Cited by 2,626Wnt/β-catenin signaling in development and cancerCancer Cells and MetastasisHedgehog Signaling Pathway Studies

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Wnt signaling in cancer

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Zhan, T, Rindtorff, N, Boutros, M·2017·Oncogene

DOI 10.1038/onc.2016.304PMC PMC5357762

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Abstract

Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components of Wnt pathways and describe their impact on cancer development. Furthermore, we highlight expanding functions of Wnt signaling for both solid and liquid tumors. We also describe current findings how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control. Finally, we provide an overview of current strategies to antagonize Wnt signaling in cancer and challenges that are associated with such approaches.

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Authors: Zhan, T., Rindtorff, N., & Boutros, M.
Affiliations: German Cancer Research Center (DE)
Corresponding author: Boutros, M
ORCID: Zhan, T
Rindtorff, N
Boutros, M
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2016-09-12
Volume: 36
Issue: 11
Pages: 1461-1473
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/onc.2016.304
PMC: PMC5357762
OpenAlex: W2520632143
Cited by: 2,626
References: 213
Citations by year: 2026: 136 · 2025: 230 · 2024: 273 · 2023: 348 · 2022: 382 · 2021: 380 · 2020: 321 · 2019: 274 · 2018: 181 · 2017: 80 · 2016: 15
FWCI: 16.55
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/4.0 (tdm)
Locations: Oncogene (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: Deutsches Krebsforschungszentrum
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
Keywords: Wnt signaling, carcinogenesis, colorectal cancer, cancer stem cells, metastasis, liquid tumors, stemness
MeSH terms: Animals, Antineoplastic Agents, Cell Transformation, Neoplastic, Humans, Mutation, Neoplasm Metastasis, Neoplasms, Protein Binding, Neoplastic Stem Cells, Tumor Escape, Wnt Proteins, beta Catenin, Molecular Targeted Therapy, Wnt Signaling Pathway

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