Cited by 947Rheumatoid Arthritis Research and TherapiesBone Metabolism and DiseasesOsteoarthritis Treatment and Mechanisms

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Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

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Schett, Georg, Gravallese, Ellen·2012·Nature Reviews Rheumatology

DOI 10.1038/nrrheum.2012.153PMC PMC4096779

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Abstract

Bone erosion is a central feature of rheumatoid arthritis and is associated with disease severity and poor functional outcome. Erosion of periarticular cortical bone, the typical feature observed on plain radiographs in patients with rheumatoid arthritis, results from excessive local bone resorption and inadequate bone formation. The main triggers of articular bone erosion are synovitis, including the production of proinflammatory cytokines and receptor activator of nuclear factor κB ligand (RANKL), as well as antibodies directed against citrullinated proteins. Indeed, both cytokines and autoantibodies stimulate the differentiation of bone-resorbing osteoclasts, thereby stimulating local bone resorption. Although current antirheumatic therapy inhibits both bone erosion and inflammation, repair of existing bone lesions, albeit physiologically feasible, occurs rarely. Lack of repair is due, at least in part, to active suppression of bone formation by proinflammatory cytokines. This Review summarizes the substantial progress that has been made in understanding the pathophysiology of bone erosions and discusses the improvements in the diagnosis, monitoring and treatment of such lesions.

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Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670
The Pathogenesis of Rheumatoid Arthritis
McInnes, I. B., & Schett, G. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1004965 · Cited by 5,514
Self-citation
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439
2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative
Aletaha, D., Neogi, T., Silman, A. J., Funovits, J., Felson, D. T., Bingham, C. O., Birnbaum, N. S., Burmester, G. R., Bykerk, V. P., Cohen, M. D., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.138461 · Cited by 4,959
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,224
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
Cytokines in the pathogenesis of rheumatoid arthritis
McInnes, I. B., & Schett, G. A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2094 · Cited by 2,575
Self-citation
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
Takayanagi, H. (2007) · Nature Reviews Immunology · doi:10.1038/nri2062 · Cited by 1,878
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.
Kong, Y.-Y., Feige, U., Sarosi, I., Bolon, B., Tafuri, A., Morony, S., Capparelli, C., Li, J., Elliott, R., McCabe, S., et al. (1999) · Nature · doi:10.1038/46303 · Cited by 1,856
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789
Genetic regulation of osteoclast development and function
Teitelbaum, S. L., & Ross, F. P. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1122 · Cited by 1,720
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
Kotake, S., Udagawa, N., Takahashi, N., Matsuzaki, K., Itoh, K., Ishiyama, S., Saito, S., Inoue, K., Kamatani, N., Gillespie, M. T., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5703 · Cited by 1,709
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
Sato, K., Suematsu, A., Okamoto, K., Yamaguchi, A., Morishita, Y., Kadono, Y., Tanaka, S., Kodama, T., Akira, S., Iwakura, Y., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061775 · Cited by 1,554
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2593 · Cited by 1,526
TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand
Lam, J., Takeshita, S., Barker, J. E., Kanagawa, O., Ross, F. P., & Teitelbaum, S. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci11176 · Cited by 1,440
Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial
Grigor, C., Capell, H. A., Stirling, A., McMahon, A. D., Lock, P. W., VALLANCE, R., Porter, D. R., & Kincaid, W. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16676-2 · Cited by 1,436
Interleukin-17 and Type 17 Helper T Cells
Miossec, P., Korn, T., & Kuchroo, V. K. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0707449 · Cited by 1,409
Dickkopf-1 is a master regulator of joint remodeling
Diarra, D., Stolina, M., Polzer, K., Zwerina, J., Ominsky, M. S., Dwyer, D., Korb, A., Smolen, J. S., Hoffmann, M. H., Scheinecker, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1538 · Cited by 1,308
Self-citation
IL-6 is produced by osteoblasts and induces bone resorption.
Ishimi, Y., Miyaura, C., Jin, C., Akatsu, T., Abe, E., Nakamura, Y. K., Yamaguchi, A., Yoshiki, S., Matsuda, T., Hirano, T., et al. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.10.3297 · Cited by 1,128
IL-17 Stimulates the Production and Expression of Proinflammatory Cytokines, IL-β and TNF-α, by Human Macrophages
Jovanović, D., Battista, J. A. D., Martel‐Pelletier, J., Jolicoeur, F. C., He, Y., Zhang, M., Mineau, F., & Pelletier, J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.7.3513 · Cited by 1,062
TRANCE Is a Novel Ligand of the Tumor Necrosis Factor Receptor Family That Activates c-Jun N-terminal Kinase in T Cells
Wong, B. R., Rho, J., Arron, J. R., Robinson, E. A., Orlinick, J. R., Chao, M. V., Kalachikov, S. M., Cayani, E., Bartlett, F. S., Frankel, W. N., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.25190 · Cited by 1,042
Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis
Fleischmann, R., Kremer, J. M., Cush, J. J., Schulze‐Koops, H., Connell, C. A., Bradley, J. D., Gruben, D. C., Wallenstein, G. V., Zwillich, S. H., & Kanik, K. S. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1109071 · Cited by 1,028
A Cross-Sectional Study
Drozdzowska, B., Pluskiewicz, W., Halaba, Z. P., Misiołek, H., & Beck, B. R. (2005) · Cited by 984
IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages.
