The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment
Open accessAbstract
Bone erosion is a central feature of rheumatoid arthritis and is associated with disease severity and poor functional outcome. Erosion of periarticular cortical bone, the typical feature observed on plain radiographs in patients with rheumatoid arthritis, results from excessive local bone resorption and inadequate bone formation. The main triggers of articular bone erosion are synovitis, including the production of proinflammatory cytokines and receptor activator of nuclear factor κB ligand (RANKL), as well as antibodies directed against citrullinated proteins. Indeed, both cytokines and autoantibodies stimulate the differentiation of bone-resorbing osteoclasts, thereby stimulating local bone resorption. Although current antirheumatic therapy inhibits both bone erosion and inflammation, repair of existing bone lesions, albeit physiologically feasible, occurs rarely. Lack of repair is due, at least in part, to active suppression of bone formation by proinflammatory cytokines. This Review summarizes the substantial progress that has been made in understanding the pathophysiology of bone erosions and discusses the improvements in the diagnosis, monitoring and treatment of such lesions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“TNF-α can also indirectly increase RANKL expression and affect osteoclast differentiation by activating osteoblasts, B cells, and T cells [88].”
From Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature (2024) · cites this paper as [88]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“RANKL-dependent pathways activated by pro-inflammatory cytokines can induce osteoclast formation, therefore, enhancing osteoclast activity [87, 88].”
From Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature (2024) · cites this paper as [88]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670
The Pathogenesis of Rheumatoid Arthritis
McInnes, I. B., & Schett, G. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1004965 · Cited by 5,514
Self-citationOsteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439
Aletaha, D., Neogi, T., Silman, A. J., Funovits, J., Felson, D. T., Bingham, C. O., Birnbaum, N. S., Burmester, G. R., Bykerk, V. P., Cohen, M. D., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.138461 · Cited by 4,959
Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,224
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
Cytokines in the pathogenesis of rheumatoid arthritis
McInnes, I. B., & Schett, G. A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2094 · Cited by 2,576
Self-citationOsteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
Takayanagi, H. (2007) · Nature Reviews Immunology · doi:10.1038/nri2062 · Cited by 1,878
Kong, Y.-Y., Feige, U., Sarosi, I., Bolon, B., Tafuri, A., Morony, S., Capparelli, C., Li, J., Elliott, R., McCabe, S., et al. (1999) · Nature · doi:10.1038/46303 · Cited by 1,856
Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789
Research works printed but not linked: 2
- Baker, W. M. The formation of abnormal synovial cysts in the connection with the joints. St Bartolomews Hospital Reports 21, 177–190 (1855).
- Sato, K. et al. TH17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J. Exp. Med. 203, 2673–2682 (2006). · DOI · Paper page
Cited by
Sorted by citations
Items 701–800 of 946
MicroRNAs and Immune-Related Disorders
Abdallah, H. Y., Elkaffas, R. H., & Aglan, S. A. (2024) · Epigenetics and human health · doi:10.1007/978-3-031-64788-8_8 · Cited by 2
