Neuronal circuits for fear and anxiety

Emotion circuits in the brain

LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444

Ultrasensitive fluorescent proteins for imaging neuronal activity

Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474

Functional Neuroimaging of Anxiety: A Meta-Analysis of Emotional Processing in PTSD, Social Anxiety Disorder, and Specific Phobia

Etkin, A., & Wager, T. D. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07030504 · Cited by 3,391

Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?

Fanselow, M. S., & Dong, H.-W. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.031 · Cited by 3,358

Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective

Grupe, D. W., & Nitschke, J. B. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3524 · Cited by 2,007

The Neuropsychology of Anxiety

Gray, J. A., & McNaughton, N. (2003) · doi:10.1093/acprof:oso/9780198522713.001.0001 · Cited by 1,953

Neurons in medial prefrontal cortex signal memory for fear extinction

Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836

The Amygdaloid Complex: Anatomy and Physiology

SAH, P., FABER, E. S. L., LOPEZ DE ARMENTIA, M., & POWER, J. (2003) · Physiological Reviews · doi:10.1152/physrev.00002.2003 · Cited by 1,745

Functional organization of the hippocampal longitudinal axis

Strange, B. A., Witter, M. P., Lein, E. S., & Moser, E. I. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3785 · Cited by 1,738

The endogenous cannabinoid system controls extinction of aversive memories

Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728

The Paraventricular Nucleus of the Thalamus as an Integrating and Relay Node in the Brain Anxiety Network

Kirouac, G. J. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.627633 · Cited by 140

Mechanisms of social buffering of fear in zebrafish

Faustino, A. I., Tacão-Monteiro, A., & Oliveira, R. F. (2017) · Scientific Reports · doi:10.1038/srep44329 · Cited by 151

Fear, Anxiety, and the Amygdala

Sah, P. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.013 · Cited by 137

Tac1-Expressing Neurons in the Periaqueductal Gray Facilitate the Itch-Scratching Cycle via Descending Regulation

Gao, Z., Chen, W., Liu, M., Chen, X., Wan, L., Zhang, X., Yuan, L., Lin, J.-K., Wang, M., Zhou, L., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.11.010 · Cited by 136

Zona Incerta: An Integrative Node for Global Behavioral Modulation

Wang, X., Chou, X.-L., Zhang, L. I., & Tao, H. W. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.11.007 · Cited by 129

Use of cannabidiol in anxiety and anxiety-related disorders

Skelley, J. W., Deas, C. M., Curren, Z., & Ennis, J. (2019) · Journal of the American Pharmacists Association · doi:10.1016/j.japh.2019.11.008 · Cited by 142

Role of the bed nucleus of the stria terminalis in aversive learning and memoryPreprint

Goode, T. D., & Maren, S. (2017) · Learning & Memory · doi:10.1101/lm.044206.116 · Cited by 149

Brainstem Circuits for Locomotion

Leiras, R., Cregg, J. M., & Kiehn, O. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-082321-025137 · Cited by 137

Neural Circuits for Emotion

Malézieux, M., Klein, A. S., & Gogolla, N. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-111020-103314 · Cited by 144

Associative and predictive hippocampal codes support memory-guided behaviors

Liu, C., Todorova, R., Tang, W., Oliva, A., & Fernández‐Ruiz, A. (2023) · Science · doi:10.1126/science.adi8237 · Cited by 150

Startle potentiation to uncertain threat as a psychophysiological indicator of fear-based psychopathology: An examination across multiple internalizing disorders.

Gorka, S. M., Lieberman, L., Shankman, S. A., & Phan, K. L. (2017) · Journal of Abnormal Psychology · doi:10.1037/abn0000233 · Cited by 131

Animal models in psychiatric research: The RDoC system as a new framework for endophenotype-oriented translational neuroscience

Anderzhanova, E. A., Kirmeier, T., & Wotjak, C. T. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2017.03.003 · Cited by 137

Synaptic encoding of fear memories in the amygdala

Ressler, R. L., & Maren, S. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.08.012 · Cited by 138

A paradigm shift in translational psychiatry through rodent neuroethology

Shemesh, Y., & Chen, A. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01913-z · Cited by 134

Cellular and oscillatory substrates of fear extinction learning

Davis, P. W., Zaki, Y., Maguire, J. L., & Reijmers, L. G. J. E. (2017) · Nature Neuroscience · doi:10.1038/nn.4651 · Cited by 127