Jovanović, D., Battista, J. A. D., Pelletier, J., Jolicoeur, F. C., He, Y., Zhang, M., Mineau, F., & Martel‐Pelletier, J. (1998) · PubMed · Cited by 973
Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
Poole, K. E. S., Van Bezooijen, R. L., Loveridge, N., Hamersma, H., Papapoulos, S. E., Löwik, C. W., & Reeve, J. (2005) · The FASEB Journal · doi:10.1096/fj.05-4221fje · Cited by 965
Tofacitinib or Adalimumab versus Placebo in Rheumatoid Arthritis
van Vollenhoven, R., Fleischmann, R., Cohen, S. B., Lee, E. B., Meijide, J. A. G., Wagner, S., Forejtová, Š., Zwillich, S. H., Gruben, D. C., Koncz, T., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1112072 · Cited by 947
Bone versus immune system
Arron, J. R., & Choi, Y. (2000) · Nature · doi:10.1038/35046196 · Cited by 828
TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis.
Pettit, A. R., Ji, H., von Stechow, D., Müller, R., Goldring, S. R., Choi, Y., Benoist, C., & Gravallese, E. M. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63016-7 · Cited by 807
Self-citation
An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis
Brown, A. K., Conaghan, P. G., Karim, Z., Quinn, M. A., Ikeda, K., PETERFY, C. G., Hensor, E. M. A., Wakefield, R. J., O’Connor, P., & Emery, P. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23945 · Cited by 779
SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor
Semënov, M., Tamai, K., & He, X. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504308200 · Cited by 771
Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin
Steffen, U., Georgess, D., Bang, H., Bözec, A., Axmann, R., Ossipova, E., Jakobsson, P., Baum, W., Nimmerjahn, F., Szarka, E., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60975 · Cited by 764
Self-citation
Interleukin‐6 deficient mice are protected from bone loss caused by estrogen depletion.
Poli, V., Balena, R. F., Fattori, E., Markatos, A., Yamamoto, M., Tanaka, H., Ciliberto, G., Rodan, G. A., & Costantini, F. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06368.x · Cited by 745
How to diagnose rheumatoid arthritis early: A prediction model for persistent (erosive) arthritis
VISSER, H. K. A., le Cessie, S., Vos, K., Breedveld, F. C., & Hazes, J. M. W. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10117 · Cited by 730
Genetic Control of Bone Formation
Karsenty, G., Kronenberg, H. M., & Settembre, C. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113308 · Cited by 667
Mechanisms of TNF-α– and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis
Ritchlin, C. T., Haas-Smith, S. A., Li, P., Hicks, D. G., & Schwarz, E. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16069 · Cited by 613
Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage
Shi, J., Knevel, R., Suwannalai, P., van der Linden, M. P. M., Janssen, G. M. C., van Veelen, P. A., Levarht, N. E. W., Mil, A. H. M. V. D. H., Cerami, A., Huizinga, T. W. J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114465108 · Cited by 595
Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve‐month, multicenter, randomized, double‐blind, placebo‐controlled, phase II clinical trial
Cohen, S. B., Dore, R. K., Lane, N. E., Ory, P. A., PETERFY, C. G., Sharp, J. T., van der Heijde, D. M. F. M., Zhou, L., Tsuji, W. H., Newmark, R., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23417 · Cited by 579
Osteoclasts are essential for TNF-α–mediated joint destruction
Redlich, K., Hayer, S., Ricci, R., David, J., Tohidast-Akrad, M., Kollias, G. A., Steiner, G. E., Smolen, J. S., Wagner, E. F., & Schett, G. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15582 · Cited by 534
Self-citation
Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis.
