Ubiquitin sets the timer: impacts on aging and longevity

The ubiquitin code

Komander, D., & Rape, M. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060310-170328 · Cited by 3,679 · see citing works

The genetics of ageing

Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739 · see citing works

Collapse of proteostasis represents an early molecular event in <i>Caenorhabditis elegans</i> aging

Ben-Zvi, A., Miller, E. A., & Morimoto, R. I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902882106 · Cited by 649 · see citing works

Can autophagy promote longevity?

Madeo, F., Tavernarakis, N., & Kroemer, G. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-842 · Cited by 429 · see citing works

Regulation of the Nrf2–Keap1 Antioxidant Response by the Ubiquitin Proteasome System: An Insight into Cullin-Ring Ubiquitin Ligases

Villeneuve, N. F., Lau, A., & Zhang, D. D. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3211 · Cited by 423 · see citing works

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

Vilchez, D., Morantte, I., Liu, Z., Douglas, P. M., Merkwirth, C., Rodrigues, A. P. C., Manning, G., & Dillin, A. (2012) · Nature · doi:10.1038/nature11315 · Cited by 413 · see citing works

Lessons from C. elegans: signaling pathways for longevity

Lapierre, L. R., & Hansen, M. (2012) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2012.07.007 · Cited by 331 · see citing works

A Stress-Responsive System for Mitochondrial Protein Degradation

Heo, J.-M., Livnat-Levanon, N., Taylor, E. B., Jones, K. T., Dephoure, N., Ring, J., Xie, J., Brodsky, J. L., Madeo, F., Gygi, S. P., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.021 · Cited by 304 · see citing works

Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae

Krügel, U., Robison, B., Dange, T., Kahlert, G., Delaney, J. R., Kotireddy, S., Tsuchiya, M., Tsuchiyama, S. K., Murakami, C. J., Schleit, J., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002253 · Cited by 243 · see citing works

Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity

Henis‐Korenblit, S., Zhang, P., Hansen, M., McCormick, M. A., Lee, S., Cary, M. P., & Kenyon, C. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002575107 · Cited by 236 · see citing works

Regulation of FOXO protein stability via ubiquitination and proteasome degradation

Huang, H., & Tindall, D. J. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.007 · Cited by 227 · see citing works

The WD40 Repeat Protein WDR-23 Functions with the CUL4/DDB1 Ubiquitin Ligase To Regulate Nuclear Abundance and Activity of SKN-1 in Caenorhabditis elegans

Choe, K. P., Przybysz, A. J., & Strange, K. B. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01811-08 · Cited by 186 · see citing works

Mitochondrial quality control by the ubiquitin–proteasome system

Taylor, E. B., & Rutter, J. P. (2011) · Biochemical Society Transactions · doi:10.1042/bst0391509 · Cited by 181 · see citing works

Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD

Lim, P. J., Danner, R., Liang, J., Doong, H., Harman, C. A., Srinivasan, D., Rothenberg, C., Wang, H., Ye, Y., Fang, S., et al. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200903024 · Cited by 169 · see citing works

Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy

Digaleh, H., Kiaei, M., & Khodagholi, F. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1409-y · Cited by 137 · see citing works

A conserved ubiquitination pathway determines longevity in response to diet restriction

Carrano, A. C., Liu, Z., Dillin, A. G., & Hunter, T. R. (2009) · Nature · doi:10.1038/nature08130 · Cited by 131 · see citing works

Aging and regulated protein degradation: who has the UPPer hand?

Vernace, V. A., Schmidt‐Glenewinkel, T., & Figueiredo‐Pereira, M. E. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00329.x · Cited by 110 · see citing works

Pathogenesis of Human Mitochondrial Diseases Is Modulated by Reduced Activity of the Ubiquitin/Proteasome System

Segref, A., Kevei, É., Pokrzywa, W., Schmeißer, K., Mansfeld, J., Livnat‐Levanon, N., Ensenauer, R. E., Glickman, M. H., Ristow, M., & Hoppe, T. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.016 · Cited by 103 · see citing works

A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative-stress adaptation in mammals, C. elegans and D. melanogaster

Pickering, A. M., Staab, T. A., Tower, J., Sieburth, D., & Davies, K. J. A. (2012) · Journal of Experimental Biology · doi:10.1242/jeb.074757 · Cited by 96 · see citing works

Caretaker or undertaker? The role of the proteasome in aging

Gaczynska, M. E., Osmulski, P. A., & Ward, W. F. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00246-3 · Cited by 83 · see citing works

The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis

Kuhlbrodt, K., Janiesch, P. C., Kevei, É., Segref, A., Barikbin, R., & Hoppe, T. (2011) · Nature Cell Biology · doi:10.1038/ncb2200 · Cited by 81 · see citing works

Enhancing protein disaggregation restores proteasome activity in aged cells

Andersson, V., Hanzén, S., Liu, B., Molin, M., & Nyström, T. (2013) · Aging · doi:10.18632/aging.100613 · Cited by 81 · see citing works

