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Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment
Open accessAbstract
Bone erosion is a central feature of rheumatoid arthritis and is associated with disease severity and poor functional outcome. Erosion of periarticular cortical bone, the typical feature observed on plain radiographs in patients with rheumatoid arthritis, results from excessive local bone resorption and inadequate bone formation. The main triggers of articular bone erosion are synovitis, including the production of proinflammatory cytokines and receptor activator of nuclear factor κB ligand (RANKL), as well as antibodies directed against citrullinated proteins. Indeed, both cytokines and autoantibodies stimulate the differentiation of bone-resorbing osteoclasts, thereby stimulating local bone resorption. Although current antirheumatic therapy inhibits both bone erosion and inflammation, repair of existing bone lesions, albeit physiologically feasible, occurs rarely. Lack of repair is due, at least in part, to active suppression of bone formation by proinflammatory cytokines. This Review summarizes the substantial progress that has been made in understanding the pathophysiology of bone erosions and discusses the improvements in the diagnosis, monitoring and treatment of such lesions.
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“TNF-α can also indirectly increase RANKL expression and affect osteoclast differentiation by activating osteoblasts, B cells, and T cells [88].”
From Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature (2024) · cites this paper as [88]
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“RANKL-dependent pathways activated by pro-inflammatory cytokines can induce osteoclast formation, therefore, enhancing osteoclast activity [87, 88].”
From Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature (2024) · cites this paper as [88]
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Cites
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670
The Pathogenesis of Rheumatoid Arthritis
McInnes, I. B., & Schett, G. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1004965 · Cited by 5,514
Self-citationOsteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439
Aletaha, D., Neogi, T., Silman, A. J., Funovits, J., Felson, D. T., Bingham, C. O., Birnbaum, N. S., Burmester, G. R., Bykerk, V. P., Cohen, M. D., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.138461 · Cited by 4,959
Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,224
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
Cytokines in the pathogenesis of rheumatoid arthritis
McInnes, I. B., & Schett, G. A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2094 · Cited by 2,575
Self-citationOsteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
Takayanagi, H. (2007) · Nature Reviews Immunology · doi:10.1038/nri2062 · Cited by 1,878
Kong, Y.-Y., Feige, U., Sarosi, I., Bolon, B., Tafuri, A., Morony, S., Capparelli, C., Li, J., Elliott, R., McCabe, S., et al. (1999) · Nature · doi:10.1038/46303 · Cited by 1,856
Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789
Flagged first, then by citations
Research works printed but not linked: 2
- Baker, W. M. The formation of abnormal synovial cysts in the connection with the joints. St Bartolomews Hospital Reports 21, 177–190 (1855).
- Sato, K. et al. TH17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J. Exp. Med. 203, 2673–2682 (2006). · DOI · Paper page
Cited by
Sorted by citations
Items 401–500 of 946
Li, S., Li, R., Xu, Y., Baak, J. P. A., Gao, J., Shu, J.-Q., Jing, L., Meng, X., Wen, C., Gan, Y., et al. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/5523870 · Cited by 17
