The gut microbiome regulates the increases in depressive-type behaviors and in inflammatory processes in the ventral hippocampus of stress vulnerable rats

Fast and accurate short read alignment with Burrows-Wheeler transform

Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607

Fast and accurate long-read alignment with Burrows-Wheeler transform.

Li, H., & Durbin, R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp698 · Cited by 12,063

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549

Microglia: a sensor for pathological events in the CNS

Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888

Stress and Depression

Hammen, C. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143938 · Cited by 2,979

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872

The blood-brain barrier/neurovascular unit in health and disease

Hawkins, B. T., & Davis, T. P. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.4 · Cited by 2,661

Gut–brain axis: How the microbiome influences anxiety and depression

Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460 · cited 4×

The Neurocircuitry of Fear, Stress, and Anxiety Disorders

Shin, L. M., & Liberzon, I. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.83 · Cited by 2,083

The Microbiota-Gut-Brain Axis

Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286

The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders

Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857

Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation

Wang, Z., Chen, W.-H., Li, S.-X., He, Z.-M., Zhu, W.-L., Ji, Y.-B., Wang, Z., Zhu, X.-M., Yuan, K., Bao, Y.-P., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01113-1 · Cited by 307

Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

D’Amato, A., Di Cesare Mannelli, L., Lucarini, E., Man, A. L., Le Gall, G., Branca, J. J. V., Ghelardini, C., Amedei, A., Bertelli, E., Regoli, M., et al. (2020) · Microbiome · doi:10.1186/s40168-020-00914-w · Cited by 269

Vagus Nerve and Underlying Impact on the Gut Microbiota-Brain Axis in Behavior and Neurodegenerative Diseases

Han, Y., Wang, B., Gao, H., He, C., Hua, R., Liang, C., Zhang, S., Wang, Y., Xin, S., & Xu, J. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s384949 · Cited by 265

Effect of fecal microbiota transplant on symptoms of psychiatric disorders: a systematic review

Chinna Meyyappan, A., Forth, E., Wallace, C. J. K., & Milev, R. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02654-5 · Cited by 254

Associations between disordered gut microbiota and changes of neurotransmitters and short-chain fatty acids in depressed mice

Wu, M., Tian, T., Mao, Q., Zou, T., Zhou, C., Xie, J., & Chen, J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01038-3 · Cited by 237

The microbiota-immune axis as a central mediator of gut-brain communication

Fung, T. C. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104714 · Cited by 234

The gut microbiome modulates gut–brain axis glycerophospholipid metabolism in a region-specific manner in a nonhuman primate model of depression

Zheng, P., Wu, J., Zhang, H., Perry, S. W., Yin, B., Tan, X., Chai, T., Liang, W., Huang, Y., Li, Y., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0744-2 · Cited by 202

Intestinal epithelial barrier functions in ageing

Branca, J. J. V., Gulisano, M., & Nicoletti, C. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100938 · Cited by 165

Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression

Bertollo, A. G., Santos, C. F., Bagatini, M. D., & Ignácio, Z. M. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1541075 · Cited by 183

Cancer and stress: NextGen strategies

Cui, B., Peng, F., Lu, J., He, B., Su, Q., Luo, H., Deng, Z., Jiang, T., Su, K., Huang, Y., et al. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.11.005 · Cited by 152

Investigating causality with fecal microbiota transplantation in rodents: applications, recommendations and pitfalls

Gheorghe, C. E., Ritz, N. L., Martin, J. A., Wardill, H. R., Cryan, J. F., & Clarke, G. A. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1941711 · Cited by 156

Microbiota‐gut‐brain axis as a regulator of reward processes

García‐Cabrerizo, R., Carbia, C., O’Riordan, K. J., Schellekens, H., & Cryan, J. F. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15284 · Cited by 150

Multi-omics data reveals the disturbance of glycerophospholipid metabolism caused by disordered gut microbiota in depressed mice

Tian, T., Mao, Q., Xie, J., Wang, Y., Shao, W., Zhong, Q., & Chen, J. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.10.002 · Cited by 151

