Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling

Analysis of protein-coding genetic variation in 60,706 humans

Exome Aggregation Consortium, Lek, M., Karczewski, K. J., Minikel, E. V., Samocha, K. E., Banks, E., Fennell, T., O’Donnell-Luria, A. H., Ware, J. S., Hill, A. J., et al. (2016) · Nature · doi:10.1038/nature19057 · Cited by 9,587 · see citing works

The contribution of de novo coding mutations to autism spectrum disorder

Iossifov, I., O’Roak, B. J., Sanders, S. J., Ronemus, M., Krumm, N., Levy, D., Stessman, H. A., Witherspoon, K. T., Vives, L., Patterson, K. E., et al. (2014) · Nature · doi:10.1038/nature13908 · Cited by 2,585 · see citing works

Lifeact: a versatile marker to visualize F-actin

Riedl, J., Crevenna, A. H., Kessenbrock, K., Yu, J. H., Neukirchen, D., Bista, M., Bradke, F., Jenne, D., Holak, T. A., Werb, Z., et al. (2008) · Nature Methods · doi:10.1038/nmeth.1220 · Cited by 2,189 · see citing works

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

O’Roak, B. J., Vives, L., Girirajan, S., Karakoc, E., Krumm, N., Coe, B. P., Levy, R., Ko, A., Lee, C., Smith, J. D., et al. (2012) · Nature · doi:10.1038/nature10989 · Cited by 2,165 · see citing works

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

Sanders, S. J., Murtha, M. T., Gupta, A. R., Murdoch, J. D., Raubeson, M. J., Willsey, A. J., Ercan-Sencicek, A. G., DiLullo, N. M., Parikshak, N. N., Stein, J. L., et al. (2012) · Nature · doi:10.1038/nature10945 · Cited by 2,084 · see citing works

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

Darnell, J. C., Van Driesche, S. J., Zhang, C., Hung, K. Y. S., Mele, A., Fraser, C. E., Stone, E. F., Chen, C., Fak, J. J., Chi, S. W., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.013 · Cited by 2,072 · see citing works

Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism

Study, P. A. R. I. S., Jamain, S., Quach, H., Betancur, C., Råstam, M., Colineaux, C., Gillberg, I. C., Soderstrom, H., Giros, B., Leboyer, M., et al. (2003) · Nature Genetics · doi:10.1038/ng1136 · Cited by 1,851 · see citing works

Association between Microdeletion and Microduplication at 16p11.2 and Autism

Weiss, L. A., Shen, Y., Korn, J. M., Arking, D. E., Miller, D. T., Fossdal, R., Saemundsen, E., Stefansson, H., Ferreira, M. A. R., Green, T., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa075974 · Cited by 1,666 · see citing works

Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders

Durand, C. M., Betancur, C., Boeckers, T. M., Bockmann, J., Chaste, P., Fauchereau, F., Nygren, G., Rastam, M., Gillberg, I. C., Anckarsäter, H., et al. (2007) · Nature Genetics · doi:10.1038/ng1933 · Cited by 1,602 · see citing works

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

Peça, J., Feliciano, C., Ting, J. T., Wang, W., Wells, M. F., Venkatraman, T. N., Lascola, C. D., Fu, Z., & Feng, G. (2011) · Nature · doi:10.1038/nature09965 · Cited by 1,570 · see citing works

Prevalence and architecture of de novo mutations in developmental disorders

Study, D. D. D. (2017) · Nature · doi:10.1038/nature21062 · Cited by 1,480 · see citing works

Insights into autism spectrum disorder genomic architecture and biology from 71 risk loci

Sanders, S. J., He, X., Willsey, A. J., Ercan-Sencicek, A. G., Samocha, K. E., Cicek, A. E., Murtha, M. T., Bal, V. H., Bishop, S. L., Dong, S., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.016 · Cited by 1,430 · see citing works

Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders

O’Roak, B. J., Vives, L., Fu, W., Egertson, J. D., Stanaway, I. B., Phelps, I. G., Carvill, G., Kumar, A., Lee, C., Ankenman, K., et al. (2012) · Science · doi:10.1126/science.1227764 · Cited by 1,240 · see citing works

Pten Regulates Neuronal Arborization and Social Interaction in Mice

Kwon, C.-H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., Li, Y., Baker, S. J., & Parada, L. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.023 · Cited by 970 · see citing works

