Left Ventricular Mass and +276 G/G Single Nucleotide Polymorphism of the Adiponectin Gene in Uncomplicated Obesity
Abstract
The single nucleotide polymorphism at position 276 in the adiponectin gene (APM1/ACDC +276 G>T) and left ventricular mass (LVM) have been associated with increased cardiovascular risk. We sought to evaluate whether +276 G>T variants in the adiponectin gene are correlated with LVM in uncomplicated obese subjects. APM1/ACDC +276 G>T single nucleotide polymorphism, echocardiographic indexed LVM (LVM/body surface area and LVM/height 2.7), insulin sensitivity by euglycemic clamp, and plasma adiponectin levels were analyzed in 62 obese subjects without complications (51 women and 11 men; mean age, 34.2 ± 10.2 years; BMI, 38.6 ± 9.1 kg/m 2). Forty lean subjects formed the control group for LVM evaluation. We found 23 (37%) uncomplicated obese subjects with the APM1/ACDC +276 G/G genotype, 25 (40%) with the G/T genotype, and 14 (23%) with the T/T genotype. G/G uncomplicated obese subjects showed significant higher LVM/body surface area and LVM/height 2.7 (within the normal range in the majority of them) than uncomplicated obese subjects carrying the G/T and T/T genotypes (p < 0.01 and p < 0.05, respectively). This study showed that LVM is significantly higher in uncomplicated obese subjects carrying the G/G genotype at position 276 of the human adiponectin gene.
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Increased left ventricular mass was observed in uncomplicated obese subjects carrying the G/G genotype at position 276 of the human adiponectin gene.
“Genetic studies have also pointed to an important role of adiponectin in heart failure with increased left ventricular mass observed in uncomplicated obese subjects carrying the G/G genotype at position 276 of the human adiponectin gene (154).”
From Cardiac remodeling in obesity (2008) · cites this paper as [154]
Cites
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425 · see citing works
Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings
Devereux, R. B., Alonso, D. R., Lutas, E. M., Gottlieb, G. J., Campo, E., Sachs, I., & Reichek, N. (1986) · The American Journal of Cardiology · doi:10.1016/0002-9149(86)90771-x · Cited by 6,226 · see citing works
Koren, M. J., Devereux, R. B., Casale, P. N., Savage, D. D., & Laragh, J. H. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-5-345 · Cited by 2,366 · see citing works
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
Pischon, T. (2004) · JAMA · doi:10.1001/jama.291.14.1730 · Cited by 1,762 · see citing works
SIMONE, G. D., Daniels, S. R., Devereux, R. B., Meyer, R. A., Roman, M. J., DIVITIIS, O. D., & Alderman, M. H. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90385-z · Cited by 1,727 · see citing works
Association of Hypoadiponectinemia With Coronary Artery Disease in Men
Kumada, M., Kihara, S., Sumitsuji, S., Kawamoto, T., Matsumoto, S., Ouchi, N., Arita, Y., Okamoto, Y., Shimomura, I., Hiraoka, H., et al. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000048856.22331.50 · Cited by 1,419 · see citing works
Left Ventricular Mass and Incidence of Coronary Heart Disease in an Elderly Cohort
Levy, D. A., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-110-2-101 · Cited by 700 · see citing works
Devereux, R. B. (1987) · Hypertension · doi:10.1161/01.hyp.9.2_pt_2.ii19 · Cited by 552 · see citing works
