Proteogenomic Characterization of Endometrial Carcinoma
Open accessAbstract
We undertook a comprehensive proteogenomic characterization of 95 prospectively collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. This analysis revealed possible new consequences of perturbations to the p53 and Wnt/β-catenin pathways, identified a potential role for circRNAs in the epithelial-mesenchymal transition, and provided new information about proteomic markers of clinical and genomic tumor subgroups, including relationships to known druggable pathways. An extensive genome-wide acetylation survey yielded insights into regulatory mechanisms linking Wnt signaling and histone acetylation. We also characterized aspects of the tumor immune landscape, including immunogenic alterations, neoantigens, common cancer/testis antigens, and the immune microenvironment, all of which can inform immunotherapy decisions. Collectively, our multi-omic analyses provide a valuable resource for researchers and clinicians, identify new molecular associations of potential mechanistic significance in the development of endometrial cancers, and suggest novel approaches for identifying potential therapeutic targets.
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CPTAC and ICPC collaborators have comprehensively characterized 13 cancer types at the proteogenomics level, with all datasets publicly accessible.
“Collectively, CPTAC and ICPC collaborators have comprehensively characterized 13 cancer types at the proteogenomics level, with all datasets publicly accessible109–117.”
From A high-stringency blueprint of the human proteome (2020) · cites this paper as [110]
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“Circular RNAs (circRNAs) have recently drawn interest for their role in tumor biology (Chen et al., 2019; Dragomir and Calin, 2018; Hansen et al., 2013; Kristensen et al., 2018; Vo et al., 2019).”
BackgroundSelf-citationNCBI’s Database of Genotypes and Phenotypes: dbGaP
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Self-citationCyclin A-cdk1-Dependent Phosphorylation of Bora Is the Triggering Factor Promoting Mitotic Entry
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- Authors
- Dou, Y., Kawaler, E. A., Cui Zhou, D., Gritsenko, M. A., Huang, C., Blumenberg, L., Karpova, A., Petyuk, V. A., Savage, S. R., Satpathy, S., Liu, W., Wu, Y., Tsai, C.-F., Wen, B., Li, Z., Cao, S., Moon, J., Shi, Z., Cornwell, M., Wyczalkowski, M. A., Chu, R. K., Vasaikar, S., Zhou, H., Gao, Q., Moore, R. J., Li, K., Sethuraman, S., Monroe, M. E., Zhao, R., Heiman, D., Krug, K., Clauser, K., Kothadia, R., Maruvka, Y., Pico, A. R., Oliphant, A. E., Hoskins, E. L., Pugh, S. L., Beecroft, S. J. I., Adams, D. W., Jarman, J. C., Kong, A., Chang, H.-Y., Reva, B., Liao, Y., Rykunov, D., Colaprico, A., Chen, X. S., Czekański, A., Jędryka, M., Matkowski, R., Wiznerowicz, M., Hiltke, T., Boja, E., Kinsinger, C. R., Mesri, M., Robles, A. I., Rodriguez, H., Mutch, D., Fuh, K., Ellis, M. J., DeLair, D., Thiagarajan, M., Mani, D. R., Getz, G., Noble, M., Nesvizhskii, A. I., Wang, P., Anderson, M. L., Levine, D. A., Smith, R. D., Payne, S. H., Ruggles, K. V., Rodland, K. D., Ding, L., Zhang, B., Liu, T., Fenyö, D., Agarwal, A., Anurag, M., Avtonomov, D., Birger, C., Birrer, M. J., Boca, S. M., Bocik, W. E., Borate, U., Borucki, M., Burke, M. C., Cai, S., Calinawan, A., Carr, S. A., Carter, S., Castro, P., Cerda, S., Chaikin, M., Chan, D. W., Chan, D., Charamut, A., Chen, F., Chen, J., Chen, L., Chen, L. S., Chesla, D., Chheda, M. G., Chinnaiyan, A. M., Chowdhury, S., Cieslik, M. P., Clark, D. J., Cottingham, S., Culpepper, H., Day, J., De