Convergence of genes and cellular pathways dysregulated in autism spectrum disorders

Pinto, D., Delaby, E., Merico, D., Barbosa, M., Merikangas, A., Klei, L., Thiruvahindrapuram, B., Xu, X., Ziman, R., Wang, Z., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.03.018 · Cited by 969 · see citing works

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder

C Yuen, R. K., Merico, D., Bookman, M., L Howe, J., Thiruvahindrapuram, B., Patel, R. V., Whitney, J., Deflaux, N., Bingham, J., Wang, Z., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4524 · Cited by 844 · see citing works

FMRP targets distinct mRNA sequence elements to regulate protein expression

Ascano, M., Mukherjee, N., Bandaru, P., Miller, J. B., Nusbaum, J. D., Corcoran, D. L., Langlois, C., Munschauer, M., Dewell, S., Hafner, M., et al. (2012) · Nature · doi:10.1038/nature11737 · Cited by 701 · see citing works

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

Won, H., Lee, H.-R., Gee, H. Y., Mah, W., Kim, J.-I., Lee, J., Ha, S., Chung, C., Jung, E. S., Cho, Y. S., et al. (2012) · Nature · doi:10.1038/nature11208 · Cited by 695 · see citing works

Hippocampal–prefrontal input supports spatial encoding in working memory

Spellman, T., Rigotti, M., Ahmari, S. E., Fusi, S., Gogos, J. A., & Gordon, J. A. (2015) · Nature · doi:10.1038/nature14445 · Cited by 693 · see citing works

Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2

Schmeisser, M. J., Ey, E., Wegener, S., Bockmann, J., Stempel, A. V., Kuebler, A., Janssen, A.-L., Udvardi, P. T., Shiban, E., Spilker, C., et al. (2012) · Nature · doi:10.1038/nature11015 · Cited by 638 · see citing works

The Ste20 group kinases as regulators of MAP kinase cascades

Dan, I., Watanabe, N. M., & Kusumi, A. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)01980-8 · Cited by 629 · see citing works

Recurrent reciprocal 16p11.2 rearrangements associated with global developmental delay, behavioural problems, dysmorphism, epilepsy, and abnormal head size

Shinawi, M., Liu, P., Kang, S.-H. L., Shen, J., Belmont, J. W., Scott, D. A., Probst, F. J., Craigen, W. J., Graham, B. H., Pursley, A., et al. (2010) · Journal of Medical Genetics · doi:10.1136/jmg.2009.073015 · Cited by 580 · see citing works

Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases

Stessman, H. A. F., Xiong, B., Coe, B. P., Wang, T., Hoekzema, K., Fenckova, M., Kvarnung, M., Gerdts, J., Trinh, S., Cosemans, N., et al. (2017) · Nature Genetics · doi:10.1038/ng.3792 · Cited by 559 · see citing works

Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism

Jamain, S., Radyushkin, K., Hammerschmidt, K., Granon, S., Boretius, S., Varoqueaux, F., Ramanantsoa, N., Gallego, J., Ronnenberg, A., Winter, D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711555105 · Cited by 556 · see citing works

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3

Wang, X., McCoy, P. A., Rodriguiz, R. M., Pan, Y., Je, H. S., Roberts, A. C., Kim, C. J., Berrios, J., Colvin, J. S., Bousquet-Moore, D., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr212 · Cited by 537 · see citing works

Whole-genome sequencing of quartet families with autism spectrum disorder

Yuen, R. K. C., Thiruvahindrapuram, B., Merico, D., Walker, S., Tammimies, K., Hoang, N., Chrysler, C., Nalpathamkalam, T., Pellecchia, G., Liu, Y., et al. (2015) · Nature Medicine · doi:10.1038/nm.3792 · Cited by 514 · see citing works

Projections from neocortex mediate top-down control of memory retrieval

Rajasethupathy, P., Sankaran, S., Marshel, J. H., Kim, C. K., Ferenczi, E., Lee, S. Y., Berndt, A., Ramakrishnan, C., Jaffe, A., Lo, M., et al. (2015) · Nature · doi:10.1038/nature15389 · Cited by 509 · see citing works

22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia

Karayiorgou, M., Simon, T. J., & Gogos, J. A. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2841 · Cited by 474 · see citing works

Detection of Clinically Relevant Genetic Variants in Autism Spectrum Disorder by Whole-Genome Sequencing

