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Cited by 74Blood Pressure and Hypertension StudiesCardiovascular and exercise physiologyHeart Rate Variability and Autonomic Control

Abnormal Neurovascular Control during Sympathoexcitation in Obesity

Kuniyoshi, Fátima H.S., Trombetta, Ivani C., Batalha, Luciana T., Rondon, Maria U.P.B., Laterza, Mateus C., Gowdak, Márcia M.G., Barretto, Antonio C.P., Halpern, Alfredo +3 more·2003·Obesity Research
DOI 10.1038/oby.2003.190
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Abstract

Objective: We tested the hypothesis that muscle sympathetic nerve activity (MSNA) and forearm vascular resistance (FVR) would be augmented during mental stress or cold pressor test in healthy obese individuals compared with healthy lean individuals. Research Methods and Procedures: Twenty‐nine healthy obese women and 12 age‐matched healthy lean women were involved in the study. MSNA was directly measured from the peroneal nerve using microneurography. Forearm blood flow was measured by venous occlusion plethysmography. Blood pressure (BP) was monitored noninvasively by an automatic BP cuff, and heart rate (HR) was measured by electrocardiogram. Stroop color word test was performed for 4 minutes, and the cold pressor test was performed for 2 minutes. Results: Baseline MSNA and FVR were greater in the obese group than in the lean group. BP and HR were similar between groups. During mental stress, MSNA and FVR were greater in obese individuals than in lean individuals, although the magnitude of response was similar between groups. BP and HR similarly increased in obese and lean individuals. During the cold pressor test, MSNA, FVR, and BP were greater in obese individuals, but the magnitude of response was similar between groups. HR increased similarly during the cold pressor test in both obese and lean individuals. Discussion: Obesity increases MSNA and FVR during mental stress and the cold pressor test. This inappropriate neurovascular control can be expected to have an adverse effect on the risk factors for cardiovascular events and, hence, should be considered in the treatment of obese patients.

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Authors
Kuniyoshi, F. H. S., Trombetta, I. C., Batalha, L. T., Rondon, M. U. P. B., Laterza, M. C., Gowdak, M. M. G., Barretto, A. C. P., Halpern, A., Villares, S. M. F., Lima, E. G., & Negrão, C. E.
Affiliations
  • Universidade de São Paulo (BR)
  • Universidade Federal do Espírito Santo (BR)
Corresponding author
Negrão, Carlos E.
ORCID
Venue
Obesity Research
Publisher
Wiley
Published
2003-11
Volume
11
Issue
11
Pages
1411-1419
ISSN
  • 1071-7323 (ISSN-L)
  • 1550-8528
DOI
10.1038/oby.2003.190
OpenAlex
W1970643432
Cited by
74
References
27
Citations by year
2025: 2 · 2024: 3 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 10 · 2013: 6 · 2012: 5
FWCI
1.98
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3232 d)
Locations
  • Obesity Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fundação de Amparo à Pesquisa do Estado de São Paulo
  • Universidade de São Paulo
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
obesity, muscle sympathetic nerve activity, forearm vascular resistance, sympathetic nervous system, neurovascular control, psychological stress, cold pressor test, blood pressure, heart rate, forearm blood flow, cardiovascular risk
MeSH terms
Adult, Blood Pressure, Cold Temperature, Female, Forearm, Heart Rate, Humans, Immersion, Muscles, Obesity, Peroneal Nerve, Plethysmography, Stress, Psychological, Sympathetic Nervous System, Vascular Resistance

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