Neuronal circuits for fear and anxiety

Emotion circuits in the brain

LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444

Ultrasensitive fluorescent proteins for imaging neuronal activity

Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474

Functional Neuroimaging of Anxiety: A Meta-Analysis of Emotional Processing in PTSD, Social Anxiety Disorder, and Specific Phobia

Etkin, A., & Wager, T. D. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07030504 · Cited by 3,391

Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?

Fanselow, M. S., & Dong, H.-W. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.031 · Cited by 3,358

Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective

Grupe, D. W., & Nitschke, J. B. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3524 · Cited by 2,007

The Neuropsychology of Anxiety

Gray, J. A., & McNaughton, N. (2003) · doi:10.1093/acprof:oso/9780198522713.001.0001 · Cited by 1,953

Neurons in medial prefrontal cortex signal memory for fear extinction

Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836

The Amygdaloid Complex: Anatomy and Physiology

SAH, P., FABER, E. S. L., LOPEZ DE ARMENTIA, M., & POWER, J. (2003) · Physiological Reviews · doi:10.1152/physrev.00002.2003 · Cited by 1,745

Functional organization of the hippocampal longitudinal axis

Strange, B. A., Witter, M. P., Lein, E. S., & Moser, E. I. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3785 · Cited by 1,738

The endogenous cannabinoid system controls extinction of aversive memories

Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728

NMDA Receptor–Dependent Synaptic Potentiation via APPL1 Signaling Is Required for the Accessibility of a Prefrontal Neuronal Assembly in Retrieving Fear Extinction

Hua, S., Ding, J.-J., Sun, T., Chen, G., Zhang, Y., Yu, Z.-H., Cao, Y., Zhong, L.-H., Wu, Y., Guo, L., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.02.013 · Cited by 12

miR-483-5p offsets functional and behavioural effects of stress in male mice through synapse-targeted repression of Pgap2 in the basolateral amygdala

Mucha, M. W., Skrzypiec, A. E., Kolenchery, J. B., Brambilla, V., Patel, S., Labrador-Ramos, A., Kudla, L., Murrall, K., Skene, N., Dymicka-Piekarska, V., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37688-2 · Cited by 14

Potentiation of cholinergic and corticofugal inputs to the lateral amygdala in threat learning

Asokan, M. M., Watanabe, Y. L., Kimchi, E. Y., & Polley, D. B. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113167 · Cited by 15

The lateral septum and anterior hypothalamus act in tandem to regulate burying in the shock-probe test but not open-arm avoidance in the elevated plus-maze

Lamontagne, S. J., Olmstead, M. C., & Menard, J. L. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.07.034 · Cited by 11

Neurophysiological assessment of animal welfare

Tilbrook, A. J., & Ralph, C. R. (2017) · Animal Production Science · doi:10.1071/an17312 · Cited by 12

The Biological Bridge Between Behavioral Inhibition and Psychopathology

Sylvester, C. M., & Pine, D. S. (2018) · Springer eBooks · doi:10.1007/978-3-319-98077-5_14 · Cited by 12

Anxiolytic activity of paraoxon is associated with alterations in rat brain glutamatergic system

Zare, Z., Tehrani, M., Rezaei, N., Ghalebarzand, B. D., & Mohammadi, M. (2018) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2018.12.001 · Cited by 12

The plus maze and scototaxis test are not valid behavioral assays for anxiety assessment in the South African clawed frog

Coleman, R. B., Aguirre, K. N., Spiegel, H. P., Pecos, C., Carr, J. A., & Harris, B. N. (2019) · Journal of Comparative Physiology A · doi:10.1007/s00359-019-01351-3 · Cited by 12

Fear-induced increases in loss aversion are linked to increased neural negative-value coding

Schulreich, S., Gerhardt, H., Meshi, D., & Heekeren, H. R. (2020) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsaa091 · Cited by 16

Angiotensin-converting enzyme 2 activator, DIZE in the basolateral amygdala attenuates the tachycardic response to acute stress by modulating glutamatergic tone