The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging

Leiser, S. F., & Kaeberlein, M. R. (2010) · Biological Chemistry · doi:10.1515/bc.2010.123 · Cited by 77 · see citing works

The stationary phase model of aging in yeast for the study of oxidative stress and age-related neurodegeneration

Chen, Q., Ding, Q., & Keller, J. N. (2005) · Biogerontology · doi:10.1007/s10522-004-7379-6 · Cited by 71 · see citing works

Insulin/IGF-1 Signaling Regulates Proteasome Activity through the Deubiquitinating Enzyme UBH-4

Matilainen, O., Arpalahti, L., Rantanen, V., Hautaniemi, S., & Holmberg, C. I. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.012 · Cited by 67 · see citing works

Cellular aging is associated with increased ubiquitylation of histone H2B in yeast telomeric heterochromatin

Rhie, B., Song, Y.-H., Ryu, H., & Ahn, S. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.09.017 · Cited by 43 · see citing works

E3Net: A System for Exploring E3-mediated Regulatory Networks of Cellular Functions

Han, Y.-W., Lee, H.-D., Park, J. C., & Yi, G. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.o111.014076 · Cited by 40 · see citing works

Ubiquilin-1 Overexpression Increases the Lifespan and Delays Accumulation of Huntingtin Aggregates in the R6/2 Mouse Model of Huntington's Disease

Safren, N., Ayadi, A. E., Chang, L., Terrillion, C. E., Gould, T. D., Boehning, D. F., & Monteiro, M. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087513 · Cited by 40 · see citing works

Mutation in E1, the Ubiquitin Activating Enzyme, Reduces Drosophila Lifespan and Results in Motor Impairment

Liu, H.-Y., & Pfleger, C. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0032835 · Cited by 37 · see citing works

Altered intracellular protein degradation in aging: A possible cause of proliferative arrest

Dice, J. F. (1989) · Experimental Gerontology · doi:10.1016/0531-5565(89)90051-x · Cited by 34 · see citing works

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Zhong, Q., Xiao, X., Qiu, Y., Xu, Z., Chen, C., Chong, B., Zhao, X., Hai, S., Li, S., An, Z., et al. (2023) · MedComm · doi:10.1002/mco2.261 · Cited by 442 · see citing works

The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging‐Related Diseases from Eukaryotic and Prokaryotic Model Organisms

Santos, A. L., Sinha, S., & Lindner, A. B. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1941285 · Cited by 168 · see citing works

Glucose Transporter 1–Dependent Glycolysis Is Increased during Aging-Related Lung Fibrosis, and Phloretin Inhibits Lung Fibrosis

Cho, S. J., Moon, J.-S., Lee, C.-M., Choi, A. M. K., & Stout-Delgado, H. W. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0225oc · Cited by 133 · see citing works

Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity

Ma, S., Upneja, A., Galecki, A., Tsai, Y.-M., Burant, C. F., Raskind, S., Zhang, Q., Zhang, Z. D., Seluanov, A., Gorbunova, V., et al. (2016) · eLife · doi:10.7554/elife.19130 · Cited by 89 · see citing works

Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology

Tramutola, A., Di Domenico, F., Barone, E., Arena, A., Giorgi, A., di Francesco, L., Schininà, M. E., Coccia, R., Head, E., Butterfield, D. A., et al. (2017) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2016.6686 · Cited by 49 · see citing works

GHK and DNA: Resetting the human genome to health

Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2014) · BioMed Research International · doi:10.1155/2014/151479 · Cited by 39 · see citing works

Loss of <i>Fis1</i> impairs proteostasis during skeletal muscle aging in <i>Drosophila</i>

Lee, T., Chen, P., Su, M. P., Li, J., Chang, Y., Liu, R., Juan, H., Yang, J., Chan, S., Tsai, Y., et al. (2021) · Aging Cell · doi:10.1111/acel.13379 · Cited by 27 · see citing works

Life and destruction: ubiquitin-mediated proteolysis in aging and longevity

Hoppe, T. (2010) · F1000 Biology Reports · doi:10.3410/b2-79 · Cited by 13 · see citing works

Interplay between the Ubiquitin Proteasome System and Ubiquitin-Mediated Autophagy in Plants

Su, T., Yang, M., Wang, P., Zhao, Y., & Ma, C. (2020) · Cells · doi:10.3390/cells9102219 · Cited by 49 · see citing works

Feeding the machine: mechanisms of proteasome-catalyzed degradation of ubiquitinated proteins

Crews, C. M. (2003) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(03)00104-2 · Cited by 3 · see citing works

Ubiquitin conjugating enzymes in the regulation of the autophagy-dependent degradation pathway

Ikeda, F. (2020) · Matrix Biology · doi:10.1016/j.matbio.2020.11.004 · Cited by 16 · see citing works

Selective autophagy: ubiquitin-mediated recognition and beyond

Kraft, C., Peter, M., & Hofmann, K. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-836 · Cited by 639 · see citing works