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Neuronal circuitry for pain processing in the dorsal horn
Open accessAbstract
Neurons in the spinal dorsal horn process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception. The dorsal horn provides numerous potential targets for the development of novel analgesics and is thought to undergo changes that contribute to the exaggerated pain felt after nerve injury and inflammation. Despite its obvious importance, we still know little about the neuronal circuits that process sensory information, mainly because of the heterogeneity of the various neuronal components that make up these circuits. Recent studies have begun to shed light on the neuronal organization and circuitry of this complex region.
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“Activated microglia released numerous inflammatory mediators (IL-1β, TNF-α, NO, and ROS) that led to changes in protein expression, as well as reached synapse endings, promoted glutamate release, and affected neuronal action potentials, thereby resulting in abnormal neural circuits (Todd, 2010, Ma et al., 2021, Costigan et al., 2009, Inoue and Tsuda, 2018, Chen et al., 2018).”
From Picroside Ⅱ attenuates neuropathic pain by regulating inflammation and spinal excitatory synaptic transmission (2024) · cites this paper as Todd, 2010
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“Nerve injury induces hyperexcitability, thereby causing functional alterations in the neuronal network such as loss of function of inhibitory neurons in the dorsal horn, and results in neuropathic pain (Prescott et al, 2014;Todd, 2010).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Todd, 2010
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- Todd, A. J. in Handbook of Clinical Neurology 3rd Series, Pain. (Eds Cervero, F. and Jensen, T. S.) 61–76 (Elsevier, Edinburgh, 2006).
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Self-citationSpinal Circuits Transmitting Mechanical Pain and Itch
Duan, B., Cheng, L., & Ma, Q. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0136-z · Cited by 135
Yu, T., Zhang, X., Shi, H., Tian, J., Sun, L., Hu, X., Cui, W., & Du, D. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1425-4 · Cited by 132
Boyle, K. A., Gradwell, M. A., Yasaka, T., Dickie, A. C., Polgár, E., Ganley, R. P., Orr, D. P. H., Watanabe, M., Abraira, V. E., Kuehn, E. D., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.040 · Cited by 131
General Principles of Neuronal Co-transmission: Insights From Multiple Model Systems
Svensson, E., Apergis‐Schoute, J., Burnstock, G., Nusbaum, M. P., Parker, D., & Schiöth, H. B. (2019) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00117 · Cited by 134
A Quantitative Study of Inhibitory Interneurons in Laminae I-III of the Mouse Spinal Dorsal Horn
Polgár, E., Durrieux, C., Hughes, D. I., & Todd, A. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078309 · Cited by 132
Self-citationCircuitry and plasticity of the dorsal horn – Toward a better understanding of neuropathic pain
West, S. J., Bannister, K., Dickenson, A. H., & Bennett, D. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.020 · Cited by 129
The integrative role of orexin/hypocretin neurons in nociceptive perception and analgesic regulation
Inutsuka, A., Yamashita, A., Chowdhury, S., Nakai, J., Ohkura, M., Taguchi, T., & Yamanaka, A. (2016) · Scientific Reports · doi:10.1038/srep29480 · Cited by 123
Osseward, P. J., Amin, N. D., Moore, J. D., Temple, B. A., Barriga, B. K., Bachmann, L. C., Beltran, F., Gullo, M., Clark, R. C., Driscoll, S. P., et al. (2021) · Science · doi:10.1126/science.abe0690 · Cited by 115
Temperature Sensation: From Molecular Thermosensors to Neural Circuits and Coding Principles
Xiao, R., & Xu, X. Z. S. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-031220-095215 · Cited by 114
Spinal presynaptic inhibition in pain control.
Guo, D., & Hu, J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.032 · Cited by 96
Andersen, H. H., Akiyama, T., Nattkemper, L. A., van Laarhoven, A. I. M., Elberling, J., Yosipovitch, G., & Arendt‐Nielsen, L. (2018) · Pain · doi:10.1097/j.pain.0000000000001220 · Cited by 113
Deconstructing arousal into wakeful, autonomic and affective varieties
Satpute, A. B., Kragel, P. A., Barrett, L. F., Wager, T. D., & Bianciardi, M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.01.042 · Cited by 118
Metadata
- Authors
- Todd, A. J.
- Affiliations
- University of Glasgow (GB)
- Corresponding author
- Todd, Andrew J.
- ORCID
- Todd, Andrew J.
- Venue
- Nature Reviews Neuroscience
- Published
- 2010-11-11
- Volume
- 11
- Issue
- 12
- Pages
- 823-836
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC3277941
- OpenAlex
- W2059635921
- Cited by
- 1,475
- References
- 162
- Citations by year
- 2026: 100 · 2025: 114 · 2024: 95 · 2023: 108 · 2022: 122 · 2021: 137 · 2020: 106 · 2019: 125 · 2018: 85 · 2017: 85 · 2016: 90 · 2015: 86 · 2014: 75 · 2013: 76 · 2012: 39
- FWCI
- 4.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- Funders
- Wellcome Trust (076976)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- dorsal horn, spinal cord, pain processing, neural circuits, hyperalgesia, allodynia, sensory neurons, analgesic targets, nerve injury, inflammation, pain perception
- MeSH terms
- Afferent Pathways, Animals, Brain, Disease Models, Animal, Humans, Nerve Net, Nociceptors, Pain, Posterior Horn Cells
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