Both corepressor proteins SMRT and N‐CoR exist in large protein complexes containing HDAC3
Open accessAbstract
We present evidence that both corepressors SMRT and N-CoR exist in large protein complexes with estimated sizes of 1.5-2 MDa in HeLa nuclear extracts. Using a combination of conventional and immunoaffinity chromatography, we have successfully isolated a SMRT complex and identified histone deacetylase 3 (HDAC3) and transducin (beta)-like I (TBL1), a WD-40 repeat-containing protein, as the subunits of the purified SMRT complex. We show that the HDAC3-containing SMRT and N-CoR complexes can bind to unliganded thyroid hormone receptors (TRs) in vitro. We demonstrate further that in Xenopus oocytes, both SMRT and N-CoR also associate with HDAC3 in large protein complexes and that injection of antibodies against HDAC3 or SMRT/N-CoR led to a partial relief of repression by unliganded TR/RXR. These findings thus establish both SMRT and N-CoR complexes as bona fide HDAC-containing complexes and shed new light on the molecular pathways by which N-CoR and SMRT function in transcriptional repression.
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HDAC3 appears to be uniquely recruited to the SMRT/NCoR complex, where it interacts with a conserved deacetylase-activation-domain (DAD) within SMRT or NCoR.
“In contrast, HDAC3 appears to be uniquely recruited to the SMRT/NCoR complex where it interacts with a conserved deacetylase-activation-domain (DAD) within SMRT or NCoR8,10,12,24,25,26.”
From Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate (2012) · cites this paper as [8]
The section “SMRT and N-CoR complexes as a new class of HDAC-containing complexes” establishes that HDAC3 is a stable subunit of both complexes, and “HDAC3 may interact directly with N-CoR” maps regions that interact with HDAC3. The paper does not identify a conserved deacetylase-activation domain (DAD) in either corepressor or establish that HDAC3 is uniquely recruited to these complexes; its discussion considers the recruitment of multiple HDACs. Page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredHDACs 1, 2 and 3 require association with large multisubunit corepressor complexes for maximal activity.
“HDACs 1, 2 and 3 require association with large multisubunit corepressor complexes for maximal activity7-12.”
From Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate (2012) · cites this paper as [8]
The section “SMRT and N-CoR complexes as a new class of HDAC-containing complexes” reports that HDAC3 is a stable component of large corepressor complexes, and “The majority of SMRT and N-CoR complexes may contain HDAC3” reports strong deacetylase activity in those complexes. The Introduction also describes an HDAC1/2-containing mSin3 complex. None of these passages establishes that association with a complex is required for maximal activity of HDACs 1, 2, and 3. (LLM, conf=0.86)
Experimental — accuracy not yet measuredRecent studies indicate that the corepressors N-CoR and SMRT are preferentially assembled into the HDAC3 complex, but not into the HDAC1 or HDAC2 complex, suggesting that HDAC3 has a functional activity distinct from those of other class I histone deacetylases.
“recent studies indicate that the corepressors N-CoR and SMRT are preferentially assembled into the HDAC3 complex, but not into the HDAC1 or HDAC2 complex, suggesting that HDAC3 has a functional activity distinct from those of other class I histone deacetylases (27, 58).”
From Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element (2002) · cites this paper as [27]
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Cites
Antibodies, a laboratory manual
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318 · see citing works
Antibodies: A laboratory manual
J.L. (1989) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(89)90307-1 · Cited by 5,141 · see citing works
Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain
Gu, W., & Roeder, R. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80521-8 · Cited by 2,559 · see citing works
The coregulator exchange in transcriptional functions of nuclear receptors
Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233 · see citing works
Hörlein, A., Näär, A. M., Heinzel, T., Torchia, J., Gloss, B. R., Kurokawa, R., Ryan, A. K., Kamei, Y., Söderström, M., Glass, C. K., et al. (1995) · Nature · doi:10.1038/377397a0 · Cited by 2,035 · see citing works
Nuclear Receptor Coregulators: Cellular and Molecular Biology
McKenna, N. J., Lanz, R. B., & O’Malley, B. W. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0366 · Cited by 1,905 · see citing works
A transcriptional co-repressor that interacts with nuclear hormone receptors
Chen, J. D., & Evans, R. M. (1995) · Nature · doi:10.1038/377454a0 · Cited by 1,794 · see citing works
Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase
Nagy, L., Kao, H.-Y., Chakravarti, D., Lin, R. J., Hassig, C. A., Ayer, D. E., Schreiber, S. L., & Evans, R. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80218-4 · Cited by 1,230 · see citing works
A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression
Heinzel, T., Lavinsky, R. M., Mullen, T.-M., Söderström, M., Laherty, C. D., Torchia, J., Yang, W., Brard, G., Ngo, S. D., Davie, J., et al. (1997) · Nature · doi:10.1038/387043a0 · Cited by 1,210 · see citing works
A positive role for histone acetylation in transcription factor access to nucleosomal DNA
Lee, D. Y., Hayes, J. J., Pruss, D., & Wolffe, A. P. (1993) · Cell · doi:10.1016/0092-8674(93)90051-q · Cited by 1,122 · see citing works
Xue, Y., Wong, J., Moreno, G. T., Young, M. K., Côté, J., & Wang, W. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80299-3 · Cited by 983 · see citing works
Self-citationA direct link between core histone acetylation and transcriptionally active chromatin.
Hebbes, T. R., Thorne, A. W., & Crane‐Robinson, C. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02956.x · Cited by 921 · see citing works
Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
Alland, L., Muhle, R., Hou, H., Potes, J., Chin, L., Schreiber‐Agus, N., & DePinho, R. A. (1997) · Nature · doi:10.1038/387049a0 · Cited by 841 · see citing works
Purification and biochemical heterogeneity of the mammalian SWI‐SNF complex.
Wang, W., Côté, J., Xue, Y., Zhou, S., Khavari, P. A., Biggar, S. R., Muchardt, C., Kalpana, G. V., Goff, S. P., Yaniv, M., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00921.x · Cited by 839 · see citing works
Nuclear Receptor Coregulators: Cellular and Molecular Biology
McKenna, N. J. (1999) · Endocrine Reviews · doi:10.1210/er.20.3.321 · Cited by 782 · see citing works
Three proteins define a class of human histone deacetylases related to yeast Hda1p
Grozinger, C. M., Hassig, C. A., & Schreiber, S. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.4868 · Cited by 770 · see citing works
Histone acetylases and deacetylases in cell proliferation
Kouzarides, T. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80006-9 · Cited by 602 · see citing works
A histone deacetylase corepressor complex regulates the Notch signal transduction pathwayPreprint
Kao, H., Ordentlich, P., Koyano‐Nakagawa, N., Tang, Z., Downes, M., Kintner, C. R., Evans, R. M., & Kadesch, T. R. (1998) · Genes & Development · doi:10.1101/gad.12.15.2269 · Cited by 579 · see citing works
Histone Deacetylases and SAP18, a Novel Polypeptide, Are Components of a Human Sin3 Complex
Zhang, Y., Iratni, R., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (1997) · Cell · doi:10.1016/s0092-8674(00)80216-0 · Cited by 578 · see citing works
