The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2
Open accessAbstract
The basic helix–loop–helix transcription factors oligodendrocyte transcription factor 1 (OLIG1) and OLIG2 are structurally similar and, to a first approximation, coordinately expressed in the developing CNS and postnatal brain. Despite these similarities, it was apparent from early on after their discovery that OLIG1 and OLIG2 have non-overlapping developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes. Here, we summarize more recent insights into the separate roles of these transcription factors in the postnatal brain during repair processes and in neurological disease states, including multiple sclerosis and malignant glioma. We discuss how the unique functions of OLIG1 and OLIG2 may reflect their distinct genetic targets, co-regulator proteins and/or post-translational modifications.
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Zhang, P., Kishimoto, Y., Grammatikakis, I., Gottimukkala, K., Cutler, R. G., Zhang, S., Abdelmohsen, K., Bohr, V. A., Misra Sen, J., Gorospe, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0372-9 · Cited by 977
Spatial profiling of chromatin accessibility in mouse and human tissues
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Metadata
- Authors
- Meijer, D. H., Kane, M. F., Mehta, S., Liu, H., Harrington, E., Taylor, C. M., Stiles, C. D., & Rowitch, D. H.
- Venue
- Nature Reviews Neuroscience
- Published
- 2012-11-20
- Volume
- 13
- Issue
- 12
- Pages
- 819-831
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2081314633
- Cited by
- 172
- References
- 18
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- green
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