Single Units in the Medial Prefrontal Cortex with Anxiety-Related Firing Patterns Are Preferentially Influenced by Ventral Hippocampal Activity
Open accessAbstract
The medial prefrontal cortex (mPFC) and ventral hippocampus (vHPC) functionally interact during innate anxiety tasks. To explore the consequences of this interaction, we examined task-related firing of single units from the mPFC of mice exploring standard and modified versions of the elevated plus maze (EPM), an innate anxiety paradigm. Hippocampal local field potentials (LFPs) were simultaneously monitored. The population of mPFC units distinguished between safe and aversive locations within the maze, regardless of the nature of the anxiogenic stimulus. Strikingly, mPFC units with stronger task-related activity were more strongly coupled to theta-frequency activity in the vHPC LFP. Lastly, task-related activity was inversely correlated with behavioral measures of anxiety. These results clarify the role of the vHPC-mPFC circuit in innate anxiety and underscore how specific inputs may be involved in the generation of behaviorally relevant neural activity within the mPFC.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
vHPC-originating theta rhythms potentially enable the mPFC to construct representations of aversive features in the environment.
“vHPC-originating theta rhythms potentially enable the mPFC to construct representations of aversive features in the environment”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [136]
mPFC neurons with strong task-related responses are strongly coupled to the vHPC theta rhythm.
“mPFC neurons with strong task-related responses are strongly coupled to the vHPC theta rhythm136.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [136]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Pellow, S., & File, S. E. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90552-6 · Cited by 1,534 · see citing works
Regional dissociations within the hippocampus-memory and anxiety
Bannerman, D. M., Rawlins, J. N. P., McHugh, S. B., Deacon, R. M. J., Yee, B. K., Bast, T., Zhang, W.-N., Pothuizen, H. H. J., & Feldon, J. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.004 · Cited by 1,462 · see citing works
Medial Frontal Cortex Mediates Perceptual Attentional Set Shifting in the Rat
Birrell, J. M., & Brown, V. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04320.2000 · Cited by 1,421 · see citing works
A review of the validity and variability of the Elevated Plus-Maze as an animal model of anxiety
Hogg, S. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02126-4 · Cited by 1,169 · see citing works
Theta rhythms coordinate hippocampal-prefrontal interactions in a spatial memory task
Jones, M. W., & Wilson, M. A. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030402 · Cited by 1,036 · see citing works
Prefrontal phase locking to hippocampal theta oscillations
Siapas, A. G., Lubenov, E. V., & Wilson, M. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.028 · Cited by 1,014 · see citing works
Reduced fear expression after lesions of the ventral hippocampus
Kjelstrup, K. G., Tuvnes, F. A., Steffenach, H.-A., Murison, R., Moser, E. I., & Moser, M.-B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152112399 · Cited by 912 · see citing works
Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult
Gross, C. T., Zhuang, X., Stark, K. L., Ramboz, S., Oosting, R. S., Kirby, L. G., Santarelli, L., Beck, S. G., & Hen, R. (2002) · Nature · doi:10.1038/416396a · Cited by 906 · see citing works
Barthó, P., Hirase, H., Monconduit, L., Zugaro, M. B., Harris, K. D., & Buzsáki, G. (2004) · Journal of Neurophysiology · doi:10.1152/jn.01170.2003 · Cited by 888 · see citing works
Ethopharmacological analysis of rat behavior on the elevated plus-maze
Cruz, A. P. D. M., Frei, F., & Graeff, F. G. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90472-3 · Cited by 822 · see citing works
Serotonin receptor 1A knockout: An animal model of anxiety-related disorder
Ramboz, S., Oosting, R. S., Amara, D. A., Kung, H. F., Blier, P., Mendelsohn, M. M., Mann, J. J., Brunner, D., & Hen, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14476 · Cited by 813 · see citing works
Adhikari, A., Topiwala, M. A., & Gordon, J. A. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.002 · Cited by 729 · see citing works
Self-citationImpaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia
Sigurdsson, T., Stark, K. L., Karayiorgou, M., Gogos, J. A., & Gordon, J. A. (2010) · Nature · doi:10.1038/nature08855 · Cited by 702 · see citing works
Self-citationBehavior-dependent short-term assembly dynamics in the medial prefrontal cortex
Fujisawa, S., Amarasingham, A., Harrison, M. T., & Buzsáki, G. (2008) · Nature Neuroscience · doi:10.1038/nn.2134 · Cited by 679 · see citing works
Quantitative measures of cluster quality for use in extracellular recordings
Schmitzer-Torbert, N. C., Jackson, J. C., Henze, D. A., Harris, K., & Redish, A. D. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.09.066 · Cited by 642 · see citing works
The learning curve: implications of a quantitative analysis.