Updated review of research on the gut microbiota and their relation to depression in animals and human beings

Yang, Z., Li, J., Gui, X., Shi, X., Bao, Z., Han, H., & Li, M. D. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0729-1 · Cited by 139

Stress and cancer: The mechanisms of immune dysregulation and management

Liu, Y.-X., Tian, S., Ning, B., Huang, T., Li, Y., & Wei, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1032294 · Cited by 137

Microbiota-brain interactions: Moving toward mechanisms in model organisms

Nagpal, J. K., & Cryan, J. F. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.036 · Cited by 110

Ergothioneine, a metabolite of the gut bacterium Lactobacillus reuteri, protects against stress-induced sleep disturbances

Matsuda, Y., Ozawa, N., Shinozaki, T., Wakabayashi, K.-I., Suzuki, K., Kawano, Y., Ohtsu, I., & Tatebayashi, Y. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0855-1 · Cited by 108

Dectin-1 signaling on colonic γδ T cells promotes psychosocial stress responses

Zhu, X., Sakamoto, S., Ishii, C., Smith, M. D., Ito, K., Obayashi, M., Unger, L., Hasegawa, Y., Kurokawa, S., Kishimoto, T., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01447-8 · Cited by 99

Berberine regulates fecal metabolites to ameliorate 5-fluorouracil induced intestinal mucositis through modulating gut microbiota

Chen, H., Zhang, F., Li, R., Liu, Y., Wang, X., Zhang, X., Xu, C., Li, Y., Guo, Y., & Yao, Q. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109829 · Cited by 98

Purging and the body in the therapeutic use of ayahuasca

Fotiou, E., & Gearin, A. K. (2019) · Social Science & Medicine · doi:10.1016/j.socscimed.2019.112532 · Cited by 102

Volatility as a Concept to Understand the Impact of Stress on the Microbiome

Bastiaanssen, T. F. S., Gururajan, A., van de Wouw, M., Moloney, G. M., Ritz, N. L., Long-Smith, C. M., Wiley, N., Murphy, A., Lyte, J. M., Fouhy, F., et al. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105047 · Cited by 93

Interactions between central nervous system and peripheral metabolic organs

Zeng, W., Yang, F., Shen, W. L., Zhan, C., Zheng, P., & Hu, J. (2022) · Science China Life Sciences · doi:10.1007/s11427-021-2103-5 · Cited by 103

The change of gut microbiota in MDD patients under SSRIs treatment

Shen, Y., Yang, X., Li, G., Gao, J., & Liang, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-94481-1 · Cited by 94

Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway

Shan, B., Ai, Z., Zeng, S., Song, Y., Song, J., Zeng, Q., Liao, Z., Wang, T., Huang, C. C., & Su, D. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104699 · Cited by 86

Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats

Lv, W., Liu, C., Yu, L., Zhou, J., Li, Y., Xiong, Y., Guo, A., Chao, L., Qu, Q., Guang-wei, W., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1241894 · Cited by 85

The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes

Sarubbo, F., Cavallucci, V., & Pani, G. (2022) · Cells · doi:10.3390/cells11030382 · Cited by 89

Posttraumatic stress disorder is associated with altered gut microbiota that modulates cognitive performance in veterans with cirrhosis

Bajaj, J. S., Sikaroodi, M., Fagan, A., Heuman, D. M., Gilles, H., Gavis, E. A., Fuchs, M. A., González‐Maeso, J., Nizam, S., Gillevet, P. M., et al. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00194.2019 · Cited by 84

cAMP-PKA cascade: An outdated topic for depression?