Sex differences in fear extinction

Velasco, E. R., Florido, A., Milad, M. R., & Andero, R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.020 · Cited by 132

The Neural Basis of Escape Behavior in Vertebrates

Branco, T., & Redgrave, P. (2020) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-100219-122527 · Cited by 134

Significant Neuroanatomical Variation Among Domestic Dog Breeds

Hecht, E. E., Smaers, J. B., Dunn, W. D., Kent, M., Preuss, T. M., & Gutman, D. A. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0303-19.2019 · Cited by 138

A VTA to Basal Amygdala Dopamine Projection Contributes to Signal Salient Somatosensory Events during Fear Learning

Tang, W., Kochubey, O., Kintscher, M., & Schneggenburger, R. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1796-19.2020 · Cited by 131

Bidirectional control of fear memories by cerebellar neurons projecting to the ventrolateral periaqueductal grey

Frontera, J. L., Aïssa, H. B., Sala, R. W., Mailhes‐Hamon, C., Georgescu, I. A., Léna, C., & Popa, D. (2020) · Nature Communications · doi:10.1038/s41467-020-18953-0 · Cited by 126

A feedback neural circuit for calibrating aversive memory strength

Ozawa, T., Ycu, E. A., Kumar, A., Yeh, L.-F., Ahmed, T., Koivumaa, J., & Johansen, J. P. (2016) · Nature Neuroscience · doi:10.1038/nn.4439 · Cited by 129

Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model

Huang, C., Irwin, M. G., Wong, G. T. C., & Chang, R. C. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1163-z · Cited by 128

New Insights into the Pivotal Role of the Amygdala in Inflammation-Related Depression and Anxiety Disorder

Hu, P., Lü, Y., Pan, B., & Zhang, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911076 · Cited by 139

Distinct projections from the infralimbic cortex exert opposing effects in modulating anxiety and fear

Chen, Y.-H., Wu, J., Hu, N.-Y., Zhuang, J.-P., Li, W., Zhang, S.-R., Li, X.-W., Yang, J., & Gao, T. (2021) · Journal of Clinical Investigation · doi:10.1172/jci145692 · Cited by 126

Microglia maintain structural integrity during fetal brain morphogenesis

Lawrence, A. R., Canzi, A., Bridlance, C., Olivié, N., Lansonneur, C., Catale, C., Pizzamiglio, L., Kloeckner, B., Silvin, A., Munro, D. A. D., et al. (2024) · Cell · doi:10.1016/j.cell.2024.01.012 · Cited by 126

The cerebellum in fear and anxiety-related disorders

Moreno, J. M. M. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.04.002 · Cited by 128

A cFos activation map of remote fear memory attenuation

Silva, B. A., Burns, A. M., & Gräff, J. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5000-y · Cited by 118

Allopregnanolone Mediates Affective Switching Through Modulation of Oscillatory States in the Basolateral AmygdalaPreprint

Antonoudiou, P., Colmers, P. L. W., Walton, N. L., Weiss, G. L., Smith, A. C., Nguyen, D. P., Lewis, M., Quirk, M. C., Barros, L., Melón, L. C., et al. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3614121 · Cited by 114

The neurobiological basis of sex differences in learned fear and its inhibition

Day, H. L. L., & Stevenson, C. W. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14602 · Cited by 114

Parvalbumin interneurons constrain the size of the lateral amygdala engram

Morrison, D. J., Rashid, A. J., Yiu, A. P., Yan, C., Frankland, P. W., & Josselyn, S. A. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.07.007 · Cited by 122

Prevention of unpredictable chronic stress-related phenomena in zebrafish exposed to bromazepam, fluoxetine and nortriptyline

Marcon, M., Herrmann, A. P., Mocelin, R., Rambo, C. L., Koakoski, G., de Abreu, M. S., Conterato, G. M. M., Kist, L. W., Bogo, M. R., Zanatta, L. C. B., et al. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4408-5 · Cited by 124

β−Arrestins: Structure, Function, Physiology, and Pharmacological Perspectives

Wess, J., Oteng, A., Rivera‐Gonzalez, O., Gurevich, E. V., & Gurevich, V. V. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000302 · Cited by 116

Psychometrics and the neuroscience of individual differences: Internal consistency limits between-subjects effects.

