Here, we have investigated the postmitotic function of Nkx2-1 in the migration of interneurons originating in the MGE. Experimental manipulations and mouse genetics show that downregulation of Nkx2-1 expression in postmitotic cells is necessary for the migration of interneurons to the cortex, whereas maintenance of Nkx2-1 expression is required for interneuron migration to the striatum. Nkx2-1 exerts this role in the migration of MGE-derived interneurons by directly regulating the expression of a guidance receptor, Neuropilin-2, which enables interneurons to invade the developing striatum. Our results demonstrate a role for the cell-fate determinant Nkx2-1 in regulating neuronal migration by direct transcriptional regulation of guidance receptors in postmitotic cells.
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Nkx2-1 represses Nrp1 and Nrp2, and whether Nkx2-1 is on or off in postmitotic MGE interneurons determines whether they target the striatum or the cortex.
“Interestingly, the expression of these receptors (Nrp1 and Nrp2) is repressed by Nkx2-1, and so the expression (Nkx2-1ON) or downregulation (Nkx2-1OFF) of this transcription factor in postmitotic interneurons born in the MGE determine whether they are targeted to the striatum or the cerebral cortex, respectively (Nóbrega-Pereira et al., 2008).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Nóbrega-Pereira et al., 2008
Expression of Nkx2.1 represses transcription of neuropilin-2, a receptor necessary for migrating interneuron repulsion by semaphorin 3F expressed in the striatum.
“Expression of Nkx2.1 represses transcription of neuropilin-2 (842), a receptor necessary for migrating interneuron repulsion by semaphorin 3F expressed in the striatum”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [842]
The choice of migratory path appears to be an intrinsic property of cells dependent on their region of origin and ultimate destination, and governed by different transcription factors.
“The choice of migratory path appears to be an intrinsic property of cells dependent on their region of origin and ultimate destination, and governed by different transcription factors”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [842]
MGE progenitors preferentially express Nkx2.1, which must be downregulated in migrating postmitotic cells for them to avoid the striatum and reach the cortex.
“MGE progenitors preferentially express the transcription factor Nkx2.1 (147, 148, 829, 1233), which must be downregulated in migrating postmitotic cells in order for them to avoid the striatum and reach the cortex”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [842]
In mouse, NKX2-1 is downregulated in MGE-derived interneurons destined for neocortex but persists for unknown reasons in some human cortical interneurons.
“which–in the mouse–is downregulated in MGE-derived interneurons destined for the neocortex37 but persists for unknown reasons in some human cortical interneurons38”
From Innovations present in the primate interneuron repertoire (2020) · cites this paper as [37]
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Cites
The Molecular Biology of Axon Guidance
Tessier‐Lavigne, M., & Goodman, C. S. (1996) · Science · doi:10.1126/science.274.5290.1123 · Cited by 3,295 · see citing works
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121 · see citing works
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089 · see citing works
Interneuron Migration from Basal Forebrain to Neocortex: Dependence on <i>Dlx</i> Genes
Anderson, S. A., Eisenstat, D. D., Shi, L., & Rubenstein, J. L. R. (1997) · Science · doi:10.1126/science.278.5337.474 · Cited by 1,462 · see citing works
Self-citationMolecular Mechanisms of Axon Guidance
Dickson, B. J. (2002) · Science · doi:10.1126/science.1072165 · Cited by 1,431 · see citing works
Striatal interneurones: chemical, physiological and morphological characterization
Kawaguchi, Y., Wilson, C. J., Augood, S. J., & Emson, P. C. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)98374-8 · Cited by 1,197 · see citing works
The origin and specification of cortical interneurons