Gravallese, E. M., Harada, Y., Wang, J. T., Gorn, A. H., Thornhill, T. S., & Goldring, S. R. (1998) · Europe PMC (PubMed Central) · Cited by 509
Self-citation
Mechanisms of TNF-α– and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis
Ritchlin, C. T., Haas-Smith, S. A., Li, P., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200316069 · Cited by 506
Methods of scoring the progression of radiologic changes in rheumatoid arthritis. Correlation of radiologic, clinical and laboratory abnormalities
Sharp, J. T., Lidsky, M. D., Collins, L. C., & Moreland, J. (1971) · Arthritis & Rheumatism · doi:10.1002/art.1780140605 · Cited by 500
Osteoclasts are essential for TNF-α-mediated joint destruction.
Redlich, K., Hayer, S., Ricci, R., David, J.-P., Tohidast-Akrad, M., Kollias, G., Steiner, G., Smolen, J. S., Wagner, E. F., & Schett, G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215582 · Cited by 474
Self-citation
The links between joint damage and disability in rheumatoid arthritis
Scott, D. L., Pugner, K., Kaarela, K., Doyle, D., Woolf, A. D., Holmes, J., & Hieke, K. (2000) · Lara D. Veeken · doi:10.1093/rheumatology/39.2.122 · Cited by 472
The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase
Mócsai, A., Humphrey, M. B., Ziffle, J. V., Hu, Y., Burghardt, A. J., Spusta, S. C., Majumdar, S., Lanier, L. L., Lowell, C. A., & Nakamura, M. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401602101 · Cited by 467
Anticitrullinated protein/peptide antibody assays in early rheumatoid arthritis for predicting five year radiographic damage
Meyer, O., Labarre, C., Dougados, M., Goupille, P., Cantagrel, A. G., Dubois, A., Nicaise‐Roland, P., Sibilia, J., & Combe, B. G. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.62.2.120 · Cited by 452
Bone edema scored on magnetic resonance imaging scans of the dominant carpus at presentation predicts radiographic joint damage of the hands and feet six years later in patients with rheumatoid arthritis
McQueen, F. M., Benton, N., Perry, D. H., Crabbe, J., Robinson, E. T., Yeoman, S., McLean, L., & Stewart, N. R. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11162 · Cited by 423
Treg cells suppress osteoclast formation: A new link between the immune system and bone
Zaiss, M. M., Axmann, R., Zwerina, J., Polzer, K., Gückel, E., Skapenko, A., Schulze‐Koops, H., Horwood, N., Cope, A. P., & Schett, G. A. (2007) · Arthritis & Rheumatism · doi:10.1002/art.23138 · Cited by 402
Self-citation
Anti-CCP antibody test predicts the disease course during 3 years in early rheumatoid arthritis (the Swedish TIRA project)
Kastbom, A., Strandberg, G., Lindroos, A., & Skogh, T. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.016808 · Cited by 399
An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis
Weinblatt, M. E., Kavanaugh, A., Genovese, M. C., Musser, T. K., Grossbard, E. B., & Magilavy, D. B. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1000500 · Cited by 386
Progression of radiologic damage in patients with rheumatoid arthritis in clinical remission
Molenaar, E. T. H., Voskuyl, A. E., Dinant, H. J., Bezemer, P. D., Boers, M., & Dijkmans, B. A. C. (2004) · Arthritis & Rheumatism · doi:10.1002/art.11481 · Cited by 384
Osteoprotegerin Reduces Osteoclast Numbers and Prevents Bone Erosion in Collagen-Induced Arthritis
Romas, E., Sims, N. A., Hards, D. K., Lindsay, M., Quinn, J. W. M., Ryan, P. F. J., Dunstan, C. R., Martin, T. J., & Gillespie, M. T. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64417-3 · Cited by 368
Effects of Interleukin-1 on Bone Turnover in Normal Mice*
Boyce, B. F., Aufdemorte, T. B., Garrett, I. R., Yates, A. J. P., & Mundy, G. R. (1989) · Endocrinology · doi:10.1210/endo-125-3-1142 · Cited by 363
Joint Erosions and Patients with Early Rheumatoid Arthritis
van der Heijde, D. M. F. M. (1995) · Lara D. Veeken · doi:10.1093/rheumatology/xxxiv.suppl_2.74 · Cited by 323
TNF-induced structural joint damage is mediated by IL-1
Zwerina, J., Redlich, K., Polzer, K., Joosten, L., Krönke, G., Distler, J., Hess, A., Pundt, N., Pap, T., Hoffmann, O., et al. (2007) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0610812104 · Cited by 322
Self-citation
Low-Dose Prednisone Inclusion in a Methotrexate-Based, Tight Control Strategy for Early Rheumatoid Arthritis
Bakker, M. F., Jacobs, J. W. G., Welsing, P. M. J., Verstappen, S. M. M., Tekstra, J., Ton, E., Geurts, M. A. W., van der Werf, J. H., van Albada-Kuipers, G. A., Veen, Z. N. J.-D., et al. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-156-5-201203060-00004 · Cited by 322
Very recent onset rheumatoid arthritis: clinical and serological patient characteristics associated with radiographic progression over the first years of disease
Machold, K. P., Stamm, T., Nell, V. P. K., Pflugbeil, S., Aletaha, D., Steiner, G. E., Uffmann, M., & Smolen, J. S. (2006) · Lara D. Veeken · doi:10.1093/rheumatology/kel237 · Cited by 301
Magnetic resonance imaging findings in 84 patients with early rheumatoid arthritis: bone marrow oedema predicts erosive progression
Haavardsholm, E. A., BÃ¸yesen, P., Ã˜stergaard, M., Schildvold, A., & Kvien, T. K. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.071977 · Cited by 293
Tumor necrosis factor α-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin.