Gallistel, C., Fairhurst, S. P., & Balsam, P. (2004) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0404965101 · Cited by 587 · see citing works
Burgos-Robles, A., Vidal-Gonzalez, I., & Quirk, G. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0378-09.2009 · Cited by 530 · see citing works
Burgos-Robles, A., Vidal-Gonzalez, I., Santini, E., & Quirk, G. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.021 · Cited by 516 · see citing works
Double dissociation of function within the hippocampus: Spatial memory and hyponeophagia.
Bannerman, D. M., Deacon, R. M. J., Offen, S., Friswell, J., Grubb, M. S., & Rawlins, J. N. P. (2002) · Behavioral Neuroscience · doi:10.1037//0735-7044.116.5.884 · Cited by 357 · see citing works
Double dissociation of function within the hippocampus: Spatial memory and hyponeophagia.
Bannerman, D. M., Deacon, R. M. J., Offen, S., Friswell, J., Grubb, M., & Rawlins, J. N. P. (2002) · Behavioral Neuroscience · doi:10.1037/0735-7044.116.5.884 · Cited by 357 · see citing works
Jung, M. W., Qin, Y. F., McNaughton, B. L., & Barnes, C. A. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.5.437 · Cited by 307 · see citing works
Rat Prefrontal Cortical Neurons Selectively Code Strategy Switches
Rich, E. L., & Shapiro, M. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6068-08.2009 · Cited by 253 · see citing works
Kolb, B. E., Nonneman, A. J., & Singh, R. K. (1974) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0036970 · Cited by 252 · see citing works
Shah, A. A., & Treit, D. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02299-6 · Cited by 196 · see citing works
Differential role of the medial and lateral prefrontal cortices in fear and anxiety.
Lacroix, L. P., Spinelli, S., Heidbreder, C. A., & Feldon, J. (2000) · Behavioral Neuroscience · doi:10.1037//0735-7044.114.6.1119 · Cited by 185 · see citing works
Pratt, W. E., & Mizumori, S. J. Y. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00204-2 · Cited by 179 · see citing works
Dissociation of item and order spatial memory in rats following medial prefrontal cortex lesions
Kesner, R. P., & Holbrook, T. H. (1987) · Neuropsychologia · doi:10.1016/0028-3932(87)90056-x · Cited by 173 · see citing works
Increased Fear Response to Contextual Cues in Mice Lacking the 5-HT1A Receptor
Klemenhagen, K. C., Gordon, J. A., David, D. J. P., Hen, R., & Gross, C. T. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300774 · Cited by 167 · see citing works
Self-citationDifferential role of the medial and lateral prefrontal cortices in fear and anxiety.
Lacroix, L. P., Spinelli, S., Heidbreder, C. A., et al. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.6.1119 · Cited by 167 · see citing works
Swerdlow, N. R., BRAFF, D. L., Geyer, M. A., Lipska, B. K., Weinberger, D. R., & Jaskiw, G. E. (1995) · Psychopharmacology · doi:10.1007/bf02246438 · Cited by 164 · see citing works
Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats
Murphy, K., Kubin, Z. J., Shepherd, J. N., & Ettinger, R. H. (2009) · Phytomedicine · doi:10.1016/j.phymed.2009.10.020 · Cited by 162 · see citing works
Identification of the Hippocampal Input to Medial Prefrontal Cortex In Vitro
Parent, M. A., Wang, L., Su, J., Netoff, T. I., & Yuan, L. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp108 · Cited by 149 · see citing works
Effects of medial prefrontal cortex cytotoxic lesions in mice
Deacon, R. M. J., Penny, C., & Rawlins, J. N. P. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00225-5 · Cited by 143 · see citing works
Sullivan, R. M., & Gratton, A. P. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03328-5 · Cited by 142 · see citing works
Using multi-neuron population recordings for neural prosthetics
Chapin, J. K. (2004) · Nature Neuroscience · doi:10.1038/nn1234 · Cited by 138 · see citing works
Melo, F. H. C., Venâncio, E. T., de Sousa, D. P., Fonteles, M. M. D. F., Vasconcelos, S. M. M., Viana, G. S. D. B., & de Sousa, F. C. F. (2009) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2009.00788.x · Cited by 127 · see citing works
Acute effects of bergamot oil on anxiety‐related behaviour and corticosterone level in rats
Saiyudthong, S., & Marsden, C. A. (2010) · Phytotherapy Research · doi:10.1002/ptr.3325 · Cited by 117 · see citing works
