Cited by 149Vagus Nerve Stimulation ResearchPain Mechanisms and TreatmentsNeuropeptides and Animal Physiology

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Role of peripheral nerve fibres in acute and chronic inflammation in arthritis

Pongratz, Georg, Straub, Rainer H.·2013·Nature Reviews Rheumatology

DOI 10.1038/nrrheum.2012.181

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Abstract

The peripheral nervous system takes an active part in inflammatory processes by regulating effector cell function and reallocation of energy to the immune system. During acute inflammation, rapid neuronal reorganization and change of activity takes place. The hallmarks of this process are an increase in systemic sympathetic activity, a decrease in systemic parasympathetic activity and loss of sympathetic nerve fibres from sites of inflammation concomitant with increased innervation with sensory nerve fibres and increased sensory nerve fibre activity. On a systemic level, the increase in sympathetic activity (and decrease in parasympathetic activity) is necessary to provide enough energy to nourish the activated immune system. In locally inflamed tissue, the decrease in sympathetic nerve fibre density results in reduced anti-inflammatory signalling and, together with neuropeptides released from sensory nerve fibres, promotes local inflammation. In acute inflammation, this 'inflammatory configuration' of the peripheral nervous system favours the rapid clearance of antigenic threats. However, in chronic autoimmune inflammation, these changes of the peripheral nervous system lead to an unfavourable situation with ongoing energy reallocation and continuous local destruction. As an example of a chronic inflammatory condition, we discuss evidence for neuroimmune regulation in autoimmune arthritis with a focus on the sympathetic nervous system.

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Authors: Pongratz, G., & Straub, R. H.
Affiliations: University Hospital Regensburg (DE)
Corresponding author: Straub, Rainer H.
ORCID: Pongratz, Georg
Straub, Rainer H.
Venue: Nature Reviews Rheumatology
Publisher: Springer Science and Business Media LLC
Published: 2012-11-13
Volume: 9
Issue: 2
Pages: 117-126
ISSN: 1759-4790 (ISSN-L)
1759-4804
DOI: 10.1038/nrrheum.2012.181
OpenAlex: W2033176002
Cited by: 149
References: 104
Citations by year: 2026: 4 · 2025: 13 · 2024: 15 · 2023: 10 · 2022: 13 · 2021: 15 · 2020: 15 · 2019: 13 · 2018: 10 · 2017: 6 · 2016: 6 · 2015: 16 · 2014: 7 · 2013: 6
FWCI: 0.87
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Rheumatology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: peripheral nervous system, neuroimmune regulation, acute inflammation, chronic inflammation, autoimmune arthritis, sympathetic nervous system, parasympathetic nervous system, sensory nerve fibers, sympathetic denervation, neuropeptides, energy reallocation
MeSH terms: Acute Disease, Arthritis, Chronic Disease, Humans, Immune System, Inflammation, Nerve Fibers, Peripheral Nerves

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Role of peripheral nerve fibres in acute and chronic inflammation in arthritis

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