Hajcak, G., Meyer, A. M., & Kotov, R. (2017) · Journal of Abnormal Psychology · doi:10.1037/abn0000274 · Cited by 116

Differential effects of negative emotion on memory for items and associations, and their relationship to intrusive imagery

Bisby, J. A., & Burgess, N. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2017.07.012 · Cited by 123

The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm

Ernst, T., Brol, A. E., Gratz, M., Ritter, C., Bingel, U., Schlamann, M. U., Maderwald, S., Quick, H. H., Merz, C. J., & Timmann, D. (2019) · eLife · doi:10.7554/elife.46831 · Cited by 124

Intercalated amygdala clusters orchestrate a switch in fear state

Hagihara, K. M., Bukalo, O., Zeller, M., Aksoy‐Aksel, A., Karalis, N., Limoges, A., Rigg, T., Campbell, T. L., Mendez, A., Weinholtz, C. A., et al. (2021) · Nature · doi:10.1038/s41586-021-03593-1 · Cited by 119

Paraventricular Thalamus Balances Danger and Reward

Choi, E. A., & McNally, G. P. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3320-16.2017 · Cited by 120

The central nucleus of the amygdala and the construction of defensive modes across the threat-imminence continuum

Moscarello, J. M., & Penzo, M. A. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01130-5 · Cited by 112

A Discrete Dorsal Raphe to Basal Amygdala 5-HT Circuit Calibrates Aversive Memory

Sengupta, A., & Holmes, A. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.029 · Cited by 123

Activation of astrocytes in hippocampus decreases fear memory through adenosine A1 receptors

Li, Y., Li, L., Wu, J., Zhu, Z., Feng, X., Qin, L., Zhu, Y., Sun, L., Liu, Y., Qiu, Z., et al. (2020) · eLife · doi:10.7554/elife.57155 · Cited by 120

Measuring learning in human classical threat conditioning: Translational, cognitive and methodological considerations

Ojala, K. E., & Bach, D. R. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.019 · Cited by 127

The Nature and Neurobiology of Fear and Anxiety: State of the Science and Opportunities for Accelerating Discovery

Grogans, S. E., Bliss‐Moreau, E., Buss, K. A., Clark, L. A., Fox, A. S., Keltner, D. J., Cowen, A., Kim, J. J., Kragel, P. A., MacLeod, C., et al. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105237 · Cited by 135

Robust is not necessarily reliable: From within-subjects fMRI contrasts to between-subjects comparisons

Infantolino, Z. P., Luking, K. R., Sauder, C. L., Curtin, J. J., & Hajcak, G. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.02.024 · Cited by 108

Systemic inflammation induces anxiety disorder through CXCL12/CXCR4 pathway

Yang, L., Wang, M., Guo, Y., Sun, T., Li, Y., Yang, Q., Zhang, K., Liu, S.-B., Zhao, M., & Wu, Y. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.03.001 · Cited by 113

A cortico-collicular circuit for orienting to shelter during escape

Campagner, D., do Vale, R. D., Tan, Y. L., Ιορδανίδου, Π., Arocas, O. P., Claudi, F., Stempel, A. V., Keshavarzi, S., Petersen, R. S., Margrie, T. W., et al. (2022) · Nature · doi:10.1038/s41586-022-05553-9 · Cited by 111

Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development

Falcón‐Moya, R., Pérez-Rodríguez, M., Prius-Mengual, J., Andrade‐Talavera, Y., Arroyo‐García, L. E., Pérez-Artés, R., Mateos‐Aparicio, P., Guerra‐Gomes, S., Oliveira, J. F., Flores, G., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18024-4 · Cited by 110

NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety

Zhang, X., Liu, Y., Hong, X., Li, X., Meshul, C. K., Moore, C., Yang, Y., Han, Y., Li, W., Qi, X., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25956-y · Cited by 115

Active avoidance and attentive freezing in the face of approaching threat

Wendt, J., Löw, A., Weymar, M., Lotze, M., & Hamm, A. O. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.06.054 · Cited by 103

Survival circuits and risk assessment

McNaughton, N., & Corr, P. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.01.018 · Cited by 73

Role of Human Ventromedial Prefrontal Cortex in Learning and Recall of Enhanced Extinction

