AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome
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Malonyl CoA represses CPT1 to inhibit acylcarnitine import, and its levels dictate the balance of fat synthesis or oxidation within a cell.
“Malonyl CoA, generated by the enzyme acetyl CoA carboxylase (ACC), represses CPT1 to inhibit acylcarnitine import.53 Malonyl CoA is the initiating metabolite for FAS, and its levels dictate the balance of fat synthesis or oxidation within a cell.”
From The multifaceted contributions of mitochondria to cellular metabolism (2018) · cites this paper as [53]
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- Authors
- Ruderman, N., & Prentki, M.
- Affiliations
- Boston University (US)
- Centre Hospitalier de l’Université de Montréal (CA)
- Venue
- Nature Reviews Drug Discovery
- Published
- 2004-04-01
- Volume
- 3
- Issue
- 4
- Pages
- 340-351
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W1983336199
- Semantic Scholar
- ff013aa7272ad9b1a90aa52d7a0383e343b6f8ec
- Cited by
- 451
- References
- 168
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 12 · 2023: 11 · 2022: 23 · 2021: 17 · 2020: 19 · 2019: 21 · 2018: 13 · 2017: 22 · 2016: 19 · 2015: 14 · 2014: 27 · 2013: 22 · 2012: 21
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- AMPK, malonyl-CoA, metabolic syndrome, insulin resistance, obesity, fatty acid metabolism, ectopic fat deposition, AMPK activators, therapeutic target, type 2 diabetes, atherosclerosis
- MeSH terms
- Adenylate Kinase, Animals, Fatty Acids, Humans, Malonyl Coenzyme A, Signal Transduction, Metabolic Syndrome
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