Wonders, C. P., & Anderson, S. A. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1954 · Cited by 980 · see citing works
Self-citationSussel, L., Marin, O., Kimura, S., & Rubenstein, J. L. R. (1999) · Development · doi:10.1242/dev.126.15.3359 · Cited by 873 · see citing works
Self-citationLavdas, A. A., Grigoriou, M., Pachnis, V., & Parnavelas, J. G. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-18-07881.1999 · Cited by 765 · see citing works
Wichterle, H., Turnbull, D. H., Nery, S., Fishell, G., & Alvarez-Buylla, A. (2001) · Development · doi:10.1242/dev.128.19.3759 · Cited by 722 · see citing works
Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches
Machold, R. P., Hayashi, S., Rutlin, M. L., Muzumdar, M. D., Nery, S. V., Corbin, J. G., Gritli-Linde, A., Dellovade, T., Porter, J. A., Rubin, L. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00561-0 · Cited by 710 · see citing works
Longitudinal organization of the anterior neural plate and neural tube
Shimamura, K., Hartigan-O’Connor, D. J., Martı́nez, S., Puelles, L., & Rubenstein, J. L. R. (1995) · Development · doi:10.1242/dev.121.12.3923 · Cited by 657 · see citing works
Origin and Molecular Specification of Striatal Interneurons
Marín, Ó., Anderson, S. A., & Rubenstein, J. L. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06063.2000 · Cited by 627 · see citing works
Self-citationNK-2Homeobox Genes and Heart Development
Harvey, R. P. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0212 · Cited by 579 · see citing works
Bohinski, R., di Lauro, R., & Whitsett, J. A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5671-5681.1994 · Cited by 561 · see citing works
Flames, N., Pla, R., Gelman, D. M., Rubenstein, J. L. R., Puelles, L., & Marín, O. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2750-07.2007 · Cited by 560 · see citing works
Ericson, J., Muhr, J., Placzek, M., Lints, T., Jessel, T. M., & Edlund, T. (1995) · Cell · doi:10.1016/0092-8674(95)90536-7 · Cited by 553 · see citing works
Bohinski, R. J., Lauro, R. D., & Whitsett, J. A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5671 · Cited by 524 · see citing works
Transcriptional Codes and the Control of Neuronal Identity
Shirasaki, R., & Pfaff, S. L. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142916 · Cited by 522 · see citing works
Stenman, J. M., Toresson, H., & Campbell, K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00167.2003 · Cited by 508 · see citing works
Young neurons from medial ganglionic eminence disperse in adult and embryonic brain
Wichterle, H., Garcia-Verdugo, J. M., Herrera, D. G., & Alvarez-Buylla, A. (1999) · Nature Neuroscience · doi:10.1038/8131 · Cited by 506 · see citing works
Semaphorins command cells to move
Kruger, R. P., Aurandt, J., & Guan, K. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1740 · Cited by 496 · see citing works
LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons.
Sharma, K., Sheng, H. Z., Lettieri, K., Li, H., Karavanov, A., Potter, S., Westphal, H., & Pfaff, S. (1998) · Cell · doi:10.1016/s0092-8674(00)81704-3 · Cited by 461 · see citing works
Sorting of Striatal and Cortical Interneurons Regulated by Semaphorin-Neuropilin Interactions
Marı́n, O., Yaron, A., Bagri, A., Tessier-Lavigne, M., & Rubenstein, J. L. R. (2001) · Science · doi:10.1126/science.1061891 · Cited by 433 · see citing works
Self-citationShort- and long-range attraction of cortical GABAergic interneurons by neuregulin-1
Flames, N., Long, J. E., Garratt, A. N., Fischer, T. M., Gassmann, M., Birchmeier, C., Lai, C., Rubenstein, J. L. R., & Marı́n, O. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.028 · Cited by 431 · see citing works
Self-citationFogarty, M., Grist, M., Gelman, D., Marín, O., Pachnis, V., & Kessaris, N. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1629-07.2007 · Cited by 412 · see citing works
Self-citationMuhr, J., Andersson, E., Persson, M., Jessell, T., & Ericson, J. (2001) · Cell · doi:10.1016/s0092-8674(01)00283-5 · Cited by 412 · see citing works
Slit proteins: key regulators of axon guidance, axonal branching, and cell migration.