Iwata, T., Ito, H., Furu, M., Hashimoto, M., Fujii, T., Ishikawa, M., Yamakawa, N., Terao, C. C., Azukizawa, M., Hamamoto, Y., et al. (2015) · Osteoporosis International · doi:10.1007/s00198-015-3256-1 · Cited by 17
Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption
Binder, N. B., Miller, C. H., Yoshida, M., Inoue, K., Nakano, S., Hu, X., Ivashkiv, L. B., Schett, G. A., Pernis, A. B., Goldring, S. R., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601716 · Cited by 18
Self-citationSargın, G., Köse, R., & Şentürk, T. (2018) · European Journal of Rheumatology · doi:10.5152/eurjrheum.2018.18099 · Cited by 17
Osteoclastic microRNAs and their translational potential in skeletal diseases
Inoue, K., Nakano, S., & Zhao, B. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00761-4 · Cited by 18
Biomaterials for Modulating the Immune Microenvironment in Rheumatoid Arthritis
Wang, Q., Ji, J., Huang, D., & Gao, C. (2025) · BME Frontiers · doi:10.34133/bmef.0102 · Cited by 18
Lopalco, G., Cito, A., Iannone, F., Diekhoff, T., Poddubnyy, D., & Proft, F. N. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1599995 · Cited by 21
Shindo, S., Nakamura, S., Hawthorne, A., Heidari, A., Pastore, M. R., Okamoto, M., Suzuki, M., Salinas, M., Memida, T., Minond, D., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1661538 · Cited by 15
Li, S., Zhou, C., Xu, Y., Wang, Y., Li, L., Pelekos, G., Ziebolz, D., Schmalz, G., & Qin, Z. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.702661 · Cited by 17
Thomas, J., Bansback, N. J., Barber, C. E. H., Wells, G. A., & Hazlewood, G. S. (2022) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2022.101812 · Cited by 16
Fang, W., Mao, Y., Wang, H., Sugimori, H., Kiuch, S., Sutherland, K. L., & Kamishima, T. (2024) · Japanese Journal of Radiology · doi:10.1007/s11604-024-01592-6 · Cited by 16
Registration-Based Morphometry for Shape Analysis of the Bones of the Human Wrist
Joshi, A. A., Leahy, R. M., Badawi, R. D., & Chaudhari, A. J. (2015) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2015.2476817 · Cited by 16
Scharmga, A. M. J., Peters, M., van Tubergen, A. M., van den Bergh, J. P., de Jong, J. J. A., Loeffen, D. V., van Rietbergen, B., Weijers, R. E., & Geusens, P. (2016) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-016-1148-y · Cited by 16
Neto, M. F., & Figueiredo, M. L. (2017) · Arthritis · doi:10.1155/2017/6365857 · Cited by 16
Lewiecki, E. M., Bilezikian, J. P., CAREY, J. J., Dell, R. M., Gordon, C. M., Harris, S. T., McClung, M. R., Miller, P. D., & Rosenblatt, M. (2017) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2017.10.041 · Cited by 16
A DNA-Methylated Sight on Autoimmune Inflammation Network across RA, pSS, and SLE
Wang, X., Lei, D., Ding, J., Liu, S., Li, T., Zhang, F., Peng, J., & Xu, J. (2018) · Journal of Immunology Research · doi:10.1155/2018/4390789 · Cited by 16
Bone Resorption Activity in Mature Osteoclasts
Kiyoi, T. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8802-0_22 · Cited by 16
Ling, Y., Yang, J., Hua, D., Wang, D., Zhao, C., Weng, L., Yue, D., Cai, X., Meng, Q., Chen, J., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.693777 · Cited by 16
Zhou, Q., Zhou, Y., Chen, H., Wang, Z., Tang, Z., & Liu, J. (2014) · Europe PMC (PubMed Central) · Cited by 16
Autoantibody-Mediated Bone Loss
Steffen, U., Kittan, N. A., & Schett, G. A. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-013-0185-9 · Cited by 16
Self-citationShimizu, T., Takahata, M., Kimura, H., Kameda, Y., Endo, K., Hamano, H., Hiratsuka, S., Ota, M., Sato, D., Ito, T., et al. (2016) · Osteoporosis International · doi:10.1007/s00198-016-3781-6 · Cited by 16