The expression of RBPJ and its potential role in rheumatoid arthritis
Chen, S., Zhao, W., Du, J., Chen, S., Li, J., Shen, B., Zhou, Y., & Chen, S. (2024) · BMC Genomics · doi:10.1186/s12864-024-10804-2 · Cited by 2
Therkildsen, J., Klose‐Jensen, R., Hänel, M., Langdahl, B. L., Thomsen, J. S., Manske, S. L., Keller, K. K., & Hauge, E. (2024) · Joint Bone Spine · doi:10.1016/j.jbspin.2024.105812 · Cited by 2
Qin, Y., Shirakawa, J., Xu, C., Chen, R., Xu, Y., Ng, C., Nakano, S., Elguindy, M. M., Deng, Z., Prasanth, K. V., et al. (2024) · eLife · doi:10.7554/elife.98900.3 · Cited by 11
Systemische versus lokale Demineralisation bei der rheumatoiden Arthritis
Hoffmann, T., Pflug, C., Schulze, W., & Pfeil, A. (2025) · Zeitschrift für Rheumatologie · doi:10.1007/s00393-025-01624-0 · Cited by 2
Izquierdo, Y. E., Páramo, E. C., Castañeda, L. M., Gómez, S. V., & Zambrano, F. S. (2017) · Revista Colombiana de Reumatología · doi:10.1016/j.rcreu.2016.10.004 · Cited by 2
Place de l’échographie articulaire pour le diagnostic et le suivi d’une PR
Goff, B. L. (2017) · Revue du Rhumatisme Monographies · doi:10.1016/j.monrhu.2017.07.003 · Cited by 2
Izquierdo, Y. E., Calvo-Páramo, E., Castañeda-Castillo, L. M., Gómez-Correa, S. V., & Zambrano, F. S. (2017) · Revista de la Facultad de Medicina · doi:10.15446/revfacmed.v65n2.59228 · Cited by 2
Hussein, M. S., Gaber, R. A., Elsabagh, H. M., & Rageh, E. M. (2021) · Egyptian Rheumatology and Rehabilitation · doi:10.1186/s43166-021-00067-0 · Cited by 2
Simoni, P., Moussaddykine, S., Malaise, O., Mustapha, S. B., Gómez, M. P. A., & Leucio, A. D. (2021) · Cureus · doi:10.7759/cureus.15823 · Cited by 2
New Insights into Bone Loss in RA
Andreev, D., & Bözec, A. (2021) · Osteologie/Osteology · doi:10.1055/a-1577-2719 · Cited by 2
Tissot, A. C., & Brinkmann, U. (2017) · Springer eBooks · doi:10.1007/978-3-319-42252-7_5 · Cited by 2
Jabali, A. H. (2022) · The Journal of Contemporary Dental Practice · doi:10.5005/jp-journals-10024-3349 · Cited by 2
Anti-Osteoporotic Potential of Water Extract of Anethum graveolens L. Seeds
Jang, S., Lee, S.-J., Hwang, Y., & Ha, H. (2023) · Nutrients · doi:10.3390/nu15194302 · Cited by 2
Sclerostin and IL-1Ra in Rheumatoid Iraqi Patients after Biological Therapy
Abdal-Wahab, S. T., Kadhim, H. S., Alqasim, A. M. Z., & Gorial, F. I. (2016) · International Journal of Current Microbiology and Applied Sciences · doi:10.20546/ijcmas.2016.509.082 · Cited by 2
Azuaga-Piñango, A. B., & Peris, P. (2020) · Medicina Clínica · doi:10.1016/j.medcli.2019.12.005 · Cited by 2
Effect of antiresorptive and bone forming treatments in bone erosions in rheumatoid arthritis
Azuaga-Piñango, A. B., & Peris, P. (2020) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2019.12.001 · Cited by 2
-, K. F., Fang, W., Okino, T., Sutherland, K. L., Furusaki, A., Sagawa, A., & Kamishima, T. (2020) · Journal of X-Ray Science and Technology · doi:10.3233/xst-200694 · Cited by 2
Turajane, K., Ji, G., Chinenov, Y. V., Chao, M., Ayturk, U. M., Greenblatt, M. B., Ivashkiv, L. B., Bostrom, M. P., & Yang, X. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.27.424462 · Cited by 2
Inflammation aiguë, inflammation chronique : arthrite rhumatoïde (AR) et ostéoarthrite (OA)
Calvino, B. (2023) · Douleurs Évaluation - Diagnostic - Traitement · doi:10.1016/j.douler.2023.04.003 · Cited by 1
Evbuomwan, O., van Rensburg, B. J. J., Engelbrecht, G., Driver, C. H. S., Labuschagne, M. J., Sempa, J. B., & Horn-Lodewyk, J. (2023) · Nuclear Medicine and Molecular Imaging · doi:10.1007/s13139-023-00823-4 · Cited by 1