Silva, C. C., Correa, A. M., Kushmerick, C., Sharma, N. M., Patel, K. P., Almeida, J. F., Moreira, F. A., Ferreira, A. J., & Fontes, M. A. P. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102076 · Cited by 12

Rap1b but not Rap1a in the forebrain is required for learned fear

Chen, W., Pan, H., He, Y., Wang, X., Zhang, W., & Pan, B. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00469-1 · Cited by 12

PEN Receptor GPR83 in Anxiety-Like Behaviors: Differential Regulation in Global vs Amygdalar Knockdown

Fakira, A. K., Lueptow, L. M., Trimbake, N. A., & Devi, L. A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.675769 · Cited by 11

Enhanced and Unified Anatomical Labeling for a Common Mouse Brain AtlasPreprint

Chon, U., Vanselow, D. J., Cheng, K. C., & Kim, Y. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/636175 · Cited by 12

Prolonged epigenetic and synaptic plasticity alterations following single exposure to a psychedelic in mice

de la Fuente Revenga, M., Zhu, B., Guevara, C. A., Naler, L. B., Saunders, J. M., Zhou, Z., Toneatti, R., Sierra, S., Wolstenholme, J. T., Beardsley, P. M., et al. (2021) · doi:10.1101/2021.02.24.432725 · Cited by 11

A neural circuit from the dorsal CA3 to the dorsomedial hypothalamus mediates balance between risk exploration and defense

Zhong, C., Wang, L., Cao, Y., Sun, C., Huang, J., Wang, X., Pan, S., He, S., Kx, H., Lu, Z., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111570 · Cited by 12

Artificial fear neural circuit based on noise triboelectric nanogenerator and photoelectronic neuromorphic transistor

Ke, S., Wang, F., Fu, C., Mao, H., Zhu, Y., Wang, X., Wan, C., & Wan, Q. (2023) · Applied Physics Letters · doi:10.1063/5.0167011 · Cited by 11

“NO” Time in Fear Response: Possible Implication of Nitric-Oxide-Related Mechanisms in PTSD

Fronza, M. G., Ferreira, B. F., Pavan-Silva, I., Guimarães, F. S., & Lisboa, S. F. D. S. (2023) · Molecules · doi:10.3390/molecules29010089 · Cited by 13

Neural correlates of recalled sadness, joy, and fear states: a source reconstruction EEG study

Proverbio, A. M., & Cesati, F. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1357770 · Cited by 12

Olfactory bulb-medial prefrontal cortex theta synchronization is associated with anxiety

Mooziri, M., Moghaddam, A. S., Mirshekar, M. A., & Raoufy, M. R. (2024) · Scientific Reports · doi:10.1038/s41598-024-63101-z · Cited by 11

Neuronal HIPK2-HDAC3 axis regulates mitochondrial fragmentation to participate in stroke injury and post-stroke anxiety like behavior

Yang, M., Zhu, H., Peng, L., Yin, T., Sun, S., Du, Y., Li, J., Liu, J., & Wang, S. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114906 · Cited by 11

Serotonergic Input into the Cerebellar Cortex Modulates Anxiety-Like Behavior

Chin, P. W., & Augustine, G. J. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1825-24.2024 · Cited by 12

Distinct oxytocin signaling pathways synergistically mediate rescue-like behavior in mice

Zhang, F., Liu, J., Wen, J., Zhang, Z.-Y., Li, Y., Song, E., Hu, L., & Chen, Z. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2423374122 · Cited by 14

Parvalbumin interneurons gate amygdala excitability and response to chronic stress via kainate receptor-driven tonic GABAB receptor-mediated inhibition

Ryazantseva, M., Liiwand, M., Shteinikov, V., Kunnari, A.-J., Sulku, J., & Lauri, S. E. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03093-y · Cited by 11

The Emotional Brain

Pessoa, L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802381-5.00046-4 · Cited by 11

Directional spread of activity in synaptic networks of the human lateral amygdala

