Long-term variability and reproducibility of resting human muscle nerve sympathetic activity at rest, as reassessed after a decade
Abstract
Human muscle nerve sympathetic activity measured by microneurography during supine rest is known to vary considerably between healthy subjects, whereas in a given individual the level of muscle nerve sympathetic activity is stable over weeks and months. To further characterize long-term variability or reproducibility microneurographic recordings of muscle nerve sympathetic activity were performed in 15 healthy, normotensive subjects (mean age 51 years) who had undergone the same procedure between 10 and 14 years earlier (mean 12 years). The range of muscle nerve sympathetic activity was 9-59 in the first and 13-61 bursts/min in the second recording. Subjects maintained the level of muscle nerve sympathetic activity displayed previously, although with a slight but significant tendency to a higher outflow with increasing age. It is concluded that muscle nerve sympathetic activity is characterized by large inter-individual differences and strong intra-individual reproducibility over many years, with a tendency to increase with age. The age relationship is only in a minor part responsible for the variability, the cause of which remains unexplained. Because of the marked difference between individuals, strict normality criteria are difficult to define when comparing groups of subjects. There remains the risk of either obtaining spurious differences or obscuring a true abnormality. This is unlikely to apply when results in individual subjects are compared.
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In a controlled environment, MSNA is very stable within subjects, even over several weeks to months.
“However, in a controlled environment, MSNA is very stable within subjects, even over several weeks to months (13, 44).”
From Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans (2008) · cites this paper as [13]
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- Authors
- Fagius, J., & Wallin, B. G.
- Affiliations
- Uppsala University Hospital (SE)
- Sahlgrenska University Hospital (SE)
- ORCID
- Fagius, Jan
- Venue
- Clinical Autonomic Research
- Published
- 1993-06
- Volume
- 3
- Issue
- 3
- Pages
- 201-205
- ISSN
- 0959-9851 (ISSN-L)
- 1619-1560
- OpenAlex
- W2004644362
- Cited by
- 227
- References
- 30
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 14 · 2019: 6 · 2018: 8 · 2017: 11 · 2016: 7 · 2015: 10 · 2014: 8 · 2013: 11 · 2012: 11
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Clinical Autonomic Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- sympathetic activity, long-term variability, reproducibility, individual differences, intra-individual stability, aging, supine rest, microneurography, autonomic nervous system
- MeSH terms
- Adult, Aged, Aging, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuromuscular Junction, Reference Values, Rest, Sympathetic Nervous System, Reproducibility of Results
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