Wang, J., Hoshino, T., Redner, R. L., Kajigaya, S., & Liu, J. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10860 · Cited by 511 · see citing works
Self-citationGlass, C. K., Lipkin, S. M., Devary, O. V., & Rosenfeld, M. G. (1989) · Cell · doi:10.1016/0092-8674(89)90016-0 · Cited by 478 · see citing works
Baniahmad, A., Steiner, C., Köhne, A. C., & Renkawitz, R. (1990) · Cell · doi:10.1016/0092-8674(90)90532-j · Cited by 461 · see citing works
Nawaz, Z., Lonard, D. M., Smith, C. L., Lev-Lehman, E., Tsai, S. Y., Tsai, M., & O’Malley, B. W. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1182 · Cited by 445 · see citing works
Self-citationParthun, M. R., Widom, J., & Gottschling, D. E. (1996) · Cell · doi:10.1016/s0092-8674(00)81325-2 · Cited by 440 · see citing works
Yang, W., Yao, Y., Sun, J.-M., Davie, J., & Seto, E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.44.28001 · Cited by 433 · see citing works
Kao, H., Downes, M., Ordentlich, P., & Evans, R. M. (2000) · Genes & Development · doi:10.1101/gad.14.1.55 · Cited by 424 · see citing works
Thyroid hormone receptor β is essential for development of auditory function
Forrest, D., Erway, L. C., Ng, L., Altschuler, R. A., & Curran, T. (1996) · Nature Genetics · doi:10.1038/ng0796-354 · Cited by 370 · see citing works
Hong, S.-H., David, G., Wong, C.-W., Dejean, A., & Privalsky, M. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9028 · Cited by 341 · see citing works
Huang, E. Y., Zhang, J., Miska, E. A., Guenther, M. G., Kouzarides, T., & Lazar, M. A. (2000) · Genes & Development · doi:10.1101/gad.14.1.45 · Cited by 325 · see citing works
Characterization of a human RPD3 ortholog, HDAC3
Emiliani, S., Fischle, W., Lint, C. M. V., Al-Abed, Y., & Verdin, E. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2795 · Cited by 292 · see citing works
Baniahmad, A., Leng, X., Burris, T. P., Tsai, S. Y., Tsai, M., & O’Malley, B. W. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.1.76 · Cited by 249 · see citing works
Transcription: In tune with the histones
Wolffe, A. P. (1994) · Cell · doi:10.1016/0092-8674(94)90229-1 · Cited by 241 · see citing works
Zamir, I., Harding, H. P., Atkins, G. B., Hörlein, A., Glass, C. K., Rosenfeld, M. G., & Lazar, M. A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.10.5458 · Cited by 227 · see citing works
Dhordain, P., Quief, S., Lantoine, D., Kerckaert, J., Albagli, O., Lin, R. J., & Evans, R. M. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.20.4645 · Cited by 227 · see citing works
Wong, J., Shi, Y., & Wolffe, A. P. (1995) · Genes & Development · doi:10.1101/gad.9.21.2696 · Cited by 226 · see citing works
Self-citationProteasomal regulation of nuclear receptor corepressor-mediated repressionPreprint
Zhang, J., Guenther, M. G., Carthew, R. W., & Lazar, M. A. (1998) · Genes & Development · doi:10.1101/gad.12.12.1775 · Cited by 223 · see citing works
Dressel, U., Thormeyer, D., Altincicek, B., Paululat, A., Eggert, M., Schneider, S., Tenbaum, S. P., Renkawitz, R., & Baniahmad, A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3383 · Cited by 200 · see citing works
Unique forms of human and mouse nuclear receptor corepressor SMRT.
Ordentlich, P., Downes, M., Xie, W., Genin, A., Spinner, N., & Evans, R. (1999) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.96.6.2639 · Cited by 183 · see citing works
Wong, J., Patterton, D., Imhof, A., Guschin, D. Y., Shi, Y., & Wolffe, A. P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.2.520 · Cited by 162 · see citing works
Self-citationHistone acetylation in chromatin and chromosomes
Turner, B. M., & O’Neill, L. P. (1995) · Seminars in Cell Biology · doi:10.1006/scel.1995.0031 · Cited by 150 · see citing works
Park, E.-J., Schroen, D. J., Yang, M., Li, H. Z., Li, L., & Chen, J. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3519 · Cited by 129 · see citing works
Li, J., O’Malley, B. W., & Wong, J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.6.2031-2042.2000 · Cited by 126 · see citing works
Self-citationCasanova, J., Helmer, E., Selmi‐Ruby, S., Qi, J.-S., Au-Fliegner, M., Desai-Yajnik, V., Koudinova, N. V., Yarm, F., Raaka, B. M., & Samuels, H. H. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5756-5765.1994 · Cited by 123 · see citing works
