The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Pain, catastrophizing, and depression in the rheumatic diseases
Abstract
Persistent and disabling pain is the hallmark of osteoarthritis, rheumatoid arthritis, fibromyalgia, and various other rheumatologic conditions. However, disease severity (as measured by 'objective' indices such as those that employ radiography or serology) is only marginally related to patients' reports of pain severity, and pain-related presentation can differ widely between individuals with ostensibly similar conditions (for example, grade 4 osteoarthritis of the knee). Increasing evidence in support of the biopsychosocial model of pain suggests that cognitive and emotional processes are crucial contributors to inter-individual differences in the perception and impact of pain. This Review describes the growing body of literature relating depression and catastrophizing to the experience of pain and pain-related sequelae across a number of rheumatic diseases. Depression and catastrophizing are consistently associated with the reported severity of pain, sensitivity to pain, physical disability, poor treatment outcomes, and inflammatory disease activity, and potentially with early mortality. A variety of pathways, from cognitive to behavioral to neurophysiological, seem to mediate these deleterious effects. Collectively, depression and catastrophizing are critically important variables in understanding the experience of pain in patients with rheumatologic disorders. Pain, depression, and catastrophizing might all be uniquely important therapeutic targets in the multimodal management of a range of such conditions.
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“PC occurs at higher rates in people with FM compared with other rheumatologic populations.”
From Effectiveness of cognitive behaviour therapy for the treatment of catastrophisation in patients with fibromyalgia: A randomised controlled trial (2011) · cites this paper as [22]
In the citing paper
“Moreover, there is often an even stronger relationship between PC and key clinical outcomes, such as pain intensity and pain sensitivity, in comparison with other rheumatologic diseases [20-22].”
From Effectiveness of cognitive behaviour therapy for the treatment of catastrophisation in patients with fibromyalgia: A randomised controlled trial (2011) · cites this paper as [22]
In the citing paper
“the presence of a supportive partner has been associated with reduced symptom burden (including less pain), improved quality of life, and fewer symptoms of distress in patients with chronic lymphocytic leukemia 92, metastatic breast cancer 93, 94, and other cancer types such as colorectal cancer95, 96.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [92]
In the citing paper
“Catastrophizing is linked to the intensity of pain and the severity of depression, which are markers of maladjustment (34, 40).”
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Cao, P., Li, Y., Tang, Y., Ding, C., & Hunter, D. J. (2020) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2020.1732924 · Cited by 94
“IL-1 is expressed in the cartilage, synovium, and synovial fluid of OA patients [93].”
Predictors of change in bodily pain in early rheumatoid arthritis: An inception cohort study
McWilliams, D. F., Zhang, W., Mansell, J., Kiely, P. D. W., Young, A., & Walsh, D. A. (2012) · Arthritis Care & Research · doi:10.1002/acr.21723 · Cited by 89
“High depression indices have been associated with greater pain in other studies of RA (38), and we found that bodily pain at baseline was associated with worse mental health scores.”
ResultWaning of “Conditioned Pain Modulation”: A Novel Expression of Subtle Pronociception in Migraine
Nahman‐Averbuch, H., Granovsky, Y., Coghill, R. C., Yarnitsky, D., Sprecher, E., & Weissman‐Fogel, I. (2013) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12117 · Cited by 89
“Higher pain catastrophizing scores were found in chronic pain patients(51,52) and were associated with pain severity and sensitivity.(53) In line with these reports, in the current study, it was found that pain catastrophizing scores differed between patients and healthy subjects, and it was correlated with the clini-”
ResultDeep Dyspareunia and Sexual Quality of Life in Women With Endometriosis
Shum, L. K., Bedaiwy, M. A., Allaire, C., Williams, C., Noga, H. L., Albert, A., Lisonkova, S., & Yong, P. J. (2018) · Sexual Medicine · doi:10.1016/j.esxm.2018.04.006 · Cited by 88
“It is known that pain catastrophizing and depression are associated with chronic pain severity and negatively affect QoL.38,39 Depression has been associated with SQoL in terms of sexual desire, sexual arousal, sexual cognition, and orgasmic functions.40 Conversely, struggles with sexual function could result in depre…”
InfluentialEdwards, R. R., Dolman, A. J., Michna, E., Katz, J. N., Nedeljković, S. S., Janfaza, D. R., Isaac, Z., Martel, M. O., Jamison, R. N., & Wasan, A. D. (2016) · Pain Medicine · doi:10.1093/pm/pnw010 · Cited by 87
Self-citationLazaridou, A., Martel, M. O., Cornelius, M. C., Franceschelli, O., Campbell, C. M., Smith, M. T., Haythornthwaite, J. A., Wright, J. R., & Edwards, R. R. (2018) · Pain Medicine · doi:10.1093/pm/pny129 · Cited by 94
“Catastrophizing is hypothesized to contribute to clinical outcomes in chronic pain, in part by impacting health behaviors such as exercise [24]; specifically, the fear avoidance model suggests that catastrophizing about pain initiates a cycle of pain-related fear, impairment, and disability [25–28].”
