Kynurenines in the mammalian brain: when physiology meets pathology

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Subanesthetic Doses of Ketamine Stimulate Psychosis in Schizophrenia

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How Oxidative Stress Induces Depression?

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Indoleamine and tryptophan 2,3-dioxygenases as important future therapeutic targets

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The Kynurenine Pathway in Acute Kidney Injury and Chronic Kidney Disease

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Endogenous kynurenic acid regulates extracellular GABA levels in the rat prefrontal cortex

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Cerebrospinal fluid kynurenines in multiple sclerosis; relation to disease course and neurocognitive symptoms

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Activation of kynurenine pathway in ex vivo fibroblasts from patients with bipolar disorder or schizophrenia: Cytokine challenge increases production of 3-hydroxykynurenine

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Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls

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Pro-Inflammatory Cytokines: Potential Links between the Endocannabinoid System and the Kynurenine Pathway in Depression

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Astrocytes revisited: concise historic outlook on glutamate homeostasis and signaling

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Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s disease

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Altered serum levels of kynurenine metabolites in patients affected by cluster headache

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Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder: An exploratory pilot case-control study

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Early-Life Stress Modulates Gut Microbiota and Peripheral and Central Inflammation in a Sex-Dependent Manner

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Disturbed Amino Acid Metabolism in HIV: Association with Neuropsychiatric Symptoms

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Sickness: From the focus on cytokines, prostaglandins, and complement factors to the perspectives of neurons

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Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity

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Quinolinic Acid and Nuclear Factor Erythroid 2-Related Factor 2 in Depression: Role in Neuroprogression

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Neuroprotective Natural Products’ Regulatory Effects on Depression via Gut–Brain Axis Targeting Tryptophan

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The Neurobiology of Bipolar Disorder: An Integrated Approach

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Deletion of TDO2, IDO-1 and IDO-2 differentially affects mouse behavior and cognitive function

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Crosstalk between Tryptophan Metabolism and Cardiovascular Disease, Mechanisms, and Therapeutic Implications

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16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy

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Kynurenine Pathway in Autism Spectrum Disorders in Children

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Systematic Review on the Involvement of the Kynurenine Pathway in Stroke: Pre-clinical and Clinical Evidence

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Biological subtyping of psychiatric syndromes as a pathway for advances in drug discovery and personalized medicine

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Inflammation Theories in Psychotic Disorders: A Critical Review

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Kynurenine Aminotransferase Isozyme Inhibitors: A Review

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Neuroinflammation and glial cell activation in mental disorders

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Linking atypical depression and insulin resistance-related disorders via low-grade chronic inflammation: Integrating the phenotypic, molecular and neuroanatomical dimensions

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Kynurenines in the Pathogenesis of Multiple Sclerosis: Therapeutic Perspectives

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The Role of the Kynurenine Pathway in the Pathophysiology of Frailty, Sarcopenia, and Osteoporosis

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Microbial-Derived Tryptophan Metabolites and Their Role in Neurological Disease: Anthranilic Acid and Anthranilic Acid Derivatives

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The role of the kynurenine pathway in cardiovascular disease

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Development of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington’s Disease

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Inflammation-Induced Catabolism of Tryptophan and Tyrosine in Acute Ischemic Stroke

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Interleukin-6 and depressive symptom severity in response to physical exercise

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Gut Microbiota Regulation and Their Implication in the Development of Neurodegenerative Disease

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Major Developments in the Design of Inhibitors along the Kynurenine Pathway

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Brain-immune crosstalk in the treatment of major depressive disorder

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The Role of Physical Exercise and Omega-3 Fatty Acids in Depressive Illness in the Elderly

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Tryptophan via serotonin/kynurenine pathways abnormalities in a large cohort of aggressive inmates: markers for aggression

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Association of Increased Treg Cell Levels With Elevated Indoleamine 2,3‐Dioxygenase Activity and an Imbalanced Kynurenine Pathway in Interferon‐Positive Primary Sjögren's Syndrome

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Markers of fungal translocation are elevated during post-acute sequelae of SARS-CoV-2 and induce NF-κB signaling

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Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging

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Restraint Stress during Pregnancy Rapidly Raises Kynurenic Acid Levels in Mouse Placenta and Fetal Brain

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Stress, Inflammation, and Cellular Vulnerability during Early Stages of Affective Disorders: Biomarker Strategies and Opportunities for Prevention and Intervention

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Major Depressive Disorder and gut microbiota – Association not causation. A scoping review

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The Footprint of Kynurenine Pathway in Neurodegeneration: Janus-Faced Role in Parkinson’s Disorder and Therapeutic Implications

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Modulation of Hippocampal Synaptic Transmission by the Kynurenine Pathway Member Xanthurenic Acid and Other VGLUT Inhibitors

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Tetrahydrobiopterin Biosynthesis as a Potential Target of the Kynurenine Pathway Metabolite Xanthurenic Acid

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Glycyrrhizic acid ameliorates the kynurenine pathway in association with its antidepressant effect

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Alterations in serum kynurenine pathway metabolites in individuals with high neocortical amyloid-β load: A pilot study

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A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites

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Inflammation, negative affect, and amyloid burden in Alzheimer’s disease: Insights from the kynurenine pathway

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Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening

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Kynurenic acid, by targeting α7 nicotinic acetylcholine receptors, modulates extracellular GABA levels in the rat striatumin vivo

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An exceptionally high content of kynurenic acid in chestnut honey and flowers of chestnut tree

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The Kynurenine Pathway in the Acute and Chronic Phases of Cerebral Ischemia

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Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity

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Regulation of kynurenine metabolism by a ketogenic diet

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Temporomandibular disorders and mental health: shared etiologies and treatment approaches

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Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity

Tomlinson, L., Leiton, C. V., & Colognato, H. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.09.016 · Cited by 65

Serum concentrations of kynurenines in adult patients with attention-deficit hyperactivity disorder (ADHD): a case–control study

Aarsland, T. I. M., Landaas, E. T., Hegvik, T., Ulvik, A., Halmøy, A., Ueland, P. M., & Haavik, J. (2015) · Behavioral and Brain Functions · doi:10.1186/s12993-015-0080-x · Cited by 62

Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase-2 and Kynurenine 3-Monooxygenase, Enzymes of the Kynurenine Pathway, Significantly Diminishes Neuropathic Pain in a Rat Model

Rojewska, E., Ciapała, K., Piotrowska, A., Makuch, W., & Mika, J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00724 · Cited by 56

Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition

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Dynamics of Tryptophan Metabolic Pathways in Human Placenta and Placental-Derived Cells: Effect of Gestation Age and Trophoblast Differentiation

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Kynurenine metabolism and inflammation-induced depressed mood: a human experimental study

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The contribution of age-related changes in the gut-brain axis to neurological disorders

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Neuroactive Kynurenines as Pharmacological Targets: New Experimental Tools and Exciting Therapeutic Opportunities

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Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress

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Anthranilic Acid: A Potential Biomarker and Treatment Target for Schizophrenia.

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NAD+ Metabolism and Regulation: Lessons From Yeast

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Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

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Therapeutic potential of targeting the receptor for advanced glycation end products (RAGE) by small molecule inhibitors

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