Bassi, M. T., Ramesar, R., Caciotti, B., Winship, I., Grandi, A. D., Riboni, M., Townes, P. L., Beighton, P., Ballabio, A., & Borsani, G. (1999) · The American Journal of Human Genetics · doi:10.1086/302408 · Cited by 106 · see citing works
A Strategy for Rapid, High-Confidence Protein Identification
Qin, J., Fenyö, D., Zhao, Y., Hall, W. W., Chao, D. M., Wilson, C. J., Young, R. A., & Chait, B. T. (1997) · Analytical Chemistry · doi:10.1021/ac970488v · Cited by 90 · see citing works
Self-citationebi regulates epidermal growth factor receptor signaling pathways in DrosophilaPreprint
Dong, X., Tsuda, L., Zavitz, K. H., Lin, M. Z., Li, S., Carthew, R. W., & Zipursky, S. L. (1999) · Genes & Development · doi:10.1101/gad.13.8.954 · Cited by 90 · see citing works
Ciana, P., Braliou, G. G., Demay, F., Lindern, M. V., Barettino, D., Beug, H., & Stunnenberg, H. G. (1998) · The EMBO Journal · doi:10.1093/emboj/17.24.7382 · Cited by 35 · see citing works
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Histone Deacetylase Inhibitors as Anticancer Drugs
Eckschlager, T., Plch, J., Stiborova, M., & Hrabeta, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071414 · Cited by 1,206 · see citing works
Rosenfeld, M. G., Lunyak, V. V., & Glass, C. K. (2006) · Genes & Development · doi:10.1101/gad.1424806 · Cited by 952 · see citing works
Fischle, W., Dequiedt, F., Hendzel, M. J., Guenther, M. G., Lazar, M. A., Voelter, W., & Verdin, E. (2002) · Molecular Cell · doi:10.1016/s1097-2765(01)00429-4 · Cited by 754 · see citing works
Gao, L., Cueto, M. A., Asselbergs, F., & Atadja, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111871200 · Cited by 744 · see citing works
Class II histone deacetylases: versatile regulators
Verdin, E., Dequiedt, F., & Kasler, H. G. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00073-8 · Cited by 664 · see citing works
The SMRT and N-CoR Corepressors Are Activating Cofactors for Histone Deacetylase 3
Guenther, M. G., Barak, O., & Lazar, M. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.18.6091-6101.2001 · Cited by 611 · see citing works
Wilson, A. J., Byun, D.-S., Popova, N., Murray, L. B., L'Italien, K., Sowa, Y., Arango, D., Velcich, A., Augenlicht, L. H., & Mariadason, J. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510023200 · Cited by 575 · see citing works
Deconstructing repression: evolving models of co-repressor action
Perissi, V., Jepsen, K., Glass, C. K., & Rosenfeld, M. G. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2736 · Cited by 532 · see citing works
Coregulator codes of transcriptional regulation by nuclear receptors
Rosenfeld, M. G., & Glass, C. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100041200 · Cited by 509 · see citing works
Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate
Watson, P. J., Fairall, L., Santos, G. M., & Schwabe, J. W. R. (2012) · Nature · doi:10.1038/nature10728 · Cited by 505 · see citing works
HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation
McQuown, S. C., Barrett, R. M., Matheos, D. P., Post, R. J., Rogge, G. A., Alenghat, T., Mullican, S. E., Jones, S., Rusche, J. R., Lazar, M. A., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5052-10.2011 · Cited by 507 · see citing works
Yoon, H., Chan, D. W., Huang, Z., Li, J., Fondell, J. D., Qin, J., & Wong, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg120 · Cited by 444 · see citing works
Self-citationZhang, J., Kalkum, M., Chait, B. T., & Roeder, R. G. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00468-9 · Cited by 414 · see citing works
N-CoR Mediates DNA Methylation-Dependent Repression through a Methyl CpG Binding Protein Kaiso
Yoon, H.-G., Chan, D. W., Reynolds, A. B., Qin, J., & Wong, J. (2003) · Molecular Cell · doi:10.1016/j.molcel.2003.08.008 · Cited by 408 · see citing works
Self-citationRetinoic acid receptors: From molecular mechanisms to cancer therapy
di Masi, A., Leboffe, L., De Marinis, E., Pagano, F., Cicconi, L., Rochette-Egly, C., Lo-Coco, F., Ascenzi, P., & Nervi, C. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.12.003 · Cited by 403 · see citing works
Functional significance of histone deacetylase diversity