Young, S., Demir, E., Dhanasekaran, S. M., Dhir, R., Domagalski, M. J., Dottino, P., Druker, B., Duffy, E., Dyer, M., Edwards, N. J., Edwards, R., Elburn, K., Field, J. B., Francis, A., Gabriel, S., Geffen, Y., Geiszler, D., Gillette, M. A., Godwin, A. K., Grady, P., Hannick, L., Hariharan, P., Hilsenbeck, S., Hindenach, B., Hoadley, K. A., Hong, R., Hostetter, G., Hsieh, J. J., Hu, Y., Ittmann, M. M., Jaehnig, E., Jewell, S. D., Ji, J., Jones, C. D., Karabon, R., Ketchum, K. A., Khan, M., Kim, B.-J., Krek, A., Krubit, T., Kumar-Sinha, C., Leprevost, F. D., Lewis, M., Li, Q. K., Li, Y., Liu, H., Lubinski, J., Ma, W., Madan, R., Malc, E., Malovannaya, A., Mareedu, S., Markey, S. P., Marrero-Oliveras, A., Martignetti, J., McDermott, J., McGarvey, P. B., McGee, J., Mieczkowski, P., Modugno, F., Montgomery, R., Newton, C. J., Omenn, G. S., Paulovich, A. G., Perou, A. M., Petralia, F., Piehowski, P., Polonskaya, L., Qi, L., Richey, S., Robinson, K., Roche, N., Rohrer, D. C., Schadt, E. E., Schnaubelt, M., Shi, Y., Skelly, T., Sokoll, L. J., Song, X., Stein, S. E., Suh, J., Tan, D., Tansil, D., Teo, G. C., Thangudu, R. R., Tognon, C., Traer, E., Tyner, J., Um, K. S., Valley, D. R., Vatanian, N., Vats, P., Velvulou, U., Vernon, M., Wang, L.-B., Wang, Y., Webster, A., Westbrook, T., Wheeler, D., Whiteaker, J. R., Wilson, G. D., Zakhartsev, Y., Zelt, R., Zhang, H., Zhang, Y., Zhang, Z., & Zhao, G.
- Affiliations
- Baylor College of Medicine (US)
- NYU Langone Health (US)
- Pacific Northwest National Laboratory (US)
- Washington University in St. Louis (US)
- Broad Institute (US)
- The University of Texas MD Anderson Cancer Center (US)
- Gladstone Institutes (US)
- Brigham Young University (US)
- University of Michigan (US)
- Icahn School of Medicine at Mount Sinai (US)
- University of Miami (US)
- Wroclaw Medical University (PL)
- Poznan University of Medical Sciences (PL)
- National Cancer Institute (US)
- Frederick National Laboratory for Cancer Research (US)
- University of South Florida (US)
- Corresponding author
- Rodland, Karin D.
- Ding, Li
- Zhang, Bing
- Liu, Tao
- Fenyö, David
- ORCID
- Dou, Yongchao
- Kawaler, Emily A.
- Huang, Chen
- Blumenberg, Lili
- Karpova, Alla
- Petyuk, Vladislav A.
- Savage, Sara R.
- Satpathy, Shankha
- Liu, Wenke
- Wu, Yige
- Tsai, Chia-Feng
- Wen, Bo
- Li, Zhi
- Cao, Song
- Moon, Jamie
- Shi, Zhiao
- Cornwell, MacIntosh
- Wyczalkowski, Matthew A.
- Chu, Rosalie K.
- Vasaikar, Suhas
- Zhou, Hua
- Gao, Qingsong
- Moore, Ronald J.
- Li, Kai
- Sethuraman, Sunantha
- Monroe, Matthew E.
- Zhao, Rui
- Heiman, David
- Krug, Karsten
- Clauser, Karl
- Kothadia, Ramani
- Maruvka, Yosef
- Pico, Alexander R.
- Hoskins, Emily L.
- Pugh, Samuel L.
- Kong, Andy
- Chang, Hui-Yin
- Reva, Boris
- Liao, Yuxing
- Rykunov, Dmitry
- Colaprico, Antonio
- Chen, Xi Steven
- Czekański, Andrzej
- Jędryka, Marcin
- Matkowski, Rafał
- Wiznerowicz, Maciej
- Hiltke, Tara
- Boja, Emily
- Kinsinger, Christopher R.
- Mesri, Mehdi
- Robles, Ana I.
- Rodriguez, Henry
- Mutch, David
- Fuh, Katherine
- Ellis, Matthew J.