Graebenitz, S., Cerina, M., Lesting, J., Kedo, O., Gorji, A., Pannek, H. W., Hans, V., Zilles, K., Pape, H., & Speckmann, E. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.03.009 · Cited by 11

The Role of Hormonal and Reproductive Status in the Treatment of Anxiety Disorders in Women

Tang, S., & Graham, B. M. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9705-0_26 · Cited by 16

5-HT7 receptors enhance inhibitory synaptic input to principal neurons in the mouse basal amygdala

Kusek, M., Siwiec, M., Sowa, J. E., Bobula, B., Bilecki, W., Ciurej, I., Kaczmarczyk-Jarosz, M., Kowalczyk, T., Maćkowiak, M., Hess, G., et al. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108779 · Cited by 11

Prefrontal GABAA(δ)R Promotes Fear Extinction through Enabling the Plastic Regulation of Neuronal Intrinsic Excitability

Pan, H., Liu, X., He, Y., Zhou, J., Liao, C.-Z., You, W.-J., Jiang, S.-Y., Qin, X., Chen, W., Fei, E., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0689-22.2022 · Cited by 11

Effects of 3-methylmethcathinone on conditioned place preference and anxiety-like behavior: Comparison with methamphetamine

Chen, Y., Zhang, L., Ding, Z., Wu, X., Wang, G., & Shi, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.975820 · Cited by 11

Cerebellum and Emotion Memory

Mark, M. D., Pakusch, J., Ernst, T., & Timmann, D. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-99550-8_5 · Cited by 11

Analysis of lateral orbitofrontal cortex activation on acquisition of fear extinction and neuronal activities in fear circuit

Shih, C.-C., Chang, M. Y.-H., Chiou, R.-J., & Chang, C. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02545-3 · Cited by 10

Whole-brain afferent input mapping to functionally distinct brainstem noradrenaline cell types

Cuevas, J. N. S., Watanabe, M., Uematsu, A., & Johansen, J. P. (2023) · Neuroscience Research · doi:10.1016/j.neures.2023.04.004 · Cited by 11

Dynamic competition between large-scale functional networks differentiates fear conditioning and extinction in humans

Marstaller, L., Burianová, H., & Reutens, D. C. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.04.008 · Cited by 11

Housing and road transport modify the brain neurotransmitter systems of pigs: Do pigs raised in different conditions cope differently with unknown environments?

Arroyo, L., Valent, D., Carreras, R., Peña, R., Sabrià, J., Velarde, A., & Bassols, A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210406 · Cited by 11

Altered motor, anxiety-related and attentional task performance at baseline associate with multiple gene copies of the vesicular acetylcholine transporter and related protein overexpression in ChAT::Cre+ rats

Mantanona, C. P., Alsiö, J., Elson, J. L., Fisher, B. M., Dalley, J. W., Bussey, T. J., & Pienaar, I. S. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01957-y · Cited by 13

Dorsal Bed Nucleus of the Stria Terminalis-Subcortical Output Circuits Encode Positive Bias in Pavlovian Fear and Reward

Kaouane, N., Ada, S., Hausleitner, M., & Haubensak, W. E. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.772512 · Cited by 12

Involvement of nitric oxide in the neurobiology of fear-like behavior

Medeiros, K. A. A. L., Almeida-Souza, T. H., Silva, R. S., Franco, H. S., Santos, E. V., de Gois, A. M., Leal, P. C., & dos Santos, J. R. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.04.003 · Cited by 11

Evidence for involvement of NK3 receptors in the anxiogenic-like effect of SP6-11(C-terminal), a metabolite of substance P, in rats evaluated in the elevated plus-maze

Duarte, F. S., Duzzioni, M., Leme, L. R., Smith, S. D. P., & de Lima, T. C. M. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.02.003 · Cited by 11

Erratum: Neuronal circuits for fear and anxiety

Tovote, P., Fadok, J. P., & Lüthi, A. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3984 · Cited by 11

