Purification and functional characterization of the human N‐CoR complex: the roles of HDAC3, TBL1 and TBLR1
Open accessAbstract
Corepressors N-CoR and SMRT participate in diverse repression pathways and exist in large protein complexes including HDAC3, TBL1 and TBLR1. However, the roles of these proteins in SMRT-N-CoR complex function are largely unknown. Here we report the purification and functional characterization of the human N-CoR complex. The purified N-CoR complex contains 10-12 associated proteins, including previously identified components and a novel actin-binding protein IR10. We show that TBL1/TBLR1 associates with N-CoR through two independent interactions: the N-terminal region and the C-terminal WD-40 repeats interact with the N-CoR RD1 and RD4 region, respectively. In vitro, TBL1/TBLR1 bind histones H2B and H4, and, importantly, repression by TBL1/TBLR1 correlates with their interaction with histones. By using specific small interference RNAs (siRNAs), we demonstrate that HDAC3 is essential, whereas TBL1 and TBLR1 are functionally redundant but essential for repression by unliganded thyroid hormone receptor. Together, our data reveal the roles of HDAC3 and TBL/TBLR1 and provide evidence for the functional importance of histone interaction in repression mediated by SMRT-N-CoR complexes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HDAC3 appears to be uniquely recruited to the SMRT/NCoR complex, where it interacts with a conserved deacetylase-activation-domain (DAD) within SMRT or NCoR.
“In contrast, HDAC3 appears to be uniquely recruited to the SMRT/NCoR complex where it interacts with a conserved deacetylase-activation-domain (DAD) within SMRT or NCoR8,10,12,24,25,26.”
From Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate (2012) · cites this paper as [25]
The section on TBL1/TBLR1–histone interactions states that SMRT and N-CoR interact directly with HDAC3 through a deacetylase-activating domain (DAD). But the Introduction and the section on HDAC3’s role describe HDAC3 as the primary or major associated HDAC, not the unique one; the Introduction also mentions associations with other HDACs. Our copy does not establish that the DAD is conserved. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262 · see citing works
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756 · see citing works
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964 · see citing works
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,759 · see citing works
The coregulator exchange in transcriptional functions of nuclear receptors
Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233 · see citing works
Hörlein, A., Näär, A. M., Heinzel, T., Torchia, J., Gloss, B. R., Kurokawa, R., Ryan, A. K., Kamei, Y., Söderström, M., Glass, C. K., et al. (1995) · Nature · doi:10.1038/377397a0 · Cited by 2,035 · see citing works
Dent, S., Denu, J. M., & Allis, C. D. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.81 · Cited by 1,844 · see citing works
A transcriptional co-repressor that interacts with nuclear hormone receptors
Chen, J. D., & Evans, R. M. (1995) · Nature · doi:10.1038/377454a0 · Cited by 1,794 · see citing works
Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase
Nagy, L., Kao, H.-Y., Chakravarti, D., Lin, R. J., Hassig, C. A., Ayer, D. E., Schreiber, S. L., & Evans, R. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80218-4 · Cited by 1,230 · see citing works
A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression
Heinzel, T., Lavinsky, R. M., Mullen, T.-M., Söderström, M., Laherty, C. D., Torchia, J., Yang, W., Brard, G., Ngo, S. D., Davie, J., et al. (1997) · Nature · doi:10.1038/387043a0 · Cited by 1,210 · see citing works
Analysis of gene function in somatic mammalian cells using small interfering RNAs
Elbashir, S. M. (2002) · Methods · doi:10.1016/s1046-2023(02)00023-3 · Cited by 1,094 · see citing works
Chromatin Structure and Function
Nicolini, C. A. (1979) · Springer eBooks · doi:10.1007/978-1-4684-0973-4 · Cited by 1,030 · see citing works
Xue, Y., Wong, J., Moreno, G. T., Young, M. K., Côté, J., & Wang, W. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80299-3 · Cited by 983 · see citing works
Self-citationZhang, Y., LeRoy, G., Seelig, H.-P., Lane, W. S., & Reinberg, D. (1998) · Cell · doi:10.1016/s0092-8674(00)81758-4 · Cited by 814 · see citing works
Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
Wade, P. A., Gégonne, A., Jones, P. L., Ballestar, E., Aubry, F., & Wolffe, A. P. (1999) · Nature Genetics · doi:10.1038/12664 · Cited by 811 · see citing works
Both corepressor proteins SMRT and N‐CoR exist in large protein complexes containing HDAC3
Li, J., Wang, J., Wang, J., Nawaz, Z., Liu, J. M., Qin, J., & Wong, J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.16.4342 · Cited by 629 · see citing works
Self-citationThe SMRT and N-CoR Corepressors Are Activating Cofactors for Histone Deacetylase 3
Guenther, M. G., Barak, O., & Lazar, M. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.18.6091-6101.2001 · Cited by 611 · see citing works
Histone acetylases and deacetylases in cell proliferation
Kouzarides, T. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80006-9 · Cited by 602 · see citing works
Histone Deacetylases and SAP18, a Novel Polypeptide, Are Components of a Human Sin3 Complex
Zhang, Y., Iratni, R., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (1997) · Cell · doi:10.1016/s0092-8674(00)80216-0 · Cited by 578 · see citing works
Combinatorial roles of the nuclear receptor corepressor in transcription and development.