- DeLair, Deborah
- Thiagarajan, Mathangi
- Mani, D.R.
- Getz, Gad
- Noble, Michael
- Nesvizhskii, Alexey I.
- Wang, Pei
- Anderson, Matthew L.
- Levine, Douglas A.
- Smith, Richard D.
- Payne, Samuel H.
- Ruggles, Kelly V.
- Rodland, Karin D.
- Ding, Li
- Zhang, Bing
- Liu, Tao
- Fenyö, David
- Agarwal, Anupriya
- Anurag, Meenakshi
- Avtonomov, Dmitry
- Birrer, Michael J.
- Boca, Simina M.
- Bocik, William E.
- Borate, Uma
- Burke, Meghan C.
- Cai, Shuang
- Calinawan, Anna
- Carr, Steven A.
- Chan, Daniel W.
- Chan, Doug
- Chen, Feng
- Chen, Lijun
- Chheda, Milan G.
- Chinnaiyan, Arul M.
- Chowdhury, Shrabanti
- Cieslik, Marcin P.
- Clark, David J.
- Demir, Emek
- Dhanasekaran, Saravana Mohan
- Dhir, Rajiv
- Domagalski, Marcin J.
- Druker, Brian
- Duffy, Elizabeth
- Dyer, Maureen
- Edwards, Nathan J.
- Edwards, Robert
- Francis, Alicia
- Gabriel, Stacey
- Geffen, Yifat
- Geiszler, Daniel
- Gillette, Michael A.
- Godwin, Andrew K.
- Hannick, Linda
- Hoadley, Katherine A.
- Hong, Runyu
- Hostetter, Galen
- Hsieh, James J.
- Hu, Yingwei
- Ittmann, Michael M.
- Jaehnig, Eric
- Jewell, Scott D.
- Ji, Jiayi
- Jones, Corbin D.
- Ketchum, Karen A.
- Kim, Beom-Jun
- Krek, Azra
- Leprevost, Felipe D.
- Li, Qing Kay
- Li, Yize
- Liu, Hongwei
- Ma, Weiping
- Madan, Rashna
- Malc, Ewa
- Malovannaya, Anna
- McGarvey, Peter B.
- Mieczkowski, Piotr
- Modugno, Francesmary
- Omenn, Gilbert S.
- Paulovich, Amanda G.
- Petralia, Francesca
- Piehowski, Paul
- Rohrer, Daniel C.
- Schadt, Eric E.
- Schnaubelt, Michael
- Shi, Yan
- Sokoll, Lori J.
- Song, Xiaoyu
- Stein, Stephen E.
- Suh, James
- Teo, Guo Ci
- Thangudu, Ratna R.
- Tognon, Cristina
- Traer, Elie
- Tyner, Jeffrey
- Vats, Pankaj
- Wang, Liang-Bo
- Wang, Ying
- Westbrook, Thomas
- Wheeler, David
- Whiteaker, Jeffrey R.
- Wilson, George D.
- Zhang, Hui
- Zhang, Yuping
- Zhang, Zhen
- Zhao, Grace
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 180
- Issue
- 4
- Pages
- 729-748.e26
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC7233456
- OpenAlex
- W3006211741
- Cited by
- 485
- References
- 188
- Citations by year
- 2026: 47 · 2025: 67 · 2024: 82 · 2023: 93 · 2022: 80 · 2021: 82 · 2020: 33
- FWCI
- 45.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- School of Medicine, New York University
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Keywords
- endometrial cancer, proteogenomics, endometrioid carcinoma, serous carcinoma, p53 pathway, Wnt/β-catenin signaling, circular RNA, epithelial-mesenchymal transition, histone acetylation, tumor immune microenvironment, neoantigens, cancer-testis antigens, immunotherapy, therapeutic target, tumor subtypes
- MeSH terms
- Acetylation, Animals, Antigens, Neoplasm, Carcinoma, Female, Humans, Phosphorylation, Protein Processing, Post-Translational, Signal Transduction, Gene Expression Regulation, Neoplastic, Endometrial Neoplasms, Microsatellite Repeats, Proteome, Feedback, Physiological, MicroRNAs, Genomic Instability, Mice, Epithelial-Mesenchymal Transition, Transcriptome
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