Anxiety and Beyond: Diversity in Ventral Hippocampus Circuits and Function

van der Veldt, S., Bagot, R. C., Ciocchi, S., Ito, R., Kheirbek, M. A., MacAskill, A. F., & Amilhon, B. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1304-25.2025 · Cited by 12

Environmental Enrichment Facilitates Anxiety in Conflict-Based Tests but Inhibits Predator Threat-Induced Defensive Behaviour in Male Mice

dos Anjos‐Garcia, T., Kanashiro, A., Campos, A. C., & Coimbra, N. C. (2022) · Neuropsychobiology · doi:10.1159/000521184 · Cited by 10

Tasipimidine, a novel orally administered alpha-2 adrenoceptor agonist, alleviates canine acute anxiety associated with owner departure—A pilot study

Korpivaara, M., Huhtinen, M. K., Pohjanjousi, P., & Overall, K. L. (2022) · Journal of Veterinary Behavior · doi:10.1016/j.jveb.2022.11.003 · Cited by 10

Genotype determining aerobic exercise capacity associates with behavioral plasticity in middle-aged rats

Mäkinen, E., Wikgren, J., Pekkala, S., Koch, L. G., Britton, S. L., Nokia, M. S., & Lensu, S. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114331 · Cited by 9

Neural representations of anxiety in adolescents with anorexia nervosa: a multivariate approach

Seiger, R., Reggente, N., Majid, D. S. A., Ly, R., Tadayonnejad, R., Strober, M. A., & Feusner, J. D. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02581-5 · Cited by 11

What is Learned Determines How Pavlovian Conditioned Fear is Consolidated in the Brain

Leake, J., Leidl, D. M., Lay, B. P. P., Fam, J. P., Giles, M. C., Qureshi, O. A., Westbrook, R. F., & Holmes, N. M. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0513-23.2023 · Cited by 10

Increased excitatory amino acid transporter 2 levels in basolateral amygdala astrocytes mediate chronic stress–induced anxiety-like behavior

Xu, X., Xuan, S., Chen, S., Liu, D., Xiao, Q., & Tu, J. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01411 · Cited by 10

Exploring Neural Correlates between Anxiety and Inhibitory Ability: Evidence from Task‐Based fNIRS

Wang, D., Lin, B., Huang, Y., Chong, Z. Y., Du, J., Yuan, Q., Tang, Y., Xu, Q., & Xu, W. (2024) · Depression and Anxiety · doi:10.1155/2024/8680134 · Cited by 12

Neuromodulation of inhibitory synaptic transmission in the basolateral amygdala during fear and anxiety

Fu, X., & Tasker, J. G. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1421617 · Cited by 10

The Bed Nucleus of the Stria Terminalis: Translational Deep Brain Stimulation to Reduce Anxiety

Luyten, L. (2020) · The Neuroscientist · doi:10.1177/1073858419898381 · Cited by 10

Triadimefon triggers circling behavior and conditioned place preference/aversion in zebrafish in a dose dependent manner

Paredes‐Zúñiga, S., Ormeño, F., & Allende, M. L. (2021) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2021.106979 · Cited by 10

Perceived Coping Mitigates Anxiety Symptoms in the Context of COVID-19 Stress in an Urban University Student Sample

Rudenstine, S., Schulder, T., Ettman, C. K., & Galea, S. (2022) · Psychological Reports · doi:10.1177/00332941221074038 · Cited by 10

The Limbic System

ten Donkelaar, H. J., Insausti, R., van Domburg, P., Küsters, B., Hashizume, Y., & Hori, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-41878-6_14 · Cited by 12

Evaluating an internet-delivered fear conditioning and extinction protocol using response times and affective ratings

Björkstrand, J., Pine, D. S., & Frick, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-07999-3 · Cited by 13

Implication of the Central Nucleus of the Amygdala in Cardiovascular Regulation and Limiting Maximum Exercise Performance During High-intensity Exercise in Rats

Tsukioka, K., Yamanaka, K., & Waki, H. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.06.005 · Cited by 10