Gao, F., Yang, S., Wang, J., & Zhu, G. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113030 · Cited by 83

Review of microbiota gut brain axis and innate immunity in inflammatory and infective diseases

Yuan, C., He, Y., Xie, K., Feng, L., Gao, S., & Cai, L. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1282431 · Cited by 87

Raw and wine processed Schisandra chinensis attenuate anxiety like behavior via modulating gut microbiota and lipid metabolism pathway

Song, Y., Shan, B., Zeng, S., Zhang, J., Chen, J., Liao, Z., Wang, T., Zeng, Q., He, H., Wei, F.-Q., et al. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113426 · Cited by 77

Multi-strain Probiotic Formulation Reverses Maternal Separation and Chronic Unpredictable Mild Stress-Generated Anxiety- and Depression-like Phenotypes by Modulating Gut Microbiome–Brain Activity in Rats

Dandekar, M. P., Palepu, M. S. K., Satti, S., Jaiswal, Y., Singh, A. A., Dash, S. P., Gajula, S. N. R., & Sonti, R. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00143 · Cited by 75

Gut microbiota determines the social behavior of mice and induces metabolic and inflammatory changes in their adipose tissue

Agranyoni, O., Meninger-Mordechay, S., Uzan-Yulzari, A., Oren, Z., Salmon‐Divon, M., Rodin, D., Raz, O., Koman, I. E., Koren, O., Pinhasov, A., et al. (2021) · npj Biofilms and Microbiomes · doi:10.1038/s41522-021-00193-9 · Cited by 78

Depression phenotype identified by using single nucleotide exact amplicon sequence variants of the human gut microbiome

Stevens, B. R., Roesch, L. F. W., Dobbler, P. T., Russell, J. T., Pepine, C. J., Holbert, R. C., Raizada, M. K., & Triplett, E. W. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0652-5 · Cited by 69

The emerging role of the gut microbiome in posttraumatic stress disorder

Ke, S., Hartmann, J., Ressler, K. J., Liu, Y., & Koenen, K. C. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.09.005 · Cited by 73

Bifidobacterium: a probiotic for the prevention and treatment of depression

Li, J., Wang, J., Wang, M., Zheng, L., Cen, Q., Wang, F., Li, Z., Pang, R., & Zhang, A. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1174800 · Cited by 75

The gut microbiome and neuropsychiatric disorders: implications for attention deficit hyperactivity disorder (ADHD)

Mathee, K., Cickovski, T., Deoraj, A., Stollstorff, M., & Narasimhan, G. (2019) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001112 · Cited by 72

Puerarin ameliorates depression-like behaviors of with chronic unpredictable mild stress mice by remodeling their gut microbiota

Song, X., Wang, W., Ding, S., Liu, X., Wang, Y., & Ma, H. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.04.037 · Cited by 66

Supplementation of Sesamin Alleviates Stress-Induced Behavioral and Psychological Disorders via Reshaping the Gut Microbiota Structure

Wang, Q., Jia, M., Zhao, Y., Yan, H., Pan, J., Yu, H., Yan, S., Dai, X., Liu, X., & Liu, Z. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b03652 · Cited by 69

The relationship between gut microbiota and inflammatory response, learning and memory in mice by sleep deprivation

Zhang, M., Zhang, M., Kou, G., & Li, Y. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1159771 · Cited by 66

Gut microbiota and neuropsychiatric disorders: Implications for neuroendocrine-immune regulation

Ge, T., Yao, X., Zhao, H., Yang, W., Zou, X., Peng, F., Li, B., & Cui, R. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105909 · Cited by 62

Stressed to the Core: Inflammation and Intestinal Permeability Link Stress-Related Gut Microbiota Shifts to Mental Health Outcomes

Madison, A. A., & Bailey, M. T. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.10.014 · Cited by 68

The Gut Microbiome Modulates the Changes in Liver Metabolism and in Inflammatory Processes in the Brain of Chronic Unpredictable Mild Stress Rats

Lv, W.-J., Wu, X.-L., Chen, W.-Q., Li, Y.-F., Zhang, G.-F., Chao, L.-M., Zhou, J.-H., Guo, A., Liu, C., & Guo, S.-N. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7902874 · Cited by 61

Priming of microglia with dysfunctional gut microbiota impairs hippocampal neurogenesis and fosters stress vulnerability of mice

He, H., He, H., Mo, L., You, Z., & Zhang, J. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.10.031 · Cited by 62