BackgroundSelf-citationLarsen, D. B., Laursen, M. B., Edwards, R. R., Simonsen, O. H., Arendt‐Nielsen, L., & Petersen, K. K. (2020) · Pain Medicine · doi:10.1093/pm/pnaa402 · Cited by 89
“It is generally accepted that chronic pain patients [18] who report high pain catastrophizing also report higher pain intensity and poorer pain-related outcomes, possibly due to, for example, maladaptive coping approaches and increased central pain processing [29, 40].”
Self-citationThompson, E. L., Broadbent, J., Bertino, M. D., & Staiger, P. K. (2016) · The Clinical Journal of Pain · doi:10.1097/ajp.0000000000000235 · Cited by 84
Cotchett, M., Lennecke, A., Medica, V. G., Whittaker, G. A., & Bonanno, D. R. (2017) · The Foot · doi:10.1016/j.foot.2017.03.003 · Cited by 86
“371 Evidence has also emerged that high levels of pain catastrophising might influence 372 pain and function via behavioural pathways and this might be influenced by 373 symptoms of depression [37].”
BackgroundInfluentialChronic Pain After Breast Surgery: A Prospective, Observational Study
Spivey, T., Gutowski, E. D., Zinboonyahgoon, N., King, T. A., Dominici, L. S., Edwards, R. R., Golshan, M. A., & Schreiber, K. L. (2018) · Annals of Surgical Oncology · doi:10.1245/s10434-018-6644-x · Cited by 83
Self-citationPain hypersensitivity in juvenile idiopathic arthritis: a quantitative sensory testing study
Cornelissen, L., Donado, C., Kim, J., Chiel, L. E., Zurakowski, D., Logan, D. E., Meier, P. M., Sethna, N. F., Blankenburg, M. R., Zernikow, B., et al. (2014) · Pediatric Rheumatology · doi:10.1186/1546-0096-12-39 · Cited by 83
“We created a general model for each QST parameter that included potential variables associated with the change in sensory thresholds and pain [24].”
MethodSalaffi, F., Giacobazzi, G., & Carlo, M. D. (2018) · Pain Research and Management · doi:10.1155/2018/8564215 · Cited by 82
“As in healthy people, in RA patients, factors of acute and chronic psychological distress can enhance central pain processing [91, 95].”