Dunsmoor, J. E., Kroes, M. C. W., Li, J., Daw, N. D., Simpson, H. B., & Phelps, E. A. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2713-18.2019 · Cited by 110

Neural correlates of aversive anticipation: An activation likelihood estimate meta-analysis across multiple sensory modalities

Andrzejewski, J. A., Greenberg, T., & Carlson, J. M. (2019) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-019-00747-7 · Cited by 100

Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening

Marcus, D. J., Bedse, G., Gaulden, A. D., Ryan, J. D., Kondev, V., Winters, N. D., Rosas-Vidal, L. E., Altemus, M., Mackie, K., Lee, F. S., et al. (2020) · Neuron · doi:10.1016/j.neuron.2019.12.024 · Cited by 104

An affective neuroscience model of boosting resilience in adults

Tabibnia, G. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.05.005 · Cited by 115

Optogenetic silencing of a corticotropin-releasing factor pathway from the central amygdala to the bed nucleus of the stria terminalis disrupts sustained fear

Asok, A., Draper, A., Hoffman, A. F., Schulkin, J. A., Lupica, C. R., & Rosen, J. B. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.79 · Cited by 103

Connectome-Based Predictive Modeling of Individual Anxiety

Wang, Z., Goerlich, K. S., Ai, H., Aleman, A., Luo, Y., & Xu, P. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa407 · Cited by 105

Rodent models of impaired fear extinction

Singewald, N., & Holmes, A. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5054-x · Cited by 110

Cannabinoid Regulation of Fear and Anxiety: an Update

Papagianni, E. P., & Stevenson, C. W. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1026-z · Cited by 108

Empathy for Distress in Humans and Rodents

Chen, J. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0135-0 · Cited by 102

How Human Amygdala and Bed Nucleus of the Stria Terminalis May Drive Distinct Defensive Responses

Klumpers, F., Kroes, M. C. W., Baas, J. M. P., & Fernández, G. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3830-16.2017 · Cited by 101

Corticostriatal control of defense behavior in mice induced by auditory looming cues

Li, Z., Wei, J., Zhang, G., Huang, J., Zingg, B., Wang, X., Tao, H. W., & Zhang, L. I. (2021) · Nature Communications · doi:10.1038/s41467-021-21248-7 · Cited by 95

Concepts, goals and the control of survival-related behaviors

Feldman Barrett, L., & Finlay, B. L. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.10.001 · Cited by 89

d-Serine as the gatekeeper of NMDA receptor activity: implications for the pharmacologic management of anxiety disorders

Wolosker, H., & Balu, D. T. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00870-x · Cited by 106

Projection specificity in heterogeneous locus coeruleus cell populations: implications for learning and memoryPreprint

Uematsu, A., Tan, B. Z., & Johansen, J. P. (2015) · Learning & Memory · doi:10.1101/lm.037283.114 · Cited by 89

Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses

Niu, M., Kasai, A., Tanuma, M., Seiriki, K., Igarashi, H., Kuwaki, T., Nagayasu, K., Miyaji, K., Ueno, H., Tanabe, W., et al. (2022) · Science Advances · doi:10.1126/sciadv.abi6375 · Cited by 98

The role of the hippocampus in the consolidation of emotional memories during sleep

Pronier, É., Morici, J. F., & Girardeau, G. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.08.003 · Cited by 101

Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework

Hur, J., Stockbridge, M. D., Fox, A. S., & Shackman, A. J. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.03.012 · Cited by 95

Effects of Early Life Stress on the Developing Basolateral Amygdala-Prefrontal Cortex Circuit: The Emerging Role of Local Inhibition and Perineuronal Nets

Guadagno, A., Belliveau, C., Mechawar, N., & Walker, C. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.669120 · Cited by 98

Modulation of anxiety and fear via distinct intrahippocampal circuits

Engin, E., Smith, K. S., Gao, Y., Nagy, D., Foster, R. A., Tsvetkov, E., Keist, R., Crestani, F., Fritschy, J.-M., Bolshakov, V. Y., et al. (2016) · eLife · doi:10.7554/elife.14120 · Cited by 91