Li, Y., Wang, Y., Xu, L., Liu, C., Cui, J., Huang, Y., Li, S., Wang, Y., & Dong, B. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1375871 · Cited by 1
Zhao, H., Wang, Y., & Ren, J. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.107239 · Cited by 1
The journey of patients with musculoskeletal complaints in Europe: a cross-sectional European survey
Wagner, M., Otón, T., Muehlensiepen, F., Stratingh, K., Loza, E., Knevel, R., & Carmona, L. (2025) · Rheumatology International · doi:10.1007/s00296-025-05863-x · Cited by 1
Sharma, S., Hum, R. M., Nair, N., Marshall, L. M., Storrie, A., Bowes, J., MacGregor, A. J., Yates, M. M., Morris, A. P., Verstappen, S. M. M., et al. (2025) · Annals of the Rheumatic Diseases · doi:10.1016/j.ard.2025.04.007 · Cited by 2
Sun, Y., Xu, C., Ouyang, M., & Han, Y. (2025) · Rheumatology & autoimmunity · doi:10.1002/rai2.70020 · Cited by 1
Choi, Y. J., Kim, J., Jung, J.-Y., Suh, C., Chung, Y., & Kim, H. (2025) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2025.101631 · Cited by 1
Zhang, R., Kou, N., Liu, F., Zhou, H., & Ren, L. (2025) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-025-09206-6 · Cited by 1
Knapp, G., Langenstein, J., Bauer, N. B., Stötzel, S., Heiß, C., Jahed, V., Alzweiri, M. H., Biehl, C., & Khassawna, T. E. (2025) · Nutrients · doi:10.3390/nu17213353 · Cited by 1
Li, J., Bian, Y., Han, Y., Lan, M., Sun, W., & Wang, J. (2025) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s555600 · Cited by 1
Inflammation and Bone Remodeling in Gout: Roles of OPG, RANKL, and MMP-8
Yiğit, E., Cüre, O., Yiğit, M. H., & Atak, M. (2025) · Clinical and Experimental Health Sciences · doi:10.33808/clinexphealthsci.1716636 · Cited by 1
Lewis, K. J., Bent, J. A., Brolinson, P. G., Keter, D. L., Lumpkin, E. A., Mundo, J., Napadow, V., Reed, W. R., Russell, B. S., Tang, S. Y., et al. (2026) · Musculoskeletal Science and Practice · doi:10.1016/j.msksp.2025.103470 · Cited by 1
Subchondral bone abnormalities in the knee: imaging techniques, regional anatomy, and pathology
van Rilland, E. D. Z., Boutin, R. D., & Stevens, K. J. (2026) · Skeletal Radiology · doi:10.1007/s00256-026-05125-2 · Cited by 1
Geng, S., Guan, Y., Ye, Z., Zhao, D., Jiang, Y., Fu, J., Sheng, H., Yang, S., Liu, H., Deng, F., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1789493 · Cited by 1
Ou, Y., Wu, F., He, C., Luo, S., Guo, Z., Zhang, Y., Hu, R., Xu, Y., Tang, X., Zhao, Y., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-71194-5 · Cited by 1
The Impact of Targeted Therapies on the Bone-Vascular Axis in Psoriasis: A Narrative Review
Zeng, H., 陳佑瑞, & Yang, L. (2026) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s595065 · Cited by 1
Wang, Y., Dowling, S. D., Maciuch, J., Rodriguez, V., Mayer, M., Mian, K., Therron, T., Makinde, H. M., Cuda, C. M., Winter, D. R., et al. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag077 · Cited by 1
Luo, T.-T., He, L.-X., Yin, Q., Wang, Z.-F., & Zuo, J. (2026) · Journal of Inflammation Research · doi:10.2147/jir.s600186 · Cited by 1
Simon, A., Simon, V., Alimy, A., Schleid, K., Ocokoljic, A., Bartosik, M., Kroge, S. V., Mussawy, H., Amling, M., Beil, F. T., et al. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.06.035 · Cited by 1
CHIP protects rheumatoid arthritis progression by targeting TRAF6 in arthritis animal models
Liu, J., Kaijian, F. A. N., Yang, Y., Tang, Y., Zheng, S. G., & Wang, T. (2026) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2026.101175 · Cited by 1
Gong, Y., Zeng, W., Liao, Y., Xie, X., Qin, Z., Li, C., & Zhang, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1926935 · Cited by 1