Jepsen, K., Hermanson, O., Onami, T. M., Gleiberman, A., Lunyak, V., Mcevilly, R., Kurokawa, R., Kumar, V., Liu, F. C., Seto, E., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00064-7 · Cited by 545 · see citing works
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness
Guenther, M. G., Lane, W. S., Fischle, W., Verdin, E., Lazar, M. A., & Shiekhattar, R. (2000) · Genes & Development · doi:10.1101/gad.14.9.1048 · Cited by 489 · see citing works
Glass, C. K., Lipkin, S. M., Devary, O. V., & Rosenfeld, M. G. (1989) · Cell · doi:10.1016/0092-8674(89)90016-0 · Cited by 478 · see citing works
Baniahmad, A., Steiner, C., Köhne, A. C., & Renkawitz, R. (1990) · Cell · doi:10.1016/0092-8674(90)90532-j · Cited by 461 · see citing works
Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.Preprint
Edmondson, D. G., Smith, M. M., & Roth, S. Y. (1996) · Genes & Development · doi:10.1101/gad.10.10.1247 · Cited by 456 · see citing works
Kao, H., Downes, M., Ordentlich, P., & Evans, R. M. (2000) · Genes & Development · doi:10.1101/gad.14.1.55 · Cited by 424 · see citing works
Zhang, J., Kalkum, M., Chait, B. T., & Roeder, R. G. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00468-9 · Cited by 414 · see citing works
The histone deacetylase-3 complex contains nuclear receptor corepressors
Wen, Y.-D., Perissi, V., Staszewski, L. M., Yang, W.-M., Krones, A., Glass, C. K., Rosenfeld, M. G., & Seto, E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7202 · Cited by 378 · see citing works
Huang, E. Y., Zhang, J., Miska, E. A., Guenther, M. G., Kouzarides, T., & Lazar, M. A. (2000) · Genes & Development · doi:10.1101/gad.14.1.45 · Cited by 325 · see citing works
Underhill, C., Qutob, M. S., Yee, S.-P., & Torchia, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007864200 · Cited by 323 · see citing works
Wong, J., Shi, Y., & Wolffe, A. P. (1995) · Genes & Development · doi:10.1101/gad.9.21.2696 · Cited by 226 · see citing works
Self-citationUnique forms of human and mouse nuclear receptor corepressor SMRT.