Iacobellis, G., Pistilli, D., Gucciardo, M., Leonetti, F., Miraldi, F., Brancaccio, G., GALLO, P., & Gioia, C. R. T. D. (2005) · Cytokine · doi:10.1016/j.cyto.2004.11.002 · Cited by 445 · see citing works
Self-citationMenzaghi, C., Ercolino, T., Paola, R. D., Berg, A. H., Warram, J. H., Scherer, P. E., Trischitta, V., & Doria, A. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2306 · Cited by 426 · see citing works
Influence of Excess Fat on Cardiac Morphology and Function: Study in Uncomplicated Obesity
Iacobellis, G., Ribaudo, M. C., Leto, G., Zappaterreno, A., Vecci, E., Di Mario, U., & Leonetti, F. (2002) · Obesity Research · doi:10.1038/oby.2002.104 · Cited by 257 · see citing works
Self-citationPrevalence of Uncomplicated Obesity in an Italian Obese Population
Iacobellis, G., Ribaudo, M. C., Zappaterreno, A., Iannucci, C. V., & Leonetti, F. (2005) · Obesity Research · doi:10.1038/oby.2005.130 · Cited by 151 · see citing works
Self-citationBacci, S., Menzaghi, C., Ercolino, T., Ma, X., Rauseo, A., Salvemini, L., Vigna, C., Fanelli, R., Mario, U. D., Doria, A., et al. (2004) · Diabetes Care · doi:10.2337/diacare.27.8.2015 · Cited by 132 · see citing works
Filippi, E., Sentinelli, F., Romeo, S., Arca, M., Berni, A., Tiberti, C., Verrienti, A., Fanelli, M., Fallarino, M., Sorropago, G., et al. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0667-z · Cited by 124 · see citing works
Qi, L., Li, T., Rimm, E. B., Zhang, C., Rifai, N., Hunter, D., Doria, A., & Hu, F. B. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1607 · Cited by 122 · see citing works
González‐Sánchez, J. L., Zabena, C. A., Martínez‐Larrad, M. T., Fernández, C., Pérez‐Barba, M., Laakso, M., & Serrano‐Ríos, M. (2005) · Obesity Research · doi:10.1038/oby.2005.91 · Cited by 121 · see citing works
Hong, S. J., Park, C. G., Seo, H. S., Oh, D. J., & Ro, Y. M. (2004) · Blood Pressure · doi:10.1080/08037050410021397 · Cited by 121 · see citing works
Huang, J., Yen, C., Chiang, H.-W., Hung, K., Tsai, T., & Wu, K. (2004) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2004.02.017 · Cited by 115 · see citing works
Adapted Changes in Left Ventricular Structure and Function in Severe Uncomplicated Obesity
Iacobellis, G., Ribaudo, M. C., Zappaterreno, A., Iannucci, C. V., Di Mario, U., & Leonetti, F. (2004) · Obesity Research · doi:10.1038/oby.2004.201 · Cited by 89 · see citing works
Self-citationJang, Y., Lee, J. H., Chae, J. S., Kim, O., Koh, S. J., Kim, J. Y., Cho, H., Lee, J. E., & Ordovás, J. M. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.4.760 · Cited by 82 · see citing works
Relationship of Insulin Sensitivity and Left Ventricular Mass in Uncomplicated Obesity
Iacobellis, G., Ribaudo, M. C., Zappaterreno, A., Vecci, E., Tiberti, C., Mario, U. D., & Leonetti, F. (2003) · Obesity Research · doi:10.1038/oby.2003.73 · Cited by 82 · see citing works
Self-citationMea, P. D., Lupia, M., BANDOLIN, V., Guzzon, S., Sonino, N., Vettor, R., & Fallo, F. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.08.029 · Cited by 76 · see citing works
Iacobellis, G. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.09.012 · Cited by 34 · see citing works
Self-citationKazuo, K. A. R. A., Boutin, P., Mori, Y., Tobe, K., Christian Dina, C., Yasuda, K., Yamauchi, T., Otabe, S., Okada, T., 江藤一弘, et al. (2002) · Institutional Repositories DataBase (IRDB) · doi:10.2337/diabetes.51.2.536
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Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736 · see citing works
Adipose tissue: friend or foe?