Redlich, K., Hayer, S., Maier, A., Dunstan, C. R., Tohidast‐Akrad, M., Lang, S., Türk, B., Pietschmann, P., Woloszczuk, W., Haralambous, S., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10097 · Cited by 285
Self-citation
Chondroclasts and osteoclasts at subchondral sites of erosion in the rheumatoid joint
Bromley, M., & Woolley, D. E. (1984) · Arthritis & Rheumatism · doi:10.1002/art.1780270902 · Cited by 285
Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo
Axmann, R., Böhm, C., Krönke, G., Zwerina, J., Smolen, J., & Schett, G. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24781 · Cited by 263
Self-citation
Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis.
Firestein, G. S., Xu, W. D., Townsend, K., Broide, D. H., Alvaro-Gracia, J., Glasebrook, A. L., & Zvaifler, N. J. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.168.5.1573 · Cited by 247
Evaluation of bone mineral density, bone metabolism, osteoprotegerin and receptor activator of the NFκB ligand serum levels during treatment with infliximab in patients with rheumatoid arthritis.
Vis, M., Havaardsholm, E. A., Haugeberg, G., Uhlig, T., Voskuyl, A. E., van de Stadt, R. J., Dijkmans, B. A. C., Woolf, A. D., Kvien, T. K., & Lems, W. F. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.044198 · Cited by 246
Osteoblast Function Is Compromised at Sites of Focal Bone Erosion in Inflammatory Arthritis
Walsh, N. C., Reinwald, S., Manning, C. A., Condon, K. W., Iwata, K., Burr, D. B., & Gravallese, E. M. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090320 · Cited by 236
Self-citation
Therapeutic targeting of Janus kinases
Pesu, M., Laurence, A. D. J., Kishore, N. N., Zwillich, S. H., Chan, G. L., & O’Shea, J. J. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00644.x · Cited by 232
RANK Signaling Is Not Required for TNFα-Mediated Increase in CD11bhi Osteoclast Precursors but Is Essential for Mature Osteoclast Formation in TNFα-Mediated Inflammatory Arthritis
Li, P., Schwarz, E. M., O'Keefe, R. J., Ma, L., Boyce, B. F., & Xing, L. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.0301233 · Cited by 220
Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis
Zaiss, M. M., Frey, B., Heß, A., Zwerina, J., Luther, J., Nimmerjahn, F., Engelke, K., Kollias, G. A., Hünig, T., Schett, G. A., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903841 · Cited by 214
Self-citation
Different stages of rheumatoid arthritis: features of the synovium in the preclinical phase
van de Sande, M. G. H., de Hair, M. J. H., van der Leij, C., Klarenbeek, P. L., Bos, W. H., Smith, M., Maas, M. M., de Vries, N., van Schaardenburg, D., Dijkmans, B. A. C., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.139527 · Cited by 212
Predictors of radiographic joint damage in patients with early rheumatoid arthritis
Jansen, L. M. A., van der Horst-Bruinsma, I. E., van Schaardenburg, D., Bezemer, P. D., & Dijkmans, B. A. C. (2001) · Annals of the Rheumatic Diseases · doi:10.1136/ard.60.10.924 · Cited by 205
CTLA-4 directly inhibits osteoclast formation
Axmann, R., Herman, S., Zaiss, M. M., Franz, S., Polzer, K., Zwerina, J., i, M. H., Smolen, J. S., & Schett, G. A. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.080713 · Cited by 201
Self-citation
Periarticular bone structure in rheumatoid arthritis patients and healthy individuals assessed by high‐resolution computed tomography
Stach, C. M., Bäuerle, M., Englbrecht, M., Krönke, G., Engelke, K., Manger, B., & Schett, G. A. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27252 · Cited by 188
Self-citation
Magnetic resonance imaging of wrist and finger joints in healthy subjects occasionally shows changes resembling erosions and synovitis as seen in rheumatoid arthritis
Ejbjerg, B., Narvestad, E., Rostrup, E., Szkudlarek, M., Jacobsen, S., Thomsen, H. S., & Østergaard, M. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20135 · Cited by 177
Changes in hand and generalised bone mineral density in patients with recent-onset rheumatoid arthritis
Güler-Yüksel, M., Allaart, C. F., Goekoop-Ruiterman, Y. P. M., Vries-Bouwstra, J. K. D., van Groenendael, J. H. L. M., Mallee, C., de Bois, M. H. W., Breedveld, F. C., Dijkmans, B. A. C., & Lems, W. F. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.086348 · Cited by 164
Inhibition of RANK Expression and Osteoclastogenesis by TLRs and IFN-γ in Human Osteoclast Precursors