Ordentlich, P., Downes, M., Xie, W., Genin, A., Spinner, N., & Evans, R. (1999) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.96.6.2639 · Cited by 183 · see citing works
Wong, J., Patterton, D., Imhof, A., Guschin, D. Y., Shi, Y., & Wolffe, A. P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.2.520 · Cited by 162 · see citing works
Self-citationSharma, D., & Fondell, J. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122004799 · Cited by 160 · see citing works
Self-citationPark, E.-J., Schroen, D. J., Yang, M., Li, H. Z., Li, L., & Chen, J. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3519 · Cited by 129 · see citing works
Li, J., Lin, Q., Wang, W., Wade, P. A., & Wong, J. (2002) · Genes & Development · doi:10.1101/gad.962502 · Cited by 126 · see citing works
Self-citationMultiple N-CoR Complexes Contain Distinct Histone Deacetylases
Jones, P. L., Sachs, L. M., Rouse, N., Wade, P. A., & Shi, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000879200 · Cited by 98 · see citing works
A Strategy for Rapid, High-Confidence Protein Identification
Qin, J., Fenyö, D., Zhao, Y., Hall, W. W., Chao, D. M., Wilson, C. J., Young, R. A., & Chait, B. T. (1997) · Analytical Chemistry · doi:10.1021/ac970488v · Cited by 90 · see citing works
Self-citationHistone-Dependent Association of Tup1-Ssn6 with Repressed Genes In Vivo
Davie, J. K., Trumbly, R. J., & Dent, S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.3.693-703.2002 · Cited by 80 · see citing works
In vivo repression of an erythroid‐specific gene by distinct corepressor complexes
RIETVELD, L. E. G., Caldenhoven, E., & Stunnenberg, H. G. (2002) · The EMBO Journal · doi:10.1093/emboj/21.6.1389 · Cited by 43 · see citing works
cDNA Cloning of a Novel WD Repeat Protein Mapping to the 9q22.3 Chromosomal Region
Zaphiropoulos, P. G., & Toftgård, R. (1996) · DNA and Cell Biology · doi:10.1089/dna.1996.15.1049 · Cited by 27 · see citing works
Ohashi, H., Yang, Y.-F., & Walfish, P. G. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91015-5 · Cited by 21 · see citing works
Flagged first, then by citations
1 of the 42 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Molecular Aspects of Thyroid Hormone Actions
Cheng, S.-Y., Leonard, J. L., & Davis, P. J. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0007 · Cited by 1,384 · see citing works
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ
Pascual, G., Fong, A. L., Ogawa, S., Gamliel, A., Li, A. C., Perissi, V., Rose, D. W., Willson, T. M., Rosenfeld, M. G., & Glass, C. K. (2005) · Nature · doi:10.1038/nature03988 · Cited by 1,251 · see citing works
Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases
Whetstine, J. R., Nottke, A. C., Lan, F., Huarte, M., Smolikov, S., Chen, Z., Spooner, E., Li, E., Zhang, G., Colaiácovo, M. P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.03.028 · Cited by 1,046 · see citing works
Rosenfeld, M. G., Lunyak, V. V., & Glass, C. K. (2006) · Genes & Development · doi:10.1101/gad.1424806 · Cited by 952 · see citing works
Fujimoto, A., Furuta, M., Totoki, Y., Tsunoda, T., Kato, M., Shiraishi, Y., Tanaka, H., Taniguchi, H., Kawakami, Y., Ueno, M., et al. (2016) · Nature Genetics · doi:10.1038/ng.3547 · Cited by 696 · see citing works
Overview of nomenclature of nuclear receptors
Germain, P., Staels, B., Dacquet, C., Spedding, M., & Laudet, V. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.2 · Cited by 688 · see citing works
PPARs and molecular mechanisms of transrepression
Ricote, M., & Glass, C. K. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.02.013 · Cited by 567 · see citing works
Perissi, V., Aggarwal, A. K., Glass, C. K., Rose, D. W., & Rosenfeld, M. G. (2004) · Cell · doi:10.1016/s0092-8674(04)00133-3 · Cited by 566 · see citing works
Deconstructing repression: evolving models of co-repressor action
Perissi, V., Jepsen, K., Glass, C. K., & Rosenfeld, M. G. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2736 · Cited by 532 · see citing works
Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate
Watson, P. J., Fairall, L., Santos, G. M., & Schwabe, J. W. R. (2012) · Nature · doi:10.1038/nature10728 · Cited by 505 · see citing works
Controlling nuclear receptors: the circular logic of cofactor cycles
Perissi, V., & Rosenfeld, M. G. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1680 · Cited by 507 · see citing works
Combinatorial roles of nuclear receptors in inflammation and immunity
Glass, C. K., & Ogawa, S. (2005) · Nature reviews. Immunology · doi:10.1038/nri1748 · Cited by 463 · see citing works
Histone Deacetylase Inhibitors
Marks, P. A., Richon, V. M., Miller, T., & Kelly, W. K. (2004) · Advances in cancer research · doi:10.1016/s0065-230x(04)91004-4 · Cited by 424 · see citing works
N-CoR Mediates DNA Methylation-Dependent Repression through a Methyl CpG Binding Protein Kaiso
Yoon, H.-G., Chan, D. W., Reynolds, A. B., Qin, J., & Wong, J. (2003) · Molecular Cell · doi:10.1016/j.molcel.2003.08.008 · Cited by 408 · see citing works
Self-citationRetinoic acid receptors: From molecular mechanisms to cancer therapy
di Masi, A., Leboffe, L., De Marinis, E., Pagano, F., Cicconi, L., Rochette-Egly, C., Lo-Coco, F., Ascenzi, P., & Nervi, C. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.12.003 · Cited by 403 · see citing works
Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates
Millard, C. J., Watson, P. J., Celardo, I., Gordiyenko, Y., Cowley, S. M., Robinson, C. V., Fairall, L., & Schwabe, J. W. R. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.05.020 · Cited by 396 · see citing works
Bhaskara, S., Chyla, B., Amann, J. M., Knutson, S. K., Cortez, D., Sun, Z., & Hiebert, S. W. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.030 · Cited by 369 · see citing works
Choi, K., Jung, M. G., Lee, Y., Yoon, J. C., Kwon, S. H., Kang, H., Kim, M., Cha, J., Kim, Y. J., Jun, W. J., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2442 · Cited by 354 · see citing works
Self-citationHistone deacetylation in epigenetics: An attractive target for anticancer therapy
Mai, A., Massa, S., Rotili, D., Cerbara, I., Valente, S., Pezzi, R., Simeoni, S., & Ragno, R. (2005) · Medicinal Research Reviews · doi:10.1002/med.20024 · Cited by 324 · see citing works
The role of corepressors in transcriptional regulation by nuclear hormone receptors.
Privalsky, M. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.032802.155556 · Cited by 335 · see citing works
Involvement of Arabidopsis HOS15 in histone deacetylation and cold tolerance
Zhu, J., Jeong, J. C., Zhu, Y., Sokolchik, I., Miyazaki, S., Zhu, J., Hasegawa, P. M., Bohnert, H. J., Shi, H., Yun, D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801029105 · Cited by 307 · see citing works
Corepressors selectively control the transcriptional activity of PPARγ in adipocytesPreprint
Guan, H.-P., Ishizuka, T., Chui, P. C., Lehrke, M., & Lazar, M. A. (2005) · Genes & Development · doi:10.1101/gad.1263305 · Cited by 293 · see citing works
Ju, B., Solum, D., Song, E. J., Lee, K.-J., Rose, D., Glass, C., & Rosenfeld, M. (2004) · Cell · doi:10.1016/j.cell.2004.11.017 · Cited by 285 · see citing works
Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks
Knutson, S. K., Chyla, B. J., Amann, J. M., Bhaskara, S., Huppert, S. S., & Hiebert, S. W. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.51 · Cited by 271 · see citing works
Zhu, P., Baek, S. H., Bourk, E., Ohgi, K., Garcia-Bassets, I., Sanjo, H., Akira, S., Kotol, P., Glass, C., Rosenfeld, M., et al. (2006) · Cell · doi:10.1016/j.cell.2005.12.032 · Cited by 268 · see citing works
Endocrine-disrupting chemicals and fatty liver disease
Foulds, C., Treviño, L., York, B., & Walker, C. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.42 · Cited by 217 · see citing works
Sun, Z., Feng, D., Fang, B., Mullican, S. E., You, S.-H., Lim, H., Everett, L. J., Nabel, C. S., Li, Y., Selvakumaran, V., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.10.022 · Cited by 247 · see citing works
Zhang, X. M., Ozawa, Y., Lee, H., Wen, Y., Tan, T., Wadzinski, B. E., & Seto, E. (2005) · Genes & Development · doi:10.1101/gad.1286005 · Cited by 222 · see citing works
