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Neuronal circuitry for pain processing in the dorsal horn

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Todd, Andrew J.·2010·Nature Reviews Neuroscience

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Abstract

Neurons in the spinal dorsal horn process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception. The dorsal horn provides numerous potential targets for the development of novel analgesics and is thought to undergo changes that contribute to the exaggerated pain felt after nerve injury and inflammation. Despite its obvious importance, we still know little about the neuronal circuits that process sensory information, mainly because of the heterogeneity of the various neuronal components that make up these circuits. Recent studies have begun to shed light on the neuronal organization and circuitry of this complex region.

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Morphology and somatotopic organization of the central terminals of hindlimb hair follicle afferents in the rat lumbar spinal cord
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Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABAA receptors from synapses in laminae I–II of the ipsilateral spinal dorsal horn
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Translocation of GluR1-Containing AMPA Receptors to a Spinal Nociceptive Synapse during Acute Noxious Stimulation
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P boutons in lamina IX of the rodent spinal cord express high levels of glutamic acid decarboxylase-65 and originate from cells in deep medial dorsal horn
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NK-1 Receptor Immunoreactivity in Distinct Morphological Types of Lamina I Neurons of the Primate Spinal Cord
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TRPA1‐expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord
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Ultrastructural changes of the central scalloped (C1) primary afferent endings of synaptic glomeruli in the substantia gelatinosa Rolandi of the rat after peripheral neurotomy
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Evidence against cholera toxin B subunit as a reliable tracer for sprouting of primary afferents following peripheral nerve injury
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Postnatal changes in the Rexed lamination and markers of nociceptive afferents in the superficial dorsal horn of the rat
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The neuropeptide Y Y1 receptor is a somatic receptor on dorsal root ganglion neurons and a postsynaptic receptor on somatostatin dorsal horn neurons
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A quantitative study of brainstem projections from lamina I neurons in the cervical and lumbar enlargement of the rat
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Large Projection Neurons in Lamina I of the Rat Spinal Cord That Lack the Neurokinin 1 Receptor Are Densely Innervated by VGLUT2-Containing Axons and Possess GluR4-Containing AMPA Receptors
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Expression of A‐type K+ channel α subunits Kv4.2 and Kv4.3 in rat spinal lamina II excitatory interneurons and colocalization with pain‐modulating molecules
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Soma size distinguishes projection neurons from neurokinin 1 receptor-expressing interneurons in lamina I of the rat lumbar spinal dorsal horn
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A distinct thermoreceptive subregion of lamina I in nucleus caudalis of the owl monkey
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The neuropeptide tyrosine Y1R is expressed in interneurons and projection neurons in the dorsal horn and area X of the rat spinal cord
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Responses to 5-HT in morphologically identified neurons in the rat substantia gelatinosa in vitro
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Phosphorylation of ERK in Neurokinin 1 Receptor-Expressing Neurons in Laminae III and IV of the Rat Spinal Dorsal Horn Following Noxious Stimulation
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Distribution of P2X 3 ‐immunoreactive fibers in hairy and glabrous skin of the rat
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Sensitization of lamina I spinoparabrachial neurons parallels heat hyperalgesia in the chronic constriction injury model of neuropathic pain
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Functional properties and axon terminations of interneurons in laminae III-V of the mammalian spinal dorsal horn in vitro
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Synaptic relationships between hair follicle afferents and neurones expressing GABA and glycine‐like immunoreactivity in the spinal cord of the rat
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Neurons in laminae III and IV of the rat spinal cord with the neurokinin-1 receptor receive few contacts from unmyelinated primary afferents which do not contain substance P
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Response Characterstics of Spinothalamic Tract Neurons That Project to the Posterior Thalamus in Rats
Zhang, X., & Giesler, G. J. (2005) · Journal of Neurophysiology · doi:10.1152/jn.01237.2004 · Cited by 41
Upregulation of Substance P in Low-Threshold Myelinated Afferents Is Not Required for Tactile Allodynia in the Chronic Constriction Injury and Spinal Nerve Ligation Models
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Cells in laminae III and IV of the rat spinal cord which possess the neurokinin‐1 receptor receive monosynaptic input from myelinated primary afferents
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Two populations of neurokinin 1 receptor-expressing projection neurons in lamina I of the rat spinal cord that differ in AMPA receptor subunit composition and density of excitatory synaptic input
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Characterization of neurons that express preprotachykinin B in the dorsal horn of the rat spinal cord
Polgár, E., Furuta, T., Kaneko, T., & Todd, A. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.12.021 · Cited by 36
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The Caudal Medullary Ventrolateral Reticular Formation in Nociceptive‐Cardiovascular Integration. An Experimental Study in the Rat
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Todd, A. J. in Handbook of Clinical Neurology 3rd Series, Pain. (Eds Cervero, F. and Jensen, T. S.) 61–76 (Elsevier, Edinburgh, 2006).

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Authors: Todd, A. J.
Affiliations: University of Glasgow (GB)
Corresponding author: Todd, Andrew J.
ORCID: Todd, Andrew J.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2010-11-11
Volume: 11
Issue: 12
Pages: 823-836
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn2947
PMC: PMC3277941
OpenAlex: W2059635921
Cited by: 1,475
References: 162
Citations by year: 2026: 100 · 2025: 114 · 2024: 95 · 2023: 108 · 2022: 122 · 2021: 137 · 2020: 106 · 2019: 125 · 2018: 85 · 2017: 85 · 2016: 90 · 2015: 86 · 2014: 75 · 2013: 76 · 2012: 39
FWCI: 4.69
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
Funders: Wellcome Trust (076976)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: dorsal horn, spinal cord, pain processing, neural circuits, hyperalgesia, allodynia, sensory neurons, analgesic targets, nerve injury, inflammation, pain perception
MeSH terms: Afferent Pathways, Animals, Brain, Disease Models, Animal, Humans, Nerve Net, Nociceptors, Pain, Posterior Horn Cells

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Neuronal circuitry for pain processing in the dorsal horn

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