Ji, J.-D., Park‐Min, K., Shen, Z., Fajardo, R. J., Goldring, S. R., McHugh, K. P., & Ivashkiv, L. B. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900072 · Cited by 162
No overall progression and occasional repair of erosions despite persistent inflammation in adalimumab-treated rheumatoid arthritis patients: results from a longitudinal comparative MRI, ultrasonography, CT and radiography study
Døhn, U. M., Ejbjerg, B., Boonen, A. E. R. C. H., Hetland, M. L., Hansen, M. S., Knudsen, L. S., Hansen, A., Madsen, O. R., Hasselquist, M., Møller, J. M., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.123729 · Cited by 160
Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway
Matzelle, M. M., Gallant, M. A., Condon, K. W., Walsh, N. C., Manning, C. A., Stein, G. S., Lian, J. B., Burr, D. B., & Gravallese, E. M. (2011) · Arthritis & Rheumatism · doi:10.1002/art.33504 · Cited by 154
Self-citation
Osteoimmunology and osteoporosis
Geusens, P., & Lems, W. F. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3375 · Cited by 150
Association of early radiographic damage with impaired physical function in rheumatoid arthritis: A ten‐year, longitudinal observational study in 238 patients
Ødegård, S., Landewé, R., van der Heijde, D. M. F. M., Kvien, T. K., Mowinckel, P., & Uhlig, T. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21548 · Cited by 150
Inflammation is preceded by tumor necrosis factor‐dependent infiltration of mesenchymal cells in experimental arthritis
Marinova-Mutafchieva, L., Williams, R. O., Funa, N. S., Maini, R. N., & Zvaifler, N. J. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10126 · Cited by 139
Blood‐induced joint damage: A canine in vivo study
Roosendaal, G., TeKoppele, J. M., Vianen, M. E., van den Berg, H. M., Lafeber, F. P. J. G., & Bijlsma, J. W. J. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199905)42:5 · Cited by 137
The multiple faces of autoimmune-mediated bone loss
Schett, G. A., & David, J. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.190 · Cited by 135
Self-citation
A Novel Role of IL-15 in the Development of Osteoclasts: Inability to Replace Its Activity with IL-2
Ogata, Y., Kukita, A., Kukita, T., Komine, M., Miyahara, A., Miyazaki, S., & Kohashi, O. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.5.2754 · Cited by 134
Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritis.
Redlich, K., Görtz, B., Hayer, S., Zwerina, J., Doerr, N., Kostenuik, P., Bergmeister, H., Kollias, G., Steiner, G., Smolen, J. S., et al. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63144-6 · Cited by 134
Self-citation
A comparative study of periarticular bone lesions in rheumatoid arthritis and psoriatic arthritis
Finzel, S., Englbrecht, M., Engelke, K., Stach, C. M., & Schett, G. A. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.132423 · Cited by 134
Self-citation
The Pattern of Bone Erosion in the Hand and Wrist in Rheumatoid Arthritis
Martel, W., Hayes, J. T., & Duff, I. F. (1965) · Radiology · doi:10.1148/84.2.204 · Cited by 132
Repair of bone erosions in rheumatoid arthritis treated with tumour necrosis factor inhibitors is based on bone apposition at the base of the erosion
Finzel, S., Rech, J., Schmidt, S., Engelke, K., Englbrecht, M., Stach, C., & Schett, G. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.148395 · Cited by 126
Self-citation
Rheumatoid arthritis bone erosion volumes on CT and MRI: reliability and correlations with erosion scores on CT, MRI and radiography
Døhn, U. M., Ejbjerg, B., Hasselquist, M., Narvestad, E., Court‐Payen, M., Szkudlarek, M., Møller, J. M., Thomsen, H., & Østergaard, M. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.072520 · Cited by 123
Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation
Zaiss, M. M., Sarter, K., Hess, A., Engelke, K., Böhm, C., Nimmerjahn, F., Voll, R., Schett, G., & David, J. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27535 · Cited by 122
Self-citation
Radiological damage in patients with rheumatoid arthritis on sustained remission
Cohen, G., Gossec, L., Dougados, M., Cantagrel, A. G., Goupille, P., Daurès, J., Rincheval, N., & Combe, B. G. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.057497 · Cited by 121
Role of metacarpophalangeal joint anatomic factors in the distribution of synovitis and bone erosion in early rheumatoid arthritis
Tan, A. L., Tanner, S. F., Conaghan, P. G., Radjenovic, A., O’Connor, P., Brown, A. K., Emery, P., & McGonagle, D. G. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10963 · Cited by 119
