Cited by 15Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityCardiovascular Function and Risk Factors

Left Ventricular Mass and +276 G/G Single Nucleotide Polymorphism of the Adiponectin Gene in Uncomplicated Obesity

Iacobellis, Gianluca, Petrone, Antonio, Leonetti, Frida, Buzzetti, Raffaella·2006·Obesity

Abstract

The single nucleotide polymorphism at position 276 in the adiponectin gene (APM1/ACDC +276 G>T) and left ventricular mass (LVM) have been associated with increased cardiovascular risk. We sought to evaluate whether +276 G>T variants in the adiponectin gene are correlated with LVM in uncomplicated obese subjects. APM1/ACDC +276 G>T single nucleotide polymorphism, echocardiographic indexed LVM (LVM/body surface area and LVM/height 2.7), insulin sensitivity by euglycemic clamp, and plasma adiponectin levels were analyzed in 62 obese subjects without complications (51 women and 11 men; mean age, 34.2 ± 10.2 years; BMI, 38.6 ± 9.1 kg/m 2). Forty lean subjects formed the control group for LVM evaluation. We found 23 (37%) uncomplicated obese subjects with the APM1/ACDC +276 G/G genotype, 25 (40%) with the G/T genotype, and 14 (23%) with the T/T genotype. G/G uncomplicated obese subjects showed significant higher LVM/body surface area and LVM/height 2.7 (within the normal range in the majority of them) than uncomplicated obese subjects carrying the G/T and T/T genotypes (p < 0.01 and p < 0.05, respectively). This study showed that LVM is significantly higher in uncomplicated obese subjects carrying the G/G genotype at position 276 of the human adiponectin gene.

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Crossref · 10.1038/oby.2006.48

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  • Increased left ventricular mass was observed in uncomplicated obese subjects carrying the G/G genotype at position 276 of the human adiponectin gene.

    “Genetic studies have also pointed to an important role of adiponectin in heart failure with increased left ventricular mass observed in uncomplicated obese subjects carrying the G/G genotype at position 276 of the human adiponectin gene (154).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [154]

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Authors
Iacobellis, G., Petrone, A., Leonetti, F., & Buzzetti, R.
Affiliations
Sapienza University of Rome (IT)
Corresponding author
Buzzetti, Raffaella
Venue
Obesity
Publisher
Wiley
Published
2006-03
Volume
14
Issue
3
Pages
368-372
ISSN
  • 1930-7381 (ISSN-L)
  • 1930-739X
OpenAlex
W1997005357
Cited by
15
References
24
Citations by year
2021: 1 · 2019: 1 · 2018: 1 · 2013: 1 · 2012: 2
FWCI
0.98
Type
journal article
Language
en
Open access
closed
Locations
  • Obesity (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
left ventricular mass, adiponectin gene, genetic polymorphism, cardiovascular risk, insulin sensitivity, plasma adiponectin, echocardiography, genotype association
MeSH terms
Adult, Blood Glucose, Cardiovascular Diseases, Echocardiography, Female, Genotype, Heart Ventricles, Humans, Insulin, Male, Middle Aged, Obesity, Risk Factors, Body Mass Index, Polymorphism, Single Nucleotide, Adiponectin

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