Adhikari, A., Sigurdsson, T., Topiwala, M. A., & Gordon, J. A. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.06.019 · Cited by 111 · see citing works
Self-citationMedial Prefrontal Cortex Supports Recollection, But Not Familiarity, in the Rat
Farovik, A., Dupont, L. M., Arce, M., & Eichenbaum, H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3662-08.2008 · Cited by 101 · see citing works
Shah, A. A., Sjovold, T., & Treit, D. (2004) · Brain Research · doi:10.1016/j.brainres.2004.08.061 · Cited by 98 · see citing works
Broersen, L. M., & Uylings, H. B. M. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00312-7 · Cited by 87 · see citing works
Burton, B. G., Hok, V., Save, E., & Poucet, B. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.11.045 · Cited by 86 · see citing works
Shah, A. A., & Treit, D. (2003) · Brain Research · doi:10.1016/j.brainres.2003.10.015 · Cited by 78 · see citing works
Medial prefrontal transection enhances social interaction
Gonzalez, L. E., Rujano, M. A., Tucci, S. A., Paredes, D., Silva, E., Alba, G., & Hernández, L. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02931-0 · Cited by 70 · see citing works
Stern, C. A. J., Monte, F. H. D., Gazarini, L., Carobrez, A. P., & Bertoglio, L. J. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.080 · Cited by 70 · see citing works
Kanegawa, N., Suzuki, C., & Ohinata, K. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.12.008 · Cited by 70 · see citing works
Cacucci, F., Wills, T. J., Lever, C., Giese, K. P., & O'Keefe, J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1704-07.2007 · Cited by 69 · see citing works
Lisboa, S. F. D. S., Stecchini, M. F., Corrêa, F. M. D. A., Guimarães, F. S., & Resstel, L. B. M. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.048 · Cited by 62 · see citing works
Asenapine restores cognitive flexibility in rats with medial prefrontal cortex lesions
Tait, D. S., Marston, H. M., Shahid, M., & Brown, V. J. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1364-8 · Cited by 58 · see citing works
Klein, J., Winter, C., Coquery, N., Heinz, A., Morgenstern, R., Kupsch, A. R., & Juckel, G. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.04.036 · Cited by 57 · see citing works
Anxiolytic-like effect of the monoterpene 1,4-cineole in mice
Gomes, P. B., Feitosa, M. L., Silva, M. I. G., Noronha, E. C., Moura, B. A., Venâncio, E. T., Rios, E. R. V., de Sousa, D. P., Vasconcelos, S. M. M., Fonteles, M. M. D. F., et al. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.05.019 · Cited by 57 · see citing works
Peters, Y. M., O’Donnell, P., & Carelli, R. M. (2005) · Synapse · doi:10.1002/syn.20129 · Cited by 49 · see citing works
Micale, V., Cristino, L., Tamburella, A., Petrosino, S., Leggio, G. M., Drago, F., & Marzo, V. D. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.06.015 · Cited by 44 · see citing works
Characterization of 5-HT1A/1B−/− mice: An animal model sensitive to anxiolytic treatments
Guilloux, J., David, D. J. P., Xia, L., Nguyen, H. T., Rainer, Q., Guiard, B. P., Repérant, C., Deltheil, T., Tóth, M., Hen, R., et al. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.009 · Cited by 44 · see citing works
Isolation of anxiolytic principle from ethanolic root extract of Cardiospermum halicacabum
Kumar, R., Murugananthan, G., Nandakumar, K., & Talwar, S. (2010) · Phytomedicine · doi:10.1016/j.phymed.2010.07.002 · Cited by 41 · see citing works
Taxidis, J., Coomber, B., Mason, R., & Owen, M. R. (2010) · Biological Cybernetics · doi:10.1007/s00422-010-0370-1 · Cited by 34 · see citing works
Evaluation of Anxiolytic-like Effects of Some Short-Acting Benzodiazepine Hypnotics in Mice
Nishino, T., Takeuchi, T., Takechi, K., et al. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08107fp · Cited by 32 · see citing works
Calza, A., Sogliano, C., Santoru, F., Marra, C., Angioni, M. M., Mostallino, M. C., Biggio, G., & Concas, A. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06696.x · Cited by 30 · see citing works
Leggio, G. M., Micale, V., Foll, B. L., Mazzola, C., Nóbrega, J. N., & Drago, F. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.05.006 · Cited by 29 · see citing works
Gemmell, C., Anderson, M. I., & O’Mara, S. M. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00402-8 · Cited by 29 · see citing works