BackgroundNandi, M., Schreiber, K. L., Martel, M. O., Cornelius, M. C., Campbell, C. M., Haythornthwaite, J. A., Smith, M. T., Wright, J., Aglio, L. S., Strichartz, G. R., et al. (2019) · Biology of Sex Differences · doi:10.1186/s13293-019-0237-7 · Cited by 83
Self-citationCANUE: A Theoretical Model of Pain as an Antecedent for Substance Use
Ferguson, E. G., Zale, E. L., Ditre, J. W., Wesolowicz, D. M., Stennett, B., Robinson, M., & Boissoneault, J. (2020) · Annals of Behavioral Medicine · doi:10.1093/abm/kaaa072 · Cited by 82
“psychosocial and pain literature [128] and the existing”
Edwards, R. R., Campbell, C. M., Schreiber, K. L., Meints, S. M., Lazaridou, A., Martel, M. O., Cornelius, M. C., Xu, X., Jamison, R. N., Katz, J. N., et al. (2022) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-022-05239-3 · Cited by 80
Self-citationWorry and catastrophizing about pain in youth: A reappraisal
Eccleston, C., Fisher, E. A., Vervoort, T., & Crombez, G. (2012) · Pain · doi:10.1016/j.pain.2012.02.039 · Cited by 79
Alda, M., Luciano, J. V., Andrés, E., Serrano-Blanco, A., Rodero, B., del Hoyo, Y. L., Roca, M., Moreno, S., Magallón, R., & García-Campayo, J. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3496 · Cited by 77
“Moreover, there is often an even stronger relationship between PC and key clinical outcomes, such as pain intensity and pain sensitivity, in comparison with other rheumatologic diseases [20-22].”
ResultLoggia, M. L., Berna, C., Kim, J., Cahalan, C. M., Martel, M.-O., Gollub, R. L., Wasan, A. D., Napadow, V., & Edwards, R. R. (2015) · The Journal of Pain · doi:10.1016/j.jpain.2015.04.003 · Cited by 74
“maintaining pain and disability in this and other pain disorders.(6) In fact, FM is characterized by a strong association with psychiatric comorbidities, including anxiety and depression, and has been considered an affective spectrum disorder.”
InfluentialSelf-citationCatastrophizing Interferes with Cognitive Modulation of Pain in Women with Fibromyalgia
Ellingson, L. D., Stegner, A. J., Schwabacher, I. J., Lindheimer, J. B., & Cook, D. B. (2018) · Pain Medicine · doi:10.1093/pm/pny008 · Cited by 76
Abrecht, C. R., Cornelius, M. C., Wu, A. W., Jamison, R. N., Janfaza, D. R., Urman, R. D., Campbell, C. M., Smith, M. T., Haythornthwaite, J. A., Edwards, R. R., et al. (2018) · Pain Medicine · doi:10.1093/pm/pny020 · Cited by 80
Self-citationBrown, C. A., El‐Deredy, W., & Jones, A. K. P. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12420 · Cited by 71
“FM is associated with psychological co-morbidities such as anxiety and depression (Thieme et al., 2004), pain catastrophizing (Hassett et al., 2000), and cognitive impairments (Baumstark et al., 1993), which are, to an extent, shared by patients with OA (Edwards et al., 2011).”
BackgroundComorbidities in rheumatic diseases need special consideration during the COVID-19 pandemic
Ahmed, S., Gasparyan, A. Y., & Zimba, O. (2021) · Rheumatology International · doi:10.1007/s00296-020-04764-5 · Cited by 78
“In chronic painful conditions like arthritis, there is catastrophising and thus, concomitant depression arising out of such inadept defence mechanisms [4].”
BackgroundRelationship of Negative Affect and Outcome of an Opioid Therapy Trial Among Low Back Pain Patients
Jamison, R. N., Edwards, R. R., Liu, X., Ross, E. L., Michna, E., Warnick, M., & Wasan, A. D. (2012) · Pain Practice · doi:10.1111/j.1533-2500.2012.00575.x · Cited by 71
Self-citationPain in rheumatoid arthritis: a critical review
Sarzi‐Puttini, P., Salaffi, F., Franco, M. D., Bazzichi, L., Cassisi, G., Casale, R., Cazzola, M., Stisi, S., Battellino, M., & Atzeni, F. (2014) · Reumatismo · doi:10.4081/reumatismo.2014.760 · Cited by 74
“Psychological factors influence pain reporting in RA (46, 47), and high depression indices have been associated with greater RA pain (48).”