A Role of BDNF in the Depression Pathogenesis and a Potential Target as Antidepressant: The Modulator of Stress Sensitivity “Shati/Nat8l-BDNF System” in the Dorsal Striatum

Miyanishi, H., & Nitta, A. (2021) · Pharmaceuticals · doi:10.3390/ph14090889 · Cited by 57

Alterations of the Gut Microbiota in Response to Total Sleep Deprivation and Recovery Sleep in Rats

Wang, Z., Yuan, K., Ji, Y.-B., Li, S.-X., Shi, L., Wang, Z., Zhou, X.-Y., Bao, Y.-P., Xie, W., Han, Y., et al. (2022) · Nature and Science of Sleep · doi:10.2147/nss.s334985 · Cited by 56

Gastrointestinal (non-systemic) antibiotic rifaximin differentially affects chronic stress-induced changes in colon microbiome and gut permeability without effect on behavior

Kuti, D., Winkler, Z., Horváth, K., Juhász, B., Paholcsek, M., Stágel, A., Gulyás, G., Czeglédi, L., Ferenczi, S., & Kovács, K. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.12.004 · Cited by 55

Probiotics Treatment Improves Hippocampal Dependent Cognition in a Rodent Model of Parkinson’s Disease

Xie, C., & Prasad, A. A. (2020) · Microorganisms · doi:10.3390/microorganisms8111661 · Cited by 59

Beyond the lesion site: minocycline augments inflammation and anxiety-like behavior following SCI in rats through action on the gut microbiota

Schmidt, E. K. A., Raposo, P. J. F., Espin, A. T., Fenrich, K. K., & Fouad, K. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02123-0 · Cited by 53

Gut microbiota alterations promote traumatic stress susceptibility associated with p-cresol-induced dopaminergic dysfunctions

Laudani, S., Torrisi, S. A., Alboni, S., Bastiaanssen, T. F. S., Benatti, C., Rivi, V., Moloney, R. D., Fuochi, V., Furneri, P. M., Drago, F., et al. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.11.004 · Cited by 53

Gut Microbiome and Neurodevelopmental Disorders: A Link Yet to Be Disclosed

Iliodromiti, Z., Triantafyllou, A., Tsaousi, M., Pouliakis, A., Petropoulou, C., Sokou, R., Volaki, P., Boutsikou, Τ., & Iacovidou, N. M. (2023) · Microorganisms · doi:10.3390/microorganisms11020487 · Cited by 56

Inflamed brain: Targeting immune changes and inflammation for treatment of depression

Sakamoto, S., Zhu, X., Hasegawa, Y., Karma, S., Obayashi, M., Alway, E., & Kamiya, A. (2021) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13286 · Cited by 51

Impacts of microbiota and its metabolites through gut-brain axis on pathophysiology of major depressive disorder

Chen, C.-Y., Wang, Y., Lei, L., & Zhang, Y. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122815 · Cited by 54

Resilience or susceptibility to traumatic stress: Potential influence of the microbiome

Tanelian, A., Nankova, B. B., Miari, M., Nahvi, R. J., & Sabban, E. L. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100461 · Cited by 52

Review of multi-omics data resources and integrative analysis for human brain disorders

Dong, X., Liu, C., & Dozmorov, M. (2021) · Briefings in Functional Genomics · doi:10.1093/bfgp/elab024 · Cited by 47

The hippocampus in stress susceptibility and resilience: Reviewing molecular and functional markers

Larosa, A., & Wong, T. P. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110601 · Cited by 50

Impact of gut microbiota on neurogenesis and neurological diseases during infancy

Cerdó, T., Diéguez, E., & Campoy, C. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.11.006 · Cited by 47

Butyrate emerges as a crucial effector of Zhi-Zi-Chi decoctions to ameliorate depression via multiple pathways of brain-gut axis

Liu, J., Fang, Y., Cui, L.-X., Wang, Z., Luo, Y., Gao, C., Ge, W., Huang, T., Wen, J., & Zhou, T. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112861 · Cited by 47

Hypericum perforatum L. attenuates depression by regulating Akkermansia muciniphila, tryptophan metabolism and NFκB-NLRP2-Caspase1-IL1β pathway