Jiang, Y.-H., Yuen, R. K. C., Jin, X., Wang, M., Chen, N., Wu, X., Ju, J., Mei, J., Shi, Y., He, M., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.06.012 · Cited by 474 · see citing works

Altered proliferation and networks in neural cells derived from idiopathic autistic individuals

Marchetto, M. C., Belinson, H., Tian, Y., Freitas, B. C., Fu, C., Vadodaria, K. C., Beltrao-Braga, P. C., Trujillo, C. A., Mendes, A. P. D., Padmanabhan, K., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.95 · Cited by 466 · see citing works

Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments

Etherton, M. R., Blaiss, C. A., Powell, C. M., & Südhof, T. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910297106 · Cited by 447 · see citing works

KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant

Golzio, C., Willer, J., Talkowski, M. E., Oh, E. C., Taniguchi, Y., Jacquemont, S., Reymond, A., Sun, M., Sawa, A., Gusella, J. F., et al. (2012) · Nature · doi:10.1038/nature11091 · Cited by 410 · see citing works

Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses

Clement, J. P., Aceti, M., Creson, T. K., Ozkan, E. D., Shi, Y., Reish, N. J., Almonte, A. G., Miller, B. H., Wiltgen, B. J., Miller, C. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.045 · Cited by 385 · see citing works

Smaller Dendritic Spines, Weaker Synaptic Transmission, but Enhanced Spatial Learning in Mice Lacking Shank1

Hung, A. Y., Futai, K., Sala, C., Valtschanoff, J. G., Ryu, J., Woodworth, M. A., Kidd, F. L., Sung, C. C., Miyakawa, T., Bear, M. F., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3032-07.2008 · Cited by 350 · see citing works

Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function

Etherton, M. R., Földy, C., Sharma, M., Tabuchi, K., Liu, X., Shamloo, M., Malenka, R. C., & Südhof, T. C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111093108 · Cited by 340 · see citing works

Refining the role of de novo protein-truncating variants in neurodevelopmental disorders by using population reference samples

Kosmicki, J. A., Samocha, K. E., Howrigan, D. P., Sanders, S. J., Slowikowski, K., Lek, M., Karczewski, K. J., Cutler, D. J., Devlin, B., Roeder, K., et al. (2017) · Nature Genetics · doi:10.1038/ng.3789 · Cited by 340 · see citing works

Lifeact mice for studying F-actin dynamics

Riedl, J., Flynn, K. C., Raducanu, A., Gärtner, F. C., Beck, G., Bösl, M. R., Bradke, F., Maßberg, S., Aszódi, A., Sixt, M., et al. (2010) · Nature Methods · doi:10.1038/nmeth0310-168 · Cited by 333 · see citing works

Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism

Horev, G., Ellegood, J., Lerch, J. P., Son, Y.-E. E., Muthuswamy, L., Vogel, H., Krieger, A. M., Buja, A., Henkelman, R. M., Wigler, M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114042108 · Cited by 330 · see citing works

A 600 kb deletion syndrome at 16p11.2 leads to energy imbalance and neuropsychiatric disorders

Zufferey, F., Sherr, E. H., Beckmann, N. D., Hanson, E., Maillard, A. M., Hippolyte, L., Macé, A., Ferrari, C., Kutalik, Z., Andrieux, J., et al. (2012) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2012-101203 · Cited by 326 · see citing works

Rapid Golgi Analysis Method for Efficient and Unbiased Classification of Dendritic Spines

Risher, W. C., Ustunkaya, T., Singh Alvarado, J., & Eroglu, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107591 · Cited by 325 · see citing works

Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity

Ellegood, J., Anagnostou, E., Babineau, B. A., Crawley, J. N., Lin, L., Genestine, M., DiCicco-Bloom, E., Lai, J. K. Y., Foster, J. A., Peñagarikano, O., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.98 · Cited by 288 · see citing works

Single Units in the Medial Prefrontal Cortex with Anxiety-Related Firing Patterns Are Preferentially Influenced by Ventral Hippocampal Activity

Adhikari, A., Topiwala, M. A., & Gordon, J. A. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.027 · Cited by 285 · see citing works

Increased Gene Dosage of <i>Ube3a</i> Results in Autism Traits and Decreased Glutamate Synaptic Transmission in Mice

