The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Pain, catastrophizing, and depression in the rheumatic diseases
Abstract
Persistent and disabling pain is the hallmark of osteoarthritis, rheumatoid arthritis, fibromyalgia, and various other rheumatologic conditions. However, disease severity (as measured by 'objective' indices such as those that employ radiography or serology) is only marginally related to patients' reports of pain severity, and pain-related presentation can differ widely between individuals with ostensibly similar conditions (for example, grade 4 osteoarthritis of the knee). Increasing evidence in support of the biopsychosocial model of pain suggests that cognitive and emotional processes are crucial contributors to inter-individual differences in the perception and impact of pain. This Review describes the growing body of literature relating depression and catastrophizing to the experience of pain and pain-related sequelae across a number of rheumatic diseases. Depression and catastrophizing are consistently associated with the reported severity of pain, sensitivity to pain, physical disability, poor treatment outcomes, and inflammatory disease activity, and potentially with early mortality. A variety of pathways, from cognitive to behavioral to neurophysiological, seem to mediate these deleterious effects. Collectively, depression and catastrophizing are critically important variables in understanding the experience of pain in patients with rheumatologic disorders. Pain, depression, and catastrophizing might all be uniquely important therapeutic targets in the multimodal management of a range of such conditions.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“PC occurs at higher rates in people with FM compared with other rheumatologic populations.”
From Effectiveness of cognitive behaviour therapy for the treatment of catastrophisation in patients with fibromyalgia: A randomised controlled trial (2011) · cites this paper as [22]
In the citing paper
“Moreover, there is often an even stronger relationship between PC and key clinical outcomes, such as pain intensity and pain sensitivity, in comparison with other rheumatologic diseases [20-22].”
From Effectiveness of cognitive behaviour therapy for the treatment of catastrophisation in patients with fibromyalgia: A randomised controlled trial (2011) · cites this paper as [22]
In the citing paper
“the presence of a supportive partner has been associated with reduced symptom burden (including less pain), improved quality of life, and fewer symptoms of distress in patients with chronic lymphocytic leukemia 92, metastatic breast cancer 93, 94, and other cancer types such as colorectal cancer95, 96.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [92]
In the citing paper
“Catastrophizing is linked to the intensity of pain and the severity of depression, which are markers of maladjustment (34, 40).”
Citations
Cites
Burden of major musculoskeletal conditions.
(2003) · Europe PMC (PubMed Central) · Cited by 3,521
Pain catastrophizing: a critical review.
Quartana, P. J., Campbell, C. M., & Edwards, R. R. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.34 · Cited by 1,405
Self-citationDiatchenko, L., Slade, G. D., Nackley, A. G., Bhalang, K., Sigurdsson, A., Belfer, I., Goldman, D., Xu, K., Shabalina, S. A., Shagin, D., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi013 · Cited by 1,280
Pain catastrophizing and neural responses to pain among persons with fibromyalgia
Gracely, R. H. (2004) · Brain · doi:10.1093/brain/awh098 · Cited by 892
Pain Catastrophizing and Kinesiophobia: Predictors of Chronic Low Back Pain
Picavet, H. S. J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf136 · Cited by 744
Behavioural treatment for chronic low-back pain
Henschke, N., Ostelo, R. W., van Tulder, M. W., Vlaeyen, J. W., Morley, S., Assendelft, W. J., & Main, C. J. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002014.pub3 · Cited by 718
Coping with rheumatoid arthritis pain: catastrophizing as a maladaptive strategy
Keefe, F. J., Brown, G. K., Wallston, K. A., & Caldwell, D. S. (1989) · Pain · doi:10.1016/0304-3959(89)90152-8 · Cited by 694
Smeets, R. J. E. M., Vlaeyen, J. W. S., Kester, A. D. M., & Knottnerus, J. A. (2006) · The Journal of Pain · doi:10.1016/j.jpain.2005.10.011 · Cited by 629
Catastrophizing and pain in arthritis, fibromyalgia, and other rheumatic diseases
Edwards, R. R., Bingham, C. O., Bathon, J. M., & Haythornthwaite, J. A. (2006) · Arthritis Care & Research · doi:10.1002/art.21865 · Cited by 511
Self-citationZautra, A. J., Davis, M. C., Reich, J. W., Nicassario, P., Tennen, H., Finan, P., Kratz, A., Parrish, B., & Irwin, M. R. (2008) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.76.3.408 · Cited by 430 · cited 1×
“In a study of patients with RA, an intervention that focused on mindfulness meditation was particularly effective in those with a history of depression, who showed improvements in pain, mood, inflammation, and joint tenderness”
Research works printed but not linked: 1
- Wolff, B. et al. Pain catastrophizing, physiological indexes, and chronic pain severity: tests of mediation and moderation models. J. Behav. Med. 31, 105–114 (2008). · DOI
Cited by
Sorted by citations
Sharma, L. (2021) · New England Journal of Medicine · doi:10.1056/nejmcp1903768 · Cited by 1,089
The role of psychosocial processes in the development and maintenance of chronic pain
Edwards, R. R., Dworkin, R. H., Sullivan, M. D., Turk, D. C., & Wasan, A. D. (2016) · The Journal of Pain · doi:10.1016/j.jpain.2016.01.001 · Cited by 954
“As we will describe in the Distress section, longitudinal, observational research supports a strong bidirectional link between mood disorders and persistent pain; the development of an enduring pain condition confers a substantially increased risk for the subsequent diagnosis of an affective disorder, and psychosocial…”
InfluentialSelf-citationEhde, D. M., Dillworth, T. M., & Turner, J. A. (2014) · American Psychologist · doi:10.1037/a0035747 · Cited by 879
Evaluating psychosocial contributions to chronic pain outcomes
Meints, S. M., & Edwards, R. R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.017 · Cited by 719
“and increased pain sensitivity for low back pain and joint pain (Edwards et al., 2011).”
Self-citationComorbid depression in medical diseases
Gold, S. M., Köhler‐Forsberg, O., Moss-Morris, R. E., Mehnert-Theuerkauf, A., Miranda, J. J., Bullinger, M., Steptoe, A., Whooley, M. A., & Otte, C. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0200-2 · Cited by 583
Metadata
- Authors
- Edwards, R. R., Cahalan, C., Mensing, G., Smith, M., & Haythornthwaite, J. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Johns Hopkins University (US)
- Corresponding author
- Edwards, Robert R.
- Venue
- Nature Reviews Rheumatology
- Published
- 2011-02-01
- Volume
- 7
- Issue
- 4
- Pages
- 216-224
- ISSN
- 1759-4790 (ISSN-L)
- 1759-4804
- OpenAlex
- W1986268428
- Cited by
- 596
- References
- 123
- Citations by year
- 2026: 25 · 2025: 29 · 2024: 30 · 2023: 44 · 2022: 48 · 2021: 55 · 2020: 47 · 2019: 54 · 2018: 48 · 2017: 42 · 2016: 30 · 2015: 35 · 2014: 39 · 2013: 31 · 2012: 29
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Update notices
- correction (2011-06-03)
- Open access
- closed
- Locations
- Nature Reviews Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- pain catastrophizing, depression, rheumatic diseases, chronic pain, biopsychosocial model of pain, osteoarthritis, rheumatoid arthritis, fibromyalgia, pain sensitivity, disability, treatment outcomes, inflammatory disease activity, mortality, multimodal pain management
- MeSH terms
- Depression, Disability Evaluation, Helplessness, Learned, Humans, Pain, Rheumatic Diseases, Treatment Failure, Pain Threshold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
