Cited by 1,786Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

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Neuronal circuits for fear and anxiety

Tovote, Philip, Fadok, Jonathan Paul, Lüthi, Andreas·2015·Nature Reviews Neuroscience

DOI 10.1038/nrn3945

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Abstract

Decades of research has identified the brain areas that are involved in fear, fear extinction, anxiety and related defensive behaviours. Newly developed genetic and viral tools, optogenetics and advanced in vivo imaging techniques have now made it possible to characterize the activity, connectivity and function of specific cell types within complex neuronal circuits. Recent findings that have been made using these tools and techniques have provided mechanistic insights into the exquisite organization of the circuitry underlying internal defensive states. This Review focuses on studies that have used circuit-based approaches to gain a more detailed, and also more comprehensive and integrated, view on how the brain governs fear and anxiety and how it orchestrates adaptive defensive behaviours.

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Authors: Tovote, P., Fadok, J. P., & Lüthi, A.
Affiliations: Friedrich Miescher Institute (CH)
Corresponding author: Lüthi, Andreas
ORCID: Tovote, Philip
Fadok, Jonathan Paul
Lüthi, Andreas
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2015-05-20
Volume: 16
Issue: 6
Pages: 317-331
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn3945
OpenAlex: W1547865271
Semantic Scholar: c2361b90aa8185adfda7e7329fc00f24a5a64602
Cited by: 1,786
References: 195
Citations by year: 2026: 141 · 2025: 174 · 2024: 188 · 2023: 184 · 2022: 186 · 2021: 176 · 2020: 173 · 2019: 154 · 2018: 163 · 2017: 123 · 2016: 103 · 2015: 21
FWCI: 13.59
Type: journal article
Language: en
Update notices: erratum (2015-06-10)
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Brain Research Foundation
Novartis Foundation
National Alliance for Research on Schizophrenia and Depression
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: fear, anxiety, neural circuits, fear extinction, defensive behavior, neuronal connectivity, optogenetics, in vivo imaging, genetic instruments
MeSH terms: Animals, Anxiety, Brain, Fear, Humans, Neural Pathways

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Neuronal circuits for fear and anxiety

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