Brose, K., & Tessier-Lavigne, M. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00066-5 · Cited by 381 · see citing works
Hand, R., Bortone, D. S., Mattar, P. A., Nguyen, L., Heng, J. I., Guerrier, S., Boutt, E., Peters, E. C., Barnes, A. P., Parras, C. M., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.032 · Cited by 358 · see citing works
The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes
Butt, S. J. B., Sousa, V. H., Fuccillo, M. V., Hjerling-Leffler, J., Miyoshi, G., Kimura, S., & Fishell, G. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.031 · Cited by 330 · see citing works
Self-citationKania, A., Johnson, R. L., & Jessell, T. (2000) · Cell · doi:10.1016/s0092-8674(00)00022-2 · Cited by 302 · see citing works
Kania, A., & Jessell, T. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00292-7 · Cited by 281 · see citing works
Transcriptional Regulation of Cortical Neuron Migration by POU Domain Factors
McEvilly, R. J., de Diaz, M. O., Schonemann, M. D., Hooshmand, F., & Rosenfeld, M. G. (2002) · Science · doi:10.1126/science.1067132 · Cited by 271 · see citing works
Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons
Sugitani, Y., Nakai, S., Minowa, O., Nishi, M., Jishage, K.-I., Kawano, H., Mori, K., Ogawa, M., & Noda, T. (2002) · Genes & Development · doi:10.1101/gad.978002 · Cited by 259 · see citing works
Hadjantonakis, A., Macmaster, S., & Nagy, A. (2002) · BMC Biotechnology · doi:10.1186/1472-6750-2-11 · Cited by 236 · see citing works
Yaron, A., Huang, P., Cheng, H.-J., & Tessier‐Lavigne, M. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.013 · Cited by 220 · see citing works
NKX2.1 specifies cortical interneuron fate by activatingLhx6
Du, T., Xu, Q., Ocbina, P. J. R., & Anderson, S. A. (2008) · Development · doi:10.1242/dev.015123 · Cited by 220 · see citing works
Self-citationCoupling of cell migration with neurogenesis by proneural bHLH factors
Ge, W., He, F., Kim, K. J., Blanchi, B., Coskun, V., Nguyen, L., Wu, X., Zhao, J., Heng, J. I., Martinowich, K., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510419103 · Cited by 220 · see citing works
Francis-Lang, H., Price, M., Polycarpou‐Schwarz, M., & Lauro, R. D. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.2.576-588.1992 · Cited by 213 · see citing works
Patterning and axon guidance of cranial motor neurons
Guthrie, S. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2254 · Cited by 201 · see citing works
Xu, Q., Wonders, C. P., & Anderson, S. A. (2005) · Development · doi:10.1242/dev.02090 · Cited by 184 · see citing works
Self-citationThaler, J. P., Koo, S. J., Kania, A., Lettieri, K., Andrews, S. E., Cox, C. M., Jessell, T. M., & Pfaff, S. L. (2004) · Neuron · doi:10.1016/s0896-6273(04)00011-x · Cited by 180 · see citing works
Transcriptional regulation of vertebrate axon guidance and synapse formation
Polleux, F., Ince-Dunn, G., & Ghosh, A. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2118 · Cited by 168 · see citing works
Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene Lhx8
Zhao, Y., Guo, Y.-J., Tomac, A. C., Taylor, N. R., Grinberg, A., Lee, E. J., Huang, S.-P., & Westphal, H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15002 · Cited by 154 · see citing works
Genetic and epigenetic mechanisms contribute to motor neuron pathfinding
Sharma, K., Leonard, A. E., Lettieri, K., & Pfaff, S. L. (2000) · Nature · doi:10.1038/35020078 · Cited by 135 · see citing works
Corbin, J. G., Rutlin, M. L., Gaiano, N., & Fishell, G. (2003) · Development · doi:10.1242/dev.00717 · Cited by 131 · see citing works
Neuropilins as Semaphorin receptors: in vivo functions in neuronal cell migration and axon guidance.