Identification and characterization of osteoclast precursor cells
Miyamoto, T. K. (2013) · IBMS BoneKEy · doi:10.1038/bonekey.2013.80 · Cited by 1
Erosion defined: back to basics
Kay, J., & Gravallese, E. M. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.60 · Cited by 1
Self-citationDual energy X-ray absorptiometry in rheumatoid arthritis
Deodhar, A. A. (2015) · doi:10.1007/978-1-907673-91-7_8 · Cited by 1
Lamerato, L. E., Price, K., Szymialis, R., Eaddy, M. T., Ogbonnaya, A., Shih, H.-C., & Ahmad, H. (2017) · Journal of Medical Economics · doi:10.1080/13696998.2017.1391819 · Cited by 1
Kainberger, F. M., Hirtler, L., Platzgummer, H., Huber, F. A., Patsch, J., & Weidekamm, C. (2018) · Springer eBooks · doi:10.1007/978-3-319-74207-6_4 · Cited by 1
Volkava, M. V., Kundzer, E. V., Generalov, I. I., Senkovich, S. A., & Kundzer, V. I. (2019) · Vestnik of Vitebsk State Medical University · doi:10.22263/2312-4156.2019.5.77 · Cited by 1
Arenas-Sánchez, G., Cortés, L. J., Arce, M. A., Villacura, L. E. P., & Salinas, A. E. (2021) · Revista de Nutrición Clínica y Metabolismo · doi:10.35454/rncm.v4n3.292 · Cited by 3
Dráfi, F., Poništ, S., Sepodes, B. M. N., & Bauerová, K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00110-9 · Cited by 1
Scanning Electron Microscopic Analysis of the Bone-Resorption Activity in Mature Osteoclasts
Kiyoi, T. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3682-4_27 · Cited by 1
Osteoprotegerin in infection-induced acute inflammatory states in children
Giannakopoulos, A., Efthymiadou, A., Kritikou, D., & Chrysis, D. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27565 · Cited by 1
Wen, D., & Guo, D. (2024) · AME Case Reports · doi:10.21037/acr-23-112 · Cited by 1
Alivernini, S., Masserdotti, A., Magatti, M., Cargnoni, A., Papait, A., Silini, A. R., Romoli, J., Ficai, S., Mario, C. D., Gremese, E., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e41438 · Cited by 4
Yoshida, S., Temmoku, J., Saito, K., Suzuki, E., Kanno, T., Sumichika, Y., Matsumoto, H., Fujita, Y., Matsuoka, N., Asano, T., et al. (2025) · FUKUSHIMA JOURNAL OF MEDICAL SCIENCE · doi:10.5387/fms.24-00054 · Cited by 1
LncRNA NR2F1-AS1 is involved in osteogenic differentiation in fracture healing via miR-423-5p
Chen, Y., Huang, K., Ji, W., Huang, M. L., Sima, J., Jin, L., Song, H., Xiong, W., & Ma, C. (2025) · Cytotechnology · doi:10.1007/s10616-025-00786-8 · Cited by 1
Colavite, P. M., Ishikawa, L. L. W., Zorzella-Pezavento, S. F. G., de Oliveira, L. R. C., França, T. G. D., da Rosa, L. C., Chiuso‐Minicucci, F., Vieira, A. E., Francisconi, C. F., da Cunha, M. D. L. R. D. S., et al. (2015) · Cellular Microbiology · doi:10.1111/cmi.12563 · Cited by 1
Rheumatoid Arthritis and Other Inflammatory Articular Diseases
Thurlings, R. M., Tas, S. W., & Tak, P. P. (2017) · Wiley-VCH eBooks · doi:10.1002/9783527692156.ch42 · Cited by 1
Inmunopatología de la artritis reumatoide
Morel, J. (2014) · EMC - Aparato Locomotor · doi:10.1016/s1286-935x(14)69312-6 · Cited by 1
Immunological Basis of Inflammatory Arthritides
Kalliolias, G. D., & Skokos, D. (2019) · Springer eBooks · doi:10.1007/978-3-030-23022-7_1 · Cited by 1
Schett, G. A. (2016) · Zeitschrift für Rheumatologie · doi:10.1007/s00393-016-0144-9 · Cited by 1
Self-citationKugler, M., Dellinger, M., Kartnig, F., Tosevska, A., Müller, L., Preglej, T., Heinz, L. X., Kiener, H., Steiner, G., Aletaha, D., et al. (2022) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2022-eular.1804 · Cited by 1
Ahmed, N. (2015) · Figshare · Cited by 1