Jiang, Z., Wang, F., Zhao, Y., Lu, L.-F., Jiang, X., Huang, T., Yang, L., Guo, L., Weng, Z., & Liu, E. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155847 · Cited by 48

Implications of neurogenesis in depression through BDNF: rodent models, regulatory pathways, gut microbiota, and potential therapy

Han, H., Yao, J., Wu, J., Mao, S., Pan, H., Qv, L., Zhu, G., Ren, J., Yu, Y., Xuan, F., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03044-7 · Cited by 46

The emerging roles of neuroactive components produced by gut microbiota

Dezfouli, M. A., Rashidi, S. K., Yazdanfar, N., Khalili, H., Goudarzi, M., Saadi, A., & Kiani, A. A. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-10097-4 · Cited by 46

Gut microbiome promotes mice recovery from stress-induced depression by rescuing hippocampal neurogenesis

He, H., Zhao, Z., Xiao, C., Li, L., Liu, Y., Fu, J., Liao, H., Zhou, T., & Zhang, J. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106396 · Cited by 41

GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway

Hou, X., Rong, C., Wang, F., Liu, X., Sun, Y., & Zhang, H. (2020) · Neural Plasticity · doi:10.1155/2020/8858415 · Cited by 42

Maternal Distress and Offspring Neurodevelopment: Challenges and Opportunities for Pre-clinical Research Models

Fitzgerald, E., Parent, C. I., Kee, M. Z. L., & Meaney, M. J. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.635304 · Cited by 41

Resilience to the effects of social stress on vulnerability to developing drug addiction

Calpe-López, C., Martínez-Caballero, M. Á., García-Pardo, M. P., & Aguilar, M. A. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i1.24 · Cited by 38

Gut Microbial Dysbiosis and Cognitive Impairment in Bipolar Disorder: Current Evidence

Dai, W., Liu, J., Yan, Q., Teng, Z., Li, S., Yuan, H., Huang, J., Xiang, H., Tang, H., Wang, B., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.893567 · Cited by 42

Gut microbiome-derived indole-3-carboxaldehyde regulates stress vulnerability in chronic restraint stress by activating aryl hydrocarbon receptors

Chen, C., Xiao, Q., Wen, Z., Gong, F., Zhan, H., Liu, J., Li, H., & Jiao, Y. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107654 · Cited by 38

Seeking the Psilocybiome: Psychedelics meet the microbiota-gut-brain axis

Kelly, J. R., Clarke, G. A., Harkin, A., Corr, S. C., Galvin, S. D., Pradeep, V., Cryan, J. F., O’Keane, V., & Dinan, T. G. (2022) · International Journal of Clinical and Health Psychology · doi:10.1016/j.ijchp.2022.100349 · Cited by 40

Stress, inflammation, microbiome and depression

Medina-Rodriguez, E. M., Cruz, A. A., Abreu, J. C. D., & Beurel, E. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173561 · Cited by 41

PTSD, Immune System, and Inflammation

Pivac, N., Vuić, B., Šagud, M., Erjavec, G. N., Perković, M. N., Konjevod, M., Tudor, L., Štrac, D. Š., Uzun, S., Kozumplik, O., et al. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_11 · Cited by 38

Decoding the role of the gut microbiome in gut-brain axis, stress-resilience, or stress-susceptibility: A review

Sah, R. K., Nandan, A., Athira, K. V., Prashant, S. K., Sankaran, S., Jose, A., Venkidasamy, B., & Nile, S. H. (2023) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2023.103861 · Cited by 37

The Microbiota‐Gut‐Brain Connection: A New Horizon in Neurological and Neuropsychiatric Disorders

Faysal, M. F., Zehravi, M., Sutradhar, B., Amin, M. A., Shanmugarajan, T. S., Arjun, U. V. N. V., Ethiraj, S., Durairaj, A., Dayalan, G., Ahamad, S. K., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70593 · Cited by 41

The microbiota-gut-brain axis in depression: unraveling the relationships and therapeutic opportunities

Zhu, Z., Cheng, Y., Liu, X., Xu, X., Ding, W., Ling, Z., Liu, J., & Cai, G. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1644160 · Cited by 40

SCI and depression: Does inflammation commandeer the brain?