Cortical hand bone loss after 1 year in early rheumatoid arthritis predicts radiographic hand joint damage at 5-year and 10-year follow-up
Hoff, M., Haugeberg, G., Ødegård, S., Syversen, S. W., Landewé, R., van der Heijde, D. M. F. M., & Kvien, T. K. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.085985 · Cited by 117
A detailed comparative study of high‐resolution ultrasound and micro–computed tomography for detection of arthritic bone erosions
Finzel, S., Ohrndorf, S., Englbrecht, M., Stach, C. M., Messerschmidt, J., Schett, G. A., & Backhaus, M. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30285 · Cited by 117
Self-citation
How antirheumatic drugs protect joints from damage in rheumatoid arthritis
Schett, G. A., Stach, C. M., Zwerina, J., Voll, R. E., & Manger, B. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23951 · Cited by 115
Self-citation
Interleukin-6 receptor blockade induces limited repair of bone erosions in rheumatoid arthritis: a micro CT study
Finzel, S., Rech, J., Schmidt, S., Engelke, K., Englbrecht, M., & Schett, G. A. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-201075 · Cited by 115
Self-citation
IL-33 Shifts the Balance from Osteoclast to Alternatively Activated Macrophage Differentiation and Protects from TNF-α–Mediated Bone Loss
Zaiss, M. M., Kurowska‐Stolarska, M., Böhm, C., Gary, R., Scholtysek, C., Stolarski, B., Reilly, J. H., Kerr, S. C., Millar, N. L., Kamradt, T., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003487 · Cited by 114
Self-citation
Induction of osteoclast‐associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis
Herman, S., Müller, R. B., Krönke, G., Zwerina, J., Redlich, K., Hueber, A. J., Gelse, H., Neumann, E., Müller‐Ladner, U., & Schett, G. A. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23943 · Cited by 102
Self-citation
Tenosynovitis and osteoclast formation as the initial preclinical changes in a murine model of inflammatory arthritis
Hayer, S., Redlich, K., Korb, A., Hermann, S., Smolen, J. S., & Schett, G. A. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22313 · Cited by 95
Self-citation
IL-23 Inhibits Osteoclastogenesis Indirectly through Lymphocytes and Is Required for the Maintenance of Bone Mass in Mice
Quinn, J. M. W., Sims, N. A., Saleh, H., Mirosa, D., Thompson, K., Bouralexis, S., Walker, E. C., Martin, T. J., & Gillespie, M. T. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.8.5720 · Cited by 94
From bone biology to clinical outcome: state of the art and future perspectives
Schett, G. A., Saag, K. G., & Bijlsma, J. W. J. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.135061 · Cited by 86
Self-citation
Erosive progression is minimal, but erosion healing rare, in patients with rheumatoid arthritis treated with adalimumab. A 1 year investigator-initiated follow-up study using high-resolution computed tomography as the primary outcome measure
Døhn, U. M., Boonen, A. E. R. C. H., Hetland, M. L., Hansen, M. S., Knudsen, L., Hansen, A. K., Madsen, O. R., Hasselquist, M., Møller, J. M., & Østergaard, M. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.097048 · Cited by 86
Hand cortical bone mass and its associations with radiographic joint damage and fractures in 50–70 year old female patients with rheumatoid arthritis: cross sectional Oslo-Truro-Amsterdam (OSTRA) collaborative study
Haugeberg, G., Lodder, M. C., Lems, W. F., Uhlig, T., Ørstavik, R. E., Dijkmans, B. A. C., Kvien, T. K., & Woolf, A. D. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.015065 · Cited by 86
Microanatomic studies to define predictive factors for the topography of periarticular erosion formation in inflammatory arthritis
McGonagle, D. G., Tan, A. L., Døhn, U. M., Østergaard, M., & Benjamin, M. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24417 · Cited by 72
The relationship between focal erosions and generalized osteoporosis in postmenopausal women with rheumatoid arthritis
Solomon, D. H., Finkelstein, J. S., Shadick, N. A., LeBoff, M. S., Winalski, C. S., Stedman, M. R., Glass, R. J., Brookhart, M. A., Weinblatt, M. E., & Gravallese, E. M. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24551 · Cited by 71
Self-citation
Increase in expression of receptor activator of nuclear factor κB at sites of bone erosion correlates with progression of inflammation in evolving collagen‐induced arthritis