HDAC3: taking the SMRT-N-CoRrect road to repression
Karagianni, P., & Wong, J. (2007) · Oncogene · doi:10.1038/sj.onc.1210612 · Cited by 221 · see citing works
Self-citationSMRT Derepression by the IκB Kinase α
Hoberg, J. E., Yeung, F., & Mayo, M. W. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.010 · Cited by 220 · see citing works
Chromatin modifications and remodeling in plant abiotic stress responses
Luo, M., Liu, X., Singh, P., Cui, Y., Zimmerli, L., & Wu, K. (2011) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.06.008 · Cited by 220 · see citing works
Huss, J. M., Garbacz, W. G., & Xie, W. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.06.016 · Cited by 217 · see citing works
Buchholz, D. R., Paul, B. D., Fu, L., & Shi, Y. (2005) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2005.07.009 · Cited by 215 · see citing works
Integrative regulation of physiology by histone deacetylase 3
Emmett, M. J., & Lazar, M. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0076-0 · Cited by 202 · see citing works
Sharma, D., Saxena, N. K., Davidson, N. E., & Vertino, P. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0402 · Cited by 208 · see citing works
The N-CoR/Histone Deacetylase 3 Complex Is Required for Repression by Thyroid Hormone Receptor
Ishizuka, T., & Lazar, M. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5122-5131.2003 · Cited by 202 · see citing works
Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo
You, S.-H., Lim, H., Sun, Z., Broache, M., Won, K., & Lazar, M. A. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2476 · Cited by 200 · see citing works
Saksouk, N., Bhatti, M. M., Kieffer‐Jaquinod, S., Smith, A. T., Musset, K., Garin, J., Sullivan, W. J., Cesbron‐Delauw, M., & Hakimi, M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.23.10301-10314.2005 · Cited by 200 · see citing works
Li, J., & Wang, C. (2008) · Nature Cell Biology · doi:10.1038/ncb1684 · Cited by 189 · see citing works
Self-citationCRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis
Hu, H., Yang, Y., Ji, Q., Zhao, W., Jiang, B., Liu, R., Yuan, J., Liu, Q., Li, X., Zou, Y., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.10.024 · Cited by 185 · see citing works
Ogawa, S., Lozach, J., Jepsen, K., Sawka‐Verhelle, D., Perissi, V., Šášik, R., Rose, D. W., Johnson, R. S., Rosenfeld, M. G., & Glass, C. K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405786101 · Cited by 185 · see citing works
Holaska, J. M., & Wilson, K. L. (2007) · Biochemistry · doi:10.1021/bi602636m · Cited by 181 · see citing works
Unraveling the enigma: progress towards understanding the coronin family of actin regulators
Chan, K. T., Creed, S. J., & Bear, J. E. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.04.004 · Cited by 179 · see citing works
Li, D., Yea, S., Li, S., Zhu, C. X., Narla, G., Banck, M. S., Laborda, J., Tan, S., Friedman, J. M., Friedman, S. L., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500463200 · Cited by 177 · see citing works
Coronins: the return of the crown
Uetrecht, A. C., & Bear, J. E. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.06.002 · Cited by 177 · see citing works
Zampetaki, A., Zeng, L., Margariti, A., Xiao, Q., Li, H., Zhang, Z., Pepe, A. E., Wang, G., Habi, O., DEFALCO, E., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.890491 · Cited by 173 · see citing works
Demmerle, J., Koch, A. J., & Holaska, J. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.325308 · Cited by 168 · see citing works
Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery
Oberoi, J., Fairall, L., Watson, P. J., Yang, J.-C., Czimmerer, Z., Kampmann, T., Goult, B. T., Greenwood, J. A., Gooch, J. T., Kallenberger, B. C., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1983 · Cited by 165 · see citing works
Choi, K., Lee, Y., Jung, M. G., Kwon, S. H., Kim, M., Jun, W. J., Lee, J., Lee, J. M., & Yoon, H. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0239 · Cited by 167 · see citing works