Brakel, K., & Hook, M. A. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.112977 · Cited by 35

Pick fecal microbiota transplantation to enhance therapy for major depressive disorder

Meng, Y., Sun, J., & Zhang, G. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110860 · Cited by 32

Microbiome response differs among selected lines of Sydney rock oysters to ocean warming and acidification

Scanes, E., Parker, L. M., Seymour, J. R., Siboni, N., King, W. L., Wegner, K. M., Dove, M. C., O’Connor, W. A., & Ross, P. M. (2021) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiab099 · Cited by 31

Benefits of animal models to understand the pathophysiology of depressive disorders

Czéh, B., & Simon, M. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110049 · Cited by 30

Early life environment affects behavior, welfare, gut microbiome composition, and diversity in broiler chickens

de Jong, I. C., Schokker, D., Gunnink, H., van Wijhe, M., & Rebel, J. M. J. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.977359 · Cited by 29

Depression-associated gut microbes, metabolites and clinical trials

Wang, M., Song, Z., Lai, S., Tang, F., Dou, L., & Yang, F. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1292004 · Cited by 32

The gastrointestinal microbiota in the development of ME/CFS: a critical view and potential perspectives

Stallmach, A., Quickert, S., Puta, C., & Reuken, P. A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1352744 · Cited by 30

Microcystis toxin-mediated tumor promotion and toxicity lead to shifts in mouse gut microbiome

Lee, J., Lee, S., Mayta, A., Mrdjen, I., Weghorst, C. M., & Knobloch, T. J. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111204 · Cited by 29

Integrated 16S rDNA, metabolomics, and TNF-α/NF-κB signaling pathway analyses to explain the modulatory effect of Poria cocos aqueous extract on anxiety-like behavior

Zhang, D., Li, H., Luo, X., Liu, D., Wei, Q., & Ye, X. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154300 · Cited by 29

5-Fluorouracil induced dysregulation of the microbiome-gut-brain axis manifesting as depressive like behaviors in rats

Zhang, F., Chen, H., Zhang, R.-X., Liu, Y., Kong, N., Guo, Y., & Xu, M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165884 · Cited by 29

Gut microbiota regulate stress resistance by influencing microglia-neuron interactions in the hippocampus

He, H., He, H., Mo, L., Yuan, Q., Xiao, C., Ma, Q., Yi, S., Zhou, T., You, Z., & Zhang, J. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100729 · Cited by 30

Effect of gut microbiota early in life on aggressive behavior in mice

Watanabe, N., Mikami, K., Hata, T., Kimoto, K., Nishino, R., Akama, F., Yamamoto, K., Sudo, N., Koga, Y., & Matsumoto, H. (2021) · Neuroscience Research · doi:10.1016/j.neures.2021.01.005 · Cited by 28

Implications of gut microbiota dysbiosis and fecal metabolite changes in psychologically stressed mice

Zhang, Y., Zhang, J., Wu, J., Zhu, Q., Chen, C., & Li, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1124454 · Cited by 28

Systemic immunization with altered myelin basic protein peptide produces sustained antidepressant-like effects

Han, Y., Sun, C.-Y., Meng, S., Tabarak, S., Yuan, K., Cao, L., Yan, W., Xu, L., Deng, J., Zhu, W., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0470-9 · Cited by 25

MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress

Chen, Y., An, Q., Yang, S., Chen, Y.-L., Tong, L., & Ji, L.-L. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114154 · Cited by 28

NLRP3-mediated autophagy dysfunction links gut microbiota dysbiosis to tau pathology in chronic sleep deprivation

Zhao, N., 东南大学医学院神经内科, 江. 南. 2., Xiu, C., Chen, Q.-G., Liu, X.-T., Geng, F., Zhu, M., Yan, F., Zhang, Z., Ren, Q., et al. (2024) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2024.085 · Cited by 27