Ethyl pyruvate ameliorates inflammatory arthritis in mice
Jung, S. M., Lee, J., Baek, S. Y., Lee, J. H., Jang, S. G., Hong, S.-M., Park, J., Cho, M., Park, S., & Kwok, S. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.09.027 · Cited by 16
Orsolini, G., Bertoldi, I., & Rossini, M. (2020) · Clinical Rheumatology · doi:10.1007/s10067-020-04930-x · Cited by 15
Freeze, R., Yang, K. W., Haystead, T., Hughes, P. F., & Scarneo, S. A. (2023) · Pharmacology Research & Perspectives · doi:10.1002/prp2.1124 · Cited by 15
Lee, E. S., Kim, H. J., Lee, D., Kang, J. Y., Shin, D. M., & Hong, J. H. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01401-8 · Cited by 15
High-resolution imaging of bone and joint architecture in rheumatoid arthritis
Paccou, J., Edwards, M., Moss, C. L., Dennison, E. M., & Cooper, C. C. (2014) · British Medical Bulletin · doi:10.1093/bmb/ldu033 · Cited by 15
Kang, E., Kim, H., Choi, J. H., Noh, J., Kim, J., Lee, I., Choi, Y., Choi, D., An, J., Oh, W. K., et al. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4417 · Cited by 15
Turajane, K., Ji, G., Chinenov, Y. V., Chao, M., Ayturk, U. M., Suhardi, V. J., Greenblatt, M. B., Ivashkiv, L. B., Bostrom, M. P., & Yang, X. (2021) · JBMR Plus · doi:10.1002/jbm4.10535 · Cited by 19
HOTAIR and THRIL Long Non Coding RNAs and Their Target Genes in Rheumatoid Arthritis patients
Medhat, E., Ayeldeen, G. M., Ahmed, H. H., Shaker, O. G., Gheita, T. A., & Ashour, S. S. (2022) · Reports of Biochemistry and Molecular Biology · doi:10.52547/rbmb.10.4.697 · Cited by 15
Kasher, M., Williams, F. M. K., Freidin, M. B., Cherny, S. S., Malkin, I., CHARGE Inflammation Working Group, & Livshits, G. (2022) · Pain · doi:10.1097/j.pain.0000000000002728 · Cited by 15
Min, H. K., Kim, S. H., Won, J., Kim, K., Lee, J., Lee, S., & Kim, H. (2023) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.14627 · Cited by 15
RANK+TLR2+ myeloid subpopulation converts autoimmune to joint destruction in rheumatoid arthritis
Zhang, W., Noller, K., Crane, J. L., Wan, M., Wu, X., Cahan, P., & Cao, X. (2023) · eLife · doi:10.7554/elife.85553 · Cited by 15
Pro-inflammatory Cytokines Modulating Osteoclast Differentiation and Function
Seong, S., Kim, J. H., & Kim, N. (2016) · Journal of Rheumatic Diseases · doi:10.4078/jrd.2016.23.3.148 · Cited by 17
Zhai, T., Gao, C., Huo, R., Sheng, H., Sun, S., Xie, J., He, Y., Gao, H., Li, H., Zhang, J., et al. (2016) · Modern Rheumatology · doi:10.1080/14397595.2016.1220447 · Cited by 15
Scharmga, A. M. J., Peters, M., van den Bergh, J. P., Geusens, P., Loeffen, D. V., van Rietbergen, B., Schoonbrood, T. H. M., Vosse, D., Weijers, R. E., & van Tubergen, A. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200331 · Cited by 15
Ochi, J., Mori, N., Mori, Y., Mugikura, S., Hitachi, S., Itoi, E., & Takase, K. (2019) · Magnetic Resonance in Medical Sciences · doi:10.2463/mrms.mp.2019-0026 · Cited by 15
The role of anti-citrullinated protein antibody in pathogenesis of RA
Ma, H., Liang, X., Li, S., Li, W., & Li, T.-F. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01359-3 · Cited by 20
Li, Y., Cai, M., Qin, Y., Dai, X., Liang, L., Li, Z., Wen, X., Jin, H., Yang, C., & Chen, Z. (2025) · BMC Medicine · doi:10.1186/s12916-025-03945-y · Cited by 14
Zhou, Y., Dang, J., Chen, Y., Zheng, S. G., & Du, J. H. (2021) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2021.104719 · Cited by 14
Samet, J. D., Alizai, H., Chalian, M., Costelloe, C. M., Deshmukh, S. D., Kalia, V., Kamel, S. I., Mhuircheartaigh, J. N., Saade, J. Y., Walker, E. A., et al. (2023) · Skeletal Radiology · doi:10.1007/s00256-023-04367-8 · Cited by 14
Circulating interleukin-39 as a potential biomarker for rheumatoid arthritis diagnosis