The Deimination of Arginine to Citrulline
Creese, A. J., & Cooper, H. J. (2016) · doi:10.1002/9781119250906.ch7 · Cited by 1
Ferraioli, M., Conigliaro, P., Fatica, M., D’Antonio, A., Ferrigno, S., Scriffignano, S., Triggianese, P., Perrotta, F. M., Greco, E., Bergamini, A., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3377148/v1 · Cited by 1
Zhao, B., Qin, Y., Shirakawa, J., Xu, C., Chen, R., Ng, C., Nakano, S., Elguindy, M. M., Deng, Z., Prasanth, K. V., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3793919/v1 · Cited by 1
Wang, Y., Dowling, S. D., Maciuch, J., Rodriguez, V., Mayer, M., Mian, K., Therron, T., Makinde, H. M., Cuda, C. M., Winter, D. R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.13.659432 · Cited by 1
Oden, F. (2014) · Refubium (Universitätsbibliothek der Freien Universität Berlin) · doi:10.17169/refubium-4376
Svensson, M. N. D. (2014) · Gothenburg University Publications Electronic Archive (Gothenburg University)
The Role and Modulation of Pathogenic CCR6 Positive T Helper Cells in Rheumatoid Arthritis
Paulissen, S. M. J. (2015) · EUR Research Repository (Erasmus University Rotterdam)
A Study of Grouped Failure Time Data: Misapplication of Repeated Binary Responses
Braschel, M. C. (2014) · The Atrium (University of Guelph)
Lin, N., Wei, Y., Tan, W., & Zhang, M. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2015-eular.5403
A study of grouped failure time data and the misapplication of recurrent event modeling
Braschel, M. C., Darlington, G., & Klar, N. S. (2016) · Communications in Statistics - Simulation and Computation · doi:10.1080/03610918.2016.1152367
Interactions Between Multipotential Stromal Cells (MSCs) and Immune Cells During Bone Healing
El‐Jawhari, J. J., Jones, E., McGonagle, D., & Giannoudis, P. V. (2016) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-33270-3_9
Prevalence of Low Vitamin D and Disability Among Egyptian Female Patients with Rheumatoid Arthritis
Abogamal, A. F., Yasein, Y. A., Mansour, A. E., Nassar, Y., & Mahmoud, E. (2016) · International Journal of Bone and Rheumatology Research · doi:10.19070/2470-4520-1600012
Izquierdo, Y. E., Páramo, E. C., Castañeda, L. M., Gómez, S. V., & Zambrano, F. S. (2017) · Revista Colombiana de Reumatología (English Edition) · doi:10.1016/j.rcreue.2017.05.002
Malysheva, K. V., Insitute of Animal Biology NAAS, 3. V. S. S., Pavlenko, O. K., Stoika, R. S., & Korchynskyi, O. (2017) · The Animal Biology · doi:10.15407/animbiol19.02.070
Osteoimmunology: An Evolving Discipline
(2013) · Journal of Arthritis · doi:10.4172/2167-7921.1000e108
Mendes, M. T. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.41.2017.tde-28102017-113448
Nature of Perceived Bone Defects in Apparently Otherwise Healthy Individuals
Rothschild, B. M. (2017) · JCR Journal of Clinical Rheumatology · doi:10.1097/rhu.0000000000000664
Temporomandibular Joint Arthritis Resembling Bifid Condyle - A CBCT Analysis of 2 Cases
ayachandran, S., Khobre, P., & Sarala, K. (2016) · Archive of Gerontology and Geriatrics Research · doi:10.17352/aggr.000002
Ahmed, H. S., Farrag, S. E., Okasha, A. E., Othman, G., & Shady, I. (2018) · Aktuelle Rheumatologie · doi:10.1055/a-0591-2364
SAT0028 The importance of proper handling of human synovial fluid for arthritis research
Brouwers, H., von Hegedus, J. H., Toes, R. E. M., Huizinga, T. W. J., Giera, M. A., Kloppenburg, M., & Ioan‐Facsinay, A. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-eular.6587
Development of Macromolecular Prodrugs for the Treatment of Chronic Inflammatory Pain
Weber, L. P. (2018) · DigitalCommons@UNMC