Smith, S. E. P., Zhou, Y.-D., Zhang, G., Jin, Z., Stoppel, D. C., & Anderson, M. P. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002627 · Cited by 267 · see citing works

Behavioral abnormalities and circuit defects in the basal ganglia of a mouse model of 16p11.2 deletion syndrome

Portmann, T., Yang, M., Mao, R., Panagiotakos, G., Ellegood, J., Dolen, G., Bader, P. L., Grueter, B. A., Goold, C., Fisher, E., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.036 · Cited by 245 · see citing works

16p11.2 deletion and duplication: characterizing neurologic phenotypes in a large clinically ascertained cohort

Steinman, K. J., Spence, S. J., Ramocki, M. B., Proud, M. B., Kessler, S. K., Marco, E. J., Green Snyder, L., D'Angelo, D., Chen, Q., Chung, W. K., et al. (2016) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.37820 · Cited by 218 · see citing works

The 16p11.2 locus modulates brain structures common to autism, schizophrenia and obesity

16p11.2 European Consortium, Maillard, A. M., Ruef, A., Pizzagalli, F., Migliavacca, E., Hippolyte, L., Adaszewski, S., Dukart, J., Ferrari, C., Conus, P., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.145 · Cited by 217 · see citing works

Mouse model of Timothy syndrome recapitulates triad of autistic traits

Bader, P. L., Faizi, M., Kim, L. H., Owen, S. F., Tadross, M. R., Alfa, R. W., Bett, G. C. L., Tsien, R. W., Rasmusson, R. L., & Shamloo, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112667108 · Cited by 212 · see citing works

The 16p11.2 Deletion Mouse Model of Autism Exhibits Altered Cortical Progenitor Proliferation and Brain Cytoarchitecture Linked to the ERK MAPK Pathway

Pucilowska, J., Vithayathil, J., Tavares, E. J., Kelly, C., Karlo, J. C., & Landreth, G. E. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4864-13.2015 · Cited by 207 · see citing works

Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes

Gkogkas, C. G., Khoutorsky, A., Cao, R., Jafarnejad, S. M., Prager-Khoutorsky, M., Giannakas, N., Kaminari, A., Fragkouli, A., Nader, K., Price, T. J., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.064 · Cited by 201 · see citing works

Activity-Induced Protocadherin Arcadlin Regulates Dendritic Spine Number by Triggering N-Cadherin Endocytosis via TAO2β and p38 MAP Kinases

Yasuda, S., Tanaka, H., Sugiura, H., Okamura, K., Sakaguchi, T., Tran, U., Takemiya, T., Mizoguchi, A., Yagita, Y., Sakurai, T., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.020 · Cited by 193 · see citing works

Coupled oscillations mediate directed interactions between prefrontal cortex and hippocampus of the neonatal rat

Brockmann, M. D., Pöschel, B., Cichon, N., & Hanganu-Opatz, I. L. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.041 · Cited by 186 · see citing works

Opposing Brain Differences in 16p11.2 Deletion and Duplication Carriers

Qureshi, A. Y., Mueller, S., Snyder, A. Z., Mukherjee, P., Berman, J. I., Roberts, T. P. L., Nagarajan, S. S., Spiro, J. E., Chung, W. K., Sherr, E. H., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1366-14.2014 · Cited by 183 · see citing works

Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex

de Anda, F. C., Rosário, A. L., Durak, O., Tran, T. S., Gräff, J., Meletis, K., Rei, D., Soda, T., Madabhushi, R., Ginty, D. D., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3141 · Cited by 171 · see citing works

Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat

Harony-Nicolas, H., Kay, M., Hoffmann, J. D., Klein, M. E., Bozdagi-Gunal, O., Riad, M., Daskalakis, N. P., Sonar, S., Castillo, P. E., Hof, P. R., et al. (2017) · eLife · doi:10.7554/elife.18904 · Cited by 168 · see citing works

Kctd13 deletion reduces synaptic transmission via increased RhoA

Escamilla, C. O., Filonova, I., Walker, A. K., Xuan, Z. X., Holehonnur, R., Espinosa, F., Liu, S., Thyme, S. B., López-García, I. A., Mendoza, D. B., et al. (2017) · Nature · doi:10.1038/nature24470 · Cited by 165 · see citing works

The PAR-6 Polarity Protein Regulates Dendritic Spine Morphogenesis through p190 RhoGAP and the Rho GTPase