Ethanol-Induced Suppression of G Protein–Gated Inwardly Rectifying K+–Dependent Signaling in the Basal Amygdala

de Velasco, E. M. F., Tipps, M. E., Haider, B., Souders, A., Aguado, C., Rose, T. R., Vo, B. N., DeBaker, M. C., Luján, R., & Wickman, K. D. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.04.006 · Cited by 10

Adulthood bisphenol A exposure induces anxiety in male mice via downregulation of alpha-1D adrenergic receptor in paraventricular thalamus

Ji, R., Cui, M., Zhou, D., Pan, X., Xie, Y., Wu, X., Liang, X., Zhang, H., & Song, W. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115205 · Cited by 10

Resting‐state f MRI reveals changes within the anxiety and social avoidance circuitry of the brain in mice with psoriasis‐like skin lesions

Chen, T., Zhu, S., Xu, S., Wang, Y., Aji, A., Zhang, C., Wang, H., Li, F., & Chu, Y. (2023) · Experimental Dermatology · doi:10.1111/exd.14914 · Cited by 10

Non-Hebbian plasticity transforms transient experiences into lasting memories

Faress, I., Khalil, V., Hou, W., Moreno, A., Andersen, N., Fonseca, R., Piriz, J., Capogna, M., & Nabavi, S. (2023) · eLife · doi:10.7554/elife.91421 · Cited by 16

Transcranial magnetic stimulation for obsessive-compulsive disorder and post-traumatic stress disorder: A comprehensive systematic review and analysis of therapeutic benefits, cortical targets, and psychopathophysiological mechanisms

Vicheva, P., Osborne, C., Krieg, S. M., Ahmadi, R., & Shotbolt, P. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111147 · Cited by 14

Molecular mechanisms of neuroinflammation initiation and development in a model of post-traumatic stress disorder

Tuchina, O. P., Sidorova, M. V., Turkin, A., Shvaiko, D. A., Shalaginova, I. G., & Vakoliuk, I. A. (2018) · Genes and Cells · doi:10.23868/201808019 · Cited by 10

Gentle Handling Attenuates Innate Defensive Responses to Visual Threats

Liu, X., Chen, C., Liu, Y., Wang, Z., Huang, K., Wang, F., & Wang, L. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00239 · Cited by 10

Priming of LTP in amygdala and hippocampus by prior paired pulse facilitation paradigm in mice lacking brain serotonin

Gebhardt, C., Mosienko, V., Alenina, N. V., & Albrecht, D. (2018) · Hippocampus · doi:10.1002/hipo.23055 · Cited by 10

Autophosphorylation of F-actin binding domain of CaMKIIβ is required for fear learning

Kim, K., Suzuki, A., Kojima, H., Kawamura, M., Miya, K., Abe, M., Yamada, I., Furuse, T., Wakana, S., Sakimura, K., et al. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.12.003 · Cited by 11

Interleukin-4 signalling pathway underlies the anxiolytic effect induced by 3-deoxyadenosine

Gao, T., Bai, L., Hou, Y., Luo, S., Feng, L., Nie, J., Ma, Y., Xiao, L., Chen, X., Bao, H., et al. (2019) · Psychopharmacology · doi:10.1007/s00213-019-5186-7 · Cited by 10

Circadian disruption impairs fear extinction and memory of conditioned safety in mice

Clark, J. W., Hoyer, D., Cain, S. W., Phillips, A. J. K., Drummond, S. P. A., & Jacobson, L. H. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112788 · Cited by 11

Vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females

Simon, R. A., Barazanji, N., Jones, M. P., Bednarska, O., Icenhour, A., Engström, M., Hamilton, J. P., Keita, Å. V., & Walter, S. (2021) · Scientific Reports · doi:10.1038/s41598-020-80873-2 · Cited by 11

Synaptic and transcriptomic features of cortical and amygdala pyramidal neurons predict inefficient fear extinction