Venâncio, E. T., Rocha, N. F. M., Rios, E. R. V., et al. (2010) · Phytotherapy Research · doi:10.1002/ptr.3274 · Cited by 27 · see citing works
Umathe, S. N., Bhutada, P., Jain, N. S., et al. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328308f1fb · Cited by 23 · see citing works
Comparison of the predictive validity of the mirror chamber and elevated plus maze tests in mice
Paterson, N. E., Iwunze, M., Davis, S. F., Malekiani, S. A., & Hanania, T. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.02.005 · Cited by 18 · see citing works
Maternal fluoxetine treatment decreases behavioral response to dopaminergic drugs in female pups
Favaro, P. D. N., Costa, L. C., & Moreira, E. G. (2008) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2008.05.002 · Cited by 17 · see citing works
Absence of sibutramine effect on spontaneous anxiety in rats
Frassetto, S. S., Alves, I. O., Santos, M. M., Schmidt, A. E. S., Lopes, J. J., de Oliveira, P. A., Vinagre, A. S., & Pereira, P. (2010) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302010000400006 · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Sigurdsson T Stark KL Karayiorgou M Gogos JA Gordon JA 2010b Impaired hippocampal prefrontal synchrony in a genetic mouse model of schizophrenia Nature 464 763 767 20360742 PMC2864584
Cited by
Sorted by citations
Neuronal circuits for fear and anxiety
Tovote, P., Fadok, J. P., & Lüthi, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3945 · Cited by 1,786 · see citing works
The contextual brain: implications for fear conditioning, extinction and psychopathology
Maren, S., Phan, K. L., & Liberzon, I. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3492 · Cited by 1,547 · see citing works
Resolving the neural circuits of anxiety
Calhoon, G. G., & Tye, K. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4101 · Cited by 766 · see citing works
Diverging neural pathways assemble a behavioural state from separable features in anxiety
Kim, S.-Y., Adhikari, A., Lee, S. Y., Marshel, J. H., Kim, C. K., Mallory, C. S., Lo, M., Pak, S., Mattis, J., Lim, B. K., et al. (2013) · Nature · doi:10.1038/nature12018 · Cited by 666 · see citing works
Self-citationPrefrontal entrainment of amygdala activity signals safety in learned fear and innate anxiety
Likhtik, E., Stujenske, J. M., A Topiwala, M., Harris, A. Z., & Gordon, J. A. (2014) · Nature Neuroscience · doi:10.1038/nn.3582 · Cited by 577 · see citing works
Self-citationBLA to vHPC inputs modulate anxiety-related behaviors
Felix-Ortiz, A. C., Beyeler, A., Seo, C., Leppla, C. A., Wildes, C. P., & Tye, K. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.016 · Cited by 592 · see citing works
Encoding of fear learning and memory in distributed neuronal circuits
Herry, C., & Johansen, J. P. (2014) · Nature Neuroscience · doi:10.1038/nn.3869 · Cited by 474 · see citing works
Padilla-Coreano, N., Bolkan, S. S., Pierce, G. M., Blackman, D. R., Hardin, W. D., Garcia-Garcia, A. L., Spellman, T. J., & Gordon, J. A. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.011 · Cited by 463 · see citing works
Self-citationAntibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy
Kondo, A., Shahpasand, K., Mannix, R., Qiu, J., Moncaster, J., Chen, C.-H., Yao, Y., Lin, Y.-M., Driver, J. A., Sun, Y., et al. (2015) · Nature · doi:10.1038/nature14658 · Cited by 445 · see citing works
Hare, B. D., & Duman, R. S. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0685-9 · Cited by 366 · see citing works
Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment
Burgos-Robles, A., Kimchi, E. Y., Izadmehr, E. M., Porzenheim, M. J., Ramos-Guasp, W. A., Nieh, E. H., Felix-Ortiz, A. C., Namburi, P., Leppla, C. A., Presbrey, K. N., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4553 · Cited by 318 · see citing works
Fear and safety engage competing patterns of theta-gamma coupling in the basolateral amygdala
Stujenske, J. M., Likhtik, E., Topiwala, M. A., & Gordon, J. A. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.026 · Cited by 303 · see citing works
Self-citationDistributed circuits underlying anxiety
Adhikari, A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00112 · Cited by 204 · see citing works