Self-citationGeneral Molecular Biology and Architecture of Nuclear Receptors
Pawlak, M., Lefèbvre, P., & Staels, B. (2012) · Current Topics in Medicinal Chemistry · doi:10.2174/156802612799436641 · Cited by 168 · see citing works
Evert, B. O., Araujo, J., Vieira-Saecker, A. M. M., de Vos, R. A. I., Harendza, S., Klockgether, T., & Wüllner, U. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2053-06.2006 · Cited by 162 · see citing works
Ariyoshi, M., & Schwabe, J. W. R. (2003) · Genes & Development · doi:10.1101/gad.266203 · Cited by 163 · see citing works
Perissi, V., Scafoglio, C., Zhang, J., Ohgi, K. A., Rose, D. W., Glass, C. K., & Rosenfeld, M. G. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.01.020 · Cited by 160 · see citing works
Coronin 2A mediates actin-dependent de-repression of inflammatory response genes
Huang, W. J. M., Ghisletti, S., Saijo, K., Gandhi, M., Aouadi, M., Tesz, G. J., Zhang, D. X., Yao, J., Czech, M., Goode, B. L., et al. (2011) · Nature · doi:10.1038/nature09703 · Cited by 160 · see citing works
Ding, S., Liu, W., Iliuk, A. B., Ribot, C., Vallet, J., Tao, A. W., Wang, Y., Lebrun, M., & Xu, J. (2010) · The Plant Cell · doi:10.1105/tpc.110.074302 · Cited by 151 · see citing works
Genome-Wide Association Study of Suicide Attempts in Mood Disorder Patients
Perlis, R. H., Huang, J., Purcell, S., D, M. F. M., Rush, A. J., Sullivan, P. F., Hamilton, S. P., McMahon, F. J., Schulze, T. G., Potash, J. B., et al. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10040541 · Cited by 147 · see citing works
The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo
Astapova, I. I., Lee, L. J., Morales, C., Tauber, S., Bilban, M., & Hollenberg, A. N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804604105 · Cited by 149 · see citing works
The vitamin D receptor in cancer
Thorne, J. L., & Campbell, M. J. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108006964 · Cited by 149 · see citing works
Groucho/Tup1 family co-repressors in plant development
Liu, Z., & Karmarkar, V. M. (2008) · Trends in Plant Science · doi:10.1016/j.tplants.2007.12.005 · Cited by 146 · see citing works
Ki, S. H., Cho, I. J., Choi, D. W., & Kim, S. G. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.10.4150-4165.2005 · Cited by 145 · see citing works
Decreased Expression and Androgen Regulation of the Tumor Suppressor Gene INPP4B in Prostate Cancer
Hodgson, M. C., Shao, L.-J., Frolov, A., Li, R., Peterson, L. E., Ayala, G., Ittmann, M., Weigel, N. L., & Agoulnik, I. U. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2314 · Cited by 142 · see citing works
Loss of HDAC3 results in nonreceptive endometrium and female infertility
Kim, T. H., Yoo, J., Choi, K., Shin, J., Leach, R. E., Fazleabas, A. T., Young, S. L., Lessey, B. A., Yoon, H., & Jeong, J. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf7533 · Cited by 142 · see citing works
Self-citationMcCoull, W., Cheung, T., Anderson, E., Barton, P., Burgess, J., Byth, K., Cao, Q., Castaldi, M. P., Chen, H., Chiarparin, E., et al. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.8b00698 · Cited by 139 · see citing works
Malavé, T. M., & Dent, S. (2006) · Biochemistry and Cell Biology · doi:10.1139/o06-073 · Cited by 135 · see citing works
Signal Integration During Development: Mechanisms of EGFR and Notch Pathway Function and Cross-Talk
Doroquez, D. B., & Rebay, I. (2006) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230600914344 · Cited by 132 · see citing works
Buchholz, D. R., Tomita, A., Fu, L., Paul, B. D., & Shi, Y. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9026-9037.2004 · Cited by 132 · see citing works
TBL1XR1 mutations drive extranodal lymphoma by inducing a pro-tumorigenic memory fate
Venturutti, L., Teater, M., Zhai, A., Chadburn, A., Babiker, L., Kim, D., Béguelin, W., Lee, T. C., Kim, Y., Chin, C. R., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.049 · Cited by 127 · see citing works
