Chemosensory organs as models of neuronal synapses
Open accessAbstract
Neuronal synapses are important microstructures that underlie complex cognitive capacities. Recent studies, primarily in Caenorhabditis elegans and Drosophila melanogaster, have revealed surprising parallels between these synapses and the 'chemosensory synapses' that reside at the tips of chemosensory cells that respond to environmental stimuli. Similarities in the structures, mechanisms of action and specific molecules found at these sites extend to the presynaptic, postsynaptic and glial entities composing both synapse types. In this article I propose that chemosensory synapses may serve as useful models of neuronal synapses, and consider the possibility that the two synapse types derive from a common ancestral structure.
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The postsynaptic sites and the dendrites of second-order neurons could have evolved from the ciliated endings of their sensory cell precursors.
“The striking molecular and functional similarities between the sensory endings of neurons (the ‘sensory synapse’) and postsynaptic sites on neuron–neuron synapses [66] suggest that the postsynaptic sites and the dendrites of these second-order neurons could have evolved from the ciliated endings of their sensory cell precursors.”
From Origin and early evolution of neural circuits for the control of ciliary locomotion (2011) · cites this paper as [66]
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- Authors
- Shaham, S.
- Affiliations
- Rockefeller University (US)
- Corresponding author
- Shaham, Shai
- ORCID
- Shaham, Shai
- Venue
- Nature reviews. Neuroscience
- Published
- 2009-12-23
- Volume
- 11
- Issue
- 3
- Pages
- 212-217
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC2860653
- OpenAlex
- W1969331385
- Cited by
- 62
- References
- 85
- Citations by year
- 2025: 6 · 2024: 6 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 6
- FWCI
- 0.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS064273, R01NS073121)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- synapses, synapse models, presynaptic terminals, postsynaptic structures, glial cells, Caenorhabditis elegans, Drosophila melanogaster
- MeSH terms
- Animals, Drosophila melanogaster, Nerve Net, Neuroglia, Neurons, Synapses, Signal Transduction, Caenorhabditis elegans
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