Zhang, H., & Macara, I. G. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.11.020 · Cited by 159 · see citing works

Spatiotemporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cul3-RhoA pathway in psychiatric diseases

Lin, G. N., Corominas, R., Lemmens, I., Yang, X., Tavernier, J., Hill, D. E., Vidal, M., Sebat, J., & Iakoucheva, L. M. (2015) · Neuron · doi:10.1016/j.neuron.2015.01.010 · Cited by 155 · see citing works

CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency

Bidinosti, M., Botta, P., Krüttner, S., Proenca, C. C., Stoehr, N., Bernhard, M., Fruh, I., Mueller, M., Bonenfant, D., Voshol, H., et al. (2016) · Science · doi:10.1126/science.aad5487 · Cited by 151 · see citing works

TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation

Yadav, S., Osés-Prieto, J. A., Peters, C. J., Zhou, J., Pleasure, S. J., Burlingame, A. L., Jan, L. Y., & Jan, Y. N. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.006 · Cited by 139 · see citing works

Biosignaling of mammalian Ste20-related kinases

Ling, P., Lu, T., Yuan, C.-J., et al. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2007.12.019 · Cited by 133 · see citing works

Treatment during a vulnerable developmental period rescues a genetic epilepsy

Marguet, S. L., Le-Schulte, V. T. Q., Merseburg, A., Neu, A., Eichler, R., Jakovcevski, I., Ivanov, A., Hanganu-Opatz, I. L., Bernard, C., Morellini, F., et al. (2015) · Nature Medicine · doi:10.1038/nm.3987 · Cited by 125 · see citing works

Increased CYFIP1 dosage alters cellular and dendritic morphology and dysregulates mTor

Oguro-Ando, A., Rosensweig, C., Herman, E., Nishimura, Y., Werling, D., Bill, B. R., Berg, J. M., Gao, F., Coppola, G., Abrahams, B. S., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.124 · Cited by 117 · see citing works

Aberrant white matter microstructure in children with 16p11.2 deletions

Owen, J. P., Chang, Y. S., Pojman, N. J., Bukshpun, P., Wakahiro, M. L. J., Marco, E. J., Berman, J. I., Spiro, J. E., Chung, W. K., Buckner, R. L., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4495-13.2014 · Cited by 113 · see citing works

Distinct Pathways for Rule-Based Retrieval and Spatial Mapping of Memory Representations in Hippocampal Neurons

Navawongse, R., & Eichenbaum, H. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3891-12.2013 · Cited by 107 · see citing works

Common variant at 16p11.2 conferring risk of psychosis

Steinberg, S., de Jong, S., Mattheisen, M., Costas, J., Demontis, D., Jamain, S., Pietiläinen, O. P. H., Lin, K., Papiol, S., Huttenlocher, J., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2012.157 · Cited by 104 · see citing works

Autism‐Related Neuroligin‐3 Mutation Alters Social Behavior and Spatial Learning

Jaramillo, T. C., Liu, S., Pettersen, A., Birnbaum, S. G., & Powell, C. M. (2014) · Autism Research · doi:10.1002/aur.1362 · Cited by 95 · see citing works

Isolation of the Protein Kinase TAO2 and Identification of Its Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase Binding Domain

Chen, Z., Hutchison, M. R., & Cobb, M. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28803 · Cited by 95 · see citing works

PSK, a Novel STE20-like Kinase Derived from Prostatic Carcinoma That Activates the c-Jun N-terminal Kinase Mitogen-activated Protein Kinase Pathway and Regulates Actin Cytoskeletal Organization

Moore, T. M., Garg, R., Johnson, C., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4311 · Cited by 94 · see citing works

Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R

Freitag, S., Schachner, M., & Morellini, F. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00109-8 · Cited by 93 · see citing works

Spatial memory tasks in rodents: what do they model?

Morellini, F. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1668-9 · Cited by 90 · see citing works

Regulation of Stress-responsive Mitogen-activated Protein (MAP) Kinase Pathways by TAO2

Chen, Z., & Cobb, M. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100681200 · Cited by 84 · see citing works

Reversible, irreversible and effective transverse relaxation rates in normal aging brain at 3T

Sedlacik, J., Boelmans, K., Löbel, U., Holst, B., Siemonsen, S., & Fiehler, J. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.08.051 · Cited by 84 · see citing works

Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.