A Critical Role for Neocortical Processing of Threat Memory

Dalmay, T., Abs, E., Poorthuis, R. B., Hartung, J., Pu, D.-L., Onasch, S., Lozano, Y. R., Signoret-Genest, J., Tovote, P., Gjorgjieva, J., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.025 · Cited by 90

Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis

Sakakibara, Y., Sekiya, M., Saito, T., Saido, T. C., & Iijima, K. M. (2018) · BMC Neuroscience · doi:10.1186/s12868-018-0446-8 · Cited by 90

Human fear conditioning: From neuroscience to the clinic

Fullana, M. A., Dunsmoor, J. E., Schruers, K. R. J., Savage, H. S., Bach, D. R., & Harrison, B. J. (2019) · Behaviour Research and Therapy · doi:10.1016/j.brat.2019.103528 · Cited by 96

Cerebellar modulation of synaptic input to freezing-related neurons in the periaqueductal gray

Vaaga, C. E., Brown, S. T., & Raman, I. M. (2020) · eLife · doi:10.7554/elife.54302 · Cited by 89

The role of the periaqueductal gray in escape behavior

Lefler, Y., Campagner, D., & Branco, T. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.11.014 · Cited by 88

nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors

Liang, H., Chen, Z., Xiao, H., Lin, Y., Hu, Y.-Y., Chang, L., Wu, H., Wang, P., Lu, W., Zhu, D., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16198-5 · Cited by 91

Measuring maladaptive avoidance: from animal models to clinical anxiety

Ball, T. M., & Gunaydin, L. A. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01263-4 · Cited by 96

Neural Correlates of Fear in the Periaqueductal Gray

Watson, T. C., Cerminara, N. L., Lumb, B. M., & Apps, R. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1100-16.2016 · Cited by 92

The Myth of Optimality in Clinical Neuroscience

Holmes, A. J., & Patrick, L. M. (2018) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.12.006 · Cited by 89

Modulation of fear generalization by the zona incerta

Venkataraman, A., Brody, N., Reddi, P. J., Guo, J., Rainnie, D. G., & Dias, B. G. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820541116 · Cited by 87

The Role of the Rodent Insula in Anxiety

Méndez-Ruette, M., Linsambarth, S., Moraga‐Amaro, R., Quintana-Donoso, D., Méndez, L., Tamburini, G., Cornejo, F., Torres, R. F., & Stehberg, J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00330 · Cited by 96

Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning

Haaker, J., Maren, S., Andreatta, M., Merz, C. J., Richter, J., Richter, S. H., Drexler, S. M., Lange, M. D., Jüngling, K., Nees, F., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.020 · Cited by 92

Intrinsic functional connectivity of the central extended amygdala

Tillman, R. M., Stockbridge, M. D., Nacewicz, B. M., Torrisi, S., Fox, A. S., Smith, J. F., & Shackman, A. J. (2017) · Human Brain Mapping · doi:10.1002/hbm.23917 · Cited by 92

Minimizing threat via heuristic and optimal policies recruits hippocampus and medial prefrontal cortex

Korn, C. W., & Bach, D. R. (2019) · Nature Human Behaviour · doi:10.1038/s41562-019-0603-9 · Cited by 86

Memories are not written in stone: Re-writing fear memories by means of non-invasive brain stimulation and optogenetic manipulations

Borgomaneri, S., Battaglia, S., Sciamanna, G., Tortora, F., & Laricchiuta, D. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.04.036 · Cited by 90

Infant gut microbiome composition is associated with non-social fear behavior in a pilot study

Carlson, A. L., Xia, K., Azcárate-Peril, M. A., Rosin, S. P., Fine, J. P., Mu, W., Zopp, J. B., Kimmel, M., Styner, M. A., Thompson, A. L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23281-y · Cited by 85

Modulation of Fear Extinction by Stress, Stress Hormones and Estradiol: A Review

Stockhorst, U., & Antov, M. I. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00359 · Cited by 96

Ecology and Neurobiology of Fear in Free-Living Wildlife

Zanette, L., & Clinchy, M. (2020) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev-ecolsys-011720-124613 · Cited by 88

Endocannabinoids, cannabinoids and the regulation of anxiety

Petrie, G. N., Nastase, A. S., Aukema, R. J., & Hill, M. N. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108626 · Cited by 91

Fear extinction reverses dendritic spine formation induced by fear conditioning in the mouse auditory cortex

