Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm -deficient mice

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

Invited review: Oxidation of biological systems: Oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification

Kohen, R., & Nyska, A. (2002) · Toxicologic Pathology · doi:10.1080/01926230290166724 · Cited by 2,178 · see citing works

The DNA Damage Response: Ten Years After

Harper, J. W., & Elledge, S. J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.11.015 · Cited by 1,705 · see citing works

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

Shiloh, Y., & Ziv, Y. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3546 · Cited by 1,649 · see citing works

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

Barlow, C., Hirotsune, S., Paylor, R. E., Liyanage, M., Eckhaus, M., Collins, F. S., Shiloh, Y., Crawley, J. N., Ried, T., Tagle, D. A., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80086-0 · Cited by 1,450 · see citing works

ATM Activation by Oxidative Stress

Guo, Z., Kozlov, S., Lavin, M. F., Person, M. D., & Paull, T. T. (2010) · Science · doi:10.1126/science.1192912 · Cited by 1,079 · see citing works

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

Wang, L., Miura, M., Bergeron, L., Zhu, H., & Yuan, J. (1994) · Cell · doi:10.1016/s0092-8674(94)90422-7 · Cited by 836 · see citing works

Causes and consequences of aneuploidy in cancer

Gordon, D. J., Resio, B. J., & Pellman, D. S. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3123 · Cited by 818 · see citing works

Defects in regulation of apoptosis in caspase-2-deficient micePreprint

Bergeron, L., Perez, G. I., MacDonald, G., Shi, L., Sun, Y., Jurisicova, A., Varmuza, S., Latham, K. E., Flaws, J. A., Salter, J. C. M., et al. (1998) · Genes & Development · doi:10.1101/gad.12.9.1304 · Cited by 681 · see citing works

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.Preprint

Kumar, S., Kinoshita, M., Noda, M., Copeland, N. G., & Jenkins, N. A. (1994) · Genes & Development · doi:10.1101/gad.8.14.1613 · Cited by 595 · see citing works

Identification of a set of genes with developmentally down-regulated expression in the mouse brain

Kumar, S., Tomooka, Y., & Noda, M. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91747-e · Cited by 552 · see citing works

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

Elson, A., Wang, Y., Daugherty, C., Morton, C. C., Zhou, F., Campos-Torres, J., & Leder, P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13084 · Cited by 498 · see citing works

ATM activates the pentose phosphate pathway promoting anti‐oxidant defence and DNA repair

Cosentino, C., Grieco, D., & Costanzo, V. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.330 · Cited by 436 · see citing works

The ATM–p53 pathway suppresses aneuploidy-induced tumorigenesis

Li, M., Fang, X., Baker, D. J., Guo, L., Gao, X., Wei, Z., Han, S., van Deursen, J. M., & Zhang, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005960107 · Cited by 257 · see citing works

Loss of the ataxia–telangiectasia gene product causes oxidative damage in target organs

Barlow, C., Dennery, P. A., Shigenaga, M. K., Smith, M. A., Morrow, J. D., Roberts, L. J., Wynshaw-Boris, A. J., & Levine, R. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9915 · Cited by 246 · see citing works

Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice.

Kamsler, A., Daily, D., Hochman, A., Stern, N., Shiloh, Y., Rotman, G., & Barzilai, A. (2001) · PubMed · Cited by 235 · see citing works

Stress-Responsive Sestrins Link p53 with Redox Regulation and Mammalian Target of Rapamycin Signaling

Budanov, A. V. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3530 · Cited by 203 · see citing works

Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

O’Reilly, L. A., Ekert, P. G., Harvey, N. L., Marsden, V. S., Cullen, L., Vaux, D. L., Häcker, G. A., Magnusson, C., Pakusch, M., Cecconi, F., et al. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401033 · Cited by 191 · see citing works

A tumor suppressor function for caspase-2

Ho, L. H., Taylor, R. L., Dorstyn, L., Cakouros, D., Bouillet, P., & Kumar, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811928106 · Cited by 167 · see citing works

Abnormal rearrangement within the α/δ T-cell receptor locus in lymphomas from Atm-deficient mice

Liyanage, M., Ohler, Z. W., Barlow, C., Coleman, A., Pankratz, D. G., Anderson, S. M., Wynshaw-Boris, A. J., & Ried, T. (2000) · Blood · doi:10.1182/blood.v96.5.1940 · Cited by 154 · see citing works

Defective neurogenesis resulting from DNA ligase IV deficiency requires AtmPreprint

Lee, Y., Barnes, D. E., Lindahl, T. L., & McKinnon, P. J. (2000) · Genes & Development · doi:10.1101/gad.837100 · Cited by 144 · see citing works

Synthetic lethality between mutation in Atm and DNA-PK cs during murine embryogenesis

Gurley, K. E., & Kemp, C. J. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00048-3 · Cited by 142 · see citing works

Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability

Dorstyn, L., Puccini, J., Wilson, C. H., Shalini, S., Nicola, M., Moore, S., & Kumar, S. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2012.36 · Cited by 104 · see citing works

Involvement of p53 and p21 in Cellular Defects and Tumorigenesis in Atm−/− Mice

Xu, Y., Yang, E. M., Brugarolas, J., Jacks, T., & Baltimore, D. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4385 · Cited by 103 · see citing works

Caspase-2 deficiency enhances aging-related traits in mice

Zhang, Y., Padalecki, S. S., CHAUDHURI, A., deWaal, E., Goins, B., Grubbs, B. G., Ikeno, Y., Richardson, A. G., MUNDY, G., & HERMAN, B. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.030 · Cited by 96 · see citing works

Early Embryonic Lethality in PARP-1 AtmDouble-Mutant Mice Suggests a Functional Synergy in Cell Proliferation during Development

Murcia, J. M., Mark, M. P., Wendling, O., Wynshaw-Boris, A. J., & de MURCIA, G. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.5.1828-1832.2001 · Cited by 96 · see citing works

Caspase-2 as a tumour suppressor

Puccini, J., Dorstyn, L., & Kumar, S. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.87 · Cited by 95 · see citing works

Deficiency for the Ubiquitin Ligase UBE3B in a Blepharophimosis-Ptosis-Intellectual-Disability Syndrome

Basel‐Vanagaite, L., Dallapiccola, B., Ramírez‐Solis, R., Segref, A., Thiele, H., Edwards, A., Arends, M. J., Miró, X., White, J. K., Désir, J., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.10.011 · Cited by 93 · see citing works

Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice

Shalini, S., Dorstyn, L., Wilson, C., Puccini, J., Ho, L. H., & Kumar, S. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.13 · Cited by 87 · see citing works

Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice

Parsons, M. J., McCormick, L. L., Janke, L. J., Howard, A. G. A., Bouchier‐Hayes, L., & Green, D. R. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.38 · Cited by 71 · see citing works

PIDDosome-independent tumor suppression by Caspase-2

Manzl, C., Peintner, L., Krumschnabel, G., Bock, F. J., Labi, V., Drach, M. C., Newbold, A., Johnstone, R. W., & Villunger, A. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.54 · Cited by 64 · see citing works

Prenatal exposure to lipopolysaccharide results in neurodevelopmental damage that is ameliorated by zinc in mice

Chua, J. S. C., Cowley, C. J., Manavis, J., Rofe, A. M., & Coyle, P. V. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.10.002 · Cited by 43 · see citing works

Abnormal rearrangement within the α/δ T-cell receptor locus in lymphomas from Atm-deficient mice

Liyanage, M., Ohler, Z. W., Barlow, C., et al. (2000) · Blood · doi:10.1182/blood.v96.5.1940.h8001940_1940_1946 · Cited by 11 · see citing works

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works

Old, new and emerging functions of caspases

Shalini, S., Dorstyn, L., Dawar, S., & Kumar, S. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.216 · Cited by 1,267 · see citing works

Caspases Connect Cell-Death Signaling to Organismal Homeostasis

Galluzzi, L., López-Soto, A., Kumar, S., & Kroemer, G. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.020 · Cited by 350 · see citing works

Caspase-2-mediated cell death is required for deleting aneuploid cells

Dawar, S., Lim, Y., Puccini, J., White, M., Thomas, P., Bouchier-Hayes, L., Green, D. R., Dorstyn, L., & Kumar, S. (2017) · Oncogene · doi:10.1038/onc.2016.423 · Cited by 66 · see citing works

Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice

Dawar, S., Shahrin, N. H., Sladojevic, N., D'Andrea, R. J., Dorstyn, L., Hiwase, D. K., & Kumar, S. (2016) · Cell Death & Disease · doi:10.1038/cddis.2016.406 · Cited by 30 · see citing works

Identification of a new caspase homologue: caspase-14

de Craen, M. V., Loo, G., Pype, S., et al. (1998) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400444 · Cited by 143 · see citing works

Caspase cascade of apoptosis induced by satratoxin G in HL-60 cells: possible involvement of caspase-2 in direct activation of caspase-3

Nagase, M., KIMURA, J., Yoshizawa, T., et al. (2003) · JSM Mycotoxins · doi:10.2520/myco1975.2003.suppl3_255

Caspase-7: A protease involved in apoptosis and inflammation

Lamkanfi, M., & Kanneganti, T. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.09.013 · Cited by 294 · see citing works

Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling

Araya, L. E., Soni, I. V., Hardy, J. A., & Julien, O. (2021) · ACS Chemical Biology · doi:10.1021/acschembio.1c00456 · Cited by 146 · see citing works

Mechanisms of Caspase Activation

Liu, Q. (2006) · Xiandai shengwu yixue jinzhan · Cited by 1 · see citing works