Cited by 285Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Single Units in the Medial Prefrontal Cortex with Anxiety-Related Firing Patterns Are Preferentially Influenced by Ventral Hippocampal Activity

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Adhikari, Avishek, Topiwala, Mihir A., Gordon, Joshua A.·2011·Neuron

Abstract

The medial prefrontal cortex (mPFC) and ventral hippocampus (vHPC) functionally interact during innate anxiety tasks. To explore the consequences of this interaction, we examined task-related firing of single units from the mPFC of mice exploring standard and modified versions of the elevated plus maze (EPM), an innate anxiety paradigm. Hippocampal local field potentials (LFPs) were simultaneously monitored. The population of mPFC units distinguished between safe and aversive locations within the maze, regardless of the nature of the anxiogenic stimulus. Strikingly, mPFC units with stronger task-related activity were more strongly coupled to theta-frequency activity in the vHPC LFP. Lastly, task-related activity was inversely correlated with behavioral measures of anxiety. These results clarify the role of the vHPC-mPFC circuit in innate anxiety and underscore how specific inputs may be involved in the generation of behaviorally relevant neural activity within the mPFC.

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Crossref · 10.1016/j.neuron.2011.07.027

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  • vHPC-originating theta rhythms potentially enable the mPFC to construct representations of aversive features in the environment.

    “vHPC-originating theta rhythms potentially enable the mPFC to construct representations of aversive features in the environment”

    From Resolving the neural circuits of anxiety (2015) · cites this paper as [136]

  • mPFC neurons with strong task-related responses are strongly coupled to the vHPC theta rhythm.

    “mPFC neurons with strong task-related responses are strongly coupled to the vHPC theta rhythm136.”

    From Resolving the neural circuits of anxiety (2015) · cites this paper as [136]

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  1. Sigurdsson T Stark KL Karayiorgou M Gogos JA Gordon JA 2010b Impaired hippocampal prefrontal synchrony in a genetic mouse model of schizophrenia Nature 464 763 767 20360742 PMC2864584

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Authors
Adhikari, A., Topiwala, M. A., & Gordon, J. A.
Affiliations
  • Columbia University (US)
  • New York State Psychiatric Institute (US)
Corresponding author
Gordon, Joshua A.
Venue
Neuron
Publisher
Elsevier BV
Published
2011-09
Volume
71
Issue
5
Pages
898-910
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2090737759
Cited by
285
References
66
Citations by year
2026: 10 · 2025: 19 · 2024: 30 · 2023: 16 · 2022: 31 · 2021: 32 · 2020: 17 · 2019: 21 · 2018: 16 · 2017: 20 · 2016: 13 · 2015: 20 · 2014: 14 · 2013: 20 · 2012: 5
FWCI
6.33
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • International Mental Health Research Organization
  • National Institute of Mental Health (K08 MH098623, R01 MH081958, R01MH081968)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
medial prefrontal cortex, ventral hippocampus, single-unit activity, elevated plus maze, theta oscillations, hippocampal local field potentials, mice
MeSH terms
Action Potentials, Afferent Pathways, Animals, Anxiety, Avoidance Learning, Behavior, Animal, Exploratory Behavior, Hippocampus, Light, Male, Motor Activity, Neurons, Receptors, Serotonin, Statistics as Topic, Theta Rhythm, Prefrontal Cortex, Mice, Knockout, Maze Learning, Mice

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