Lai, C. S. W., Adler, A., & Gan, W. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1801504115 · Cited by 89

Extensive and spatially variable within-cell-type heterogeneity across the basolateral amygdala

O’Leary, T. P., Sullivan, K. E., Wang, L., Clements, J., Lemire, A. L., & Cembrowski, M. S. (2020) · eLife · doi:10.7554/elife.59003 · Cited by 81

Targeting presynaptic H3 heteroreceptor in nucleus accumbens to improve anxiety and obsessive-compulsive-like behaviors

Zhang, X., Peng, S., Shen, L.-P., Zhuang, Q., Li, B., Xie, S.-T., Li, Q.-X., Shi, M.-R., Ma, T.-Y., Zhang, Q., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008456117 · Cited by 85

Sex differences in fear responses: Neural circuits

Bauer, E. P. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109298 · Cited by 92

Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

Wang, Y., Cao, L., Lee, C.-Y., Matsuo, T., Wu, K., Asher, G. D., Tang, L., Saitoh, T., Russell, J., Klewe-Nebenius, D., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04324-3 · Cited by 86

Distinct serotonergic pathways to the amygdala underlie separate behavioral features of anxiety

Yu, X., Zhu, Y., Sun, Q., Deng, F., Wan, J., Zheng, D., Gong, W., Xie, S., Shen, C.-J., Fu, J., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01200-8 · Cited by 89

Sex-Dependent Regulation of Aromatase-Mediated Synaptic Plasticity in the Basolateral Amygdala

Bender, R. A., Zhou, L., Vierk, R., Brandt, N., Keller, A., Gee, C. E., Schäfer, M. K. E., & Rune, G. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1532-16.2016 · Cited by 91

Zona incerta subpopulations differentially encode and modulate anxiety

Li, Z., Rizzi, G., & Tan, K. R. (2021) · Science Advances · doi:10.1126/sciadv.abf6709 · Cited by 80

Dissociable control of unconditioned responses and associative fear learning by parabrachial CGRP neurons

Bowen, A. J., Chen, J., Huang, Y. W., Baertsch, N. A., Park, S., & Palmiter, R. D. (2020) · eLife · doi:10.7554/elife.59799 · Cited by 82

Hippocampal network oscillations at the interplay between innate anxiety and learned fear

Çalışkan, G., & Stork, O. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5109-z · Cited by 72

Left Habenular Activity Attenuates Fear Responses in Larval Zebrafish

Duboué, E. R., Hong, E., Eldred, K. C., & Halpern, M. E. (2017) · Current Biology · doi:10.1016/j.cub.2017.06.017 · Cited by 76

Flexible inhibitory control of visually evoked defensive behavior by the ventral lateral geniculate nucleus

Fratzl, A., Koltchev, A. M., Vissers, N., Tan, Y. L., Marques–Smith, A., Stempel, A. V., Branco, T., & Hofer, S. B. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.003 · Cited by 79

Ethanol Withdrawal Drives Anxiety-Related Behaviors by Reducing M-type Potassium Channel Activity in the Lateral Habenula

Kang, S., Li, J., Zuo, W., Fu, R., Gregor, D. M., Krnjević, K., Bekker, A., & Ye, J.-H. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.68 · Cited by 75

Prefrontal cortical circuits in anxiety and fear: an overview

Chen, Y., Hu, N.-Y., Yang, J., & Gao, T. (2022) · Frontiers of Medicine · doi:10.1007/s11684-022-0941-2 · Cited by 29

Bridging the Gap : Towards a cell-type specific understanding of neural circuits underlying fear behaviors

McCullough, K. M., Morrison, F. G., & Ressler, K. J. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.07.025 · Cited by 50

Pathological anxiety and function/dysfunction in the brain's fear/defense circuitry

Lang, P. J., McTeague, L. M., & Bradley, M. M. (2014) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-139012 · Cited by 36

Neuronal circuits of fear memory and fear extinction

Wotjak, C. T., & Pape, H. (2013) · e-Neuroforum · doi:10.1007/s13295-013-0046-0 · Cited by 22

Controlling the Elements: An Optogenetic Approach to Understanding the Neural Circuits of Fear

Johansen, J. P., Wolff, S. B. E., Lüthi, A., & LeDoux, J. E. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.023 · Cited by 87