Khochbin, S., Verdel, A., Lemercier, C., & Seigneurin-Berny, D. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00174-x · Cited by 366 · see citing works
Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation
Mullican, S. E., Gaddis, C. A., Alenghat, T., Nair, M. G., Giacomin, P. R., Everett, L. J., Feng, D., Steger, D. J., Schug, J., Artis, D., et al. (2011) · Genes & Development · doi:10.1101/gad.175950.111 · Cited by 314 · see citing works
Wei, W., Liu, X., Chen, J., Gao, S., Lu, L., Zhang, H., Ding, G., Wang, Z., Chen, Z., Shi, T., et al. (2017) · Cell Research · doi:10.1038/cr.2017.68 · Cited by 304 · see citing works
Self-citationLiver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks
Knutson, S. K., Chyla, B. J., Amann, J. M., Bhaskara, S., Huppert, S. S., & Hiebert, S. W. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.51 · Cited by 271 · see citing works
Pijnappel, W. W. M. P., Schaft, D., Roguev, A., Shevchenko, A., Tekotte, H., Wilm, M., Rigaut, G., Séraphin, B., Aasland, R., & Stewart, A. F. (2001) · Genes & Development · doi:10.1101/gad.207401 · Cited by 265 · see citing works
Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC
Kwon, D. Y., Zhao, Y.-T., Lamonica, J. M., & Zhou, Z. (2017) · Nature Communications · doi:10.1038/ncomms15315 · Cited by 246 · see citing works
Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
Watson, P. J., Millard, C. J., Riley, A. M., Robertson, N. S., Wright, L. C., Godage, H. Y., Cowley, S. M., Jamieson, A. G., Potter, B. V. L., & Schwabe, J. W. R. (2016) · Nature Communications · doi:10.1038/ncomms11262 · Cited by 244 · see citing works
Human HDAC7 Histone Deacetylase Activity Is Associated with HDAC3in Vivo
Fischle, W., Dequiedt, F., Fillion, M., Hendzel, M. J., Voelter, W., & Verdin, E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104935200 · Cited by 232 · see citing works
Somech, R., Shaklai, S., Geller, O., Amariglio, N., Simon, A. J., Rechavi, G., & Gal-Yam, E. N. (2005) · Journal of Cell Science · doi:10.1242/jcs.02521 · Cited by 223 · see citing works
Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR
Ebert, D. H., Gabel, H. W., Robinson, N. D., Kastan, N. R., Hu, L. S., Cohen, S., Navarro, A. J., Lyst, M. J., Ekiert, R., Bird, A. P., et al. (2013) · Nature · doi:10.1038/nature12348 · Cited by 227 · see citing works
Rett syndrome: a neurological disorder with metabolic components
Kyle, S. M., Vashi, N., & Justice, M. J. (2018) · Open Biology · doi:10.1098/rsob.170216 · Cited by 213 · see citing works
Integrative regulation of physiology by histone deacetylase 3
Emmett, M. J., & Lazar, M. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0076-0 · Cited by 202 · see citing works
Histone Deacetylase 3 Interacts with and Deacetylates Myocyte Enhancer Factor 2
Grégoire, S., Xiao, L., Nie, J., Zhang, X., Xu, M., Li, J., Wong, J., Seto, E., & Yang, X.-J. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00882-06 · Cited by 203 · see citing works
Self-citationMechanisms of endometrial progesterone resistance
Al-Sabbagh, M., Lam, E. W.-F., & Brosens, J. J. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.10.035 · Cited by 183 · see citing works
Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery
Oberoi, J., Fairall, L., Watson, P. J., Yang, J.-C., Czimmerer, Z., Kampmann, T., Goult, B. T., Greenwood, J. A., Gooch, J. T., Kallenberger, B. C., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1983 · Cited by 165 · see citing works
Structure of a BCOR Corepressor Peptide in Complex with the BCL6 BTB Domain Dimer
Ghetu, A. F., Corcoran, C. M., Cerchietti, L., Bardwell, V. J., Melnick, A., & Privé, G. G. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.026 · Cited by 168 · see citing works
Mondello, P., Tadros, S., Teater, M., Fontan, L., Chang, A. Y., Jain, N., Yang, H., Singh, S., Ying, H.-Y., Chu, C.-S., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0116 · Cited by 167 · see citing works
Hug, B. A., & Lazar, M. A. (2004) · Oncogene · doi:10.1038/sj.onc.1207674 · Cited by 112 · see citing works
Turnbull, R. E., Fairall, L., Saleh, A., Kelsall, E., Morris, K. L., Ragan, T. J., Savva, C. G., Chandru, A., Millard, C. J., Makarova, O. V., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17078-8 · Cited by 108 · see citing works
TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3
Wang, L., & Hiebert, S. W. (2001) · Oncogene · doi:10.1038/sj.onc.1204479 · Cited by 101 · see citing works
Codina, A., Love, J. D., Li, Y., Lazar, M. A., Neuhaus, D., & Schwabe, J. W. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500299102 · Cited by 95 · see citing works
HDAC3 is essential for DNA replication in hematopoietic progenitor cells
Summers, A. R., Fischer, M. A., Stengel, K. R., Zhao, Y., Kaiser, J. F., Wells, C. E., Hunt, A., Bhaskara, S., Luzwick, J. W., Sampathi, S., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci60806 · Cited by 87 · see citing works
MeCP2 co-ordinates liver lipid metabolism with the NCoR1/HDAC3 corepressor complex
Kyle, S. M., Saha, P. K., Brown, H. M., Chan, L. C., & Justice, M. J. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw156 · Cited by 84 · see citing works
Kuwata, T., Gongora, C., Kanno, Y., Sakaguchi, K., Tamura, T., Kanno, T., Basrur, V., Martinez, R., Appella, E., Golub, T., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.21.7439-7448.2002 · Cited by 69 · see citing works
Tribus, M., Galehr, J., Trojer, P., Brosch, G., Loidl, P., Marx, F., Haas, H., & Graessle, S. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.10.1736-1745.2005 · Cited by 67 · see citing works
You, S.-H., Liao, X., Weiss, R. E., & Lazar, M. A. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0501 · Cited by 61 · see citing works
Ishizuka, T., & Lazar, M. A. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0009 · Cited by 50 · see citing works
Piazza, R., Magistroni, V., Mogavero, A., Andreoni, F., Ambrogio, C., Chiarle, R., Mologni, L., Bachmann, P. S., Lock, R. B., Collini, P., et al. (2013) · Neoplasia · doi:10.1593/neo.121784 · Cited by 51 · see citing works
HDAC3 functions as a positive regulator in Notch signal transduction
Ferrante, F., Giaimo, B. D., Bartkuhn, M., Zimmermann, T., Close, V., Mertens, D., Nist, A., Stiewe, T., Meier-Soelch, J., Kracht, M., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa088 · Cited by 50 · see citing works
Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense
Guise, A., Budayeva, H., Diner, B., & Cristea, I. (2013) · Viruses · doi:10.3390/v5071607 · Cited by 43 · see citing works
Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation
Varlakhanova, N., Hahm, J. B., & Privalsky, M. L. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.10.010 · Cited by 24 · see citing works
Toro, T. B., Bryant, J. R., & Watt, T. J. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00270 · Cited by 11 · see citing works
- Authors
- Li, J., Wang, J., Wang, J., Nawaz, Z., Liu, J. M., Qin, J., & Wong, J.
- Affiliations
- National Institutes of Health (US)
- Baylor College of Medicine (US)
- Corresponding author
- Wong, Jiemin
- Venue
- The EMBO Journal
- Published
- 2000-08-15
- Volume
- 19
- Issue
- 16
- Pages
- 4342-4350
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC302030
- OpenAlex
- W2072793384
- Cited by
- 629
- References
- 47
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 13 · 2023: 20 · 2022: 18 · 2021: 14 · 2020: 19 · 2019: 12 · 2018: 20 · 2017: 17 · 2016: 22 · 2015: 21 · 2014: 16 · 2013: 24 · 2012: 38
- FWCI
- 11.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056324, DK 56324)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- SMRT, NCoR, HDAC3, TBL1, thyroid hormone receptor, retinoid X receptor, transcriptional repression, nuclear receptor corepressor, protein complex purification
- MeSH terms
- Histone Deacetylase 3, Animals, Cell Nucleus, Chromatography, Affinity, Chromatography, Gel, Chromatography, Ion Exchange, Cloning, Molecular, DNA-Binding Proteins, HeLa Cells, Histone Deacetylases, Humans, Ligands, Nuclear Proteins, Oocytes, Plasmids, Protein Binding, Receptors, Thyroid Hormone, Recombinant Proteins, Repressor Proteins, Transcription, Genetic, Xenopus, Blotting, Western, Receptors, Retinoic Acid, Two-Hybrid System Techniques, Nuclear Receptor Co-Repressor 1, Nuclear Receptor Co-Repressor 2
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