The DOI matches its Crossref record; 160 of the 162 references it cites were found in a registry or an index.
Neuronal circuitry for pain processing in the dorsal horn
Open accessAbstract
Neurons in the spinal dorsal horn process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception. The dorsal horn provides numerous potential targets for the development of novel analgesics and is thought to undergo changes that contribute to the exaggerated pain felt after nerve injury and inflammation. Despite its obvious importance, we still know little about the neuronal circuits that process sensory information, mainly because of the heterogeneity of the various neuronal components that make up these circuits. Recent studies have begun to shed light on the neuronal organization and circuitry of this complex region.
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“Activated microglia released numerous inflammatory mediators (IL-1β, TNF-α, NO, and ROS) that led to changes in protein expression, as well as reached synapse endings, promoted glutamate release, and affected neuronal action potentials, thereby resulting in abnormal neural circuits (Todd, 2010, Ma et al., 2021, Costigan et al., 2009, Inoue and Tsuda, 2018, Chen et al., 2018).”
From Picroside Ⅱ attenuates neuropathic pain by regulating inflammation and spinal excitatory synaptic transmission (2024) · cites this paper as Todd, 2010
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“Nerve injury induces hyperexcitability, thereby causing functional alterations in the neuronal network such as loss of function of inhibitory neurons in the dorsal horn, and results in neuropathic pain (Prescott et al, 2014;Todd, 2010).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Todd, 2010
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Cites
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
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Ho Kim, S., & Mo Chung, J. (1992) · Pain · doi:10.1016/0304-3959(92)90041-9 · Cited by 3,069
Spared nerve injury: an animal model of persistent peripheral neuropathic pain
Décosterd, I., & Woolf, C. J. (2000) · Pain · doi:10.1016/s0304-3959(00)00276-1 · Cited by 2,317
The cytoarchitectonic organization of the spinal cord in the cat
Rexed, B. (1952) · The Journal of Comparative Neurology · doi:10.1002/cne.900960303 · Cited by 1,675
AMPA receptor trafficking at excitatory synapses
Bredt, D. S., & Nicoll, R. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00640-8 · Cited by 1,150
Models and Mechanisms of Hyperalgesia and Allodynia
Sandkühler, J. (2009) · Physiological Reviews · doi:10.1152/physrev.00025.2008 · Cited by 1,148
Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain
Coull, J. A. M., Boudreau, D., Bachand, K., Prescott, S. A., Nault, F., Attila Gabor, S. I. K., Koninck, P. D., & Koninck, Y. D. (2003) · Nature · doi:10.1038/nature01868 · Cited by 1,118
Peripheral nerve injury triggers central sprouting of myelinated afferents
Woolf, C. J., Shortland, P. J., & Coggeshall, R. E. (1992) · Nature · doi:10.1038/355075a0 · Cited by 1,083
Descending control of nociception: Specificity, recruitment and plasticity
Heinricher, M. M., Tavares, I., Leith, J. L., & Lumb, B. M. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.009 · Cited by 953
PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity
Esteban, J. A., Shi, S.-H., Wilson, C., Nuriya, M., Huganir, R. L., & Malinow, R. (2003) · Nature Neuroscience · doi:10.1038/nn997 · Cited by 894
Flagged first, then by citations
2 of the 162 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Todd, A. J. in Handbook of Clinical Neurology 3rd Series, Pain. (Eds Cervero, F. and Jensen, T. S.) 61–76 (Elsevier, Edinburgh, 2006).
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Abraira, V. E., & Ginty, D. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.051 · Cited by 1,648
Glia and pain: Is chronic pain a gliopathy?
Ji, R., Berta, T., & Nedergaard, M. (2013) · Pain · doi:10.1016/j.pain.2013.06.022 · Cited by 1,193
Discriminative and affective touch: Sensing and feeling.
McGlone, F., Wessberg, J., & Olausson, H. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.001 · Cited by 1,112
Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential
Inoue, K., & Tsuda, M. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.2 · Cited by 908
Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain
Chen, G., Zhang, Y., Qadri, Y. J., Serhan, C. N., & Ji, R. (2018) · Neuron · doi:10.1016/j.neuron.2018.11.009 · Cited by 801
Metadata
- Authors
- Todd, A. J.
- Affiliations
- University of Glasgow (GB)
- Corresponding author
- Todd, Andrew J.
- ORCID
- Todd, Andrew J.
- Venue
- Nature Reviews Neuroscience
- Published
- 2010-11-11
- Volume
- 11
- Issue
- 12
- Pages
- 823-836
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC3277941
- OpenAlex
- W2059635921
- Cited by
- 1,475
- References
- 162
- Citations by year
- 2026: 100 · 2025: 114 · 2024: 95 · 2023: 108 · 2022: 122 · 2021: 137 · 2020: 106 · 2019: 125 · 2018: 85 · 2017: 85 · 2016: 90 · 2015: 86 · 2014: 75 · 2013: 76 · 2012: 39
- FWCI
- 4.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- Funders
- Wellcome Trust (076976)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- dorsal horn, spinal cord, pain processing, neural circuits, hyperalgesia, allodynia, sensory neurons, analgesic targets, nerve injury, inflammation, pain perception
- MeSH terms
- Afferent Pathways, Animals, Brain, Disease Models, Animal, Humans, Nerve Net, Nociceptors, Pain, Posterior Horn Cells
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