Bagri, A., & Tessier‐Lavigne, M. (2002) · PubMed · Cited by 115 · see citing works
Sequence-specific DNA recognition by the thyroid transcription factor-1 homeodomain
Damante, G., Fabbro, D., Pellizzari, L., Civitareale, D., Guazzi, S., Polycarpou‐Schwarz, M., Cauci, S., Quadrifoglio, F., Formisano, S., & Lauro, R. D. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.15.3075 · Cited by 113 · see citing works
Kusakabe, T., Kawaguchi, A., Hoshi, N., Kawaguchi, R., Hoshi, S., & Kimura, S. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0327 · Cited by 112 · see citing works
Self-citationGarcı́a-Frigola, C., Carreres, M. I., Vegar, C., Mason, C. A., & Herrera, E. (2008) · Development · doi:10.1242/dev.020693 · Cited by 111 · see citing works
Fragkouli, A., Hearn, C. J., Errington, M. L., Cooke, S. F., Grigoriou, M. E., Bliss, T., Stylianopoulou, F., & Pachnis, V. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04141.x · Cited by 103 · see citing works
García, N. V. D. M., & Jessell, T. M. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.033 · Cited by 103 · see citing works
Neuropilins as semaphorin receptors
Bagril, A., & Tessier‐Lavigne, M. (2002) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0119-0_2 · Cited by 102 · see citing works
Watada, H., Mirmira, R. G., Kalamaras, J., & German, M. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.17.9443 · Cited by 101 · see citing works
Mori, T., Yuxing, Z., Takaki, H., Takeuchi, M., Iseki, K., Hagino, S., Kitanaka, J., Takemura, M., Misawa, H., Ikawa, M., et al. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03415.x · Cited by 99 · see citing works
The optic chiasm as a midline choice point
Williams, S. E., Mason, C. A., & Herrera, E. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.01.010 · Cited by 82 · see citing works
Le, T., Du, G., Fonseca, M. A., Zhou, Q.-P., Wigle, J. T., & Eisenstat, D. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607486200 · Cited by 80 · see citing works
Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons
Müller, M., Jabs, N., Lorke, D., Fritzsch, B., & Sander, M. (2003) · Development · doi:10.1242/dev.00815 · Cited by 79 · see citing works
Getting axons onto the right path: the role of transcription factors in axon guidance
Butler, S. J., & Tear, G. (2006) · Development · doi:10.1242/dev.02762 · Cited by 78 · see citing works
Minoo, P., Hu, L., Xing, Y., Zhu, N. L., Chen, H., Li, M., Borok, Z., & Li, C. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01133-06 · Cited by 76 · see citing works
Lee, R. K., Petros, T. J., & Mason, C. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0632-08.2008 · Cited by 69 · see citing works
Yang, L., Yan, D., Bruggeman, M., Du, H., & Yan, C. (2004) · Biochemistry · doi:10.1021/bi049283o · Cited by 17 · see citing works
Structural basis of an embryonically lethal single Ala → Thr mutation in the vnd/NK-2 homeodomain
Xiang, B., Weiler, S., Nirenberg, M. W., & Ferretti, J. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7412 · Cited by 11 · see citing works
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Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889 · see citing works
Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain
Mo, A., Mukamel, E. A., Davis, F. P., Luo, C., Henry, G. L., Picard, S., Urich, M. A., Nery, J. R., Sejnowski, T. J., Lister, R., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.018 · Cited by 739 · see citing works
Development and Functional Diversification of Cortical Interneurons
Lim, L., Mi, D., Llorca, A., & Marín, O. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.009 · Cited by 714 · see citing works
Self-citationFused cerebral organoids model interactions between brain regions
Bagley, J. A., Reumann, D., Bian, S., Lévi-Strauss, J., & Knoblich, J. A. (2017) · Nature Methods · doi:10.1038/nmeth.4304 · Cited by 790 · see citing works
Guiding Neuronal Cell Migrations
Marin, O., Valiente, M., Ge, X., & Tsai, L.-H. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001834 · Cited by 417 · see citing works
Innovations present in the primate interneuron repertoire
Krienen, F. M., Goldman, M., Zhang, Q., C. H. del Rosario, R., Florio, M., Machold, R., Saunders, A., Levandowski, K., Zaniewski, H., Schuman, B., et al. (2020) · Nature · doi:10.1038/s41586-020-2781-z · Cited by 381 · see citing works
Innovations in Primate Interneuron Repertoire
Krienen, F. M., Goldman, M., Zhang, Q., del Rosario, R., Florio, M., Machold, R., Saunders, A., Levandowski, K., Zaniewski, H., Schuman, B., et al. (2019) · doi:10.1101/709501 · Cited by 372 · see citing works
