Reciprocal white matter alterations due to 16p11.2 chromosomal deletions versus duplications
Open accessAbstract
Copy number variants at the 16p11.2 chromosomal locus are associated with several neuropsychiatric disorders, including autism, schizophrenia, bipolar disorder, attention‐deficit hyperactivity disorder, and speech and language disorders. A gene dosage dependence has been suggested, with 16p11.2 deletion carriers demonstrating higher body mass index and head circumference, and 16p11.2 duplication carriers demonstrating lower body mass index and head circumference. Here, we use diffusion tensor imaging to elucidate this reciprocal relationship in white matter organization, showing widespread increases of fractional anisotropy throughout the supratentorial white matter in pediatric deletion carriers and, in contrast, extensive decreases of white matter fractional anisotropy in pediatric and adult duplication carriers. We find associations of these white matter alterations with cognitive and behavioral impairments. We further demonstrate the value of imaging metrics for characterizing the copy number variant phenotype by employing linear discriminant analysis to predict the gene dosage status of the study subjects. These results show an effect of 16p11.2 gene dosage on white matter microstructure, and further suggest that opposite changes in diffusion tensor imaging metrics can lead to similar cognitive and behavioral deficits. Given the large effect sizes found in this study, our results support the view that specific genetic variations are more strongly associated with specific brain alterations than are shared neuropsychiatric diagnoses. Hum Brain Mapp 37:2833–2848, 2016. © 2016 Wiley Periodicals, Inc.
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Self-citation
- Authors
- Chang, Y. S., Owen, J. P., Pojman, N. J., Thieu, T., Bukshpun, P., Wakahiro, M. L. J., Marco, E. J., Berman, J. I., Spiro, J. E., Chung, W. K., Buckner, R. L., Roberts, T. P. L., Nagarajan, S. S., Sherr, E. H., & Mukherjee, P.
- Affiliations
- University of California, San Francisco (US)
- Children's Hospital of Philadelphia (US)
- Simons Foundation (US)
- Columbia University Irving Medical Center (US)
- Harvard University (US)
- Corresponding author
- Mukherjee, Pratik
- ORCID
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2016-05-24
- Volume
- 37
- Issue
- 8
- Pages
- 2833-2848
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6867519
- OpenAlex
- W2407083337
- Cited by
- 81
- References
- 46
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 8 · 2018: 42 · 2017: 5 · 2016: 1
- FWCI
- 15.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Simons Foundation Autism Research Initiative
- National Institute of Mental Health (K23MH083890)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD086984)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- 16p11.2, copy number variation, chromosomal deletion, chromosomal duplication, white matter microstructure, fractional anisotropy, gene dosage, neuropsychiatric disorders, autism spectrum disorder, schizophrenia, bipolar disorder, attention deficit hyperactivity disorder, cognitive and behavioral deficits, linear discriminant analysis
- MeSH terms
- Adolescent, Adult, Brain, Child, Chromosome Deletion, Chromosomes, Human, Pair 16, Female, Heterozygote, Humans, Male, Middle Aged, Gene Dosage, Young Adult, Diffusion Tensor Imaging, Chromosome Duplication, White Matter
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