Striatal Shati/Nat8l–BDNF pathways determine the sensitivity to social defeat stress in mice through epigenetic regulation

Miyanishi, H., Muramatsu, S., & Nitta, A. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01033-2 · Cited by 24

Is fecal microbiota transplantation a useful therapeutic intervention for psychiatric disorders? A narrative review of clinical and preclinical evidence

Vasiliu, O. (2022) · Current Medical Research and Opinion · doi:10.1080/03007995.2022.2124071 · Cited by 30

Differences in gut microbiota associated with stress resilience and susceptibility to single prolonged stress in female rodents

Tanelian, A., Nankova, B. B., Cheriyan, A., Arens, C., Hu, F., & Sabban, E. L. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100533 · Cited by 25

Microbiota-Gut-Brain Axis in Major Depression: A New Therapeutic Approach

Kim, I. B., Park, S., & Kim, Y. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_10 · Cited by 27

The gut microbiota attenuates muscle wasting by regulating energy metabolism in chemotherapy-induced malnutrition rats

Chen, H., Xu, C., Zhang, F., Liu, Y., Guo, Y., & Yao, Q. (2020) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-020-04060-w · Cited by 26

Dietary switch to Western diet induces hypothalamic adaptation associated with gut microbiota dysbiosis in rats

Fouesnard, M., Zoppi, J., Pétéra, M., Gléau, L. L., Migné, C., Devime, F., Durand, S., Bénani, A., Chaffron, S., Douard, V., et al. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00796-4 · Cited by 24

A circuit of COCH neurons encodes social-stress-induced anxiety via MTF1 activation of Cacna1h

Jing, W., Zhang, T., Liu, J., Huang, X., Yu, Q., Yu, H., Zhang, Q., Li, H., Deng, M., Zhu, L., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110177 · Cited by 25

Microbiota-Induced Epigenetic Alterations in Depressive Disorders Are Targets for Nutritional and Probiotic Therapies

Nohesara, S., Abdolmaleky, H. M., Zhou, J., & Thiagalingam, S. (2023) · Genes · doi:10.3390/genes14122217 · Cited by 24

Antidepressant-like effects of hyperoside on chronic stress-induced depressive-like behaviors in mice: Gut microbiota and short-chain fatty acids

Song, A., Ru, C., Jiang, J., Qu, H., Wu, Z., Qian, F., Shen, S., Zhang, L., Wang, Z., Zhao, W., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.03.017 · Cited by 24

Interleukin-1α in the ventral hippocampus increases stress vulnerability and inflammation-related processes

Pearson-Leary, J., Eacret, D., & Bhatnagar, S. (2019) · Stress · doi:10.1080/10253890.2019.1673360 · Cited by 22

Implications of the gut microbiota in vulnerability to the social avoidance effects of chronic social defeat in male mice

Szyszkowicz, J. K., Wong, A., Anisman, H., Merali, Z., & Audet, M. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.06.009 · Cited by 97

Disordered gut microbiota and changes in short-chain fatty acids and inflammatory processes in stress-vulnerable mice

Han, W., Zheng, Y., Wang, L., & An, C. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578172 · Cited by 17

Association of lymphoid tissue‐resident commensal bacteria in mice with depressive‐like behaviors induced by chronic social defeat stress

Xie, R., Jiang, P., Li, L., Yu, B., Wang, C., Pan, Y., Rao, J., Wei, W., & Qiao, Y. (2020) · The FASEB Journal · doi:10.1096/fj.201902680rr · Cited by 8

Possible involvement of hippocampal microglia and gut microbiota in susceptibility to chronic social defeat stress inducing depressive-like behaviors

Kamimura, Y. (2020) · The Japanese Society for Neurochemistry

Dynamic alterations of depressive-like behaviors, gut microbiome, and fecal metabolome in social defeat stress mice

Li, H., Liu, P., Sun, T., Li, Y., Wu, J., Huang, Y., Yang, J., Yuan, M., Zhang, J., Yang, J., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03326-2 · Cited by 13