Dachtler, J., Ivorra, J. L., Rowland, T. E., Lever, C., Rodgers, R. J., & Clapcote, S. J. (2015) · Behavioral Neuroscience · doi:10.1037/bne0000108 · Cited by 83 · see citing works

Reciprocal white matter alterations due to 16p11.2 chromosomal deletions versus duplications

Chang, Y. S., Owen, J. P., Pojman, N. J., Thieu, T., Bukshpun, P., Wakahiro, M. L. J., Marco, E. J., Berman, J. I., Spiro, J. E., Chung, W. K., et al. (2016) · Human Brain Mapping · doi:10.1002/hbm.23211 · Cited by 81 · see citing works

Reversal of dendritic phenotypes in 16p11.2 microduplication mouse model neurons by pharmacological targeting of a network hub

Blizinsky, K. D., Diaz-Castro, B., Forrest, M. P., Schürmann, B., Bach, A. P., Martin-de-Saavedra, M. D., Wang, L., Csernansky, J. G., Duan, J., & Penzes, P. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607014113 · Cited by 76 · see citing works

MST3 Kinase Phosphorylates TAO1/2 to Enable Myosin Va Function in Promoting Spine Synapse Development

Ultanir, S. K., Yadav, S., Hertz, N. T., Oses-Prieto, J. A., Claxton, S., Burlingame, A. L., Shokat, K. M., Jan, L. Y., & Jan, Y.-N. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.025 · Cited by 75 · see citing works

Crystal Structure of the TAO2 Kinase Domain

Zhou, T., Raman, M., Gao, Y., Earnest, S. A., Zhu, C. H., Machius, M., Cobb, M. H., & Goldsmith, E. J. (2004) · Structure · doi:10.1016/j.str.2004.07.021 · Cited by 66 · see citing works

Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2

Aguilar‐Valles, A., Matta‐Camacho, E., Khoutorsky, A., Gkogkas, C. G., Nader, K., Lacaille, J., & Sonenberg, N. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4615-14.2015 · Cited by 62 · see citing works

Thalamic and Entorhinal Network Activity Differently Modulates the Functional Development of Prefrontal–Hippocampal Interactions

Hartung, H., Brockmann, M. D., Pöschel, B., Feo, V. D., & Hanganu‐Opatz, I. L. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3232-15.2016 · Cited by 53 · see citing works

Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38

Yustein, J. T., Xia, L., Kahlenburg, J. M., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206605 · Cited by 53 · see citing works

Structural Comparison of Human Mammalian Ste20-Like Kinases

Record, C. J., Chaikuad, A., Rellos, P., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011905 · Cited by 52 · see citing works

From Shortage to Surge: A Developmental Switch in Hippocampal–Prefrontal Coupling in a Gene–Environment Model of Neuropsychiatric Disorders

Hartung, H., Cichon, N. B., Feo, V. D., Riemann, S., Schildt, S., Lindemann, C., Mulert, C., Gogos, J. A., & Hanganu‐Opatz, I. L. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw274 · Cited by 47 · see citing works

JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse

Berg, J. M., Lee, C., Chen, L., Galvan, L., Cepeda, C., Chen, J. Y., Peñagarikano, O., Stein, J. L., Li, A., Oguro-Ando, A., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.031 · Cited by 45 · see citing works

Prostate-derived Sterile 20-like Kinase 1-α Induces Apoptosis

Zihni, C., Mitsopoulos, C., Tavares, I. A., Baum, B., Ridley, A. J., & Morris, J. D. H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608336200 · Cited by 37 · see citing works

Variations of the Candidate SEZ6L2 Gene on Chromosome 16p11.2 in Patients with Autism Spectrum Disorders and in Human Populations

Konyukh, M., Delorme, R., Chaste, P., Leblond, C. S., Lemière, N., Nygren, G., Anckarsäter, H. S., Råstam, M., Ståhlberg, O., Amsellem, F., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017289 · Cited by 35 · see citing works

Mice Create What–Where–When Hippocampus-Dependent Memories of Unique Experiences

Fellini, L., & Morellini, F. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2280-12.2013 · Cited by 35 · see citing works

Elevated T2-values in MRI of stroke patients shortly after symptom onset do not predict irreversible tissue infarction

Siemonsen, S., Löbel, U., Sedlacik, J., et al. (2012) · Brain · doi:10.1093/brain/aws079 · Cited by 34 · see citing works