Ying, L., Gong, L., Meng, S., Wu, X., Li, M., & Li, Y. (2023) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2023.110616 · Cited by 14
Kim, H., Choi, I. A., Umemoto, A., Bae, S., Kaneko, K., Mizuno, M., Γιαννοπούλου, Ε., Pannellini, T., Deng, L., & Park‐Min, K. (2024) · Bone Research · doi:10.1038/s41413-024-00354-4 · Cited by 15
Li, M., Deng, T., Chen, Q., Jiang, S., Li, H., Li, J., You, S., Xie, H., & Shen, B. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.01.011 · Cited by 14
Peters, M., Scharmga, A. M. J., van Tubergen, A. M., Arts, J. J. C., Loeffen, D. V., Weijers, R. E., van Rietbergen, B., Geusens, P., & van den Bergh, J. P. (2017) · Calcified Tissue International · doi:10.1007/s00223-017-0264-5 · Cited by 14
Peters, M., Scharmga, A. M. J., de Jong, J. J. A., van Tubergen, A. M., Geusens, P., Arts, J. J. C., Loeffen, D. V., Weijers, R. E., van Rietbergen, B., & van den Bergh, J. P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175829 · Cited by 14
Renner, N., Krönke, G., Rech, J., Uder, M., Janka, R., Lauer, L., Paul, D., Herz, B., Schlechtweg, P. M., Hennig, F. F., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38862 · Cited by 14
Self-citationInhibition of GSK-3β Alleviates Collagen II-Induced Rheumatoid Arthritis in Rats
Zhou, H., Liu, J., Zeng, J., Hu, B., Fang, X., & Li, L. (2016) · Medical Science Monitor · doi:10.12659/msm.897739 · Cited by 14
The role of imaging in early diagnosis and prevention of joint damage in inflammatory arthritis
Yue, J., Wu, D., & Tam, L. (2018) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2018.1476849 · Cited by 14
Nishimi, S., Isozaki, T., Wakabayashi, K., Takeuchi, H. T., & Kasama, T. (2019) · Cells · doi:10.3390/cells8010032 · Cited by 14
Surgically treated reactive arthritis of the ankle after COVID-19 infection: A case report
Shimoyama, K., Teramoto, A., Murahashi, Y., Takahashi, K., Watanabe, K., Iba, K., & Yamashita, T. (2022) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2021.12.028 · Cited by 14
Diabetes-Modifying Antirheumatic Drugs: The Roles of DMARDs as Glucose-Lowering Agents
Infante, M., Padilla, N., Alejandro, R., Caprio, M., Della‐Morte, D., Fabbri, A., & Ricordi, C. (2022) · Medicina · doi:10.3390/medicina58050571 · Cited by 17
OsteoRheumatology: a new discipline?
Favero, M., Giusti, A., Geusens, P., Goldring, S. R., Lems, W. F., Schett, G. A., & Bianchi, G. (2015) · RMD Open · doi:10.1136/rmdopen-2015-000083 · Cited by 15
Self-citationShiraishi, K., Chiba, K., Watanabe, K., Oki, N., Iwamoto, N., Amano, S., Yonekura, A., Tomita, M., Uetani, M., Kawakami, A., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0265833 · Cited by 13
B cells from old mice induce the generation of inflammatory T cells through metabolic pathways
Li, K., Romero, M., Cañardo, M., Garcia, D., Diaz, A., Blomberg, B. B., & Frasca, D. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111742 · Cited by 12
Yoshida, S., Ikedo, A., Yanagihara, Y., Sakaue, T., Saeki, N., & Imai, Y. (2024) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjae015 · Cited by 13
Ahmad, H. A., Alemao, E., Guo, Z., Iannaccone, C. K., Frits, M. L., Weinblatt, M. E., & Shadick, N. A. (2018) · Advances in Therapy · doi:10.1007/s12325-017-0657-x · Cited by 13
Peters, M., de Jong, J. J. A., Scharmga, A. M. J., van Tubergen, A. M., Geusens, P., Loeffen, D. V., Weijers, R. E., Boyd, S. K., Barnabe, C. C. M., Stok, K. S., et al. (2018) · BMC Medical Imaging · doi:10.1186/s12880-018-0255-7 · Cited by 13
ElAtta, A. S. A., Ali, Y. B. M., Bassyouni, I. H., & Talaat, R. M. (2019) · Reumatologia/Rheumatology · doi:10.5114/reum.2019.84811 · Cited by 13
Agemura, T., Hasegawa, T., Yari, S., Kikuta, J., & Ishii, M. (2021) · Immunological Medicine · doi:10.1080/25785826.2021.1944547 · Cited by 14