Subcortical origins of human and monkey neocortical interneurons
Ma, T., Wang, C., Wang, L., Zhou, X., Tian, M., Zhang, Q., Zhang, Y., Li, J., Liu, Z., Cai, Y., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3536 · Cited by 322 · see citing works
The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes
Butt, S. J. B., Sousa, V. H., Fuccillo, M. V., Hjerling-Leffler, J., Miyoshi, G., Kimura, S., & Fishell, G. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.031 · Cited by 330 · see citing works
Self-citationCXCR4 and CXCR7 Have Distinct Functions in Regulating Interneuron Migration
Wang, Y., Li, G., Stanco, A., Long, J. E., Crawford, D., Potter, G. B., Pleasure, S. J., Behrens, T., & Rubenstein, J. L. R. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.005 · Cited by 290 · see citing works
Thyroid transcription factors in development, differentiation and disease
Fernández, L. P., López-Márquez, A., & Santisteban, P. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.186 · Cited by 258 · see citing works
Chapter 3 The Developmental Integration of Cortical Interneurons into a Functional Network
Batista‐Brito, R., & Fishell, G. (2009) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(09)01203-4 · Cited by 223 · see citing works
The Cell-Intrinsic Requirement of Sox6 for Cortical Interneuron Development
Batista-Brito, R., Rossignol, E., Hjerling-Leffler, J., Denaxa, M., Wegner, M., Lefebvre, V., Pachnis, V., & Fishell, G. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.005 · Cited by 214 · see citing works
Cortical interneuron development: a tale of time and space
Hu, J. S., Vogt, D., Sandberg, M., & Rubenstein, J. L. (2017) · Development · doi:10.1242/dev.132852 · Cited by 189 · see citing works
Integration of GABAergic interneurons into cortical cell assemblies: lessons from embryos and adults
Bartolini, G., Ciceri, G., & Marín, O. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.014 · Cited by 185 · see citing works
Self-citationGeneration of interneuron diversity in the mouse cerebral cortex
Gelman, D. M., & Marín, O. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07267.x · Cited by 188 · see citing works
Flandin, P., Kimura, S., & Rubenstein, J. L. R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4228-09.2010 · Cited by 176 · see citing works
Self-citationA wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area
Gelman, D., Griveau, A., Dehorter, N., Teissier, A., Varela, C., Pla, R., Pierani, A., & Marín, O. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4068-11.2011 · Cited by 179 · see citing works
McKinsey, G. L., Lindtner, S., Trzcinski, B., Visel, A., Pennacchio, L. A., Huylebroeck, D., Higashi, Y., & Rubenstein, J. L. R. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.035 · Cited by 153 · see citing works
Genomic Perspectives of Transcriptional Regulation in Forebrain Development
Nord, A. S., Pattabiraman, K., Visel, A., & Rubenstein, J. L. R. (2015) · Neuron · doi:10.1016/j.neuron.2014.11.011 · Cited by 152 · see citing works
Flandin, P., Zhao, Y., Vogt, D., Jeong, J., Long, J., Potter, G., Westphal, H., & Rubenstein, J. L. R. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.020 · Cited by 155 · see citing works
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Brown, K. N., Chen, S., Han, Z., Lu, C.-H., Tan, X., Zhang, X.-J., Ding, L., Lopez-Cruz, A., Saur, D., Anderson, S. A., et al. (2011) · Science · doi:10.1126/science.1208884 · Cited by 152 · see citing works
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Nóbrega-Pereira, S., Gelman, D., Bartolini, G., Pla, R., Pierani, A., & Marín, O. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4023-09.2010 · Cited by 142 · see citing works
Fragkouli, A., van Wijk, N. V., Lopes, R., Kessaris, N., & Pachnis, V. (2009) · Development · doi:10.1242/dev.038083 · Cited by 135 · see citing works
Self-citationDirected migration of cortical interneurons depends on the cell-autonomous action of Sip1
van den Berghe, V., Stappers, E., Vandesande, B., Dimidschstein, J., Kroes, R., Francis, A., Conidi, A., Lesage, F., Dries, R., Cazzola, S., et al. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.009 · Cited by 120 · see citing works
Self-citationJakovcevski, I., Mayer, N., & Zecevic, N. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq245 · Cited by 124 · see citing works