Shevchenko, A., Roguev, A., Schaft, D., Buchanan, L., Habermann, B. H., Şakalar, Ç., Thomas, H., Krogan, N. J., Shevchenko, A., & Stewart, A. F. (2008) · Genome biology · doi:10.1186/gb-2008-9-11-r167 · Cited by 125 · see citing works
Yoon, H.-G., & Wong, J. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0324 · Cited by 120 · see citing works
Self-citationZhang, D., Yoon, H., & Wong, J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.15.6404-6414.2005 · Cited by 118 · see citing works
Self-citationTBL1XR1 promotes lymphangiogenesis and lymphatic metastasis in esophageal squamous cell carcinoma
Liu, L., Lin, C., Liang, W., Wu, S., Liu, A., Wu, J., Zhang, X., Ren, P., Li, M., & Song, L. (2014) · Gut · doi:10.1136/gutjnl-2013-306388 · Cited by 117 · see citing works
Reversible SUMOylation of TBL1-TBLR1 Regulates β-Catenin-Mediated Wnt Signaling
Choi, H., Choi, K., Yoo, J., Song, M., Ko, S. J., Kim, C. H., Ahn, J., Chun, K., Yook, J. I., & Yoon, H. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.05.027 · Cited by 117 · see citing works
Self-citationNegative feedback maintenance of heme homeostasis by its receptor, Rev-erbαPreprint
Wu, N., Yin, L., Hanniman, E. A., Joshi, S., & Lazar, M. A. (2009) · Genes & Development · doi:10.1101/gad.1825809 · Cited by 114 · see citing works
Tomita, A., Buchholz, D. R., & Shi, Y. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.8.3337-3346.2004 · Cited by 116 · see citing works
Reading and Function of a Histone Code Involved in Targeting Corepressor Complexes for Repression
Yoon, H., Choi, Y., Cole, P. A., & Wong, J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.25.1.324-335.2005 · Cited by 115 · see citing works
Self-citationRamakrishna, M., Williams, L. H., Boyle, S. E., Bearfoot, J. L., Sridhar, A., Speed, T. P., Gorringe, K. L., & Campbell, I. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009983 · Cited by 112 · see citing works
Hug, B. A., & Lazar, M. A. (2004) · Oncogene · doi:10.1038/sj.onc.1207674 · Cited by 112 · see citing works
Transcriptional Coregulators: Fine-Tuning Metabolism
Mouchiroud, L., Eichner, L. J., Shaw, R. J., & Auwerx, J. H. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.027 · Cited by 111 · see citing works
Müller, G. A., Quaas, M., Schümann, M., Krause, E., Padi, M., Fischer, M., Litovchick, L., DeCaprio, J. A., & Engeland, K. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr793 · Cited by 110 · see citing works
Tup1-Ssn6 Interacts with Multiple Class I Histone Deacetylases in Vivo
Davie, J. K., Edmondson, D. G., Coco, C., & Dent, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309753200 · Cited by 110 · see citing works
Transcriptional Integration of TLR2 and TLR4 Signaling at the NCoR Derepression Checkpoint
Huang, W. J. M., Ghisletti, S., Perissi, V., Rosenfeld, M. G., & Glass, C. K. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.05.023 · Cited by 109 · see citing works
Park, H. J., Baek, D., Cha, J., Liao, X., Kang, S.-H., McClung, C. R., Lee, S. Y., Yun, D., & Kim, W. (2019) · The Plant Cell · doi:10.1105/tpc.18.00721 · Cited by 105 · see citing works
Seong, A., Yoo, J., Choi, K., Lee, M.-H., Lee, Y., Lee, J., Jun, W., Kim, S., & Yoon, H. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.06.029 · Cited by 102 · see citing works
Self-citationHuman-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5pPreprint
Han, K., Gennarino, V. A., Lee, Y., Pang, K., Hashimoto‐Torii, K., Choufani, S., Raju, C. S., Oldham, M. C., Weksberg, R., RAKIC, P. T., et al. (2013) · Genes & Development · doi:10.1101/gad.207456.112 · Cited by 102 · see citing works
Adipose Is a Conserved Dosage-Sensitive Antiobesity Gene
Suh, J. M., Zeve, D., McKay, R. M., Seo, J. H., Salo, Z., Li, R., Wang, M., & Graff, J. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.001 · Cited by 96 · see citing works
Sanyal, S., Båvner, A., Haroniti, A., Nilsson, L.-M., Lundåsen, T., Rehnmark, S., Witt, M. R., Einarsson, C., Talianidis, I., Gustafsson, J.-Α., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706736104 · Cited by 95 · see citing works
Metabolic reprogramming by class I and II histone deacetylases
