The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Circular RNAs in cancer: opportunities and challenges in the field
Open accessAbstract
Circular RNA (circRNA) is a novel member of the noncoding cancer genome with distinct properties and diverse cellular functions, which is being explored at a steadily increasing pace. The list of endogenous circRNAs involved in cancer continues to grow; however, the functional relevance of the vast majority is yet to be discovered. In general, circRNAs are exceptionally stable molecules and some have been shown to function as efficient microRNA sponges with gene-regulatory potential. Many circRNAs are highly conserved and have tissue-specific expression patterns, which often do not correlate well with host gene expression. Here we review the current knowledge on circRNAs in relation to their implications in tumorigenesis as well as their potential as diagnostic and prognostic biomarkers and as possible therapeutic targets in future personalized medicine. Finally, we discuss future directions for circRNA cancer research and current caveats, which must be addressed to facilitate the translation of basic circRNA research into clinical use.
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Cites
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Circular RNAs are a large class of animal RNAs with regulatory potency
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Natural RNA circles function as efficient microRNA sponges
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Self-citationCircular RNAs are abundant, conserved, and associated with ALU repeats
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Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis
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Complementary Sequence-Mediated Exon Circularization
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Extensive translation of circular RNAs driven by N6-methyladenosine
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Transcriptome-wide Analysis of Regulatory Interactions of the RNA-Binding Protein HuR
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Cited by
The biogenesis, biology and characterization of circular RNAs
Kristensen, L. S., Andersen, M. S., Stagsted, L. V. W., Ebbesen, K. K., Hansen, T. B., & Kjems, J. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0158-7 · Cited by 4,823
Self-citationThe role of non-coding RNAs in oncology
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The emerging roles of circRNAs in cancer and oncology
Kristensen, L. S., Jakobsen, T., Hager, H., & Kjems, J. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00585-y · Cited by 1,256
Self-citationProteogenomic Characterization of Endometrial Carcinoma
Dou, Y., Kawaler, E. A., Cui Zhou, D., Gritsenko, M. A., Huang, C., Blumenberg, L., Karpova, A., Petyuk, V. A., Savage, S. R., Satpathy, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.01.026 · Cited by 485
“Discovery of a Potential Role for circRNAs in EMT Regulation Circular RNAs (circRNAs) have recently drawn interest for their role in tumor biology (Chen et al., 2019; Dragomir and Calin, 2018; Hansen et al., 2013; Kristensen et al., 2018; Vo et al., 2019).”
BackgroundWang, X., Zhang, H., Yang, H., Bai, M., Ning, T., Deng, T., Liu, R., Fan, Q., Zhu, K., Li, J., et al. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12629 · Cited by 490
Metadata
- Authors
- Kristensen, L. S., Hansen, T. B., Venø, M. T., & Kjems, J.
- Venue
- Oncogene
- Published
- 2017-10-09
- Volume
- 37
- Issue
- 5
- Pages
- 555-565
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2764294957
- Cited by
- 1,326
- References
- 12
- FWCI
- 47.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
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