Lubberts, E., Oppers‐Walgreen, B., Pettit, A. R., van den Bersselaar, L., Joosten, L. A. B., Goldring, S. R., Gravallese, E. M., & van den Berg, W. B. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10607 · Cited by 70
Self-citation
Osteoclasts—the innate immune cells of the bone
Wu, Y., Humphrey, M. B., & Nakamura, M. C. (2008) · Autoimmunity · doi:10.1080/08916930701693180 · Cited by 69
Denosumab prevents metacarpal shaft cortical bone loss in patients with erosive rheumatoid arthritis
Sharp, J. T., Tsuji, W. H., Ory, P. A., Harper-Barek, C., Wang, H., & Newmark, R. (2010) · Arthritis Care & Research · doi:10.1002/acr.20172 · Cited by 65
Repair of erosions occurs almost exclusively in damaged joints without swelling
Lukas, C., van der Heijde, D. M. F. M., Fatenajad, S., & Landewé, R. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.119156 · Cited by 65
The orally‐active and selective c‐Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen‐induced arthritis mouse model
Ohno, H., Uemura, Y., Murooka, H., Takanashi, H., Tokieda, T., Ohzeki, Y., Kubo, K., & Serizawa, I. (2007) · European Journal of Immunology · doi:10.1002/eji.200737199 · Cited by 64
Analysis of the kinetics of osteoclastogenesis in arthritic rats
Schett, G. A., Stolina, M., Bolon, B. N., Middleton, S. C., Adlam, M., Brown, H., Zhu, L., Feige, U., & Zack, D. J. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21343 · Cited by 64
Self-citation
The erosive front: a topographic study of the junction between the pannus and the subchondral plate in the macerated rheumatoid metacarpal head.
Leisen, J. C. C., Duncan, H., Riddle, J. M., & Pitchford, W. C. (1988) · PubMed · Cited by 63
Induction of immune tolerance to human type I collagen in patients with systemic sclerosis by oral administration of bovine type I collagen
McKown, K. M., Carbone, L. D., Bustillo, J., Seyer, J. M., Kang, A. H., & Postlethwaite, A. E. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200005)43:5 · Cited by 54
Anti IL‐17A therapy inhibits bone loss in TNF‐α‐mediated murine arthritis by modulation of the T‐cell balance
Zwerina, K., Koenders, M. I., Hueber, A. J., Marijnissen, R. J., Baum, W., Ruiz‐Heiland, G., Zaiss, M. M., Mclnnes, I., Joosten, L. A. B., van den Berg, W., et al. (2011) · European Journal of Immunology · doi:10.1002/eji.201141871 · Cited by 54
Self-citation
Paucity of radiographic progression in rheumatoid arthritis treated with methotrexate as the first disease modifying antirheumatic drug.
Rich, E., Moreland, L. W., & Alarcón, G. S. (1999) · PubMed · Cited by 53
Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis: a multicohort study
Knevel, R., Krabben, A., Brouwer, E., Posthumus, M. D., Wilson, A. G., Lindqvist, E., Saxne, T., de Rooy, D., Daha, N. A., van der Linden, M. P. M., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200724 · Cited by 52
Nuclear antigen histone H1 is primarily involved in lupus erythematosus cell formation
Schett, G. A., Steiner, G. E., & Smolen, J. S. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199808)41:8 · Cited by 44
Reduced trabecular bone mineral density and cortical thickness accompanied by increased outer bone circumference in metacarpal bone of rheumatoid arthritis patients: a cross-sectional study
Aeberli, D., Eser, P., Bonél, H., Widmer, J., Caliezi, G., Varisco, P.-A., Möller, B., & Villiger, P. M. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3056 · Cited by 38
Die feineren Veränderungen des Gelenkknorpels bei fungöser Synovitis und Caries der Gelenkenden
Weichselbaum, A. (1878) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf01995720 · Cited by 37
Presence of a population of CD20+,CD38? B lymphocytes with defective proliferative responsiveness in the synovial compartment of patients with rheumatoid arthritis
Reparon‐Schuijt, C. C., van Esch, W. J. E., van Kooten, C., Ezendam, N. P. M., Levarht, E. W. N., Breedveld, F. C., & Verweij, C. L. (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200109)44:9 · Cited by 34
Disease activity and severity in early inflammatory arthritis predict hand cortical bone loss
Pye, S. R., Adams, J. E., Ward, K. A., Bunn, D. K., Symmons, D. P. M., & O’Neill, T. W. (2010) · Lara D. Veeken · doi:10.1093/rheumatology/keq181 · Cited by 24
Effect of Rheumatoid Arthritis on Volumetric Bone Mineral Density and Bone Geometry, Assessed by Peripheral Quantitative Computed Tomography in Postmenopausal Women Treated with Bisphosphonates