Mihaylova, M. M., & Shaw, R. J. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.09.003 · Cited by 95 · see citing works
The in vivo role of nuclear receptor corepressors in thyroid hormone action
Astapova, I., & Hollenberg, A. N. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.07.001 · Cited by 92 · see citing works
Lazar, M. A. (2003) · Nuclear Receptor Signaling · doi:10.1621/nrs.01001 · Cited by 94 · see citing works
Transcription factor co‐repressors in cancer biology: roles and targeting
Battaglia, S., Maguire, O., & Campbell, M. J. (2010) · International Journal of Cancer · doi:10.1002/ijc.25181 · Cited by 93 · see citing works
Mutations in <i>TBL1X</i> Are Associated With Central Hypothyroidism
Heinen, C. A., Losekoot, M., Sun, Y., Watson, P. J., Fairall, L., Joustra, S. D., Zwaveling-Soonawala, N., Oostdijk, W., van den Akker, E. L. T., Alders, M., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2531 · Cited by 92 · see citing works
Nuclear Import of Histone Deacetylase 5 by Requisite Nuclear Localization Signal Phosphorylation
Greco, T. M., Yu, F., Guise, A. J., & Cristea, I. M. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.004317 · Cited by 92 · see citing works
Retinoic Acid and Histone Deacetylases Regulate Epigenetic Changes in Embryonic Stem Cells
Urvalek, A. M., & Gudas, L. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.556555 · Cited by 92 · see citing works
Gerlitz, G., Darhin, E., Giorgio, G., Franco, B., & Reiner, O. (2005) · Cell Cycle · doi:10.4161/cc.4.11.2151 · Cited by 92 · see citing works
On guard: coronin proteins in innate and adaptive immunity
Pieters, J., Müller, P., & Jayachandran, R. (2013) · Nature reviews. Immunology · doi:10.1038/nri3465 · Cited by 93 · see citing works
Hahn, Y., Bera, T. K., Gehlhaus, K., Kirsch, I. R., Pastan, I. H., & Lee, B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405490101 · Cited by 92 · see citing works
Ishii, S., KURASAWA, Y., Wong, J., & Yu‐Lee, L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710140105 · Cited by 92 · see citing works
Self-citationPeterson, T. J., Karmakar, S., Pace, M. C., Gao, T., & Smith, C. L. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00237-07 · Cited by 93 · see citing works
Shi, Y. (2009) · Thyroid · doi:10.1089/thy.2009.0041 · Cited by 87 · see citing works
Transducin Beta-Like Gene FTL1 Is Essential for Pathogenesis in Fusarium graminearum
Ding, S., Mehrabi, R., Koten, C., Kang, Z., Wei, Y., Seong, K., Kistler, H. C., & Xu, J. (2009) · Eukaryotic Cell · doi:10.1128/ec.00048-09 · Cited by 87 · see citing works
- Authors
- Yoon, H., Chan, D. W., Huang, Z., Li, J., Fondell, J. D., Qin, J., & Wong, J.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Wong, Jiemin
- ORCID
- Yoon, Ho‐Geun
- Venue
- The EMBO Journal
- Published
- 2003-03-17
- Volume
- 22
- Issue
- 6
- Pages
- 1336-1346
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC151047
- OpenAlex
- W1969097053
- Cited by
- 444
- References
- 42
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 12 · 2023: 17 · 2022: 7 · 2021: 13 · 2020: 16 · 2019: 14 · 2018: 13 · 2017: 16 · 2016: 18 · 2015: 18 · 2014: 19 · 2013: 21 · 2012: 23
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 58679, R01DK056324, R01DK058679, DK 56324)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- SMRT, HDAC3, TBL1, corepressors, transcriptional repression, histone interaction, histone H2B, histone H4, thyroid hormone receptor, actin-binding proteins, WD40 repeats, protein complex purification, functional redundancy
- MeSH terms
- Histone Deacetylase 3, Amino Acid Sequence, Cell Line, DNA-Binding Proteins, HeLa Cells, Histone Deacetylases, Histones, Humans, Microfilament Proteins, Nuclear Proteins, Peptide Fragments, Protein Binding, Receptors, Thyroid Hormone, Recombinant Proteins, Repressor Proteins, Transducin, Sequence Homology, Amino Acid, Protein Structure, Tertiary, Receptors, Cytoplasmic and Nuclear, Protein Subunits, RNA, Small Interfering
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review