Hassan, M. S., Latif, N., & Yacoub, M. H. (2012) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2012.148 · Cited by 142 · see citing works
Adiponectin and Mortality in Patients Undergoing Coronary Angiography
Pilz, S., Mangge, H., Wellnitz, B., Seelhorst, U., Winkelmann, B. R., Tiran, B., Boehm, B. O., & März, W. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0836 · Cited by 124 · see citing works
Adiponectin in Cardiovascular Inflammation and Obesity
Aprahamian, T. R., & Sam, F. (2011) · International Journal of Inflammation · doi:10.4061/2011/376909 · Cited by 122 · see citing works
Leu, H., Chung, C., Lin, S., Jong, Y.-S., Pan, W., & Chen, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019999 · Cited by 53 · see citing works
Central adiposity and left ventricular mass in obese children
Bonito, P. D., Capaldo, B., Forziato, C., Sanguigno, E., Fraia, T. D., Scilla, C., Cavuto, L., Saitta, F., Sibilio, G., & Moio, N. (2007) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.09.002 · Cited by 28 · see citing works
Genetic effects of adiponectin on blood lipids and blood pressure
Zhao, T., & Zhao, J. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03902.x · Cited by 27 · see citing works
Association of Adiponectin with Hypertension in Type 2 Diabetic Patients: the Gender Effect
Khabour, O. F., Wehaibi, S. H., Al-Azzam, S. I., Alzoubi, K. H., & El-Akawi, Z. J. (2012) · Clinical and Experimental Hypertension · doi:10.3109/10641963.2012.732645 · Cited by 17 · see citing works
Su, M., Jia, A., He, Y., & Song, Y. (2021) · Hormone and Metabolic Research · doi:10.1055/a-1543-6362 · Cited by 13 · see citing works
Radavelli‐Bagatini, S., Oliveira, I. O., Ramos, R. B., dos Santos, B. R., Wagner, M. S., Lecke, S. B., Gigante, D. P., Horta, B. L., & Spritzer, P. M. (2013) · PubMed · doi:10.3275/8966 · Cited by 12 · see citing works
Loss of Cardio-Protective Effects at the CDH13 Locus Due to Gene-Sleep Interaction: The BCAMS Study
Li, G., Feng, D., Wang, Y., Fu, J., Han, L., Li, L., Grant, S. F. A., Li, M., Li, M., & Gao, S. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.05.033 · Cited by 10 · see citing works
Adiponectin and its polymorphism: relation to coronary artery disease
Ghanem, N. S., Elsayed, N. M., Abbas, A. K., & Shaker, O. G. (2019) · The Egyptian Journal of Internal Medicine · doi:10.4103/ejim.ejim_11_19 · Cited by 1 · see citing works
Unraveling the paradoxical link between obesity and heart failure: the role of adipocytokines
Patel, J. V., Tracey, I., Hughes, E., & Lip, G. Y. H. (2009) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.09.12 · Cited by 1 · see citing works
Obesity and Cardiac Dysfunction
Sweeney, G., Litwin, S. E., & Abel, E. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_14
Puszkarska, A., & Głuszek, J. (2010)
- Authors
- Iacobellis, G., Petrone, A., Leonetti, F., & Buzzetti, R.
- Affiliations
- Sapienza University of Rome (IT)
- Corresponding author
- Buzzetti, Raffaella
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2006-03
- Volume
- 14
- Issue
- 3
- Pages
- 368-372
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W1997005357
- Cited by
- 15
- References
- 24
- Citations by year
- 2021: 1 · 2019: 1 · 2018: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- left ventricular mass, adiponectin gene, genetic polymorphism, cardiovascular risk, insulin sensitivity, plasma adiponectin, echocardiography, genotype association
- MeSH terms
- Adult, Blood Glucose, Cardiovascular Diseases, Echocardiography, Female, Genotype, Heart Ventricles, Humans, Insulin, Male, Middle Aged, Obesity, Risk Factors, Body Mass Index, Polymorphism, Single Nucleotide, Adiponectin
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