Tournis, S., Samdanis, V., Psarelis, S., Liakou, C. G., Antoniou, J. D., Γεωργούλας, Θ., Dontas, I. A., Παπαϊωάννου, Ν., Gazi, S., & Lyritis, G. P. (2012) · The Journal of Rheumatology · doi:10.3899/jrheum.110579 · Cited by 9
OSCAR, a key co-stimulation molecule for osteoclasts, is induced in patients with rheumatoid arthritis
Herman, S., Kroenke, G., Müeller, R. B., Zerina, J., Redlich, K., & Schett, G. A. (2008) · Bone · doi:10.1016/j.bone.2008.07.090 · Cited by 7
Self-citation
Genetic variants in IL-15 associate with progression of joint destruction in rheumatoid arthritis, a multi cohort study
Knevel, R., Krabben, A., Brouwer, E., Posthumus, Wilson, A. G., Saxne, T., Lindqvist, E., de Rooy, D. P. C., Daha, N. A., van der Linden, M. P. M., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-201236.14 · Cited by 5
The effects of interferon-beta treatment of synovial inflammation and expression of metalloproteinases in patients with rheumatoid arthritis
Gravellese (2000) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200002)43:2 · Cited by 2
Self-citation
The pathogenesis and prevention of joint damage in rheumatoid arthritis: advances from synovial biopsy and tissue analysis
Neidhart (2000) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200012)43:12 · Cited by 1
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Shigeyama (2000) · doi:10.1002/1529-0131(200011)43:11

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Baker, W. M. The formation of abnormal synovial cysts in the connection with the joints. St Bartolomews Hospital Reports 21, 177–190 (1855).
Sato, K. et al. TH17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J. Exp. Med. 203, 2673–2682 (2006). · DOI · Paper page

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Smolen, J. S., Aletaha, D., Barton, A. C., Burmester, G. R., Emery, P., Firestein, G. S., Kavanaugh, A., McInnes, I. B., Solomon, D. H., Strand, V., et al. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.1 · Cited by 2,534
Pathogenetic insights from the treatment of rheumatoid arthritis
McInnes, I. B., & Schett, G. A. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31472-1 · Cited by 1,420
Self-citation
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Matteo, A. D., Bathon, J. M., & Emery, P. (2023) · The Lancet · doi:10.1016/s0140-6736(23)01525-8 · Cited by 873
Osteoclasts: New Insights
Feng, X., & Teitelbaum, S. L. (2013) · Bone Research · doi:10.4248/br201301003 · Cited by 562
Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization
Yang, Y., Guo, L., Wang, Z., Liu, P., Liu, X., Ding, J., & Zhou, W. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120390 · Cited by 503

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Authors: Schett, G., & Gravallese, E.
Affiliations: Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
University of Massachusetts Chan Medical School (US)
Corresponding author: Schett, Georg
ORCID: Schett, Georg
Gravallese, Ellen
Venue: Nature Reviews Rheumatology
Publisher: Springer Science and Business Media LLC
Published: 2012-09-25
Volume: 8
Issue: 11
Pages: 656-664
ISSN: 1759-4790 (ISSN-L)
1759-4804
DOI: 10.1038/nrrheum.2012.153
PMC: PMC4096779
OpenAlex: W2032362610
Cited by: 947
References: 124
Citations by year: 2026: 72 · 2025: 72 · 2024: 89 · 2023: 75 · 2022: 82 · 2021: 89 · 2020: 80 · 2019: 75 · 2018: 73 · 2017: 74 · 2016: 53 · 2015: 52 · 2014: 35 · 2013: 26
FWCI: 5.39
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Rheumatology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders: American College of Rheumatology Research and Education Foundation
Rheumatology Research Foundation
European Commission
Deutsche Forschungsgemeinschaft
Bundesministerium für Bildung und Forschung
National Institutes of Health (5r01ar055952-05)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR055952)
Topics: Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Keywords: bone erosion, rheumatoid arthritis, bone resorption, osteoclasts, synovitis, inflammatory cytokines, RANKL, anti-citrullinated protein antibodies, bone formation, bone regeneration, radiographic erosions, antirheumatic therapy
MeSH terms: Animals, Arthritis, Rheumatoid, Bone Resorption, Cell Differentiation, Humans, Osteoclasts, Cytokines

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Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

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