Advances in nanoenabled 3D matrices for cartilage repair
Pereira, C. L., Lamghari, M., & Sarmento, B. F. C. C. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.07.033 · Cited by 13
Wu, T., Li, F., Sha, X., Li, F., Zhang, B., Ma, W., Liu, M., Yang, W., Li, H., & Tao, H. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.09.022 · Cited by 13
Shimizu, T., Cruz, A. I. D. L., Tanaka, M. S., Mamoto, K., Pedoia, V., Burghardt, A. J., Heilmeier, U., Link, T. M., Graf, J. D., Imboden, J. B., et al. (2019) · The Journal of Rheumatology · doi:10.3899/jrheum.180496 · Cited by 13
Kim, J., Kim, H., & Kim, C. (2019) · Physical Activity and Nutrition · doi:10.20463/jenb.2019.0003 · Cited by 13
Lee, A., Choi, S., Moon, K., Park, J. W., Kim, K., Yoon, S., & Youn, I. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b00084 · Cited by 13
Zheng, W., Gu, X., Hu, D., & Hao, Y. (2019) · Europe PMC (PubMed Central) · Cited by 13
Sánchez‐Maldonado, J. M., Cáliz, R., Canet, L., ter Horst, R., Bakker, O. B., den Broeder, A. A., Martínez‐Bueno, M., Canhão, H. M., Rodríguez-Ramos, A., Lupiañez, C. B., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-51255-0 · Cited by 13
Revolutionizing rheumatoid arthritis therapy: the potential of lipid nanocarriers
Alarcón, J. F., Karusan, N. R., Presciutti, C., Miras, J., Magaña, J. R., Guerra‐Rebollo, M., Borrós, S., Ahmad, N., & Fornaguera, C. (2025) · RSC Advances · doi:10.1039/d5ra04258e · Cited by 12
Kim, Y., Hayashi, M., Ono, T., Yoda, T., Takayanagi, H., & Nakashima, T. (2018) · Modern Rheumatology · doi:10.1080/14397595.2018.1553266 · Cited by 12
Hayer, S., Zeilinger, M., Weiss, V., Dumanic, M., Seibt, M., Niederreiter, B., Shvets, T., Pichler, F., Wadsak, W., Podesser, B. K., et al. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3748 · Cited by 12
lncRNA-mediated synovitis in rheumatoid arthritis: A perspective for biomarker development
Ravaei, A., Zimmer‐Bensch, G., Govoni, M., & Rubini, M. (2022) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2022.09.007 · Cited by 12
The regulation and functions of the matricellular CCN proteins induced by shear stress
Wang, Y.-K., Weng, H.-K., & Mo, F. (2023) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-023-00760-z · Cited by 12
Henning, P., Kassem, A., Westerlund, A., Lundberg, P., Engdahl, C., Lionikaite, V., Wikström, P., Wu, J., Li, L., Lindholm, C., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1383113 · Cited by 12
Therkildsen, J., Klose‐Jensen, R., Hänel, M., Langdahl, B. L., Thygesen, J., Thomsen, J. S., Manske, S. L., Keller, K. K., & Hauge, E. (2024) · Lara D. Veeken · doi:10.1093/rheumatology/keae281 · Cited by 12
Clinical application of biological agents in rheumatoid arthritis
Cheng, L., & Rong, X. (2025) · Transplant Immunology · doi:10.1016/j.trim.2025.102187 · Cited by 12
Tanaka, Y., Yamamoto, K., Takeuchi, T., Yamanaka, H., Ishiguro, N., Eguchi, K., Watanabe, A., Origasa, H., Shoji, T., Miyasaka, N., et al. (2013) · Modern Rheumatology · doi:10.3109/14397595.2013.865822 · Cited by 12
Scharmga, A. M. J., Geusens, P., Peters, M., van den Bergh, J. P., Loeffen, D. V., Schoonbrood, T. H. M., van Rietbergen, B., Vosse, D., Weijers, R. E., & van Tubergen, A. M. (2018) · Scandinavian Journal of Rheumatology · doi:10.1080/03009742.2018.1424234 · Cited by 12
Nakane-Koyachi, S., Imamura, K., Hisanaga, R., Ishihara, K., & Saitô, A. (2021) · Journal of Periodontal Research · doi:10.1111/jre.12909 · Cited by 12
Feng, S., Chen, T., Li, H., Cao, J., Liu, D., Rao, S., Liu, J., Zhang, Y., Wang, Z., Li, Y., et al. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111373 · Cited by 12
