Caspase-2-mediated cell death is required for deleting aneuploid cells
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Caspase-2, one of the most evolutionarily conserved of the caspase family, has been implicated in maintenance of chromosomal stability and tumour suppression. Caspase-2 deficient ( Casp2 −/− ) mice develop normally but show premature ageing-related traits and when challenged by certain stressors, succumb to enhanced tumour development and aneuploidy. To test how caspase-2 protects against chromosomal instability, we utilized an ex vivo system for aneuploidy where primary splenocytes from Casp2 −/− mice were exposed to anti-mitotic drugs and followed up by live cell imaging. Our data show that caspase-2 is required for deleting mitotically aberrant cells. Acute silencing of caspase-2 in cultured human cells recapitulated these results. We further generated Casp2 C320S mutant mice to demonstrate that caspase-2 catalytic activity is essential for its function in limiting aneuploidy. Our results provide direct evidence that the apoptotic activity of caspase-2 is necessary for deleting cells with mitotic aberrations to limit aneuploidy.
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Casp2−/− mice accumulate aneuploid bone marrow cells with aging; Casp2−/− malignant cells have increased aneuploidy vs wild-type.
“In line with a key role for CASP2 in the control of mitotic proficiency, the bone marrow of Casp2−/− mice accumulates aneuploid cells with aging [985], and Casp2−/− malignant cells exhibit increased levels of aneuploidy as compared to their wild-type counterparts [982, 986, 987].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [982]
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TRIM25: A Global Player of Cell Death Pathways and Promising Target of Tumor-Sensitizing Therapies
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Caspase-2 as an Oncosupressor and Metabolism Regulator: What Life Will Bring over the Long Run?
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The Caspase Family of Proteases
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Self-citation
- Authors
- Dawar, S., Lim, Y., Puccini, J., White, M., Thomas, P., Bouchier-Hayes, L., Green, D. R., Dorstyn, L., & Kumar, S.
- Affiliations
- University of South Australia (AU)
- SA Genome Editing Facility (AU)
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Kumar, S
- Venue
- Oncogene
- Published
- 2016-12-19
- Volume
- 36
- Issue
- 19
- Pages
- 2704-2714
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- PMC
- PMC5442422
- OpenAlex
- W2564390156
- Cited by
- 66
- References
- 54
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 10 · 2017: 10 · 2016: 1
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Oncogene (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- UniSA Research Outputs Repository (University of South Australia) (submittedVersion, cc-by-nc-sa)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, cc-by-nc-sa)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-sa)
- Funders
- Medical Research Council
- National Health and Medical Research Council (1103006, 1043057)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- caspase-2, aneuploidy, mitotic aberrations, chromosome stability, apoptosis, cell death, premature aging, tumor suppression, antimitotic agents, mitotic catastrophe, catalytic activity
- MeSH terms
- Aneuploidy, Animals, Humans, Apoptosis, Mice, Knockout, Oxidative Stress, Chromosomal Instability, Mice, Caspase 2
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