Laricchiuta, D., Gimenez, J., Sciamanna, G., Termine, A., Fabrizio, C., Valle, F. D., Caioli, S., Saba, L., Bardi, M. D., Balsamo, F., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113066 · Cited by 10

Evidence for M2 muscarinic receptor modulation of axon terminals and dendrites in the rodent basolateral amygdala: An ultrastructural and electrophysiological analysis

Fajardo‐Serrano, A., Liu, L., Mott, D. D., & McDonald, A. J. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.06.019 · Cited by 10

Modulation of Innate Defensive Responses by Locus Coeruleus-Superior Colliculus Circuit

Li, L., & Wang, L. (2018) · Journal of Experimental Neuroscience · doi:10.1177/1179069518792035 · Cited by 10

Selective enhancement of fear learning and resistance to extinction in a mouse model of acute early life traumaPreprint

Sneddon, E. A., Riddle, C. A., Schuh, K. M., Quinn, J. J., & Radke, A. K. (2020) · Learning & Memory · doi:10.1101/lm.052373.120 · Cited by 10

Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders

Caminski, E. S., Antunes, F. T. T., Souza, I. A., Dallegrave, E., & Zamponi, G. W. (2022) · Molecular Brain · doi:10.1186/s13041-022-00982-z · Cited by 9

3-Methyladenine ameliorates surgery-induced anxiety-like behaviors in aged mice by inhibiting autophagy-induced excessive oxidative stress

Wu, S.-T., Han, S., Xu, X.-M., Sun, H., Zhou, H., Shang, K., Liu, Z.-H., & Liang, S. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01217-3 · Cited by 9

Anxiety and dysautonomia symptoms in patients with a NaV1.7 mutation and the potential benefits of low-dose short-acting guanfacine

Collaço, R. D. C., Lammens, M., Blevins, C., Rodgers, K., Gurau, A., Yamauchi, S., Kim, C. G., Forrester, J., Liu, E., Ha, J. S., et al. (2023) · Clinical Autonomic Research · doi:10.1007/s10286-023-01004-1 · Cited by 9

Role of 5-hydroxytryptamine type 3 receptors in the regulation of anxiety reactions

Du, Y., Li, Z., Zhao, Y., Han, J., Hu, W., & Liu, Z. (2024) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2200642 · Cited by 9

The basal forebrain to lateral habenula circuitry mediates social behavioral maladaptation

Wang, J., Yang, Q., Liu, X., Li, J., Wen, Y., Hu, Y., Xu, T., Duan, S., & Xu, H. (2024) · Nature Communications · doi:10.1038/s41467-024-48378-y · Cited by 9

Looming stimuli reliably drive innate defensive responses in male rats, but not learned defensive responses

Heinemans, M., & Moita, M. A. P. (2024) · Scientific Reports · doi:10.1038/s41598-024-70256-2 · Cited by 9

The phobic brain: Morphometric features correctly classify individuals with small animal phobia

Scarano, A., Fumero, A., Baggio, T., Rivero, F., Marrero, R. J., Olivares, T., Peñate, W., Álvarez‐Pérez, Y., Pérez, J. M. B., & Grecucci, A. (2024) · Psychophysiology · doi:10.1111/psyp.14716 · Cited by 9

Novel neural pathways targeted by GLP-1R agonists and bariatric surgery

Hankir, M. K., & Lutz, T. A. (2024) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-024-03047-3 · Cited by 13

Neural Circuits of Fear and Anxiety: Insights from a Neuroethological Perspective

Melleu, F. F., & Canteras, N. S. (2024) · Physiology · doi:10.1152/physiol.00042.2024 · Cited by 9

A vagal route to memory: evidence from invasive and non-invasive electrical vagus nerve stimulation studies and areas for future clinical application

Szeska, C., Ventura‐Bort, C., Giraudier, M., & Weymar, M. (2025) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2025.1595737 · Cited by 12

Ketamine Reverses Chronic Stress‐Induced Behavioral Changes via the Expression of Ca 2+ ‐Permeable AMPA Receptors in Mice

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