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Bupropion SR Enhances Weight Loss: A 48‐Week Double‐Blind, Placebo‐ Controlled Trial

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Anderson, James W., Greenway, Frank L., Fujioka, Ken, Gadde, Kishore M., McKenney, James, O'Neil, Patrick M.·2002·Obesity Research
DOI 10.1038/oby.2002.86
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Abstract

Objective: To critically examine the efficacy of bupropion SR for weight loss. Research Methods and Procedures: This 24‐week multicenter, double‐blind, placebo‐controlled study randomized obese adults to placebo, bupropion SR 300, or 400 mg/d. Subjects were counseled on energy‐restricted diets, meal replacements, and exercise. During a 24‐week extension, placebo subjects were randomized to bupropion SR 300 or 400 mg/d in a double‐blinded manner. Results: Of 327 subjects enrolled, 227 completed 24 weeks; 192 completed 48 weeks. Percentage losses of initial body weight for subjects completing 24 weeks were 5.0%, 7.2%, and 10.1% for placebo, bupropion SR 300, and 400 mg/d, respectively. Compared with placebo, net weight losses were 2.2% (p = 0.0468) and 5.1% (p < 0.0001) for bupropion SR 300 and 400 mg/d, respectively. The percentages of subjects who lost ≥5% of initial body weight were 46%, 59%, and 83% (p vs. placebo < 0.0001) for placebo, bupropion SR 300, and 400 mg/d, respectively; weight losses of ≥10% were 20%, 33%, and 46% (p vs. placebo = 0.0008) for placebo, bupropion SR 300, and 400 mg/d, respectively. Withdrawals, changes in pulse and blood pressure did not differ significantly from placebo at 24 weeks. Subjects who completed 48 weeks maintained mean losses of initial body weight of 7.5% and 8.6% for bupropion SR 300 and 400 mg/d, respectively. Discussion: Bupropion SR 300 and 400 mg/d were well‐tolerated by obese adults and were associated with a 24‐week weight loss of 7.2% and 10.1% and sustained weight losses at 48 weeks.

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  1. [8]8. Hollander P, Elbein S, Hirsch I, et al. Role of orlistat in the treatment of obese patients with Type 2 diabetes. Diabetes Care. 1998;21:1288 -94.
  2. [11]11. Croft H, Houser T, Jamerson B, et al. Lack of weight gain in patients taking bupropion SR: a 1-year placebo-controlled study in patients with major depression. Obes Res. 2000; 9:47S.
  3. [16]16. Little R. Missing data. In: Armitage P, Colton T, eds. Ency- clopedia of Biostatistics. Chichester, NY: John Wiley; 1998, pp. 2622-35.
  4. [25]25. Ferris R, Cooper B. Mechanisms of antidepressant activity of bupropion. J Clin Psychiatry Monograph. 1993;11:2-14.
  5. [28]28. Grilo C. The role of physical activity in weight loss and weight loss management. Med Exerc Nutr Health. 1995; 4:60 -76.
  6. [39]39. Bupropion SR Enhances Weight Loss, Anderson et al. OBESITY RESEARCH Vol. 10 No. 7 July 2002 641 15508528, 2002, 7, Downloaded from https://onlinelibrary.wiley.com/doi/10.1038/oby.2002.86, Wiley Online Library on [18/08/2026]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

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Authors
Anderson, J. W., Greenway, F. L., Fujioka, K., Gadde, K. M., McKenney, J., & O'Neil, P. M.
Affiliations
  • University of Kentucky (US)
  • Pennington Biomedical Research Center (US)
  • Scripps Health (US)
  • Duke University (US)
  • Virginia Commonwealth University (US)
  • Medical University of South Carolina (US)
Corresponding author
Anderson, James W.
ORCID
Venue
Obesity Research
Publisher
Wiley
Published
2002-07
Volume
10
Issue
7
Pages
633-641
ISSN
  • 1071-7323 (ISSN-L)
  • 1550-8528
DOI
10.1038/oby.2002.86
OpenAlex
W2137700844
Semantic Scholar
afcabe0945aa1c19e393761cf39f4a47f4eeb73d
Cited by
315
References
34
Citations by year
2026: 5 · 2025: 5 · 2024: 7 · 2023: 9 · 2022: 6 · 2021: 6 · 2020: 8 · 2019: 11 · 2018: 5 · 2017: 11 · 2016: 14 · 2015: 9 · 2014: 20 · 2013: 15 · 2012: 14
FWCI
11.51
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3720 d)
Locations
  • Obesity Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
bupropion, bupropion sustained release, weight loss, obesity, appetite suppressants, hypocaloric diet, meal replacement, physical activity, weight maintenance, tolerability, blood pressure, pulse rate
MeSH terms
Adolescent, Adult, Blood Glucose, Blood Pressure, Body Constitution, Delayed-Action Preparations, Diet, Reducing, Double-Blind Method, Female, Humans, Cholesterol, HDL, Male, Middle Aged, Obesity, Placebos, Pulse, Weight Loss, Exercise, Bupropion

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