The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Adipocyte-derived exosomal miRNAs: a novel mechanism for obesity-related disease
Open accessAbstract
Background:Obesity is frequently complicated by comorbid conditions, yet how excess adipose contributes is poorly understood. Although adipocytes in obese individuals induce systemic inflammation via secreted cytokines, another potential mediator has recently been identified (i.e., adipocyte-derived exosomes). We hypothesized that adipocyte-derived exosomes contain mediators capable of activating end-organ inflammatory and fibrotic signaling pathways.Methods:We developed techniques to quantify and characterize exosomes shed by adipocytes from seven obese (age: 12–17.5 y, BMI: 33–50 kg/m2) and five lean (age: 11–19 y, BMI: 22–25 kg/m2) subjects.Results:Abundant exosomal miRNAs, but no mRNAs, were detected. Comparison of obese vs. lean visceral adipose donors detected 55 differentially expressed miRNAs (P < 0.05; fold change ≥|1.2|). qRT-PCR confirmed downregulation of miR-148b (ratio = 0.2 (95% confidence interval = 0.1, 0.6)) and miR-4269 (0.3 (0.1, 0.8)), and upregulation of miR-23b (6.2 (2.2, 17.8)) and miR-4429 (3.8 (1.1−13.4)). Pathways analysis identified TGF-β signaling and Wnt/β-catenin signaling among the top canonical pathways expected to be altered with visceral adiposity based on projected mRNA targets for the 55 differentially expressed miRNAs. A select mRNA target was validated in vitro.Conclusion:These data show that visceral adipocytes shed exosomal-mediators predicted to regulate key end-organ inflammatory and fibrotic signaling pathways.
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“Previous studies showed that visceral adipocytes promote systemic inflammation by secreting mediators such as interleukin (IL)6, tumor necrosis factor (TNF)-α, and leptin, among others (5).”
InfluentialDelivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection
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Cited by
Gurunathan, S., Kang, M.-H., Jeyaraj, M., Qasim, M., & Kim, J.-H. (2019) · Cells · doi:10.3390/cells8040307 · Cited by 1,122
Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease
Mori, M. A., Ludwig, R. G., Garcia-Martin, R., Brandão, B. B., & Kahn, C. R. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.011 · Cited by 961
Exosomes as mediators of intercellular crosstalk in metabolism
Isaac, R., Reis, F. C. G., Ying, W., & Olefsky, J. M. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.006 · Cited by 820
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Exosome engineering: Current progress in cargo loading and targeted delivery
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Metadata
- Authors
- Ferrante, S. C., Nadler, E. P., Pillai, D. K., Hubal, M. J., Wang, Z., Wang, J. M., Gordish-Dressman, H., Koeck, E., Sevilla, S., Wiles, A. A., & Freishtat, R. J.
- Venue
- Pediatric Research
- Published
- 2014-12-17
- Volume
- 77
- Issue
- 3
- Pages
- 447-454
- ISSN
- 0031-3998 (ISSN-L)
- 1530-0447
- OpenAlex
- W2055412943
- Cited by
- 305
- References
- 39
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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