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Wnt signaling in cancer
Open accessAbstract
Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components of Wnt pathways and describe their impact on cancer development. Furthermore, we highlight expanding functions of Wnt signaling for both solid and liquid tumors. We also describe current findings how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control. Finally, we provide an overview of current strategies to antagonize Wnt signaling in cancer and challenges that are associated with such approaches.
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“β-catenin, a critical mediator of the WNT signaling pathway, plays an important role in tumorigenesis.441–444”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [441]
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Metadata
- Authors
- Zhan, T., Rindtorff, N., & Boutros, M.
- Affiliations
- German Cancer Research Center (DE)
- Corresponding author
- Boutros, M
- Venue
- Oncogene
- Published
- 2016-09-12
- Volume
- 36
- Issue
- 11
- Pages
- 1461-1473
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- PMC
- PMC5357762
- OpenAlex
- W2520632143
- Cited by
- 2,626
- References
- 213
- Citations by year
- 2026: 136 · 2025: 230 · 2024: 273 · 2023: 348 · 2022: 382 · 2021: 380 · 2020: 321 · 2019: 274 · 2018: 181 · 2017: 80 · 2016: 15
- FWCI
- 16.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Oncogene (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Deutsches Krebsforschungszentrum
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- Wnt signaling, carcinogenesis, colorectal cancer, cancer stem cells, metastasis, liquid tumors, stemness
- MeSH terms
- Animals, Antineoplastic Agents, Cell Transformation, Neoplastic, Humans, Mutation, Neoplasm Metastasis, Neoplasms, Protein Binding, Neoplastic Stem Cells, Tumor Escape, Wnt Proteins, beta Catenin, Molecular Targeted Therapy, Wnt Signaling Pathway
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