Fatigue in inflammatory rheumatic disorders: pathophysiological mechanisms
Korte, S. M., & Straub, R. H. (2019) · Rheumatology · doi:10.1093/rheumatology/kez413 · Cited by 71
Egsgaard, L. L., Eskehave, T. N., Bay‐Jensen, A., Hoeck, H. C., & Arendt‐Nielsen, L. (2015) · Pain · doi:10.1016/j.pain.0000000000000011 · Cited by 68
“Also, it has been suggested that psychosocial factors such as pain catastrophizing and depression may account for a separate OA profile.(12)”
BackgroundInfluentialSmith, E., Pang, H., Ye, C., Cirrincione, C., Fleishman, S. B., Paskett, E. D., Ahles, T. A., Bressler, L. R., Le-Lindqwister, N. A., Fadul, C. E., et al. (2015) · European Journal of Cancer Care · doi:10.1111/ecc.12421 · Cited by 70
“…1999; Coker et al. 2000; Baccini et al. 2003; Meltzer-Brody et al. 2007; Humphreys et al. 2010; Barry et al. 2011; Raphael & Widom 2011) and the tendency to catastrophise about pain (believing that pain is profoundly awful) (Sullivan et al. 2001; Edwards et al. 2006, 2011; Campbell & Edwards 2009).”
BackgroundMartel, M. O., Jamison, R. N., Wasan, A. D., & Edwards, R. R. (2014) · Pain Medicine · doi:10.1111/pme.12416 · Cited by 65
“pain-related coping skills (for a review, see [17-18, 21], and poor coping has been linked to heightened reports of craving in patients with substance use problems [41-43].”
BackgroundResultInfluentialAjeganova, S., Fairé, U. D., Jogestrand, T., Frostegård, J., & Hafström, I. (2012) · The Journal of Rheumatology · doi:10.3899/jrheum.111334 · Cited by 67
Campbell, C. M., McCauley, L., Bounds, S. C., Mathur, V. A., Conn, L., Simango, M., Edwards, R. R., & Fontaine, K. R. (2012) · Arthritis Research & Therapy · doi:10.1186/ar4073 · Cited by 74
“This finding is not surprising, given the relationship between catastrophizing and pain in populations with FM and those with other functional pain syndromes [1].”
BackgroundInfluentialSelf-citationEncoding of Self‐Referential Pain Catastrophizing in the Posterior Cingulate Cortex in Fibromyalgia
Lee, J., Protsenko, E., Lazaridou, A., Franceschelli, O., Ellingsen, D., Mawla, I., Isenburg, K., Berry, M. P., Galenkamp, L., Loggia, M. L., et al. (2018) · Arthritis & Rheumatology · doi:10.1002/art.40507 · Cited by 66
“Catastrophizing is also a major contributor to pain severity in fibromyalgia (FM) (2), a chronic functional pain disorder characterized by maladaptive brain plasticity (3).”
Self-citationA prediction model for length of stay after total and unicompartmental knee replacement
Ong, P., & Pua, Y. (2013) · The Bone & Joint Journal · doi:10.1302/0301-620x.95b11.31193 · Cited by 64
Metadata
- Authors
- Edwards, R. R., Cahalan, C., Mensing, G., Smith, M., & Haythornthwaite, J. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Johns Hopkins University (US)
- Corresponding author
- Edwards, Robert R.
- Venue
- Nature Reviews Rheumatology
- Published
- 2011-02-01
- Volume
- 7
- Issue
- 4
- Pages
- 216-224
- ISSN
- 1759-4790 (ISSN-L)
- 1759-4804
- OpenAlex
- W1986268428
- Cited by
- 596
- References
- 123
- Citations by year
- 2026: 25 · 2025: 29 · 2024: 30 · 2023: 44 · 2022: 48 · 2021: 55 · 2020: 47 · 2019: 54 · 2018: 48 · 2017: 42 · 2016: 30 · 2015: 35 · 2014: 39 · 2013: 31 · 2012: 29
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Update notices
- correction (2011-06-03)
- Open access
- closed
- Locations
- Nature Reviews Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- pain catastrophizing, depression, rheumatic diseases, chronic pain, biopsychosocial model of pain, osteoarthritis, rheumatoid arthritis, fibromyalgia, pain sensitivity, disability, treatment outcomes, inflammatory disease activity, mortality, multimodal pain management
- MeSH terms
- Depression, Disability Evaluation, Helplessness, Learned, Humans, Pain, Rheumatic Diseases, Treatment Failure, Pain Threshold
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