Self-citationRichter, M., Murtaza, N., Scharrenberg, R., White, S. H., Johanns, O., Walker, S., Yuen, R. K. C., Schwanke, B., Bedürftig, B., Henis, M., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0025-5 · Cited by 169 · see citing works
Schoenfeld, T. J., Rada, P., Pieruzzini, P. R., Hsueh, B., & Gould, E. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.5352-12.2013 · Cited by 138 · see citing works
Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor
Mikulovic, S., Restrepo, C. E., Siwani, S., Bauer, P., Pupe, S., Tort, A. B. L., Kullander, K., & Leão, R. N. (2018) · Nature Communications · doi:10.1038/s41467-018-05907-w · Cited by 114 · see citing works
Lee, A. T., Cunniff, M. M., See, J. Z., Wilke, S. A., Luongo, F. J., Ellwood, I. T., Ponnavolu, S., & Sohal, V. S. (2019) · Neuron · doi:10.1016/j.neuron.2019.04.001 · Cited by 97 · see citing works
Ruggiero, R. N., Rossignoli, M. T., Marques, D. B., de Sousa, B. M., Romcy-Pereira, R. N., Lopes-Aguiar, C., & Leite, J. P. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.732360 · Cited by 111 · see citing works
Lesting, J., Daldrup, T., Narayanan, V., Himpe, C., Seidenbecher, T., & Pape, H.-C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077707 · Cited by 105 · see citing works
Hippocampal network oscillations at the interplay between innate anxiety and learned fear
Çalışkan, G., & Stork, O. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5109-z · Cited by 72 · see citing works
Rapid Acting Antidepressants in Chronic Stress Models: Molecular and Cellular Mechanisms
Hare, B. D., Ghosal, S., & Duman, R. S. (2017) · Chronic Stress · doi:10.1177/2470547017697317 · Cited by 67 · see citing works
The hippocampus and exploration: dynamically evolving behavior and neural representations
Johnson, A., Varberg, Z., Benhardus, J., Maahs, A., & Schrater, P. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00216 · Cited by 61 · see citing works
Banks, P. J., Burroughs, A. C., Barker, G. R. I., Brown, J. T., Warburton, E. C., & Bashir, Z. I. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512064112 · Cited by 42 · see citing works
Pathways for Contextual Memory: The Primate Hippocampal Pathway to Anterior Cingulate Cortex
Wang, J., John, Y., & Barbas, H. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhaa333 · Cited by 39 · see citing works
Wallis, C. U., Cockcroft, G. J., Cardinal, R. N., Roberts, A. C., & Clarke, H. F. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz015 · Cited by 30 · see citing works
Bidirectional Influence of Limbic GIRK Channel Activation on Innate Avoidance Behavior
Vo, B. N., Marron Fernandez de Velasco, E., Rose, T. R., Oberle, H., Luo, H., Hopkins, C. R., & Wickman, K. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.2787-20.2021 · Cited by 33 · see citing works
Layer-specific input to medial prefrontal cortex is linked to stress susceptibility
Solakoğlu, S. T., Erdener, Ş. E., Gliko, O., Can, A., Sümbül, U., & Eren-Koçak, E. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03258-x · Cited by 5 · see citing works
- Authors
- Adhikari, A., Topiwala, M. A., & Gordon, J. A.
- Affiliations
- Columbia University (US)
- New York State Psychiatric Institute (US)
- Corresponding author
- Gordon, Joshua A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 71
- Issue
- 5
- Pages
- 898-910
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3201792
- OpenAlex
- W2090737759
- Cited by
- 285
- References
- 66
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 30 · 2023: 16 · 2022: 31 · 2021: 32 · 2020: 17 · 2019: 21 · 2018: 16 · 2017: 20 · 2016: 13 · 2015: 20 · 2014: 14 · 2013: 20 · 2012: 5
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- International Mental Health Research Organization
- National Institute of Mental Health (K08 MH098623, R01 MH081958, R01MH081968)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- medial prefrontal cortex, ventral hippocampus, single-unit activity, elevated plus maze, theta oscillations, hippocampal local field potentials, mice
- MeSH terms
- Action Potentials, Afferent Pathways, Animals, Anxiety, Avoidance Learning, Behavior, Animal, Exploratory Behavior, Hippocampus, Light, Male, Motor Activity, Neurons, Receptors, Serotonin, Statistics as Topic, Theta Rhythm, Prefrontal Cortex, Mice, Knockout, Maze Learning, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review