CoChat
Sign Up
Cited by 89Cardiovascular Function and Risk FactorsCardiovascular Disease and AdiposityCardiovascular Effects of Exercise

Adapted Changes in Left Ventricular Structure and Function in Severe Uncomplicated Obesity

Open access
Iacobellis, Gianluca, Ribaudo, Maria Cristina, Zappaterreno, Alessandra, Iannucci, Concetta Valeria, Di Mario, Umberto, Leonetti, Frida·2004·Obesity Research
DOI 10.1038/oby.2004.201
Open this paper in CoChat — free accountOpen PDF

Abstract

Objective: A massive amount of fat tissue, as that observed in obese subjects with BMI over 50 kg/m 2, could affect cardiac morphology and performance, but few data on this issue are available. We sought to evaluate cardiac structure and function in uncomplicated severely obese subjects. Research Methods and Procedures: We studied 55 uncomplicated severely obese patients, 40 women, 15 men, mean age 35.5 ± 10.2 years, BMI 51.2 ± 8.8 kg/m 2, range 43 to 81 kg/m 2, with a history of fat excess of at least 10 years, and 55 age‐matched normal‐weight subjects (40 women, 15 men, mean BMI 23.8 ± 1.2 kg/m 2) as a control group. Each subject underwent an echocardiogram to evaluate left ventricular (LV) mass and geometry and systolic and diastolic function. Results: Severely obese subjects showed greater LV mass and indexed LV mass than normal‐weight subjects (p < 0.01 for all parameters). Nevertheless, LV mass was appropriate for sex, height 2.7, and stroke work in most (77%) uncomplicated severely obese subjects. In addition, no significant difference in LV mass indices and LV mass appropriateness between obese subjects with BMI ≥ 50 kg/m 2 and those with BMI ≤ 50 kg/m 2 was found. Obese subjects also showed higher ejection fraction and midwall shortening than normal‐weight subjects (p = 0.05 and p < 0.01, respectively), suggesting a hyperdynamic systolic function. No significant difference in systolic performance between obese subjects with BMI ≥ 50 kg/m 2 and those with BMI ≤ 50 kg/m 2 was seen. Discussion: Our data show that uncomplicated severe obesity, despite the massive fat tissue amount, is associated largely with adapted and appropriate changes in cardiac structure and function.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/oby.2004.201

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A few studies suggest that LV mass may be increased in obesity, but that the increase is appropriate for body size if obesity is truly uncomplicated.

    “A few studies suggest that LV mass may be increased in obesity, but that the increase is appropriate for body size if obesity is truly “uncomplicated” (i.e., lack of comorbid conditions such as hypertension, diabetes, coronary artery disease, etc.) (151, 155, 156).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [156]

  • Both LV cavity size and wall thickness are increased in obese subjects compared with age-matched controls.

    “In addition, the results indicate that both LV cavity size and wall thickness are increased in obese subjects compared with age-matched controls (22, 134, 151, 156, 242, 279, 377).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [156]

  • More recent data confirm the increased prevalence of LV hypertrophy in obese subjects.

    “The more recent data confirm the increased prevalence of LV hypertrophy in obese subjects.”

    From Cardiac remodeling in obesity (2008) · cites this paper as [156]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. Crisostomo LL, Araujo LM, Camara E, et al. LV mass and function in young obese women. Int J Obes Relat Metab Disord. 2001;25:233-8.
  2. Mureddu GF, de Simone G, Greco R, Rosato GF, Con- taldo F. Left ventricular filling pattern in uncomplicated obe- sity. Am J Cardiol. 1996;77:509 -14.

Cited by

Sorted by citations

Related

Authors
Iacobellis, G., Ribaudo, M. C., Zappaterreno, A., Iannucci, C. V., Di Mario, U., & Leonetti, F.
Affiliations
Sapienza University of Rome (IT)
Corresponding author
Iacobellis, Gianluca
ORCID
Venue
Obesity Research
Publisher
Wiley
Published
2004-10
Volume
12
Issue
10
Pages
1616-1621
ISSN
  • 1071-7323 (ISSN-L)
  • 1550-8528
DOI
10.1038/oby.2004.201
OpenAlex
W2006786285
Cited by
89
References
29
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2018: 2 · 2016: 10 · 2015: 5 · 2014: 4 · 2013: 9 · 2012: 6
FWCI
3.05
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2897 d)
Locations
  • Obesity Research (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
Keywords
morbid obesity, left ventricular mass, left ventricular geometry, left ventricular function, systolic function, diastolic function, ejection fraction, cardiac hypertrophy, body mass index
MeSH terms
Adaptation, Physiological, Adult, Diastole, Echocardiography, Female, Heart, Hemodynamics, Humans, Male, Myocardium, Obesity, Morbid, Systole, Body Mass Index, Ventricular Function, Left

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review