Unsupervised classification of neocortical activity patterns in neonatal and pre-juvenile rodents

Cichon, N. B., Denker, M., n, S. G. ⁄., & Hanganu‐Opatz, I. L. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00050 · Cited by 30 · see citing works

Brain MRI abnormalities and spectrum of neurological and clinical findings in three patients with proximal 16p11.2 microduplication

Filges, I., Sparagana, S., Sargent, M., Selby, K., Schlade‐Bartusiak, K., Lueder, G. T., Robichaux‐Viehoever, A., Schlaggar, B. L., Shimony, J. S., & Shinawi, M. (2014) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36605 · Cited by 30 · see citing works

DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants

Kwan, V., Meka, D. P., White, S. H., Hung, C. L.-K., Holzapfel, N. T., Walker, S., Murtaza, N., Unda, B. K., Schwanke, B., Yuen, R. K. C., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.047 · Cited by 30 · see citing works

Taok2 controls behavioral response to ethanol in mice

Kapfhamer, D., Taylor, S., Zou, M. E., et al. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00834.x · Cited by 26 · see citing works

Inositol-1,4,5-trisphosphate-3-kinase-A controls morphology of hippocampal dendritic spines

Köster, J.-D., Leggewie, B., Blechner, C., Brandt, N., Fester, L., Rune, G. M., Schweizer, M., Kindler, S., & Windhorst, S. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.10.016 · Cited by 16 · see citing works

A new tool for the quantitative analysis of dendritic filopodial motility

Tárnok, K., Gulyás, M., Bencsik, N., Ferenc, K., Pfizenmaier, K., Haußer, A., & Schlett, K. (2014) · Cytometry Part A · doi:10.1002/cyto.a.22569 · Cited by 9 · see citing works

Correlation of oxygenation and perfusion sensitive MRI with invasive micro probe measurements in healthy mice brain

Sedlacik, J., Reitz, M., Bolar, D. S., Elfar Adalsteinsson, A., Schmidt, N. O., & Fiehler, J. (2014) · Zeitschrift für Medizinische Physik · doi:10.1016/j.zemedi.2014.01.004 · Cited by 4 · see citing works

Chopped and diced: Dicer1 deletion generates myeloid dysplasia

Barber, D. L. (2012) · Blood · doi:10.1182/blood-2012-04-415034 · Cited by 2 · see citing works

16p11.2 Copy Number Variations and Neurodevelopmental Disorders

Rein, B., & Yan, Z. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.09.001 · Cited by 160 · see citing works

Increased mutation and gene conversion within human segmental duplications

Vollger, M. R., Dishuck, P. C., Harvey, W. T., DeWitt, W. S., Guitart, X., Goldberg, M. E., Rozanski, A. N., Lucas, J., Asri, M., Human Pangenome Reference Consortium, et al. (2023) · Nature · doi:10.1038/s41586-023-05895-y · Cited by 104 · see citing works

16p11 Duplication disrupts hippocampal-orbitofrontal-amygdala connectivity, revealing a neural circuit endophenotype for schizophrenia

Bristow, G. C., Thomson, D. M., Openshaw, R. L., Mitchell, E. J., Pratt, J. A., Dawson, N., & Morris, B. J. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107536 · Cited by 36 · see citing works

Overexpression of RhoA promotes the proliferation and migration of cervical cancer cells

Liu, X., Chen, D., & Liu, G. (2014) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2014.943650 · Cited by 47 · see citing works

Function of the post-translationally modified C-terminal region of rho p21.

Hori, Y. (1992) · PubMed · Cited by 2 · see citing works

Tyr42 phosphorylation of RhoA GTPase promotes tumorigenesis through nuclear factor (NF)-κB

Kim, J.-G., Choi, K.-C., Hong, C.-W., Park, H.-S., Choi, E.-K., Kim, Y.-S., & Park, J.-B. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.07.013 · Cited by 28 · see citing works

Quantitation of RhoA activation: differential binding to downstream effectors

Zhang, Y., Torsilieri, H. M., & Casanova, J. E. (2022) · Small GTPases · doi:10.1080/21541248.2022.2111945 · Cited by 4 · see citing works

RhoA regulates Schwann cell differentiation through JNK pathway

Wen, J., Tan, D., Li, L., Wang, X., Pan, M., & Guo, J. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.06.013 · Cited by 29 · see citing works