Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples

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Phases of Aβ-deposition in the human brain and its relevance for the development of AD

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<i>TREM2</i> Variants in Alzheimer's Disease

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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

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Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease

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Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain

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The Cellular Phase of Alzheimer’s Disease

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Microglia-specific localisation of a novel calcium binding protein, Iba1

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Primary age-related tauopathy (PART): a common pathology associated with human aging

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Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

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TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease

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An environment-dependent transcriptional network specifies human microglia identity

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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

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Microglial brain region-dependent diversity and selective regional sensitivities to aging

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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

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Multiplex digital spatial profiling of proteins and RNA in fixed tissue

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TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

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TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

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Spreading of pathology in neurodegenerative diseases: a focus on human studies

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Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

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Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

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Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

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Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated

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Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

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Cutting Edge: TREM-2 Attenuates Macrophage Activation

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TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

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The Levels of Soluble versus Insoluble Brain Aβ Distinguish Alzheimer's Disease from Normal and Pathologic Aging

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Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

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TREM2 sustains microglial expansion during aging and response to demyelination

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TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

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Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude

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Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease

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Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

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Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry

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Local cues establish and maintain region-specific phenotypes of basal ganglia microglia

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TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

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Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models

Lee, C. Y. D., Daggett, A., Gu, X., Jiang, L.-L., Langfelder, P., Li, X., Wang, N., Zhao, Y., Park, C. S., Cooper, Y., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.02.002 · Cited by 396 · see citing works

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

Parhizkar, S., Arzberger, T., Brendel, M., Kleinberger, G., Deußing, M., Focke, C., Nuscher, B., Xiong, M., Ghasemigharagoz, A., Katzmarski, N., et al. (2019) · doi:10.7892/boris.125653 · Cited by 352 · see citing works

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism

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Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

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Alzheimer's disease‐associated TREM2 variants exhibit either decreased or increased ligand‐dependent activation

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Microglia actions in Alzheimer's disease

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Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

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A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank

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Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

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TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy

Yuan, P., Condello, C., Keene, C. D., Wang, Y., Bird, T. D., Paul, S. M., Luo, W., Colonna, M., Baddeley, D., & Grutzendler, J. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.016 · Cited by 219 · see citing works

Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies

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Soluble phospho-tau from Alzheimer’s disease hippocampus drives microglial degeneration

Sanchez-Mejias, E., Navarro, V., Jimenez, S., Sanchez-Mico, M., Sanchez-Varo, R., Nuñez-Diaz, C., Trujillo-Estrada, L., Davila, J. C., Vizuete, M., Gutierrez, A., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1630-5 · Cited by 175 · see citing works

TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF‐κB signaling

Li, C., Zhao, B. Q., Lin, C., Gong, Z., & An, X. (2018) · Cell Biology International · doi:10.1002/cbin.10975 · Cited by 162 · see citing works

Inhomogeneous distribution of Iba‐1 characterizes microglial pathology in Alzheimer's disease

Tischer, J., Krueger, M., Mueller, W. C., Staszewski, O., Prinz, M., Streit, W. J., & Bechmann, I. (2016) · Glia · doi:10.1002/glia.23024 · Cited by 117 · see citing works

Multisite assessment of NIA‐AA guidelines for the neuropathologic evaluation of Alzheimer's disease

Montine, T. J., Monsell, S. E., Beach, T. G., Bigio, E. H., Bu, Y., Cairns, N. J., Frosch, M., Henriksen, J., Kofler, J., Kukull, W. A., et al. (2016) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2015.07.492 · Cited by 113 · see citing works

TREM2 triggers microglial density and age-related neuronal loss

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Homozygous TREM2 mutation in a family with atypical frontotemporal dementia

Ber, I. L., de Septenville, A. D., Guerreiro, R., Bras, J., Camuzat, A., Caroppo, P., Lattante, S., Couarch, P., Kabashi, E., Bouya-Ahmed, K., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.04.010 · Cited by 98 · see citing works

Microglial activation occurs late during preclinical Alzheimer's disease

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TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism

Zheng, H., Cheng, B., Li, Y., Li, X., Chen, X., & Zhang, Y.-W. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00395 · Cited by 94 · see citing works

Building an integrated neurodegenerative disease database at an academic health center

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High multiplex, digital spatial profiling of proteins and RNA in fixed tissue using genomic detection methodsPreprint

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Is APOE ε4 required for Alzheimer's disease to develop in TREM 2 p.R47H variant carriers?

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Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology

Lee, S.-H., Meilandt, W. J., Xie, L., Gandham, V. D., Ngu, H., Barck, K. H., Rezzonico, M. G., Imperio, J., Lalehzadeh, G., Huntley, M. A., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.02.010 · Cited by 300 · see citing works

Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology

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APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer’s disease

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Activated microglia mitigate Aβ-associated tau seeding and spreading

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<i>Trem2</i> promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

Liu, W., Taso, O., Wang, R., Bayram, S., Graham, A. C., Garcia-Reitboeck, P., Mallach, A., Andrews, W. D., Piers, T. M., Botia, J. A., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa209 · Cited by 214 · see citing works

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation

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The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions

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The bidirectional lung brain-axis of amyloid-β pathology: ozone dysregulates the peri-plaque microenvironment

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Insulin Resistance in Peripheral Tissues and the Brain: A Tale of Two Sites

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Microglia in Alzheimer's Disease: a Key Player in the Transition Between Homeostasis and Pathogenesis

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