Lodato, S., Tomassy, G. S., De Leonibus, E., Uzcategui, Y. G., Andolfi, G., Armentano, M., Touzot, A., Gaztelu, J. M., Arlotta, P., Menendez de la Prida, L., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6580-10.2011 · Cited by 112 · see citing works
Wide dispersion and diversity of clonally related inhibitory interneurons
Harwell, C. C., Fuentealba, L. C., Gonzalez-Cerrillo, A., Parker, P. R. L., Gertz, C. C., Mazzola, E., Garcia, M. T., Alvarez-Buylla, A., Cepko, C. L., & Kriegstein, A. R. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.030 · Cited by 106 · see citing works
Decision making during interneuron migration in the developing cerebral cortex
Guo, J., & Anton, E. S. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.12.001 · Cited by 104 · see citing works
Skorput, A. G. J., Gupta, V. P., Yeh, P. W. L., & Yeh, H. H. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1462-15.2015 · Cited by 92 · see citing works
Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons
Bartolini, G., Sánchez-Alcañiz, J. A., Osório, C., Valiente, M., García-Frigola, C., & Marín, O. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.089 · Cited by 74 · see citing works
Self-citationZimmer, G., Rudolph, J., Landmann, J., Gerstmann, K., Steinecke, A., Gampe, C., & Bolz, J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4690-11.2011 · Cited by 68 · see citing works
Diversity of Cortical Interneurons in Primates: The Role of the Dorsal Proliferative Niche
Radonjić, N. V., Ayoub, A. E., Memi, F., Yu, X., Maroof, A., Jakovcevski, I., Anderson, S. A., Rakic, P., & Zecevic, N. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.026 · Cited by 74 · see citing works
Self-citationDevelopmental specification of forebrain cholinergic neurons
Allaway, K. C., & Machold, R. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2016.11.007 · Cited by 68 · see citing works
Conserved rules in embryonic development of cortical interneurons
Laclef, C., & Métin, C. (2018) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2017.09.017 · Cited by 57 · see citing works
Transcriptional Control of Neuronal Migration in the Developing Mouse Brain
Nobrega-Pereira, S., & Marin, O. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp044 · Cited by 57 · see citing works
Neurogliaform cortical interneurons derive from cells in the preoptic area
Niquille, M., Limoni, G., Markopoulos, F., Cadilhac, C., Prados, J., Holtmaat, A., & Dayer, A. (2018) · eLife · doi:10.7554/elife.32017 · Cited by 55 · see citing works
Peyre, E., Silva, C. G., & Nguyen, L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00129 · Cited by 51 · see citing works
Disorders of thyroid morphogenesis
Abu-Khudir, R., Larrivée-Vanier, S., Wasserman, J. D., & Deladoëy, J. (2017) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2017.04.008 · Cited by 46 · see citing works
- Authors
- Nóbrega-Pereira, S., Kessaris, N., Du, T., Kimura, S., Anderson, S. A., & Marín, O.
- Affiliations
- University College London (GB)
- Cornell University (US)
- National Institutes of Health (US)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 59
- Issue
- 5
- Pages
- 733-745
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2643060
- OpenAlex
- W2099988044
- Cited by
- 256
- References
- 63
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 5 · 2023: 10 · 2022: 13 · 2021: 18 · 2020: 20 · 2019: 14 · 2018: 13 · 2017: 17 · 2016: 4 · 2015: 12 · 2014: 14 · 2013: 29 · 2012: 14
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1780 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- University of California, Santa Cruz
- National Institute of Mental Health (K02MH070031, R01MH066912)
- National Institute of Neurological Disorders and Stroke (P01NS048120)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- TTF-1, interneuron migration, medial ganglionic eminence, neuropilin-2, guidance receptors, striatum, cortical interneurons, postmitotic neurons, transcriptional repression, cell fate determination, GABAergic neurons, cholinergic neurons, telencephalon development
- MeSH terms
- Thyroid Nuclear Factor 1, Animals, Cell Count, Cell Differentiation, Cell Movement, Embryo, Mammalian, Interneurons, Luminescent Proteins, Median Eminence, Mice, Inbred C57BL, Mice, Transgenic, Nerve Tissue Proteins, Nuclear Proteins, Organ Culture Techniques, Transcription Factors, Electroporation, Homeodomain Proteins, Gene Expression Regulation, Developmental, Neuropilin-2, Chromatin Immunoprecipitation, Mice, LIM-Homeodomain Proteins
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