Luukkonen, J., Huhtakangas, J. A., Palosaari, S., Tuukkanen, J., Vuolteenaho, O. J., & Lehenkari, P. P. (2022) · Mediators of Inflammation · doi:10.1155/2022/2606916 · Cited by 12
Long noncoding RNA H19 synergizes with STAT1 to regulate SNX10 in rheumatoid arthritis
Sun, Y., Guo, Y., Chang, L., & Zhang, J. (2022) · Molecular Immunology · doi:10.1016/j.molimm.2022.11.018 · Cited by 11
Li, Y., Guan, H., Tian, R., Kong, N., Liu, G., Li, Z., Wang, K., & Yang, P. (2022) · The FASEB Journal · doi:10.1096/fj.202200572rrr · Cited by 12
Liu, F.-F., Chen, F., Yang, L., Qiu, F., Zhong, G.-Z., Gao, S., Xi, W., Lai, M., He, Q., Chen, Y., et al. (2023) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-23-254 · Cited by 12
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Kato, K., Yasojima, N., Tamura, K., Ichikawa, S., Sutherland, K. L., Kato, M., Fukae, J., Tanimura, K., Tanaka, Y., Okino, T., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-44747-6 · Cited by 12
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Arulmozhi, S., Matchado, M. S., Snijesh, V. P., Kumar, A., & Singh, S. (2018) · Informatics in Medicine Unlocked · doi:10.1016/j.imu.2018.11.001 · Cited by 11
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Gad, H. A., Abbas, H., Sayed, N. S. E., Khattab, M. A., Hassab, M. A. E., & Mansour, M. (2023) · Journal of Liposome Research · doi:10.1080/08982104.2023.2273390 · Cited by 11
Ke, L., He, Q., Jing, Q. U., Wang, X., Li, K., Gong, X., Li, L., Yu, Q., Yu, H., Yu, H., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.09.031 · Cited by 11
Mun, S. H., Bae, S., Zeng, S. L., Oh, B., Chai, C. W. E., Kim, M., Kim, H., Kalliolias, G. D., Dahia, C. L., Oh, Y., et al. (2021) · Bone Research · doi:10.1038/s41413-021-00162-0 · Cited by 11
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Svensson, M. N. D., Erlandsson, M. C., Jonsson, I., Andersson, K., & Bokarewa, M. I. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3hi1114-572rr · Cited by 11
Cordtz, R., Hawley, S. J., Prieto‐Alhambra, D., Højgaard, P., Zobbe, K., Kristensen, L. E., Overgaard, S., Odgaard, A., Soussi, B. G., & Dreyer, L. (2019) · Arthritis Care & Research · doi:10.1002/acr.23835 · Cited by 11
Chen, W., Xie, Z., Tang, P., Wang, Y., Jie, Z., Qin, A., Jiang, X., Hu, Z., & Fan, S. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1914-5 · Cited by 11
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Metadata
- Authors
- Schett, G., & Gravallese, E.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Schett, Georg
- Venue
- Nature Reviews Rheumatology
- Published
- 2012-09-25
- Volume
- 8
- Issue
- 11
- Pages
- 656-664
- ISSN
- 1759-4790 (ISSN-L)
- 1759-4804
- PMC
- PMC4096779
- OpenAlex
- W2032362610
- Cited by
- 947
- References
- 124
- Citations by year
- 2026: 72 · 2025: 72 · 2024: 89 · 2023: 75 · 2022: 82 · 2021: 89 · 2020: 80 · 2019: 75 · 2018: 73 · 2017: 74 · 2016: 53 · 2015: 52 · 2014: 35 · 2013: 26
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- American College of Rheumatology Research and Education Foundation
- Rheumatology Research Foundation
- European Commission
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- National Institutes of Health (5r01ar055952-05)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR055952)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Keywords
- bone erosion, rheumatoid arthritis, bone resorption, osteoclasts, synovitis, inflammatory cytokines, RANKL, anti-citrullinated protein antibodies, bone formation, bone regeneration, radiographic erosions, antirheumatic therapy
- MeSH terms
- Animals, Arthritis, Rheumatoid, Bone Resorption, Cell Differentiation, Humans, Osteoclasts, Cytokines
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