Inflammatory Arthritis: Rheumatoid Arthritis
Cai, Q., & Wang, T. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.62224-9
Ankle Joint in Active Rheumatoid Arthritis
Mohammed, D. F., Mahmoud, Z., & Elsaman, A. M. (2020) · Sohag Medical Journal · doi:10.21608/smj.2020.16564.1059
Isolated bone erosions likely not clinically significant
Rothschild, B. M., & Jellema, L. M. (2019) · Medical and Clinical Archives · doi:10.15761/mca.1000162
Magnetresonanztomografie peripherer Gelenke
Abrar, D. B., & Sewerin, P. (2020) · Arthritis und Rheuma · doi:10.1055/a-1161-5922
Mechanisms of bone and cartilage destruction
Harre, U., & Schett, G. A. (2020) · doi:10.1093/med/9780198831433.003.0009
Self-citationAnti-Arthritic Effect of Sogyunghwalhyel-tang-gamibang
Jo, J.-H., Im, J.-S., Kim, J.-G., Park, J.-H., Choi, H.-S., Hwang, G.-W., & Song, Y. (2021) · Journal of Korean Medicine Rehabilitation · doi:10.18325/jkmr.2021.31.1.33
Wang, Y., & Bonavida, B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821909-6.00018-3
Host defense peptides clavanins A and MO reduce in vitro osteoclastogenesis
Amorim, I. A., Lima, S. M. D. F., Cantuária, A. P. D. C., Freire, M. D. S., de Almeida, J. A., Franco, O. L., & Rezende, T. M. B. (2021) · Brazilian journal of oral sciences/Brazilian Journal of Oral Sciences · doi:10.20396/bjos.v20i00.8661512
Giant Intraosseous Cyst-Like Lesions of the Metacarpal Bones in Rheumatoid Arthritis
Fang, W., Nakagawa, I., Sutherland, K. L., Tanimura, K., & Kamishima, T. (2021) · Journal of Imaging · doi:10.3390/jimaging7070113
Davergne, T., Tekaya, R., Sellam, J., Tounadre, A., Mitrovic, S., Ruyssen‐Witrand, A., Hudry, C., Dadoun, S., Avouac, J., Fautrel, B., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-548185/v1
The Roles of TNFRSF11B Genes as a Trigger for Secondary Osteoporosis in Rheumatoid Arthritis Cases
Ali, N. A., Destiani, D. P., & Amalia, R. (2021) · Indonesian Journal of Clinical Pharmacy · doi:10.15416/ijcp.2021.10.3.234
Yu, S., Chen, J., Chen, Y., Wang, Y., Hsu, C., Lai, H., He, H.-R., & Cheng, T. (2021) · Research Square · doi:10.21203/rs.3.rs-944340/v1
Investigating the tumourigenic aspects of the bone marrow microenvironment in multiple myeloma
Ellis, B. A. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)
Metadata
- Authors
- Schett, G., & Gravallese, E.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Schett, Georg
- Venue
- Nature Reviews Rheumatology
- Published
- 2012-09-25
- Volume
- 8
- Issue
- 11
- Pages
- 656-664
- ISSN
- 1759-4790 (ISSN-L)
- 1759-4804
- PMC
- PMC4096779
- OpenAlex
- W2032362610
- Cited by
- 947
- References
- 124
- Citations by year
- 2026: 72 · 2025: 72 · 2024: 89 · 2023: 75 · 2022: 82 · 2021: 89 · 2020: 80 · 2019: 75 · 2018: 73 · 2017: 74 · 2016: 53 · 2015: 52 · 2014: 35 · 2013: 26
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- American College of Rheumatology Research and Education Foundation
- Rheumatology Research Foundation
- European Commission
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- National Institutes of Health (5r01ar055952-05)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR055952)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Keywords
- bone erosion, rheumatoid arthritis, bone resorption, osteoclasts, synovitis, inflammatory cytokines, RANKL, anti-citrullinated protein antibodies, bone formation, bone regeneration, radiographic erosions, antirheumatic therapy
- MeSH terms
- Animals, Arthritis, Rheumatoid, Bone Resorption, Cell Differentiation, Humans, Osteoclasts, Cytokines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
